Mechanistic insights into mode of action of potent natural antagonists of BACE-1 for checking Alzheimer's plaque pathology

Biochemical and Biophysical Research Communications

Volumn 443, Issue 3, 2014, Pages 1054-1059

  Dhanjal, Jaspreet Kaur ^a   Goyal, Sukriti ^b   Sharma, Sudhanshu ^c   Hamid, Rabia ^d   Grover, Abhinav ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

^b BANASTHALI UNIVERSITY   (India)

^c DELHI TECHNOLOGICAL UNIVERSITY   (India)

^d UNIVERSITY OF KASHMIR   (India)

Author keywords

Alzheimer's; BACE 1; Docking; High throughput virtual screening; Molecular dynamics simulation; Natural compound

Indexed keywords

2 [AMINO(2,2,2 TRIAMINOETHYL)AMINO]ETHANE 1,1,1 TRIAMINE; ASPARTIC PROTEINASE INHIBITOR; BETA SECRETASE 1; NATURAL PRODUCT; NOOTROPIC AGENT; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HIGH THROUGHPUT SCREENING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; PRIORITY JOURNAL;

ALZHEIMER'S; BACE-1; DOCKING; HIGH THROUGHPUT VIRTUAL SCREENING; MOLECULAR DYNAMICS SIMULATION; NATURAL COMPOUND;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; BINDING SITES; BIOCATALYSIS; BIOLOGICAL PRODUCTS; DATABASES, CHEMICAL; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PLAQUE, AMYLOID; REPRODUCIBILITY OF RESULTS; USER-COMPUTER INTERFACE;

EID: 84893651449     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.12.088     Document Type: Article

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