Increased levels of KL-6 and subsequent mortality in patients with interstitial lung diseases

Journal of Internal Medicine

Volumn 260, Issue 5, 2006, Pages 429-434

  Satoh, H ^a   Kurishima, K ^b   Ishikawa, H ^b   Ohtsuka, M ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b TSUKUBA MEDICAL CENTER HOSPITAL   (Japan)

Author keywords

Collagen disease; Idiopathic interstitial pneumonia; Interstitial lung disease; KL 6; Prognostic factor

Indexed keywords

GLYCOPROTEIN; GLYCOPROTEIN KL 6; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; COLLAGEN DISEASE; CONTROLLED STUDY; DISEASE MARKER; ENZYME IMMUNOASSAY; FEMALE; FOLLOW UP; HIGH RISK POPULATION; HUMAN; IDIOPATHIC DISEASE; INTERSTITIAL LUNG DISEASE; LUNG FIBROSIS; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRIORITY JOURNAL; PROGNOSIS; PROTEIN BLOOD LEVEL; RESPIRATORY FAILURE; SURVIVAL RATE;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, NEOPLASM; FEMALE; HUMANS; JAPAN; LUNG DISEASES, INTERSTITIAL; MALE; MIDDLE AGED; MUCIN-1; MUCINS; PROGNOSIS; PROSPECTIVE STUDIES; PULMONARY FIBROSIS; ROC CURVE; SENSITIVITY AND SPECIFICITY; STATISTICS, NONPARAMETRIC; VITAL CAPACITY;

EID: 33750018921     PISSN: 09546820     EISSN: 13652796     Source Type: Journal    
DOI: 10.1111/j.1365-2796.2006.01704.x     Document Type: Article

References (31)

1. Kohno N, Akiyama M, Kyoizumi S et al. Detection of soluble tumor-associated antigens in sera and effusions using novel monoclonal antibodies, KL-3 and KL-6, against lung adenocarcinoma. Jpn J Clin Oncol 1988; 18: 203-16.
2. Bowden DH. Alveolar response to injury. Thorax 1981; 36: 801-4.
3. Kohno N, Kyoizumi S, Awaya Y et al. New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6. Chest 1989; 96: 68-73.
4. Kohno N, Hamada H, Fujioka S et al. Circulating antigen KL-6 and lactate dehydrogenase for monitoring irradiated patients with lung cancer. Chest 1992; 102: 117-22.
5. Inoue Y, Barker E, Daniloff E et al. Pulmonary epithelial cell injury and alveolar-capillary permeability in berylliosis. Am J Respir Crit Care Med 1997; 156: 109-15.
6. Hamada H, Kohno N, Akiyama M et al. Monitoring of serum KL-6 antigen in a patient with radiation pneumonia. Chest 1992; 101: 858-60.
7. Hamada H, Kohno N, Hiwada K. A new serum tumor marker, CAM 123-6, highly specific to pulmonary adenocarcinoma. Jpn J Cancer Res 1994; 85: 211-9.
8. Kohno N, Inoue Y, Hamada H et al. Difference in sero-diagnostic values among KL-6-associated mucins classified as cluster 9 Int J Cancer Suppl 1994; 8: 81-3.
9. Oyama T, Kohno N, Yokoyama A et al. Detection of interstitial pneumonitis in patients with rheumatoid arthritis by measuring circulating levels of KL-6, a human MUC1 mucin. Lung 1997; 175: 379-85.
10. Yokoyama A, Kohno N, Hamada H et al. Circulating KL-6 predicts the outcome of rapidly progressive idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 1998; 158: 1680-4.
11. Fukaya S, Oshima H, Kato K et al. KL-6 as a novel marker for activities of interstitial pneumonia in connective tissue diseases. Rheumatol Int 2000; 19: 223-5.
12. Nakajima H, Harigai M, Hara M et al. KL-6 as a novel serum marker for interstitial pneumonia associated with collagen diseases. J Rheumatol 2000; 27: 1164-70.
13. Arai Y, Obinata K, Sato Y et al. Clinical significance of the serum surfactant protein D and KL-6 levels in patients with measles complicated by interstitial pneumonia. Eur J Pediatr 2001; 160: 425-9.
14. Ohnshi H, Yokoyama A, Kondo K et al. Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases. Am J Respir Crit Care Med 2002; 165: 378-81.
15. Ohnishi H, Yokoyama A, Yasuhara Y et al. Circulating KL-6 levels in patients with drug induced pneumonitis. Thorax 2003; 58: 872-5.
16. Yanaba K, Hasegawa M, Takehara K et al. Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis. J Rheumatol 2004; 31: 1112-20.
17. Hara R, Itami J, Komiyama T et al. Serum levels of KL-6 for predicting the occurrence of radiation pneumonitis after stereotactic radiotherapy for lung cancer. Chest 2004; 125: 340-4.
18. American Thoracic Society/European Respiratory Society. International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. Am J Respir Crit Care Med 2002; 165: 277-304.
19. Arnett FC, Edworthy SM, Bloch DA et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
20. Bohan A, Peter JB. Polymyositis and dermatomyositis. N Engl J Med 1975; 292: 344-7.
21. Subcommittee for Scleroderma Criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Arthritis Rheum 1980; 23: 581-90.
22. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725.
23. Vitali C, Bombardieri S, Jonsson R et al. Classification criteria for Sjögren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 548-54.
24. Kasukawa R, Tojo T, Miyawaki S et al. Preliminary diagnostic criteria for classification of mixed connective tissue disease. In: Kasukawa R, Sharp GC, eds. Mixed Connective Tissue Disease and Anti-nuclear Antibodies. Amsterdam: Elsevier, 1987; 41-7.
25. McNeil BJ, Keller E, Adelstein SJ. Primer on certain elements of decision making. N Engl J Med 1975; 293: 211-5.
26. Kohno N, Awaya Y, Oyama T et al. KL-6, a mucin-like glycoprotein, in bronchoalveolar lavage fluid from patients with interstitial lung disease. Am Rev Respir Dis 1993; 148: 637-42.
27. Takahashi T, Munakata M, Suzuki I et al. Serum and bronchoalveolar fluid KL-6 levels in patients with pulmonary alveolar proteinosis. Am J Respir Crit Care Med 1998; 158: 1294-8.
28. Ishizaka A, Matsuda T, Albertine KH et al. Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol 2004; 286: L1088-94.
29. Sato H, Callister ME, Mumby S et al. KL-6 levels are elevated in plasma from patients with acute respiratory distress syndrome. Eur Respir J 2004; 23: 142-5.
30. Narita M, Nakayama M, Yamada S et al. Elevated KL-6 levels in fatal measles pneumonia. Eur J Pediatr 2001; 160: 454-5.
31. Goto K, Kodama T, Sekine I et al. Serum levels of KL-6 are useful biomarkers for severe radiation pneumonitis. Lung Cancer 2001; 34: 141-8.