Downregulation of membrane type-matrix metalloproteinases in the inflamed or injured central nervous system

Journal of Neuroinflammation

Volumn 4, Issue , 2007, Pages

  Toft Hansen, Henrik ^a   Babcock, Alicia A ^a   Millward, Jason M ^a,b   Owens, Trevor ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 15; MATRIX METALLOPROTEINASE 16; MATRIX METALLOPROTEINASE 17; MATRIX METALLOPROTEINASE 24; MATRIX METALLOPROTEINASE 25; MESSENGER RNA; METALLOPROTEINASE; PROTEINASE; SCLEROPROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; BLOOD BRAIN BARRIER; BRAIN INJURY; CELL CULTURE; CELL INFILTRATION; CELL ISOLATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE MODEL; DOWN REGULATION; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; IN VIVO STUDY; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NERVOUS SYSTEM INJURY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PATHOGENESIS; PROTEIN DEGRADATION; PROTEIN FAMILY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CENTRAL NERVOUS SYSTEM DISEASE; DRUG ANTAGONISM; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; INFLAMMATION; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASES; DOWN-REGULATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INFLAMMATION; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC;

EID: 36148965872     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-4-24     Document Type: Article

References (34)

1. Rosenberg GA Matrix metalloproteinases in neuroinflammation Glia 2002, 39(3):279-291. 12203394
2. Yong VW Power C Forsyth P Edwards DR Metalloproteinases in biology and pathology of the nervous system Nat Rev Neurosci 2001, 2(7):502-511. 11433375
3. Clements JM Cossins JA Wells GM Corkill DJ Helfrich K Wood LM Pigott R Stabler G Ward GA Gearing AJ Miller KM Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitor J Neuroimmunol 1997, 74(1-2):85-94. 9119983
4. Gijbels K Galardy RE Steinman L Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases J Clin Invest 1994, 94(6):2177-2182. 330042 7989572
5. Hewson AK Smith T Leonard JP Cuzner ML Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790 Inflamm Res 1995, 44(8):345-349. 8581522
6. Liedtke W Cannella B Mazzaccaro RJ Clements JM Miller KM Wucherpfennig KW Gearing AJ Raine CS Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors Ann Neurol 1998, 44(1):35-46. 9667591
7. Kalebic T Garbisa S Glaser B Liotta LA Basement membrane collagen: degradation by migrating endothelial cells Science 1983, 221(4607):281-283. 6190230
8. Sato H Takino T Okada Y Cao J Shinagawa A Yamamoto E Seiki M A matrix metalloproteinase expressed on the surface of invasive tumour cells Nature 1994, 370(6484):61-65. 8015608
9. Hernandez-Barrantes S Bernardo M Toth M Fridman R Regulation of membrane type-matrix metalloproteinases Semin Cancer Biol 2002, 12(2):131-138. 12027585
10. Nuttall RK Pennington CJ Taplin J Wheal A Yong VW Forsyth PA Edwards DR Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells Mol Cancer Res 2003, 1(5):333-345. 12651907
11. Coussens LM Fingleton B Matrisian LM Matrix metalloproteinase inhibitors and cancer: Trials and tribulations Science 2002, 295(5564):2387-2392. 11923519
12. Overall CM Kleifeld O Tumour microenvironment - opinion: Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy Nat Rev Cancer 2006, 6(3):227-239. 16498445
13. Zucker S Pei D Cao J Lopez-Otin C Membrane type-matrix metalloproteinases (MT-MMP) Curr Top Dev Biol 2003, 54:1-74. 12696745
14. Stamenkovic I Extracellular matrix remodelling: The role of matrix metalloproteinases J Pathol 2003, 200(4):448-464. 12845612
