Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: Identification of the active components and JAK2 and gp130 as substrates

Growth Factors

Volumn 32, Issue 1, 2014, Pages 1-10

  Kershaw, Nadia J ^a,b   Laktyushin, Artem ^a   Nicola, Nicos A ^a,b   Babon, Jeffrey J ^a,b  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Cullin5; Cytokine receptor; Cytokine signaling; E3 ubiquitin ligase; JAK; SOCS3; Suppressor of cytokine signaling; Ubiquitination

Indexed keywords

GLYCOPROTEIN GP 130; INTERLEUKIN 6 RECEPTOR; JANUS KINASE 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; UBIQUITIN PROTEIN LIGASE E3;

ARTICLE; ENZYME SUBSTRATE; HUMAN; IN VITRO STUDY; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

ANIMALS; CELL LINE; CLONING, MOLECULAR; CULLIN PROTEINS; CYTOKINE RECEPTOR GP130; HUMANS; IRON-BINDING PROTEINS; JANUS KINASE 2; MICE; PHOSPHORYLATION; PROTEIN BINDING; SIGNAL TRANSDUCTION; SPODOPTERA; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TRANSCRIPTION FACTORS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION; UBIQUITINS;

EID: 84893331326     PISSN: 08977194     EISSN: 10292292     Source Type: Journal    
DOI: 10.3109/08977194.2013.877005     Document Type: Article

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