메뉴 건너뛰기




Volumn 302, Issue 2-3, 2012, Pages 299-307

Reactive oxygen species sources and biomolecular oxidative damage induced by aflatoxin B1 and fumonisin B1 in rat spleen mononuclear cells

Author keywords

Aflatoxin B1; Biomolecular oxidative damage; Fumonisin B1; Immunotoxicity; ROS sources

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; AFLATOXIN B1; CARBONYL DERIVATIVE; CYTOCHROME P450; DNA; FUMONISIN B1; HYDROGEN PEROXIDE; HYDROXYL RADICAL; LIPID; MALONALDEHYDE; PROTEIN; RADICAL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; FUMONISIN;

EID: 84897121678     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.08.012     Document Type: Article
Times cited : (151)

References (44)
  • 1
    • 77955474114 scopus 로고    scopus 로고
    • Immunotoxicological and biochemical effects of aflatoxins in rats prevented by Tunisian montmorillonite with reference to HSCAS
    • Abbès, S., Ben Salah-Abbès, J., Abdel-Wahhab, M.A., Ouslati, R., 2010. Immunotoxicological and biochemical effects of aflatoxins in rats prevented by Tunisian montmorillonite with reference to HSCAS. Immunopharmacol. Immunotoxicol. 32 (3), 514-522.
    • (2010) Immunopharmacol. Immunotoxicol , vol.32 , Issue.3 , pp. 514-522
    • Abbès, S.1    Ben Salah-Abbès, J.2    Abdel-Wahhab, M.A.3    Ouslati, R.4
  • 2
    • 78650280548 scopus 로고    scopus 로고
    • Aflatoxin B1 and ethanol co-exposure induces hepatic oxidative damage in mice
    • Adedara, I.A., Owumi, S.E., Uwaifo, A.O., Farombi, E.O., 2010. Aflatoxin B1 and ethanol co-exposure induces hepatic oxidative damage in mice. Toxicol. Ind. Health 26, 717-724.
    • (2010) Toxicol. Ind. Health , vol.26 , pp. 717-724
    • Adedara, I.A.1    Owumi, S.E.2    Uwaifo, A.O.3    Farombi, E.O.4
  • 3
    • 0021243855 scopus 로고
    • Evidence for membrane-mediated chromosomal damage by aflatoxin B1 in human lymphocytes
    • Amstad, P., Levy, A., Emerit, I., Cerutti, P., 1984. Evidence for membrane-mediated chromosomal damage by aflatoxin B1 in human lymphocytes. Carcinogenesis 5, 719-723.
    • (1984) Carcinogenesis , vol.5 , pp. 719-723
    • Amstad, P.1    Levy, A.2    Emerit, I.3    Cerutti, P.4
  • 4
    • 84857615718 scopus 로고    scopus 로고
    • Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes
    • Ayed-Boussema, I., Pascussi, J.M., Maurel, P., Bacha, H., Hassen, W., 2012. Effect of aflatoxin B1 on nuclear receptors PXR, CAR, and AhR and their target cytochromes P450 mRNA expression in primary cultures of human hepatocytes. Int. J. Toxicol. 31 (1), 86-93.
    • (2012) Int. J. Toxicol. , vol.31 , Issue.1 , pp. 86-93
    • Ayed-Boussema, I.1    Pascussi, J.M.2    Maurel, P.3    Bacha, H.4    Hassen, W.5
  • 5
    • 33646151166 scopus 로고    scopus 로고
    • Lipids and DNA oxidation in Staphylococcus aureus as a consequence of oxidative stress generated by ciprofloxacin
    • Becerra, M.C., Páez, P.L., Laróvere, L.E., Albesa, I., 2006. Lipids and DNA oxidation in Staphylococcus aureus as a consequence of oxidative stress generated by ciprofloxacin. Mol. Cell. Biochem. 285 (1-2), 29-34.
