Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1843, Issue 4, 2014, Pages 685-693

  Sharoar, Md Golam ^a,b   Islam, Md Imamul ^a   Shahnawaz, Md ^a,c   Shin, Song Yub ^a   Park, Il Seon ^a  

^a Chosun University   (South Korea)

^b UNIVERSITY OF RAJSHAHI   (Bangladesh)

^c UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

Amyloid ; Apoptosis; Apoptosome; Caspase; Intrinsic apoptosis pathway

Indexed keywords

AMYLOID BETA PROTEIN; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; PROCASPASE 9; STAUROSPORINE;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION;

AMYLOID-Β; APOPTOSIS; APOPTOSOME; CASPASE; INTRINSIC APOPTOSIS PATHWAY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; APOPTOSIS; APOPTOSOMES; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CELL-FREE SYSTEM; HELA CELLS; HUMANS; PROTEIN BINDING; SIGNAL TRANSDUCTION; STAUROSPORINE;

EID: 84893479087     PISSN: 01674889     EISSN: 18792596     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2014.01.008     Document Type: Article

References (45)

1. Esler W.P., Wolfe M.S. A portrait of Alzheimer secretases-new features and familiar faces. Science 2001, 293:1449-1454.
2. Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002, 297:353-356.
3. Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 2004, 430:631-639.
4. Price D.L., Sisodia S.S., Gandy S.E. Amyloid beta amyloidosis in Alzheimer's disease. Curr. Opin. Neurol. 1995, 8:268-274.
5. Kayed R., Head E., Thompson J.L., McIntire T.M., Milton S.C., Cotman C.W., Glabe C.G. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003, 300:486-489.
6. Neudecker P., Robustelli P., Cavalli A., Walsh P., Lundstrom P., Zarrine-Afsar A., Sharpe S., Vendruscolo M., Kay L.E. Structure of an intermediate state in protein folding and aggregation. Science 2012, 336:362-366.
7. Walsh D.M., Selkoe D.J. A beta oligomers - a decade of discovery. J. Neurochem. 2007, 101:1172-1184.
8. Duyckaerts C., Delatour B., Potier M.C. Classification and basic pathology of Alzheimer disease. Acta Neuropathol. 2009, 118:5-36.
9. Olzscha H., Schermann S.M., Woerner A.C., Pinkert S., Hecht M.H., Tartaglia G.G., Vendruscolo M., Hayer-Hartl M., Hartl F.U., Vabulas R.M. Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell 2008, 144:67-78.
10. Troy C.M., Friedman J.E., Friedman W.J. Mechanisms of p75-mediated death of hippocampal neurons. Role of caspases. J. Biol. Chem. 2002, 277:34295-34302.
11. Truzzi F., Marconi A., Atzei P., Panza M.C., Lotti R., Dallaglio K., Tiberio R., Palazzo E., Vaschieri C., Pincelli C. p75 neurotrophin receptor mediates apoptosis in transit-amplifying cells and its overexpression restores cell death in psoriatic keratinocytes. Cell Death Differ. 2011, 18:948-958.
12. Hernandez-Zimbron L.F., Luna-Munoz J., Mena R., Vazquez-Ramirez R., Kubli-Garfias C., Cribbs D.H., Manoutcharian K., Gevorkian G. Amyloid-beta peptide binds to cytochrome C oxidase subunit 1. PLoS One 2012, 7:e42344.
13. Lustbader J.W., Cirilli M., Lin C., Xu H.W., Takuma K., Wang N., Caspersen C., Chen X., Pollak S., Chaney M., Trinchese F., Liu S., Gunn-Moore F., Lue L.F., Walker D.G., Kuppusamy P., Zewier Z.L., Arancio O., Stern D., Yan S.S., Wu H. ABAD directly links Abeta to mitochondrial toxicity in Alzheimer's disease. Science 2004, 304:448-452.
14. Swerdlow R.H. Brain aging, Alzheimer's disease, and mitochondria. Biochim. Biophys. Acta 2011, 1812:1630-1639.
15. Liu T., Roh S.E., Woo J.A., Ryu H., Kang D.E. Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis. Cell Death Dis. 2013, 4:e476.
16. Hong Y.K., Lee S., Park S.H., Lee J.H., Han S.Y., Kim S.T., Kim Y.K., Jeon S., Koo B.S., Cho K.S. Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model. Biochem. Biophys. Res. Commun. 2012, 419:49-53.
17. Chong Y.H., Shin Y.J., Lee E.O., Kayed R., Glabe C.G., Tenner A.J. ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures. J. Biol. Chem. 2006, 281:20315-20325.
18. Ellerby L.M., Orr H.T. Neurodegenerative disease: cut to the chase. Nature 2006, 442:641-642.
19. Nikolaev A., McLaughlin T., O'Leary D.D., Tessier-Lavigne M. APP binds DR6 to trigger axon pruning and neuron death via distinct caspases. Nature 2009, 457:981-989.
20. Picone P., Carrotta R., Montana G., Nobile M.R., San Biagio P.L., Di Carlo M. Abeta oligomers and fibrillar aggregates induce different apoptotic pathways in LAN5 neuroblastoma cell cultures. Biophys. J. 2009, 96:4200-4211.
