TRAIL-induced programmed necrosis as a novel approach to eliminate tumor cells

BMC Cancer

Volumn 14, Issue 1, 2014, Pages

  Voigt, Susann ^a   Philipp, Stephan ^a   Davarnia, Parvin ^a   Winoto Morbach, Supandi ^a   Röder, Christian ^a   Arenz, Christoph ^b   Trauzold, Anna ^a   Kabelitz, Dieter ^a   Schütze, Stefan ^a   Kalthoff, Holger ^a   Adam, Dieter ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Ceramide; Chemotherapy; Programmed necrosis; TNF; TRAIL

Indexed keywords

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL DEATH; FLOW CYTOMETRY; GENE EXPRESSION REGULATION, NEOPLASTIC; HT29 CELLS; HUMANS; NECROSIS; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; U937 CELLS;

EID: 84893659543     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-74     Document Type: Article

References (40)

1. Degterev A, Yuan J. Expansion and evolution of cell death programmes. Nat Rev Mol Cell Biol 2008, 9:378-390. 10.1038/nrm2393, 18414491.
2. Vercammen D, Beyaert R, Denecker G, Goossens V, van Loo G, Declercq W, Grooten J, Fiers W, Vandenabeele P. Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor. J Exp Med 1998, 187:1477-1485. 10.1084/jem.187.9.1477, 2212268, 9565639.
3. Thon L, Möhlig H, Mathieu S, Lange A, Bulanova E, Winoto-Morbach S, Schütze S, Bulfone-Paus S, Adam D. Ceramide mediates caspase-independent programmed cell death. FASEB J 2005, 19:1945-1956. 10.1096/fj.05-3726com, 16319138.
4. Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol 2010, 11:700-714. 10.1038/nrm2970, 20823910.
5. Mocarski ES, Upton JW, Kaiser WJ. Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways. Nat Rev Immunol 2012, 12:79-88.
6. Strelow A, Bernardo K, Adam-Klages S, Linke T, Sandhoff K, Krönke M, Adam D. Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death. J Exp Med 2000, 192:601-611. 10.1084/jem.192.5.601, 2193270, 10974027.
7. Thon L, Mathieu S, Kabelitz D, Adam D. The murine TRAIL receptor signals caspase-independent cell death through ceramide. Exp Cell Res 2006, 312:3808-3821. 10.1016/j.yexcr.2006.08.017, 17026999.
8. Huang WC, Chen CL, Lin YS, Lin CF. Apoptotic sphingolipid ceramide in cancer therapy. J Lipids 2011, 2011:565316. 3066853, 21490804.
9. Hellwig CT, Rehm M. TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies. Mol Cancer Ther 2012, 11:3-13.
10. Guo Y, Chen C, Zheng Y, Zhang J, Tao X, Liu S, Zheng D, Liu Y. A novel anti-human DR5 monoclonal antibody with tumoricidal activity induces caspase-dependent and caspase-independent cell death. J Biol Chem 2005, 280:41940-41952. 10.1074/jbc.M503621200, 16234248.
11. Roth AG, Drescher D, Yang Y, Redmer S, Uhlig S, Arenz C. Potent and selective inhibition of acid sphingomyelinase by bisphosphonates. Angew Chem Int Ed Engl 2009, 48:7560-7563. 10.1002/anie.200903288, 19746379.
12. Samapati R, Yang Y, Yin J, Stoerger C, Arenz C, Dietrich A, Gudermann T, Adam D, Wu S, Freichel M, et al. Lung endothelial Ca2+ and permeability response to platelet-activating factor is mediated by acid sphingomyelinase and transient receptor potential classical 6. Am J Resp Crit Care Med 2012, 185:160-170. 10.1164/rccm.201104-0717OC, 22246702.
13. Egberts JH, Schniewind B, Schafmayer C, Kruse ML, Sipos B, Fändrich F, Kalthoff H, Tepel J. Establishment of a novel orthotopic xenograft model of human gallbladder carcinoma. Clin Exp Metastasis 2007, 24:141-148. 10.1007/s10585-007-9058-x, 17406986.
14. Sipos B, Möser S, Kalthoff H, Török V, Löhr M, Klöppel G. A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform. Virchows Arch 2003, 442:444-452.
15. Kurdow R, Schniewind B, Zoefelt S, Boenicke L, Boehle AS, Dohrmann P, Kalthoff H. Apoptosis by gemcitabine in non-small cell lung cancer cell line KNS62 is induced downstream of caspase 8 and is profoundly blocked by Bcl-xL over-expression. Langenbecks Arch Surg 2005, 390:243-248. 10.1007/s00423-004-0531-6, 15726400.
16. Juhl H, Helmig F, Baltzer K, Kalthoff H, Henne-Bruns D, Kremer B. Frequent expression of complement resistance factors CD46, CD55, and CD59 on gastrointestinal cancer cells limits the therapeutic potential of monoclonal antibody 17-1A. J Surg Oncol 1997, 64:222-230. 10.1002/(SICI)1096-9098(199703)64:3<222::AID-JSO9>3.0.CO;2-C, 9121154.
17. Sosna J, Voigt S, Mathieu S, Lange A, Thon L, Davarnia P, Herdegen T, Linkermann A, Rittger A, Chan FK, et al. TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. Cell Mol Life Sci 2014, 71:331-348. 10.1007/s00018-013-1381-6, 3889832, 23760205.
18. Bligh V, Dyer WJ. A rapid method of total lipid extraction. Can Biochem J Physiol 1959, 37:911-917.
19. Franken NA, Rodermond HM, Stap J, Haveman J, van Bree C. Clonogenic assay of cells in vitro. Nat Protoc 2006, 1:2315-2319. 10.1038/nprot.2006.339, 17406473.