    • (2006) Mol. Cell. Biochem. , vol.285 , Issue.1-2 , pp. 29-34
    • Becerra, M.C.1    Páez, P.L.2    Laróvere, L.E.3    Albesa, I.4
  • 6
    • 84897416692 scopus 로고    scopus 로고
    • CAST. Mycotoxins: risks in plant, animal and human. Potential economic costs of mycotoxins in United States. CAST Task force reports
    • CAST, 2003. Mycotoxins: risks in plant, animal and human. Potential economic costs of mycotoxins in United States. CAST Task force reports, pp. 136-142.
    • (2003) , pp. 136-142
  • 7
    • 33745886232 scopus 로고    scopus 로고
    • Effect of fumonisins on macrophage immune functions and gene expression of cytokines in broilers
    • Cheng, Y.H., Ding, S.T., Chang, M.H., 2006. Effect of fumonisins on macrophage immune functions and gene expression of cytokines in broilers. Arch. Anim. Nutr. 60 (4), 267-276.
    • (2006) Arch. Anim. Nutr. , vol.60 , Issue.4 , pp. 267-276
    • Cheng, Y.H.1    Ding, S.T.2    Chang, M.H.3
  • 8
    • 76049083966 scopus 로고    scopus 로고
    • Reactive oxygen species, cellular redox systems and apoptosis
    • Circu, M.L., Aw, T.Y., 2010. Reactive oxygen species, cellular redox systems and apoptosis. Free Radic. Biol. Med. 48, 749-762.
    • (2010) Free Radic. Biol. Med , vol.48 , pp. 749-762
    • Circu, M.L.1    Aw, T.Y.2
  • 9
    • 0028321912 scopus 로고
    • Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester
    • Curnutte, J.T., Erickson, R.W., Ding, J., Badwey, J.A., 1994. Reciprocal interactions between protein kinase C and components of the NADPH oxidase complex may regulate superoxide production by neutrophils stimulated with a phorbol ester. J. Biol. Chem. 269, 10813-10819.
    • (1994) J. Biol. Chem. , vol.269 , pp. 10813-10819
    • Curnutte, J.T.1    Erickson, R.W.2    Ding, J.3    Badwey, J.A.4
  • 10
    • 0034327804 scopus 로고    scopus 로고
    • The mitogenactivated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils
    • Dewas, C., Fay, M., Gougerot-Pocidalo, M.A., El-Benna, J., 2000. The mitogenactivated protein kinase extracellular signal-regulated kinase 1/2 pathway is involved in formyl-methionyl-leucyl-phenylalanine-induced p47phox phosphorylation in human neutrophils. J. Immunol. 165, 5238-5244.
    • (2000) J. Immunol. , vol.165 , pp. 5238-5244
    • Dewas, C.1    Fay, M.2    Gougerot-Pocidalo, M.A.3    El-Benna, J.4
  • 11
    • 0027680268 scopus 로고
    • Lymphocyte cytotoxicity and erythrocytic abnormalities induced in broiler chicks by fumonisins B1 and B2 and moniliformin from Fusarium proliferatum
    • Dombrink-Kurtzman, M.A., Javed, T., Bennett, G.A., Richard, J.L., Cote, L.M., Buck, W.B., 1993. Lymphocyte cytotoxicity and erythrocytic abnormalities induced in broiler chicks by fumonisins B1 and B2 and moniliformin from Fusarium proliferatum. Mycopathologia 124 (1), 47-54.
    • (1993) Mycopathologia , vol.124 , Issue.1 , pp. 47-54
    • Dombrink-Kurtzman, M.A.1    Javed, T.2    Bennett, G.A.3    Richard, J.L.4    Cote, L.M.5    Buck, W.B.6
  • 12
    • 79955878620 scopus 로고    scopus 로고
    • Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis-implication to mechanism of cell toxicity
    • Domijan, A.M., Abramov, A.Y., 2011. Fumonisin B1 inhibits mitochondrial respiration and deregulates calcium homeostasis-implication to mechanism of cell toxicity. Int. J. Biochem. Cell Biol. 43, 897-904.
