-
1
-
-
0001733810
-
N-formylmethionyl peptides as chemoattractants for leucocytes
-
Schiffmann, E., Corcoran, B. A., and Wahl, S. M. (1975) N-formylmethionyl peptides as chemoattractants for leucocytes. Proc. Natl. Acad. Sci. U.S.A. 72, 1059-1062
-
(1975)
Proc. Natl. Acad. Sci. U.S.A.
, vol.72
, pp. 1059-1062
-
-
Schiffmann, E.1
Corcoran, B.A.2
Wahl, S.M.3
-
2
-
-
0018678025
-
Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils
-
Niedel, J. E., Kahane, I., and Cuatrecasas, P. (1979) Receptor-mediated internalization of fluorescent chemotactic peptide by human neutrophils. Science 205, 1412-1414
-
(1979)
Science
, vol.205
, pp. 1412-1414
-
-
Niedel, J.E.1
Kahane, I.2
Cuatrecasas, P.3
-
3
-
-
34548588559
-
How human neutrophils kill and degrade microbes. An integrated view
-
Nauseef, W. M. (2007) How human neutrophils kill and degrade microbes. An integrated view. Immunol. Rev. 219, 88-102
-
(2007)
Immunol. Rev.
, vol.219
, pp. 88-102
-
-
Nauseef, W.M.1
-
4
-
-
67649438808
-
International union of basic and clinical pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family
-
Ye, R. D., Boulay, F., Wang, J. M., Dahlgren, C., Gerard, C., Parmentier, M., Serhan, C. N., and Murphy, P. M. (2009) International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family. Pharmacol. Rev. 61, 119-161
-
(2009)
Pharmacol. Rev.
, vol.61
, pp. 119-161
-
-
Ye, R.D.1
Boulay, F.2
Wang, J.M.3
Dahlgren, C.4
Gerard, C.5
Parmentier, M.6
Serhan, C.N.7
Murphy, P.M.8
-
5
-
-
0033557172
-
Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor
-
Gao, J. L., Lee, E. J., and Murphy, P. M. (1999) Impaired antibacterial host defense in mice lacking the N-formylpeptide receptor. J. Exp. Med. 189, 657-662
-
(1999)
J. Exp. Med.
, vol.189
, pp. 657-662
-
-
Gao, J.L.1
Lee, E.J.2
Murphy, P.M.3
-
6
-
-
77950275298
-
Circulating mitochondrial DAMPs cause inflammatory responses to injury
-
Zhang, Q., Raoof, M., Chen, Y., Sumi, Y., Sursal, T., Junger, W., Brohi, K., Itagaki, K., and Hauser, C. J. (2010) Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature 464, 104-107
-
(2010)
Nature
, vol.464
, pp. 104-107
-
-
Zhang, Q.1
Raoof, M.2
Chen, Y.3
Sumi, Y.4
Sursal, T.5
Junger, W.6
Brohi, K.7
Itagaki, K.8
Hauser, C.J.9
-
7
-
-
77957943307
-
Intravascular danger signals guide neutrophils to sites of sterile inflammation
-
McDonald, B., Pittman, K., Menezes, G. B., Hirota, S. A., Slaba, I., Waterhouse, C. C., Beck, P. L., Muruve, D. A., and Kubes, P. (2010) Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science 330, 362-366
-
(2010)
Science
, vol.330
, pp. 362-366
-
-
McDonald, B.1
Pittman, K.2
Menezes, G.B.3
Hirota, S.A.4
Slaba, I.5
Waterhouse, C.C.6
Beck, P.L.7
Muruve, D.A.8
Kubes, P.9
-
8
-
-
0025615835
-
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors
-
Boulay, F., Tardif, M., Brouchon, L., and Vignais, P. (1990) The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors. Biochemistry 29, 11123-11133
-
(1990)
Biochemistry
, vol.29
, pp. 11123-11133
-
-
Boulay, F.1
Tardif, M.2
Brouchon, L.3
Vignais, P.4
-
9
-
-
0027184065
-
Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors
-
Quehenberger, O., Prossnitz, E. R., Cavanagh, S. L., Cochrane, C. G., and Ye, R. D. (1993) Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J. Biol. Chem. 268, 18167-18175
