Enhanced expression of MMP-7 and MMP-9 in demyelinating multiple sclerosis lesions

Acta Neuropathologica

Volumn 94, Issue 6, 1997, Pages 590-598

  Cossins, Judy A ^a   Clements, John M ^a   Ford, Janice ^a   Miller, Karen M ^a   Pigott, Rod ^a   Vos, Wim ^b   Van Der Valk, Paul ^b   De Groot, Corline J A ^b  

^a British Biotech Pharmaceuticals Ltd   (United Kingdom)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Immunohistochemistry; In situ hybridisation; MMP 7; MMP 9; Multiple sclerosis

Indexed keywords

DIGOXIGENIN; GELATINASE B; MATRILYSIN; MYELIN; PROTEINASE;

ADULT; AGED; ARTICLE; BLOOD BRAIN BARRIER; BRAIN TISSUE; CASE REPORT; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEMYELINATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; MACROPHAGE; MALE; MICROGLIA; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; RNA PROBE; SPLEEN; T LYMPHOCYTE; TISSUE SECTION; TONSIL;

ADULT; AGED; AGED, 80 AND OVER; ANTIBODY SPECIFICITY; BLOTTING, WESTERN; BRAIN; COLLAGENASES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MATRIX METALLOPROTEINASE 7; MATRIX METALLOPROTEINASE 9; METALLOENDOPEPTIDASES; MIDDLE AGED; MULTIPLE SCLEROSIS; SPINAL CORD;

EID: 0030806651     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050754     Document Type: Article

References (43)

