Toward rationally redesigning bacterial two-component signaling systems using coevolutionary information

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 5, 2014, Pages

  Cheng, Ryan R ^a   Morcos, Faruck ^a   Levine, Herbert ^a   Onuchic, José N ^a  

^a RICE UNIVERSITY   (United States)

Author keywords

Covariation; Information theory; Protein recognition; Signal transduction; Statistical inference

Indexed keywords

BACTERIAL PROTEIN; TWO COMPONENT SIGNALING PROTEIN; UNCLASSIFIED DRUG;

ACCURACY; AMINO ACID SEQUENCE; ARTICLE; COEVOLUTION; IN VITRO STUDY; MOLECULAR RECOGNITION; MUTAGENESIS; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

COVARIATION; INFORMATION THEORY; PROTEIN RECOGNITION; SIGNAL TRANSDUCTION; STATISTICAL INFERENCE;

BACTERIAL PROTEINS; EVOLUTION, MOLECULAR; GENOME, BACTERIAL; MODELS, BIOLOGICAL; MUTAGENESIS; MUTATION; PHENOTYPE; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN KINASES; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 84893476565     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323734111     Document Type: Article

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