Optimization of specificity in a cellular protein interaction network by negative selection

Nature

Volumn 426, Issue 6967, 2003, Pages 676-680

  Zarrinpar, Ali ^a   Park, Sang Hyun ^a   Lim, Wendell A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GENES; OPTIMIZATION; YEAST;

INTERACTION NETWORK;

PROTEINS;

CELL PROTEIN; FUNGAL PROTEIN; LIGAND; PBS2 PROTEIN; PEPTIDE; PROTEOME; SHO1 PROTEIN; UNCLASSIFIED DRUG;

PROTEIN;

ARTICLE; BINDING AFFINITY; CELL SELECTION; CROSS REACTION; EVOLUTION; EVOLUTIONARY ADAPTATION; GENE EXPRESSION PROFILING; MODULAR PROTEIN INTERACTION DOMAIN; NEGATIVE SELECTION; NONHUMAN; PBS2 MOTIF; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; SIGNAL TRANSDUCTION; SRC HOMOLOGY 3 DOMAIN; SRC HOMOLOGY DOMAIN; YEAST;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING, COMPETITIVE; LIGANDS; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEOME; SACCHAROMYCES CEREVISIAE PROTEINS; SPECIES SPECIFICITY; SRC HOMOLOGY DOMAINS; SUBSTRATE SPECIFICITY;

EID: 0346555269     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02178     Document Type: Article

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