1. Baragi VM, Fliszar CJ, Conroy MC, Ye Q-Z, Shipley JM, Welgus HG (1994) Contribution of the C-terminal truncated domain of metalloproteinases to binding by TIMP: C-terminal truncated stromelysin and matrilysin exhibit equally compromised affinities compared to full-length stromelysin. J Biol Chem 269: 12692-12697
2. Beck J, Rondot P, Catinot L, Falcoff E, Kirchner H, Wiotzerbin J (1988) Increased production of Interferon gamma and tumour necrosis factor precedes clinical manifestations in multiple sclerosis: do cytokines trigger off exacerbations? Acta Neurol Scand 78: 318-323
3. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA (1993) Matrix metalloproteinases: a review. Crit Rev Oral Biol Med 4: 197-250
4. BÖ L, Mork S, Kong PA, Nyland H, Pardo CA, Trapp BD (1994) Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions. J Neuroimmunol 51: 135-146
5. BÖ L, Dawson TM, Wesselingh S, Mork S, Choi S, Kong PA, Hanley D, Trapp BD (1994) Induction of nitric oxide synthase in demyelinating lesions of multiple sclerosis brains. Ann Neurol 36: 778-786
6. Brosnan CF, Selmaj K, Raine CS (1988) Hypothesis: a role for tumour necrosis factor in immune-mediated demyelination and its relevance to multiple sclerosis. J Neuroimmunol 18: 87-94
7. Busiek DF, Baragi V, Nehring LC, Parks WC, Welgus HG (1995) Matrilysin expression by human mononuclear phagocytes and its regulation by cytokines and hormones. J Immunol 154: 6484-6491
8. Chandler S, Coates R, Gearing A, Lury J, Wells G, Bone E (1995) Matrix metalloproteinases degrade myelin basic protein. Neurosci Lett 201: 223-226
9. Clements JM, Cossins JA, Wells GMA, Corkill DJ, Helfrich K, Wood LM, Pigott R, Stabler G, Ward GA, Gearing AJH, Miller KM (1997) Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor. J Neuroimmunol 74: 85-94
10. De Groot CJA, Theeuwes JWM, Dijkstra CD, Van Der Valk P (1995) Postmortem delay effects on neuroglial cells and brain macrophages from Lewis rats with acute experimental allergic encephalomyelitis: an immunohistochemical and cytochemical study. J Neuroimmunol 59: 123-134
11. 1-antichymotrypsin by oxidatively activated human neutrophil metalloproteinases. J Biol Chem 267: 5005-5012
12. Gearing AJH, Beckett P, Christodoulou M, Churchill M, Clements J, Davidson AH, Drummond AH, Galloway WA, Gilbert R, Gordon JL, Leber TM, Mangan M, Miller K, Nayee P, Owen K, Patel S, Thomas W, Wells G, Wood LM, Woolley K (1994) Processing of tumour necrosis factor-α precursor by metalloproteinases. Nature 370: 555-557
13. Gijbels K, Steinman L (1994) Gelatinase B producing cells in multiple sclerosis lesions. J Cell Biochem Suppl 18D:143
14. Gijbels K, Masure S, Carton H, Opdenakker G (1992) Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders. J Neuroimmunol 41: 29-34
15. Gijbels K, Proost P, Masure S, Carton H, Billau A, Opdenakker G (1993) Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein. J Neurosci Res 36: 432-440
16. Gijbels K, Galardy RE, Steinman L (1994) Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. J Clin Invest 94: 2177-2182
17. Hanemaaijer R, Koolwijk P, Le Clercq L, De Vree WJA, Van Hinsbergh VWM (1993) Regulation of matrix metalloproteinase expression in human vein and microvascular endothelial cells. Biochem J 296: 803-809
18. Hibbs MS, Hasty KA, Seyer JM, Rang AH, Mainardi CL (1985) Biochemical and immunological characterisation of the secreted forms of human neutrophil gelatinase. J Biol Chem 260: 2493-2500
19. Imai K, Yokohama Y, Nakanishi I, Ohuchi E, Fujii Y, Nakai N, Okada Y (1995) Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. J Biol Chem 270: 6691-6697
20. Jiwa NM, Kanavaros P, Bruin PC de, Valk P van der, Horstman A, Vos W, Mullink H, Walboomers JMM, Meijer CJLM (1993) Presence of Epstein-Barr virus harbouring small and intermediate-sized cells in Hodgkins disease. Is there a relationship with Reed-Sternberg cells? J Pathol 170: 129-136
21. Khoury SJ, Hancock WW, Weiner HL (1992) Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor beta, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 176: 1355-1364
22. Laemelli UK, Favre M (1973) Maturation of the head of bacteriophage T4. J Mol Biol 80: 575-599
23. Leppert D, Waubant E, Galardy R, Bunnett NW, Hauser SL (1995) T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol 154: 4379-4389
24. Maeda A, Sobel RA (1996) Matrix metalloproteinases in the normal human central nervous system, microglial nodules, and multiple sclerosis lesions. J Neuropathol Exp Neurol 55: 300-309
25. Matrisian LM (1992) The matrix-degrading metalloproteinases. BioEssays 14: 455-463
26. McDonald WI, Miller DH, Barnes D (1992) The pathological evolution of multiple sclerosis. Neuropathol Appl Neurobiol 18: 319-334
27. McDonnell S, Wright JH, Gaire M, Matrisian LM (1994) Expression and regulation of stromelysin and matrilysin by growth factors and oncogenes. Biochem Soc Trans 22: 58-63
28. Merrill JE, Strom SR, Ellison GW, Meyers LW (1989) In vitro study of mediators of inflammation in multiple sclerosis. J Clin Immunol 9: 84-96
29. Proost P, Van Damme J, Oppendakker G (1993) Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein. Biochem Biophys Res Commun 193: 1175-1181
30. Pulford KA, Rigney EM, Micklem KJ, Jones M, Stross WP, Gatter KC, Mason DY (1989) KP1: a new monoclonal antibody that detects a monocyte/macrophage associated antigen in routinely processed tissue sections. J Clin Pathol 42: 414-421
31. Racke MK, Dhib-Jalbut S, Canella B, Albert PS, Raine CS, McFarlin DE (1991) Prevention and treatment of chronic relapsing experimental allergic encephalomyelitis by transforming growth factor-β1. J Immunol 146: 3012-3017
32. Rieckmann P, Albrecht M, Kitze B, Weber T, Tumani H, Broocks A, Luer W, Helwig A, Poser S (1995) Tumour necrosis factor-α messenger RNA expression in patients with relapsing-remitting multiple sclerosis is associated with disease activity. Ann Neurol 37: 82-88
33. Ries C, Petrides PE (1995) Cytokine regulation of matrix metalloproteinase activity and its dysfunction in disease. Biol Chem Hoppe-Seyler 376: 345-355
34. Romanic AM, Madri JA (1994) Extracellular matrix-degrading proteinases in the nervous system. Brain Pathol 4: 145-156
35. Romanic AM, Madri JA (1994) The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent. J Cell Biol 125: 1165-1178
36. Rosenberg GA, Estrada EY, Dencoff JE, Stetler-Stevenson WG (1995) Tumour necrosis factor-α-induced gelatinase B causes delayed opening of the blood-brain barrier: an expanded therapeutic window. Brain Res 703: 151-155
37. Selmaj K, Raine CS (1988) Tumor necrosis factor mediates myelin damage in organotypic cultures of nervous tissue Ann NY Acad Sci 540: 568-570
38. Selmaj K, Raine CS, Canella B, Brosnan CF (1991) Identification of lymphotoxin and tumour necrosis factor in multiple sclerosis lesions. J Clin Invest 87: 949-954
39. Shapiro SD (1994) Elastolytic metalloproteinases produced by human mononuclear phagocytes. Am J Respir Crit Care Med 150:S160-S164
40. Sharief MK, Thompson EJ (1992) In vivo relationship of tumour necrosis factor-α to blood-brain barrier damage in patients with active multiple sclerosis. J Neuroimmunol 38: 27-34
41. Wilhelm SM, Collier IE, Manner BL, Eisen AZ, Grant GA, Goldberg GI (1989) SV-40-transformed human lung fibroblasts secrete a 92 kDa type IV collagenase which is identical to that secreted by normal lung macrophages. J Biol Chem 264: 17213-17221
42. Woessner JF Jr (1992) Role of cellular proteinases and their protein inhibitors in inflammation. In: Whicher JT, Woessner JF Jr (eds) Immunology and medicine, biochemistry of inflammation. Kluwer, Dordrecht, pp 57-89
43. Woodroofe MN, Cuzner ML (1993) Cytokine mRNA expression in inflammatory multiple sclerosis: detection by non-radioactive in situ hybridization. Cytokine 5: 583-588