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 18167-18175
-
-
Quehenberger, O.1
Prossnitz, E.R.2
Cavanagh, S.L.3
Cochrane, C.G.4
Ye, R.D.5
-
10
-
-
0031577558
-
Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach
-
Quehenberger, O., Pan, Z. K., Prossnitz, E. R., Cavanagh, S. L., Cochrane, C. G., and Ye, R. D. (1997) Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach. Biochem. Biophys. Res. Commun. 238, 377-381
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.238
, pp. 377-381
-
-
Quehenberger, O.1
Pan, Z.K.2
Prossnitz, E.R.3
Cavanagh, S.L.4
Cochrane, C.G.5
Ye, R.D.6
-
11
-
-
0033198901
-
Human formyl peptide receptor function role of conserved and nonconserved charged residues
-
Lala, A., Gwinn, M., and De Nardin, E. (1999) Human formyl peptide receptor function role of conserved and nonconserved charged residues. Eur. J. Biochem. 264, 495-499
-
(1999)
Eur. J. Biochem.
, vol.264
, pp. 495-499
-
-
Lala, A.1
Gwinn, M.2
De Nardin, E.3
-
12
-
-
0034671926
-
Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu
-
Mills, J. S., Miettinen, H. M., Cummings, D., and Jesaitis, A. J. (2000) Characterization of the binding site on the formyl peptide receptor using three receptor mutants and analogs of Met-Leu-Phe and Met-Met-Trp-Leu-Leu. J. Biol. Chem. 275, 39012-39017
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39012-39017
-
-
Mills, J.S.1
Miettinen, H.M.2
Cummings, D.3
Jesaitis, A.J.4
-
13
-
-
0032562690
-
Identification of a ligand binding site in the human neutrophil formyl peptide receptor using a site-specific fluorescent photoaffinity label and mass spectrometry
-
Mills, J. S., Miettinen, H. M., Barnidge, D., Vlases, M. J., Wimer-Mackin, S., Dratz, E. A., Sunner, J., and Jesaitis, A. J. (1998) Identification of a ligand binding site in the human neutrophil formyl peptide receptor using a site-specific fluorescent photoaffinity label and mass spectrometry. J. Biol. Chem. 273, 10428-10435
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10428-10435
-
-
Mills, J.S.1
Miettinen, H.M.2
Barnidge, D.3
Vlases, M.J.4
Wimer-Mackin, S.5
Dratz, E.A.6
Sunner, J.7
Jesaitis, A.J.8
-
14
-
-
23844446792
-
Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR
-
Rabiet, M. J., Huet, E., and Boulay, F. (2005) Human mitochondria-derived N-formylated peptides are novel agonists equally active on FPR and FPRL1, while Listeria monocytogenes-derived peptides preferentially activate FPR. Eur. J. Immunol. 35, 2486-2495
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 2486-2495
-
-
Rabiet, M.J.1
Huet, E.2
Boulay, F.3
-
15
-
-
84872745841
-
Functional characterization of three mouse formyl peptide receptors
-
He, H. Q., Liao, D., Wang, Z. G., Wang, Z. L., Zhou, H. C., Wang, M. W., and Ye, R. D. (2013) Functional characterization of three mouse formyl peptide receptors. Mol. Pharmacol. 83, 389-398
-
(2013)
Mol. Pharmacol.
, vol.83
, pp. 389-398
-
-
He, H.Q.1
Liao, D.2
Wang, Z.G.3
Wang, Z.L.4
Zhou, H.C.5
Wang, M.W.6
Ye, R.D.7
-
16
-
-
84863450134
-
Impact of helix irregularities on sequence alignment and homology modeling of G protein-coupled receptors
-
Gonzalez, A., Cordomí, A., Caltabiano, G., and Pardo, L. (2012) Impact of helix irregularities on sequence alignment and homology modeling of G protein-coupled receptors. Chembiochem. 13, 1393-1399
-
(2012)
Chembiochem.
