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Volumn 36, Issue 1, 2014, Pages 1-10

Cytochrome P450 isoforms are differently up-regulated in aflatoxin B1-exposed human lymphocytes and monocytes

Author keywords

Aflatoxin B1; CYP; Lymphocytes; Monocytes; QPCR; Toll like receptor 4

Indexed keywords

AFLATOXIN B1; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 3A7; ISOPROTEIN; TOLL LIKE RECEPTOR 4;

EID: 84893421276     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2013.850506     Document Type: Article
Times cited : (48)

References (48)
  • 1
    • 84858019869 scopus 로고    scopus 로고
    • Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis
    • Olarte RA, Horn BW, Dorner JW, et al. Effect of sexual recombination on population diversity in aflatoxin production by Aspergillus flavus and evidence for cryptic heterokaryosis. Mol Ecol 2012;21:1453-1476.
    • (2012) Mol Ecol , vol.21 , pp. 1453-1476
    • Olarte, R.A.1    Horn, B.W.2    Dorner, J.W.3
  • 2
    • 84868620925 scopus 로고    scopus 로고
    • Deletion of the Aspergillus flavus Orthologue of A. Nidulans fluG reduces conidiation and promotes production of sclerotia but does not abolish aflatoxin biosynthesis
    • Chang PK, Scharfenstein LL, Mack B, et al. Deletion of the Aspergillus flavus Orthologue of A. nidulans fluG reduces conidiation and promotes production of sclerotia but does not abolish aflatoxin biosynthesis. Appl Environ Microbiol 2012;78: 7557-7563.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 7557-7563
    • Chang, P.K.1    Scharfenstein, L.L.2    Mack, B.3
  • 4
    • 84861872186 scopus 로고    scopus 로고
    • Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: Association with tumors developing in the absence of liver cirrhosis
    • Villar S, Ortiz-Cuaran S, Abedi-Ardekani B, et al. Aflatoxin-induced TP53 R249S mutation in hepatocellular carcinoma in Thailand: association with tumors developing in the absence of liver cirrhosis. PLoS ONE 2012;7:e37707.
    • (2012) PLoS ONE , vol.7
    • Villar, S.1    Ortiz-Cuaran, S.2    Abedi-Ardekani, B.3
  • 5
    • 84855760394 scopus 로고    scopus 로고
    • Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds
    • Josse R, Dumont J, Fautrel A, et al. Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds. Toxicol Appl Pharmacol 2012;258:176-187.
    • (2012) Toxicol Appl Pharmacol , vol.258 , pp. 176-187
    • Josse, R.1    Dumont, J.2    Fautrel, A.3
  • 6
    • 84856111592 scopus 로고    scopus 로고
    • 1-induced liver tumors in hepatitis virus C transgenic mice
    • 1-induced liver tumors in hepatitis virus C transgenic mice. Int J Cancer 2012;130:1347-1356.
    • (2012) Int J Cancer , vol.130 , pp. 1347-1356
    • Jeannot, E.1    Boorman, G.A.2    Kosyk, O.3
  • 7
    • 0020959529 scopus 로고
    • Vitamin A and aflatoxin: Effect on liver and colon cancer
    • Suphakarn VS, Newberne PM, Goldman M. Vitamin A and aflatoxin: effect on liver and colon cancer. Nutr Cancer 1983;5: 41-50.
    • (1983) Nutr Cancer , vol.5 , pp. 41-50
    • Suphakarn, V.S.1    Newberne, P.M.2    Goldman, M.3
  • 8
    • 0029763553 scopus 로고    scopus 로고
    • Immunosuppressant activity of aflatoxin ingestion in rabbits measured by response to Mycobacterium bovis antigen I. Cell mediated immune response measured by skin test reaction
    • Dimitri RA, Gabal MA. Immunosuppressant activity of aflatoxin ingestion in rabbits measured by response to Mycobacterium bovis antigen I. Cell mediated immune response measured by skin test reaction. Vet Hum Toxicol 1996;38:333-336.