    • (2011) Int. J. Biochem. Cell Biol. , vol.43 , pp. 897-904
    • Domijan, A.M.1    Abramov, A.Y.2
  • 13
    • 79951906204 scopus 로고    scopus 로고
    • Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone
    • Gonçalves, A.P., Máximo, V., Limac, J., Singhe, K.K., Soares, P., Videira, A., 2011. Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. Biochim. Biophys. Acta 1813 (3), 492-499.
    • (2011) Biochim. Biophys. Acta , vol.1813 , Issue.3 , pp. 492-499
    • Gonçalves, A.P.1    Máximo, V.2    Limac, J.3    Singhe, K.K.4    Soares, P.5    Videira, A.6
  • 16
    • 0033618438 scopus 로고    scopus 로고
    • Suppression of the interleukin-2 gene expression by aflatoxin B1 is mediated through the down-regulation of the NFAT and AP-1 transcription factors
    • Han, S.H., Jeon, Y.J., Yea, S.S., Yang, K.H., 1999. Suppression of the interleukin-2 gene expression by aflatoxin B1 is mediated through the down-regulation of the NFAT and AP-1 transcription factors. Toxicol Lett. 108 (1), 1-10.
    • (1999) Toxicol Lett , vol.108 , Issue.1 , pp. 1-10
    • Han, S.H.1    Jeon, Y.J.2    Yea, S.S.3    Yang, K.H.4
  • 17
    • 33845327099 scopus 로고    scopus 로고
    • Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research
    • Hwang, E.S., Kim, G.H., 2007. Biomarkers for oxidative stress status of DNA, lipids, and proteins in vitro and in vivo cancer research. Toxicology 229, 1-10.
    • (2007) Toxicology , vol.229 , pp. 1-10
    • Hwang, E.S.1    Kim, G.H.2
  • 18
    • 0027501524 scopus 로고
    • International Agency for Research in Carcinogenesis Aflatoxins
    • International Agency for Research in Carcinogenesis, 1993a. Aflatoxins. Monograph on the Evaluation of Carcinogenic Risks to Humans, vol. 56, p. 245.
    • (1993) Monograph on the Evaluation of Carcinogenic Risks to Humans , vol.56 , pp. 245
  • 19
    • 0027422316 scopus 로고
    • International Agency for Research in Carcinogenesis, Toxins derived from Fusarium moniliforme: fumonisins B1and B2 and fusarin C
    • International Agency for Research in Carcinogenesis, 1993b. Toxins derived from Fusarium moniliforme: fumonisins B1and B2 and fusarin C. Monograph on the Evaluation of Carcinogenic risks to Humans, vol. 56, p. 445.
    • (1993) Monograph on the Evaluation of Carcinogenic risks to Humans , vol.56 , pp. 445
  • 20
    • 84897387744 scopus 로고    scopus 로고
    • IPCS-WHO, Aflatoxins. (accessed 3.1.12.)
    • IPCS-WHO, 1998. Aflatoxins. Available at: (accessed 3.1.12.).
    • (1998)
  • 21
    • 84897386394 scopus 로고    scopus 로고
    • IPCS-WHO, Fumonisin B1. Environmental Health Criteria 219 (accessed 28.10.11.)
    • IPCS-WHO, 2000. Fumonisin B1. Environmental Health Criteria 219. Available at: (accessed 28.10.11.).
    • (2000)
  • 22
    • 0042591402 scopus 로고    scopus 로고
    • Nickel-induced histone hypoacetylation: the role of reactive oxygen species
    • Kang, J., Zhang, Y., Chen, J., Chen, H., Lin, C., Wang, Q., Ou, Y., 2003. Nickel-induced histone hypoacetylation: the role of reactive oxygen species. Toxicol. Sci. 74, 279-286.
    • (2003) Toxicol. Sci. , vol.74 , pp. 279-286
    • Kang, J.1    Zhang, Y.2    Chen, J.3    Chen, H.4    Lin, C.5    Wang, Q.6    Ou, Y.7
  • 23
    • 79960937440 scopus 로고    scopus 로고
    • Protective role of methanol extract of Cetraria islandica (L.) against oxidative stress and genotoxic effects of AFB in human lymphocytes in vitro
    • Kotan, E., Alpsoy, L., Anar, M., Aslan, A., Agar, G., 2011. Protective role of methanol extract of Cetraria islandica (L.) against oxidative stress and genotoxic effects of AFB in human lymphocytes in vitro. Toxicol. Ind. Health 27, 599-605.