, vol.13
, pp. 1393-1399
-
-
Gonzalez, A.1
Cordomí, A.2
Caltabiano, G.3
Pardo, L.4
-
17
-
-
85027927015
-
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
-
Wu, B., Chien, E. Y., Mol, C. D., Fenalti, G., Liu, W., Katritch, V., Abagyan, R., Brooun, A., Wells, P., Bi, F. C., Hamel, D. J., Kuhn, P., Handel, T. M., Cherezov, V., and Stevens, R. C. (2010) Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science 330, 1066-1071
-
(2010)
Science
, vol.330
, pp. 1066-1071
-
-
Wu, B.1
Chien, E.Y.2
Mol, C.D.3
Fenalti, G.4
Liu, W.5
Katritch, V.6
Abagyan, R.7
Brooun, A.8
Wells, P.9
Bi, F.C.10
Hamel, D.J.11
Kuhn, P.12
Handel, T.M.13
Cherezov, V.14
Stevens, R.C.15
-
18
-
-
0033873929
-
Comparative protein structure modeling of genes and genomes
-
Martí-Renom, M. A., Stuart, A. C., Fiser, A., Sánchez, R., Melo, F., and Sali, A. (2000) Comparative protein structure modeling of genes and genomes. Annu. Rev. Biophys. Biomol. Struct. 29, 291-325
-
(2000)
Annu. Rev. Biophys. Biomol. Struct.
, vol.29
, pp. 291-325
-
-
Martí-Renom, M.A.1
Stuart, A.C.2
Fiser, A.3
Sánchez, R.4
Melo, F.5
Sali, A.6
-
19
-
-
77957055780
-
Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G-protein coupled receptors
-
Ballesteros, J. A., and Weinstein, H. (1995) Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G-protein coupled receptors. Methods Neurosci. 25, 366-428
-
(1995)
Methods Neurosci.
, vol.25
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.2
-
20
-
-
76149120388
-
AutoDock Vina. Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
-
Trott, O., and Olson, A. J. (2010) AutoDock Vina. Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J. Comput Chem. 31, 455-461
-
(2010)
J. Comput Chem.
, vol.31
, pp. 455-461
-
-
Trott, O.1
Olson, A.J.2
-
21
-
-
34248394606
-
-
University of California, San Francisco
-
Case, D. A., Darden, T. A., Cheatham, T. E., III, Simmerling, C. L., Wang, J., Duke, R. E., Luo, R., Merz, K. M., Pearlman, D. A., Crowley, M., Walker, R. C., Zhang, W., Wang, B., Hayik, S., Roitberg, A., Seabra, G., Wong, K. F., Paesani, F., Wu, X., Brozell, S., Tsui, V., Gohlke, H., Yang, L., Tan, C., Mongan, J., Hornak, V., Cui, G., Beroza, P., Mathews, D. H., Schafmeister, C., Ross, W. S., and Kollman, P. A. (2006) AMBER9. University of California, San Francisco
-
(2006)
AMBER9
-
-
Case, D.A.1
Darden, T.A.2
Cheatham III, T.E.3
Simmerling, C.L.4
Wang, J.5
Duke, R.E.6
Luo, R.7
Merz, K.M.8
Pearlman, D.A.9
Crowley, M.10
Walker, R.C.11
Zhang, W.12
Wang, B.13
Hayik, S.14
Roitberg, A.15
Seabra, G.16
Wong, K.F.17
Paesani, F.18
Wu, X.19
Brozell, S.20
Tsui, V.21
Gohlke, H.22
Yang, L.23
Tan, C.24
Mongan, J.25
Hornak, V.26
Cui, G.27
Beroza, P.28
Mathews, D.H.29
Schafmeister, C.30
Ross, W.S.31
Kollman, P.A.32
more..