    • (1996) Vet Hum Toxicol , vol.38 , pp. 333-336
    • Dimitri, R.A.1    Gabal, M.A.2
  • 9
    • 84857615718 scopus 로고    scopus 로고
    • Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes
    • Ayed-Boussema I, Pascussi JM, Maurel P, et al. Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes. Int J Toxicol 2012;31:86-93.
    • (2012) Int J Toxicol , vol.31 , pp. 86-93
    • Ayed-Boussema, I.1    Pascussi, J.M.2    Maurel, P.3
  • 10
    • 79952088976 scopus 로고    scopus 로고
    • Aflatoxin: A 50-year odyssey of mechanistic and translational toxicology
    • Kensler TW, Roebuck BD, Wogan GN, et al. Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology. Toxicol Sci 2011;120 Suppl 1:S28-S48.
    • (2011) Toxicol Sci , vol.120 , Issue.SUPPL. 1
    • Kensler, T.W.1    Roebuck, B.D.2    Wogan, G.N.3
  • 11
    • 0028865229 scopus 로고
    • 1 metabolism in human hepatocytes in primary culture
    • 1 metabolism in human hepatocytes in primary culture. Cancer Res 1995;55: 5574-5579.
    • (1995) Cancer Res , vol.55 , pp. 5574-5579
    • Langouet, S.1    Coles, B.2    Morel, F.3
  • 12
    • 13144260727 scopus 로고    scopus 로고
    • Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction
    • Bertilsson G, Heidrich J, Svensson K, et al. Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction. Proc Natl Acad Sci USA 1998;95: 12208-12213.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 12208-12213
    • Bertilsson, G.1    Heidrich, J.2    Svensson, K.3
  • 13
    • 0036799870 scopus 로고    scopus 로고
    • The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism
    • Kliewer SA, Goodwin B, Willson TM. The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism. Endocr Rev 2002;23:687-702.
    • (2002) Endocr Rev , vol.23 , pp. 687-702
    • Kliewer, S.A.1    Goodwin, B.2    Willson, T.M.3
  • 14
    • 0032169485 scopus 로고    scopus 로고
    • The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions
    • Lehmann JM, McKee DD, Watson MA, et al. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions. J Clin Invest 1998;102:1016-1023.
    • (1998) J Clin Invest , vol.102 , pp. 1016-1023
    • Lehmann, J.M.1    McKee, D.D.2    Watson, M.A.3
  • 15
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: Synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi JM, Drocourt L, Fabre JM, et al. Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol 2000;58:361-372.
    • (2000) Mol Pharmacol , vol.58 , pp. 361-372
    • Pascussi, J.M.1    Drocourt, L.2    Fabre, J.M.3
  • 16
    • 84983727007 scopus 로고    scopus 로고
    • Effect of CYP3A4 inducer dexamethasone on hepatotoxicity oflapatinib: Clinical and in vitro evidence
    • Teo YL, Saetaew M, Chanthawong S, et al. Effect of CYP3A4 inducer dexamethasone on hepatotoxicity oflapatinib: clinical and in vitro evidence. Breast Cancer Res Treat 2012;133:703-711.
    • (2012) Breast Cancer Res Treat , vol.133 , pp. 703-711
    • Teo, Y.L.1    Saetaew, M.2    Chanthawong, S.3
  • 17
    • 84862626584 scopus 로고    scopus 로고
    • Effects of CYP induction by rifampicin on tamoxifen exposure
    • Binkhorst L, van Gelder T, Loos WJ, et al. Effects of CYP induction by rifampicin on tamoxifen exposure. Clin Pharmacol Ther 2012;92:62-67.
    • (2012) Clin Pharmacol Ther , vol.92 , pp. 62-67
    • Binkhorst, L.1    Van Gelder, T.2    Loos, W.J.3
  • 18
    • 0034719327 scopus 로고    scopus 로고
    • Quantitative analysis of constitutive and inducible CYPs mRNA expression in the HepG2 cell line using reverse transcription-competitive PCR
    • Sumida A, Fukuen S, Yamamoto I, et al. Quantitative analysis of constitutive and inducible CYPs mRNA expression in the HepG2 cell line using reverse transcription-competitive PCR. Biochem Biophys Res Commun 2000;267:756-760.
