Apoptosis by gemcitabine in non-small cell lung cancer cell line KNS62 is induced downstream of caspase 8 and is profoundly blocked by Bcl-xL over-expression

Langenbeck's Archives of Surgery

Volumn 390, Issue 3, 2005, Pages 243-248

  Kurdow, R ^a   Schniewind, B ^a   Zoefelt, S ^a   Boenicke, L ^a   Boehle, A S ^a   Dohrmann, P ^a   Kalthoff, H ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Bcl xL; Caspases; Chemotherapy; Drug resistance; Lung cancer

Indexed keywords

BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; FAS ANTIGEN; GEMCITABINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BCL XL;

ANALYTIC METHOD; APOPTOSIS; ARTICLE; CELL CLONE; CELL MEMBRANE POTENTIAL; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME SUBSTRATE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE; ORTHOTOPIC TRANSPLANTATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; STAINING; TUMOR VOLUME; XENOTRANSPLANTATION;

ANIMALS; ANTIGENS, CD95; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BCL-X PROTEIN; CARCINOMA, NON-SMALL-CELL LUNG; CASPASE 8; CASPASES; CELL LINE, TUMOR; DEOXYCYTIDINE; DNA FRAGMENTATION; FEMALE; HUMANS; IMMUNOBLOTTING; LUNG NEOPLASMS; MICE; MICE, SCID; TRANSPLANTATION, HETEROLOGOUS;

EID: 21244496347     PISSN: 14352443     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00423-004-0531-6     Document Type: Article

References (21)

1. Hickman JA (1992) Apoptosis induced by anticancer drugs. Cancer Metastasis Rev 11:121-139
2. Holzman D (1996) Apoptosis provides new targets for chemotherapy. J Natl Cancer Inst 88:1098-1100
3. Hinz S, Trauzold A, Boenicke L, Sandberg C, Beckmann S, Bayer E, Walczak H, Kalthoff H, Ungefroren H (2000) Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis. Oncogene 19:5477-5486
4. Kurdow R, Boehle AS, Haye S, Boenicke L, Schniewind B, Dohrmann P, Kalthoff H (2002) Ganciclovir prodrug therapy is effective in a murine xenotransplant model of human lung cancer. Ann Thorac Surg 73:905-910
5. Tomayko MM, Reynolds CP (1989) Determination of subcutaneous tumor size in athymic (nude) mice. Cancer Chemother Pharmacol 24:148-154
6. Friesen C, Herr I, Krammer PH, Debatin KM (1996) Involvement of the CD95 (APO-1/FAS) receptor/ligand system in drug-induced apoptosis in leukemia cells. Nat Med 2:574-577
7. Shao RG, Cao CX, Nieves-Neira W, Dimanche-Boitrel MT, Solary E, Pommier Y (2001) Activation of the Fas pathway independently of Fas ligand during apoptosis induced by camptothecin in p53 mutant human colon carcinoma cells. Oncogene 20:1852-1859
8. Fulda S, Meyer E, Friesen C, Susin SA, Kroemer G, Debatin KM (2001) Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene 20:1063-1075
9. Wu XX, Mizutani Y, Kakehi Y, Yoshida O, Ogawa O (2000) Enhancement of Fas-mediated apoptosis in renal cell carcinoma cells by adriamycin. Cancer Res 60:2912-2918
10. Martins LM, Mesner PW, Kottke TJ, Basi GS, Sinha S, Tung JS, Svingen PA, Madden BJ, Takahashi A, McCormick DJ, Earnshaw WC, Kaufmann SH (1997) Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis. Blood 90:4283-4296
11. Perkins CL, Fang G, Kim CN, Bhalla KN (2000) The role of Apaf-1, caspase-9, and bid proteins in etoposide- or paclitaxel-induced mitochondrial events during apoptosis. Cancer Res 60:1645-1653
12. Ferreira CG, Span SW, Peters GJ, Kruyt FA, Giaccone G (2000) Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res 60:7133-7141
13. Nabhan C, Gajria D, Krett NL, Gandhi V, Ghias K, Rosen ST (2002) Caspase activation is required for gemcitabine activity in multiple myeloma cell lines. Mol Cancer Ther 1:1221-1227
14. Scaffidi C, Fulda S, Srinivasan A, Friesen C, Li F, Tomaselli KJ, Debatin KM, Krammer PH, Peter ME (1998) Two CD95 (APO-1/Fas) signaling pathways. EMBO J 17:1675-1687
15. Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-1911
16. Narita M, Shimizu S, Ito T, Chittenden T, Lutz RJ, Matsuda H, Tsujimoto Y (1998) Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria. Proc Natl Acad Sci U S A 95:14681-14686
17. Leech SH, Olie RA, Gautschi O, Simoes-Wust AP, Tschopp S, Haner R, Hall J, Stahel RA, Zangemeister-Wittke U (2000) Induction of apoptosis in lung-cancer cells following Bcl-xL anti-sense treatment. Int J Cancer 86:570-576
18. Dallaporta B, Pablo M, Maisse C, Daugas E, Loeffler M, Zamzami N, Kroemer G (2000) Proteasome activation as a critical event of thymocyte apoptosis. Cell Death Differ 7:368-373
19. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM, Kroemer G (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397:441-446
20. Liu T, Brouha B, Grossman D (2004) Rapid induction of mitochondrial events and caspase-independent apoptosis in Survivin-targeted melanoma cells. Oncogene 23:39-48
21. Nicotera P, Melino G (2004) Regulation of the apoptosis-necrosis switch. Oncogene 23:2757-2765