Novel dichlorophenyl urea compounds inhibit proliferation of human leukemia HL-60 cells by inducing cell cycle arrest, differentiation and apoptosis

Investigational New Drugs

Volumn 30, Issue 4, 2012, Pages 1413-1425

  Figarola, James L ^a   Weng, Yehua ^a   Lincoln, Christopher ^a   Horne, David ^a   Rahbar, Samuel ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Cell cycle arrest; Dichlorophenyl urea; HL 60; Leukemia

Indexed keywords

1,3 BIS(3,5 DICHLOROPHENYL) 3 (3,5 DICHLORO 2 HYDROXY 4 METHYLPHENYL)UREA; 1,3 BIS(3,5 DICHLOROPHENYL)UREA; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; CASPASE 9; CD11B ANTIGEN; CD14 ANTIGEN; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; CYCLIN E2; CYTOCHROME C; DICHLOROPHENYL UREA DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RETINOIC ACID; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL STRAIN HL 60; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

APOPTOSIS; BLOTTING, WESTERN; CASPASES; CELL CYCLE CHECKPOINTS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SHAPE; CYTOCHROMES C; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; G1 PHASE CELL CYCLE CHECKPOINTS; HL-60 CELLS; HUMANS; LEUKEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MONOCYTES; PHENYLUREA COMPOUNDS; POLY(ADP-RIBOSE) POLYMERASES; PROTEOLYSIS; TIME FACTORS;

EID: 84866742125     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-011-9711-8     Document Type: Article

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