21. Fossati S., Ghiso J., Rostagno A. Insights into caspase-mediated apoptotic pathways induced by amyloid-beta in cerebral microvascular endothelial cells. Neurodegener. Dis. 2012, 10:324-328.
22. Lee do Y., Lee K.S., Lee H.J., Kim do H., Noh Y.H., Yu K., Jung H.Y., Lee S.H., Lee J.Y., Youn Y.C., Jeong Y., Kim D.K., Lee W.B., Kim S.S. Activation of PERK signaling attenuates Abeta-mediated ER stress. PLoS One 2010, 5:e10489.
23. Reubold T.F., Eschenburg S. A molecular view on signal transduction by the apoptosome. Cell. Signal. 2012, 24:1420-1425.
24. Karki P., Seong C., Kim J.E., Hur K., Shin S.Y., Lee J.S., Cho B., Park I.S. Intracellular K(+) inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release. Cell Death Differ. 2007, 14:2068-2075.
25. Beere H.M., Wolf B.B., Cain K., Mosser D.D., Mahboubi A., Kuwana T., Tailor P., Morimoto R.I., Cohen G.M., Green D.R. Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome. Nat. Cell Biol. 2000, 2:469-475.
26. Zou H., Li Y., Liu X., Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 1999, 274:11549-11556.
27. Shahnawaz M., Thapa A., Park I.S. Stable activity of a deubiquitylating enzyme (Usp2-cc) in the presence of high concentrations of urea and its application to purify aggregation-prone peptides. Biochem. Biophys. Res. Commun. 2007, 359:801-805.
28. Shahnawaz M., Sharoar M.G., Shin S.Y., Park I.S. Wild-type, Flemish, and Dutch amyloid-beta exhibit different cytotoxicities depending on Abeta40 to Abeta42 interaction time and concentration ratio. J. Pept. Sci. 2013, 19:545-553.
29. Thapa A., Woo E.R., Chi E.Y., Sharoar M.G., Jin H.G., Shin S.Y., Park I.S. Biflavonoids are superior to monoflavonoids in inhibiting amyloid-beta toxicity and fibrillogenesis via accumulation of nontoxic oligomer-like structures. Biochemistry 2011, 50:2445-2455.
30. Karki P., Dahal G.R., Park I.S. Both dimerization and interdomain processing are essential for caspase-4 activation. Biochem. Biophys. Res. Commun. 2007, 356:1056-1061.
31. Guo B., Zhai D., Cabezas E., Welsh K., Nouraini S., Satterthwait A.C., Reed J.C. Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature 2003, 423:456-461.
32. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996, 274:99-102.
33. Liu M.L., Liu M.J., Shen Y.F., Ryu H., Kim H.J., Klupsch K., Downward J., Hong S.T. Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-beta. J. Cell Sci. 2009, 122:1917-1926.
34. Purring-Koch C., McLendon G. Cytochrome c binding to Apaf-1: the effects of dATP and ionic strength. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:11928-11931.
35. Holcomb L., Gordon M.N., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., Sanders S., Zehr C., O'Campo K., Hardy J., Prada C.M., Eckman C., Younkin S., Hsiao K., Duff K. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nat. Med. 1998, 4:97-100.
36. Chou J.J., Matsuo H., Duan H., Wagner G. Solution structure of the RAIDD CARD and model for CARD/CARD interaction in caspase-2 and caspase-9 recruitment. Cell 1998, 94:171-180.
37. Park I.S., Lin C.H., Walsh C.T. Bacterial resistance to vancomycin: overproduction, purification, and characterization of VanC2 from Enterococcus casseliflavus as a D-Ala-D-Ser ligase. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:10040-10044.
38. Hu Y., Benedict M.A., Ding L., Nunez G. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J. 1999, 18:3586-3595.
39. Chafekar S.M., Baas F., Scheper W. Oligomer-specific Abeta toxicity in cell models is mediated by selective uptake. Biochim. Biophys. Acta 2008, 1782:523-531.
40. Tang D., Lahti J.M., Kidd V.J. Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis. J. Biol. Chem. 2000, 275:9303-9307.
41. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998, 94:481-490.
42. Malladi S., Challa-Malladi M., Fearnhead H.O., Bratton S.B. The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J. 2009, 28:1916-1925.
43. Scaffidi C., Schmitz I., Zha J., Korsmeyer S.J., Krammer P.H., Peter M.E. Differential modulation of apoptosis sensitivity in CD95 type I and type II cells. J. Biol. Chem. 1999, 274:22532-22538.
44. Ding H., Schauerte J.A., Steel D.G., Gafni A. beta-Amyloid (1-40) peptide interactions with supported phospholipid membranes: a single-molecule study. Biophys. J. 2012, 103:1500-1509.
45. Lashuel H.A., Hartley D., Petre B.M., Walz T., Lansbury P.T. Neurodegenerative disease: amyloid pores from pathogenic mutations. Nature 2002, 418:291.