Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritis

FASEB Journal

Volumn 16, Issue 3, 2002, Pages 379-389

  Van Den Steen, Philippe E ^a   Proost, Paul ^a   Grillet, Bernard ^a   Brand, David D ^b   Kang, Andrew H ^b   Van Damme, J O ^a   Opdenakker, Ghislain ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Autoimmunity; Gelatinase B; Glycosylation; Neutrophil; Rheumatoid arthritis

Indexed keywords

ALPHA CHEMOKINE; COLLAGEN TYPE 2; EPITOPE; GELATINASE B; INTERLEUKIN 8; LYSINE;

ANIMAL CELL; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENZYME BINDING; ENZYME GLYCOSYLATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; HYDROXYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DENATURATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION;

AMINO ACID SEQUENCE; ANIMALS; ARTHRITIS, RHEUMATOID; BINDING SITES; CATTLE; COLLAGEN TYPE II; HUMANS; IMMUNODOMINANT EPITOPES; INTERLEUKIN-8; MATRIX METALLOPROTEINASE 9; MODELS, IMMUNOLOGICAL; MOLECULAR SEQUENCE DATA; NEUTROPHILS; PEPTIDE FRAGMENTS; PROTEIN DENATURATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SUBSTRATE SPECIFICITY; SYNOVIAL FLUID;

ANIMALIA;

EID: 0036186977     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.01-0688com     Document Type: Article

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