    • (2011) Toxicol. Ind. Health , vol.27 , pp. 599-605
    • Kotan, E.1    Alpsoy, L.2    Anar, M.3    Aslan, A.4    Agar, G.5
  • 27
    • 84857479102 scopus 로고    scopus 로고
    • Effects of Saccharomyces cerevisiae extract on haematological parameters, immune function and the antioxidant defence system in breeder hens fed aflatoxin contaminated diets
    • Matur, E., Ergul, E., Akyazi, I., Eraslan, E., Inal, G., Bilgic, S., Demircan, H., 2011. Effects of Saccharomyces cerevisiae extract on haematological parameters, immune function and the antioxidant defence system in breeder hens fed aflatoxin contaminated diets. Br. Poult. Sci. 52 (5), 541-550.
    • (2011) Br. Poult. Sci , vol.52 , Issue.5 , pp. 541-550
    • Matur, E.1    Ergul, E.2    Akyazi, I.3    Eraslan, E.4    Inal, G.5    Bilgic, S.6    Demircan, H.7
  • 29
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy, M.P., 2009. How mitochondria produce reactive oxygen species. Biochem. J. 417, 1-13.
    • (2009) Biochem. J. , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 30
    • 0025726216 scopus 로고
    • A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
    • Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F., Riccardi, C., 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods. 139 (2), 271-279.
    • (1991) J. Immunol. Methods. , vol.139 , Issue.2 , pp. 271-279
    • Nicoletti, I.1    Migliorati, G.2    Pagliacci, M.C.3    Grignani, F.4    Riccardi, C.5
  • 32
    • 0027479814 scopus 로고
    • Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase
    • PART 1
    • O'Donnell, B.V., Tew, D.G., Jones, O.T., England, P.J., 1993. Studies on the inhibitory mechanism of iodonium compounds with special reference to neutrophil NADPH oxidase. Biochem. J. 290 (Pt 1), 41-49.
    • (1993) Biochem. J. 290 , pp. 41-49
    • O'Donnell, B.V.1    Tew, D.G.2    Jones, O.T.3    England, P.J.4
  • 33
    • 0034129325 scopus 로고    scopus 로고
    • Toxigenic fungi and mycotoxins
    • Pitt, J.I., 2000. Toxigenic fungi and mycotoxins. Br. Med. Bull. 56, 184-192.
    • (2000) Br. Med. Bull. , vol.56 , pp. 184-192
    • Pitt, J.I.1
  • 34
    • 79960699423 scopus 로고    scopus 로고
    • Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor
    • Ratajewski, M., Walczak-Drzewiecka, A., Salkowska, A., Dastych, J., 2011. Aflatoxins upregulate CYP3A4 mRNA expression in a process that involves the PXR transcription factor. Toxicol. Lett. 205, 146-153.
    • (2011) Toxicol. Lett. , vol.205 , pp. 146-153
    • Ratajewski, M.1    Walczak-Drzewiecka, A.2    Salkowska, A.3    Dastych, J.4
  • 35
    • 9144274479 scopus 로고    scopus 로고
    • Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress
    • Riganti, C., Gazzano, E., Polimeni, M., Costamagna, C., Bosia, A., Ghigo, D., 2004. Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress. J. Biol. Chem. 279 (46), 47726-47731.
    • (2004) J. Biol. Chem. , vol.279 , Issue.46 , pp. 47726-47731
    • Riganti, C.1    Gazzano, E.2    Polimeni, M.3    Costamagna, C.4    Bosia, A.5    Ghigo, D.6
  • 37
    • 60149106152 scopus 로고    scopus 로고
    • A review of the toxic effects and mechanisms of action of fumonisin B1
    • Stockmann-Juvala, H., Savolainen, K., 2008. A review of the toxic effects and mechanisms of action of fumonisin B1. Hum. Exp. Toxicol. 27, 799-809.