    • (2000) Biochem Biophys Res Commun , vol.267 , pp. 756-760
    • Sumida, A.1    Fukuen, S.2    Yamamoto, I.3
  • 20
    • 84857078932 scopus 로고    scopus 로고
    • Azithromycin distinctively modulates classical activation of human monocytes in vitro
    • Vrancic M, Banjanac M, Nujic K, et al. Azithromycin distinctively modulates classical activation of human monocytes in vitro. Br J Pharmacol 2012;165:1348-1360.
    • (2012) Br J Pharmacol , vol.165 , pp. 1348-1360
    • Vrancic, M.1    Banjanac, M.2    Nujic, K.3
  • 21
    • 0031772143 scopus 로고    scopus 로고
    • Cytochrome P450 1B1: A major P450 isoenzyme in human blood monocytes and macrophage subsets
    • Baron JM, Zwadlo-Klarwasser G, Jugert F, et al. Cytochrome P450 1B1: a major P450 isoenzyme in human blood monocytes and macrophage subsets. Biochem Pharmacol 1998;56:1105-1110.
    • (1998) Biochem Pharmacol , vol.56 , pp. 1105-1110
    • Baron, J.M.1    Zwadlo-Klarwasser, G.2    Jugert, F.3
  • 22
    • 0034040714 scopus 로고    scopus 로고
    • Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells
    • Krovat BC, Tracy JH, Omiecinski CJ. Fingerprinting of cytochrome P450 and microsomal epoxide hydrolase gene expression in human blood cells. Toxicol Sci 2000;55:352-360.
    • (2000) Toxicol Sci , vol.55 , pp. 352-360
    • Krovat, B.C.1    Tracy, J.H.2    Omiecinski, C.J.3
  • 23
    • 18144430252 scopus 로고    scopus 로고
    • Cytochrome P450 1A1 and 1B1 in human blood lymphocytes are not suitable as biomarkers of exposure to dioxin-like compounds: Polymorphisms and interindividual variation in expression and inducibility
    • van Duursen MB, Sanderson JT, van den Berg M. Cytochrome P450 1A1 and 1B1 in human blood lymphocytes are not suitable as biomarkers of exposure to dioxin-like compounds: polymorphisms and interindividual variation in expression and inducibility. Toxicol Sci 2005;85:703-712.
    • (2005) Toxicol Sci , vol.85 , pp. 703-712
    • Van Duursen, M.B.1    Sanderson, J.T.2    Van Den Berg, M.3
  • 24
    • 0038393307 scopus 로고    scopus 로고
    • TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident
    • Landi MT, Bertazzi PA, Baccarelli A, et al. TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accident. Carcinogenesis 2003;24:673-680.
    • (2003) Carcinogenesis , vol.24 , pp. 673-680
    • Landi, M.T.1    Bertazzi, P.A.2    Baccarelli, A.3
  • 26
    • 79953301321 scopus 로고    scopus 로고
    • In vitro effects of very low levels of aflatoxin B on free radicals production and bactericidal activity of bovine blood neutrophils
    • Mehrzad J, Klein G, Kamphues J, et al. In vitro effects of very low levels of aflatoxin B on free radicals production and bactericidal activity of bovine blood neutrophils. Vet Immunol Immunopathol 2011;141:16-25.
    • (2011) Vet Immunol Immunopathol , vol.141 , pp. 16-25
    • Mehrzad, J.1    Klein, G.2    Kamphues, J.3
  • 27
    • 84868698710 scopus 로고    scopus 로고
    • Immunological status of the progeny of breeder hens kept on ochratoxin A (OTA)-and aflatoxin B(1) (AFB(1))-contaminated feeds
    • Hassan Z, Khan MZ, Khan A, et al. Immunological status of the progeny of breeder hens kept on ochratoxin A (OTA)-and aflatoxin B(1) (AFB(1))-contaminated feeds. J Immunotoxicol 2012;9: 381-391.