15. Strongin AY Collier I Bannikov G Marmer BL Grant GA Goldberg GI Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease J Biol Chem 1995, 270(10):5331-5338. 7890645
16. Zucker S Drews M Conner C Foda HD DeClerck YA Langley KE Bahou WF Docherty AJ Cao J Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP) J Biol Chem 1998, 273(2):1216-1222. 9422789
17. Toft-Hansen H Nuttall RK Edwards DR Owens T Key metalloproteinases are expressed by specific cell types in experimental autoimmune encephalomyelitis J Immunol 2004, 173(8):5209-5218. 15470066
18. Weaver A Goncalves da Silva A Nuttall RK Edwards DR Shapiro SD Rivest S Yong VW An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization Faseb J 2005, 19(12):1668-1670. 16081501
19. Fuentes ME Durham SK Swerdel MR Lewin AC Barton DS Megill JR Bravo R Lira SA Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1 J Immunol 1995, 155(12):5769-5776. 7499865
20. Toft-Hansen H Buist R Sun XJ Schellenberg A Peeling J Owens T Metalloproteinases Control Brain Inflammation Induced by Pertussis Toxin in Mice Overexpressing the Chemokine CCL2 in the Central Nervous System J Immunol 2006, 177(10):7242-7249. 17082642
21. Babcock AA Kuziel WA Rivest S Owens T Chemokine expression by glial cells directs leukocytes to sites of axonal injury in the CNS J Neurosci 2003, 23(21):7922-7930. 12944523
22. Wells JE Rice TK Nuttall RK Edwards DR Zekki H Rivest S Yong VW An adverse role for matrix metalloproteinase 12 after spinal cord injury in mice J Neurosci 2003, 23(31):10107-10115. 14602826
23. Millward JM Caruso M Campbell IL Gauldie J Owens T IFN-gamma-induced chemokines synergize with pertussis toxin to promote T cell entry to the central nervous system J Immunol 2007, 178(12):8175-8182. 17548656
24. Babcock AA Wirenfeldt M Holm T Nielsen HH Dissing-Olesen L Toft-Hansen H Millward JM Landmann R Rivest S Finsen B Owens T Toll-like receptor 2 signaling in response to brain injury: An innate bridge to neuroinflammation J Neurosci 2006, 26(49):12826-12837. 17151286
25. Bar-Or A Nuttall RK Duddy M Alter A Kim HJ Ifergan I Pennington CJ Bourgoin P Edwards DR Yong VW Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis Brain 2003, 126(Pt 12):2738-2749. 14506071
26. Nuttall RK Silva C Hader W Bar-Or A Patel KD Edwards DR Yong VW Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia Glia 2007, 55(5):516-526. 17216595
27. Ghirnikar RS Lee YL Eng LF Inflammation in traumatic brain injury: Role of cytokines and chemokines Neurochem Res 1998, 23(3):329-340. 9482245
28. Stoll G Jander S Schroeter M Detrimental and beneficial effects of injury-induced inflammation and cytokine expression in the nervous system Adv Exp Med Biol 2002, 513:87-113. 12575818
29. Borden P Heller RA Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases Crit Rev Eukaryot Gene Expr 1997, 7(1-2): 159-178. 9034720
30. Schmid CD Sautkulis LN Danielson PE Cooper J Hasel KW Hilbush BS Sutcliffe JG Carson MJ Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia J Neurochem 2002, 83(6):1309-1320. 12472885
31. Takahashi K Rochford CD Neumann H Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2 J Exp Med 2005, 201(4):647-657. 15728241
32. McCawley LJ Matrisian LM Matrix metalloproteinases: They're not just for matrix anymore! Curr Opin Cell Biol 2001, 13(5):534-540. 11544020
33. Kang T Yi J Guo A Wang X Overall CM Jiang W Elde R Borregaard N Pei D Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils J Biol Chem 2001, 276(24):21960-21968. 11282999
34. Rostworowski M Balasingam V Chabot S Owens T Yong VW Astrogliosis in the neonatal and adult murine brain post-trauma: Elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma J Neurosci 1997, 17(10):3664-3674. 9133389