    • (2008) Hum. Exp. Toxicol. , vol.27 , pp. 799-809
    • Stockmann-Juvala, H.1    Savolainen, K.2
  • 38
    • 0032943646 scopus 로고    scopus 로고
    • Increased plasma malondialdehyde levels in glomerular disease as determined by a fully validated HPLC method
    • Templar, J., Kon, S.P., Milligan, T.P., Newman, D.J., Raftery, M.J., 1999. Increased plasma malondialdehyde levels in glomerular disease as determined by a fully validated HPLC method. Nephrol. Dial. Transplant. 14, 946- 951.
    • (1999) Nephrol. Dial. Transplant. , vol.14 , pp. 946-951
    • Templar, J.1    Kon, S.P.2    Milligan, T.P.3    Newman, D.J.4    Raftery, M.J.5
  • 39
    • 73749087124 scopus 로고    scopus 로고
    • Subchronic mycotoxicoses in Wistar rats: assessment of the in vivo and in vitro genotoxicity induced by fumonisins and aflatoxin B (1), and oxidative stress biomarkers status
    • Theumer, M.G., Canepa, M.C., Lopez, A.G., Mary, V.S., Dambolena, J.S., Rubinstein, H.R., 2010. Subchronic mycotoxicoses in Wistar rats: assessment of the in vivo and in vitro genotoxicity induced by fumonisins and aflatoxin B(1), and oxidative stress biomarkers status. Toxicology 268, 104-110.
    • (2010) Toxicology , vol.268 , pp. 104-110
    • Theumer, M.G.1    Canepa, M.C.2    Lopez, A.G.3    Mary, V.S.4    Dambolena, J.S.5    Rubinstein, H.R.6
  • 40
    • 0037447590 scopus 로고    scopus 로고
    • Immunobiological effects of AFB1 and AFB1-FB1 mixture in experimental subchronic mycotoxicoses in rats
    • Theumer, M.G., Lopez, A.G., Masih, D.T., Chulze, S.N., Rubinstein, H.R., 2003. Immunobiological effects of AFB1 and AFB1-FB1 mixture in experimental subchronic mycotoxicoses in rats. Toxicology 186, 159-170.
    • (2003) Toxicology , vol.186 , pp. 159-170
    • Theumer, M.G.1    Lopez, A.G.2    Masih, D.T.3    Chulze, S.N.4    Rubinstein, H.R.5
  • 42
    • 77952877713 scopus 로고    scopus 로고
    • Individual fumonisin exposure and sphingoid base levels in rural populations consuming maize in South Africa
    • van der Westhuizen, L., Shephard, G.S., Rheeder, J.P., Burger, H.M., 2010. Individual fumonisin exposure and sphingoid base levels in rural populations consuming maize in South Africa. Food Chem. Toxicol. 48, 1698-1703.
    • (2010) Food Chem. Toxicol. , vol.48 , pp. 1698-1703
    • van der Westhuizen, L.1    Shephard, G.S.2    Rheeder, J.P.3    Burger, H.M.4
  • 43
    • 16544376533 scopus 로고    scopus 로고
    • Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions
    • Williams, J.H., Phillips, T.D., Jolly, P.E., Stiles, J.K., Jolly, C.M., Aggarwal, D., 2004. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potential health consequences, and interventions. Am. J. Clin. Nutr. 80, 1106-1122.
    • (2004) Am. J. Clin. Nutr. , vol.80 , pp. 1106-1122
    • Williams, J.H.1    Phillips, T.D.2    Jolly, P.E.3    Stiles, J.K.4    Jolly, C.M.5    Aggarwal, D.6
  • 44
    • 38149142769 scopus 로고    scopus 로고
    • Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine
    • Zielonka, J., Vasquez-Vivar, J., Kalyanaraman, B., 2008. Detection of 2-hydroxyethidium in cellular systems: a unique marker product of superoxide and hydroethidine. Nat. Protoc. 3, 8-21.
    • (2008) Nat. Protoc , vol.3 , pp. 8-21
    • Zielonka, J.1    Vasquez-Vivar, J.2    Kalyanaraman, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.