    • (2012) J Immunotoxicol , vol.9 , pp. 381-391
    • Hassan, Z.1    Khan, M.Z.2    Khan, A.3
  • 28
    • 84880299868 scopus 로고    scopus 로고
    • Biologically relevant doses of mixed aflatoxins B and G up-regulate MyD88, TLR2, TLR4 and CD14 transcripts in human PBMC
    • Malvandi AM, Mehrzad J, Saleh-moghaddam M. Biologically relevant doses of mixed aflatoxins B and G up-regulate MyD88, TLR2, TLR4 and CD14 transcripts in human PBMC. Immunopharmacol Immunotoxicol 2013;35:528-532.
    • (2013) Immunopharmacol Immunotoxicol , vol.35 , pp. 528-532
    • Malvandi, A.M.1    Mehrzad, J.2    Saleh-Moghaddam, M.3
  • 29
    • 57049112197 scopus 로고    scopus 로고
    • T lymphocyte proliferative capacity and CD4/CD8 ratio in primiparous and pluriparous lactating cows
    • Mehrzad J, Zhao X. T lymphocyte proliferative capacity and CD4/CD8 ratio in primiparous and pluriparous lactating cows. J Dairy Res 2008;75:457-465.
    • (2008) J Dairy Res , vol.75 , pp. 457-465
    • Mehrzad, J.1    Zhao, X.2
  • 30
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti I, Migliorati G, Pagliacci MC, et al. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991;139: 271-279.
    • (1991) J Immunol Methods , vol.139 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3
  • 31
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:2002-2007.
    • (2001) Nucleic Acids Res , vol.29 , pp. 2002-2007
    • Pfaffl, M.W.1
  • 32
    • 79954599433 scopus 로고    scopus 로고
    • Aflatoxin B1-a potential endocrine disruptor up-regulates CYP19A1 in JEG-3 cells
    • Storvik M, Huuskonen P, Kyllonen T, et al. Aflatoxin B1-a potential endocrine disruptor up-regulates CYP19A1 in JEG-3 cells. Toxicol Lett 2011;202:161-167.
    • (2011) Toxicol Lett , vol.202 , pp. 161-167
    • Storvik, M.1    Huuskonen, P.2    Kyllonen, T.3
  • 33
    • 0029686554 scopus 로고    scopus 로고
    • 1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: Effect of phorone
    • 1 induced lacI mutation in liver and kidney of transgenic mice C57BL/6N: effect of phorone. Mutagenesis 1996;11:69-73.
    • (1996) Mutagenesis , vol.11 , pp. 69-73
    • Autrup, H.1    Jorgensen, E.C.2    Jensen, O.3
  • 37
    • 33646084391 scopus 로고    scopus 로고
    • Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1
    • Kamdem LK, Meineke I, Gödtel-Armbrust U, et al. Dominant contribution of P450 3A4 to the hepatic carcinogenic activation of aflatoxin B1. Chem Res Toxicol 2006;19:577-586.
    • (2006) Chem Res Toxicol , vol.19 , pp. 577-586
    • Kamdem, L.K.1    Meineke, I.2    Gödtel-Armbrust, U.3
  • 39
    • 0030339769 scopus 로고    scopus 로고
    • The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4
    • Gallagher EP, Kunze KL, Stapleton PL, et al. The kinetics of aflatoxin B1 oxidation by human cDNA-expressed and human liver microsomal cytochromes P450 1A2 and 3A4. Toxicol Appl Pharmacol 1996;141:595-606.
    • (1996) Toxicol Appl Pharmacol , vol.141 , pp. 595-606
    • Gallagher, E.P.1    Kunze, K.L.2    Stapleton, P.L.3
  • 40
    • 74049139129 scopus 로고    scopus 로고
    • Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations
    • Jorge-Nebert LF, Jiang Z, Chakraborty R, et al. Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations. Hum Mutat 2010;31: 27-40.
