Proteomic strategies for biomarker identification: Progress and challenges

Current Opinion in Molecular Therapeutics

Volumn 2, Issue 6, 2000, Pages 643-650

  Fung, E T ^a   Wright G L , Jr ^a   Dalmasso, E A ^a  

^a CIPHERGEN BIOSYSTEMS INC   (United States)

Author keywords

Biomarker; Electrophoresis; Mass spectrometry; Protein chip; SELDI; Surface enhanced laser desorption ionization

Indexed keywords

PROTEOME;

ARTICLE; DESORPTION; DIAGNOSTIC VALUE; ELECTROPHORESIS; MASS SPECTROMETRY; PROTEIN ANALYSIS;

ANIMALS; BIOLOGICAL MARKERS; BIOTECHNOLOGY; CARDIOVASCULAR DISEASES; COMMUNICABLE DISEASES; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; HUMANS; NEOPLASMS; NERVOUS SYSTEM DISEASES; PROTEOME; TUMOR MARKERS, BIOLOGICAL;

EID: 0034526162     PISSN: 14648431     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Recent advancements in surface-enhanced laser desorption/ionizafion-time of flightmass spectrometry
2. The dynamic range of protein expression: A challenge for proteomic research
3. Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology
4. Activity-based protein profiling: The serine hydrolases
5. Antibody arrays for high-throughput screening of antibody-antigen interactions
6. The potential use of laser capture microdissection to selectively obtain distinct populations of cells for proteomic analysis - Preliminary findings
7. Identification of gel-separated tumor marker proteins by mass spectrometry
8. Proteomic analysis of colonic crypts from normal, multiple intestinal neoplasia and p53-null mice: A comparison with colonic polyps
9. Proteomic analysis of the small intestine and colon epithelia of adenomatous polyposis coli gene-mutant mice by two-dimensional gel electrophorasis
10. Characterization of colonic polyps by two-dimensional gel electrophorasis
11. Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma
12. ProteinChip surface enhanced laser desorpfion/ionnization (SELDI) mass spectrometry: A novel protein biochip technology for detection of prostate cancer biomarkers in complex protein mixtures
13. Identifying the signature proteins of prostate cancer in seminal plasma by SELDI affinity mass spectrometry
14. Rapid protein display profiling of cancer progression directly from human tissue using a protein biochip
15. Characterization of intracellular prostate-specific antigen from laser capture microdissected benign and malignant prostatic epithelium
16. An approach to proteomic analysis of human tumors
17. Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties
18. Studying heart disease using the proteomic approach
19. Comparison of two-dimensional electrophoresis patterns of heat shock protein Hsp27 species in normal and cardiomyopathic hearts
20. Effects of selenium deficiency on the rat myocardial protein pattern - Investigation by two-dimensional gel electrophoresis
21. Changes in myocardial protein expression in pacing-induced canine heart failure
22. Phenotyping apolipoprotein E*3-leiden transgenic mice by two-dimensional polyacrylamide gel electrophoresis and mass spectrometric identification
23. Proteomics in molecular medicine: Applications in central nervous systems disorders
24. A comparative proteome analysis of hippocampal tissue from schizophrenic and Alzheimer's disease individuals
25. Comparative proteome analysis of the hippocampus implicates chromosome 6q in schizophrenia
26. Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder
27. Proteomic analysis of NMDA receptor-adhesion protein signaling complexes
28. Identification of proteins in the postsynaptic density fraction by mass spectrometry
29. Identification of two-dimensionally separated human cerebrospinal fluid proteins by N-terminal sequencing, matrix-assisted laser desorption/ionization mass spectrometry, nanoliquid chrometography-electrospray ionization-time of flight-mass spectrometry, and tandem mass spectrometry
30. Identification of proteins from human cerebrospinal fluid, separated by two-dimensional polyacrylamide gel electrophoresis
31. Detection of complement factor B in the cerebrospinal fluid of patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy disease using two-dimensional gel electrophoresis and mass spectrometry
32. Peptide mapping of i proteins in cerebrospinal fluid utilizing a rapid preparative two-dimensional electrophoretic procedure and matrix-assisted laser desorption/ionization mass spectrometry
33. Proteomics in medical microbiology
34. The analysis of microbial proteomes: Strategies and data exploitation
35. Characterization by two-dimensional gel electrophoresis of host proteins whose synthesis is sustained or stimulated during the course of herpes simplex virus type 1 infection
36. Comparative proteome analysis of Helicobacter pylori
37. Identification of protein vaccine candidates from Helicobacter pylori using a preparative two-dimensionai electrophoretic procedure and mass spectrometry
38. Mass spectrometric identification of mtb81, a novel serological marker for tuberculosis
39. Identification of protein changes in bladder cancer patient urine by ProteinChip SELDI affinity mass spectrometry
40. Rapid serum protein profiling using surface enhanced laser desorption ionization (SELDI): A novel approach to aid with early prostate cancer detection
41. Simultaneous measurement of free, complexed, and total PSA using a novel biochip multipmex SELDI mass spectrometry immunoassay
42. A novel biochip SELDi mass spectrometry immunoassay for quantitation of prostate specific membrane antigen (PSMA) in body fluids