20. Kaczmarek A, Vandenabeele P, Krysko DV. Necroptosis: the release of damage-associated molecular patterns and its physiological relevance. Immunity 2013, 38:209-223. 10.1016/j.immuni.2013.02.003, 23438821.
21. Sosna J, Voigt S, Mathieu S, Kabelitz D, Trad A, Janssen O, Meyer-Schwesinger C, Schütze S, Adam D. The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. Cell Commun Signal 2013, 11:76. 10.1186/1478-811X-11-76, 3850939, 24090154.
22. He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-alpha. Cell 2009, 137:1100-1111. 10.1016/j.cell.2009.05.021, 19524512.
23. Aggarwal BB, Natarajan K. Tumor necrosis factors - developments during the last decade. Eur Cytokine Netw 1996, 7:93-124.
24. Chan FK, Baehrecke EH. RIP3 finds partners in crime. Cell 2012, 148:17-18. 10.1016/j.cell.2011.12.020, 3571655, 22265396.
25. Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X. Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase. Cell 2012, 148:213-227. 10.1016/j.cell.2011.11.031, 22265413.
26. Zhao J, Jitkaew S, Cai Z, Choksi S, Li Q, Luo J, Liu ZG. Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis. Proc Natl Acad Sci U S A 2012, 109:5322-5327. 10.1073/pnas.1200012109, 3325682, 22421439.
27. Wu J, Huang Z, Ren J, Zhang Z, He P, Li Y, Ma J, Chen W, Zhang Y, Zhou X, et al. Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis. Cell Res 2013, 23:994-1006. 10.1038/cr.2013.91, 3731568, 23835476.
28. Festjens N, Vanden Berghe T, Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim Biophys Acta 2006, 1757:1371-1387. 10.1016/j.bbabio.2006.06.014, 16950166.
29. Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J. RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science 2009, 325:332-336. 10.1126/science.1172308, 19498109.
30. Linkermann A, Bräsen JH, Himmerkus N, Liu S, Huber TB, Kunzendorf U, Krautwald S. Rip1 (receptor-interacting protein kinase 1) mediates necroptosis and contributes to renal ischemia/reperfusion injury. Kidney Int 2012, 81:751-761. 10.1038/ki.2011.450, 22237751.
31. Cho YS, Challa S, Moquin D, Genga R, Ray TD, Guildford M, Chan FK. Phosphorylation-driven assembly of the RIP1-RIP3 complex regulates programmed necrosis and virus-induced inflammation. Cell 2009, 137:1112-1123. 10.1016/j.cell.2009.05.037, 2727676, 19524513.
32. Kumar A, Eby MT, Sinha S, Jasmin A, Chaudhary PM. The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. J Biol Chem 2001, 276:2668-2677. 10.1074/jbc.M008356200, 11035039.
33. Jouan-Lanhouet S, Arshad MI, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, Takahashi N, Sergent O, Lagadic-Gossmann D, Vandenabeele P, et al. TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation. Cell Death Differ 2012, 19:2003-2014. 10.1038/cdd.2012.90, 3504714, 22814620.
34. Meurette O, Rebillard A, Huc L, Le Moigne G, Merino D, Micheau O, Lagadic-Gossmann D, Dimanche-Boitrel MT. TRAIL induces receptor-interacting protein 1-dependent and caspase-dependent necrosis-like cell death under acidic extracellular conditions. Cancer Res 2007, 67:218-226. 10.1158/0008-5472.CAN-06-1610, 17210702.
35. Hunter TB, Manimala NJ, Luddy KA, Catlin T, Antonia SJ. Paclitaxel and TRAIL synergize to kill paclitaxel-resistant small cell lung cancer cells through a caspase-independent mechanism mediated through AIF. Anticancer Res 2011, 31:3193-3204.
36. Engel JB, Martens T, Hahne JC, Häusler SF, Krockenberger M, Segerer S, Djakovic A, Meyer S, Dietl J, Wischhusen J, Honig A. Effects of lobaplatin as a single agent and in combination with TRAIL on the growth of triple-negative p53-mutated breast cancers in vitro. Anticancer Drugs 2012, 23:426-436. 10.1097/CAD.0b013e32834fb8ce, 22314264.
37. Katz SI, Zhou L, Chao G, Smith CD, Ferrara T, Wang W, Dicker DT, El-Deiry WS. Sorafenib inhibits ERK1/2 and MCL-1(L) phosphorylation levels resulting in caspase-independent cell death in malignant pleural mesothelioma. Cancer Biol Ther 2009, 8:2406-2416. 10.4161/cbt.8.24.10824, 3052759, 20038816.
38. Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, et al. Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 2000, 6:797-801. 10.1038/77528, 10888929.
39. Li M, Ona VO, Guégan C, Chen M, Jackson-Lewis V, Andrews LJ, Olszewski AJ, Stieg PE, Lee JP, Przedborski S, Friedlander RM. Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science 2000, 288:335-339. 10.1126/science.288.5464.335, 10764647.
40. Cauwels A, Janssen B, Waeytens A, Cuvelier C, Brouckaert P. Caspase inhibition causes hyperacute tumor necrosis factor-induced shock via oxidative stress and phospholipase A2. Nat Immunol 2003, 4:387-393. 10.1038/ni914, 12652297.