    • (2010) Hum Mutat , vol.31 , pp. 27-40
    • Jorge-Nebert, L.F.1    Jiang, Z.2    Chakraborty, R.3
  • 41
    • 37549069338 scopus 로고    scopus 로고
    • Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects
    • Siest G, Jeannesson E, Marteau JB, et al. Transcription factor and drug-metabolizing enzyme gene expression in lymphocytes from healthy human subjects. Drug Metab Dispos 2008;36:182-189.
    • (2008) Drug Metab Dispos , vol.36 , pp. 182-189
    • Siest, G.1    Jeannesson, E.2    Marteau, J.B.3
  • 42
    • 79960699423 scopus 로고    scopus 로고
    • Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor
    • Ratajewski M, Walczak-Drzewiecka A, Salkowska A, et al. Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Toxicol Lett 2011;205: 146-153.
    • (2011) Toxicol Lett , vol.205 , pp. 146-153
    • Ratajewski, M.1    Walczak-Drzewiecka, A.2    Salkowska, A.3
  • 43
    • 34548532926 scopus 로고    scopus 로고
    • Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes
    • Nishimura M, Koeda A, Suganuma Y, et al. Comparison of inducibility of CYP1A and CYP3A mRNAs by prototypical inducers in primary cultures of human, cynomolgus monkey, and rat hepatocytes. Drug Metab Pharmacokinet 2007;22: 178-186.
    • (2007) Drug Metab Pharmacokinet , vol.22 , pp. 178-186
    • Nishimura, M.1    Koeda, A.2    Suganuma, Y.3
  • 44
    • 0028012079 scopus 로고
    • Dioxin-responsive genes: Examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction
    • VandenHeuvel JP, Clark GC, Kohn MC, et al. Dioxin-responsive genes: examination of dose-response relationships using quantitative reverse transcriptase-polymerase chain reaction. Cancer Res 1994;54:62-68.
    • (1994) Cancer Res , vol.54 , pp. 62-68
    • Vandenheuvel, J.P.1    Clark, G.C.2    Kohn, M.C.3
  • 45
    • 0031572291 scopus 로고    scopus 로고
    • Regulation of hepatic cytochrome P450 2C11 by glucocorticoids
    • Iber H, Chen Q, Sewer M, et al. Regulation of hepatic cytochrome P450 2C11 by glucocorticoids. Arch Biochem Biophys 1997;345: 305-310.
    • (1997) Arch Biochem Biophys , vol.345 , pp. 305-310
    • Iber, H.1    Chen, Q.2    Sewer, M.3
  • 46
    • 67349113389 scopus 로고    scopus 로고
    • Expression and inducibility of CYP1A1, 1A2, 1B1 by beta-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig
    • Messina A, Nannelli A, Fiorio R, et al. Expression and inducibility of CYP1A1, 1A2, 1B1 by beta-naphthoflavone and CYP2B22, 3A22, 3A29, 3A46 by rifampicin in the respiratory and olfactory mucosa of pig. Toxicol 2009;260:47-52.
    • (2009) Toxicol , vol.260 , pp. 47-52
    • Messina, A.1    Nannelli, A.2    Fiorio, R.3
  • 47
    • 80255134517 scopus 로고    scopus 로고
    • Histone deacetylase 1 is required for carbamazepine-induced CYP3A4 expression
    • Wu Y, Shi X, Liu Y, et al. Histone deacetylase 1 is required for carbamazepine-induced CYP3A4 expression. J Pharm Biomed Anal 2012;58:78-82.
    • (2012) J Pharm Biomed Anal , vol.58 , pp. 78-82
    • Wu, Y.1    Shi, X.2    Liu, Y.3
  • 48
    • 78650987626 scopus 로고    scopus 로고
    • Effects of chronic exposure of diets with reduced concentrations of aflatoxin and deoxyniva-lenol on growth and immune status of pigs
    • Chaytor AC, See MT, Hansen JA, et al. Effects of chronic exposure of diets with reduced concentrations of aflatoxin and deoxyniva-lenol on growth and immune status of pigs. J Anim Sci 2011;89: 124-135.
    • (2011) J Anim Sci , vol.89 , pp. 124-135
    • Chaytor, A.C.1    See, M.T.2    Hansen, J.A.3


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