-
22
-
-
26444467486
-
Linking agonist binding to histamine H1 receptor activation
-
Jongejan, A., Bruysters, M., Ballesteros, J. A., Haaksma, E., Bakker, R. A., Pardo, L., and Leurs, R. (2005) Linking agonist binding to histamine H1 receptor activation. Nat. Chem. Biol. 1, 98-103
-
(2005)
Nat. Chem. Biol.
, vol.1
, pp. 98-103
-
-
Jongejan, A.1
Bruysters, M.2
Ballesteros, J.A.3
Haaksma, E.4
Bakker, R.A.5
Pardo, L.6
Leurs, R.7
-
23
-
-
0034667987
-
The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor
-
He, R., Tan, L., Browning, D. D., Wang, J. M., and Ye, R. D. (2000) The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met is a potent chemotactic agonist for mouse formyl peptide receptor. J. Immunol. 165, 4598-4605
-
(2000)
J. Immunol.
, vol.165
, pp. 4598-4605
-
-
He, R.1
Tan, L.2
Browning, D.D.3
Wang, J.M.4
Ye, R.D.5
-
24
-
-
6944234939
-
A novel nonpeptide ligand for formyl peptide receptor-like 1
-
Nanamori, M., Cheng, X., Mei, J., Sang, H., Xuan, Y., Zhou, C., Wang, M. W., and Ye, R. D. (2004) A novel nonpeptide ligand for formyl peptide receptor-like 1. Mol. Pharmacol. 66, 1213-1222
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 1213-1222
-
-
Nanamori, M.1
Cheng, X.2
Mei, J.3
Sang, H.4
Xuan, Y.5
Zhou, C.6
Wang, M.W.7
Ye, R.D.8
-
25
-
-
0026718769
-
Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor
-
Ye, R. D., Cavanagh, S. L., Quehenberger, O., Prossnitz, E. R., and Cochrane, C. G. (1992) Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor. Biochem. Biophys. Res. Commun. 184, 582-589
-
(1992)
Biochem. Biophys. Res. Commun.
, vol.184
, pp. 582-589
-
-
Ye, R.D.1
Cavanagh, S.L.2
Quehenberger, O.3
Prossnitz, E.R.4
Cochrane, C.G.5
-
26
-
-
0342976013
-
A series of six ligands for the human formyl peptide receptor. Tetrapeptides with high chemotactic potency and efficacy
-
Rot, A., Henderson, L. E., Copeland, T. D., and Leonard, E. J. (1987) A series of six ligands for the human formyl peptide receptor. Tetrapeptides with high chemotactic potency and efficacy. Proc. Natl. Acad. Sci. U.S.A. 84, 7967-7971
-
(1987)
Proc. Natl. Acad. Sci. U.S.A.
, vol.84
, pp. 7967-7971
-
-
Rot, A.1
Henderson, L.E.2
Copeland, T.D.3
Leonard, E.J.4
-
27
-
-
49049098142
-
Identification of formyl peptides from Listeria monocytogenes and Staphylococcus aureus as potent chemoattractants for mouse neutrophils
-
Southgate, E. L., He, R. L., Gao, J. L., Murphy, P. M., Nanamori, M., and Ye, R. D. (2008) Identification of formyl peptides from Listeria monocytogenes and Staphylococcus aureus as potent chemoattractants for mouse neutrophils. J. Immunol. 181, 1429-1437
-
(2008)
J. Immunol.
, vol.181
, pp. 1429-1437
-
-
Southgate, E.L.1
He, R.L.2
Gao, J.L.3
Murphy, P.M.4
Nanamori, M.5
Ye, R.D.6
-
28
-
-
33751211223
-
Formyl peptide receptors. A promiscuous subfamily of G protein-coupled receptors controlling immune responses
-
Migeotte, I., Communi, D., and Parmentier, M. (2006) Formyl peptide receptors. A promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine Growth Factor Rev. 17, 501-519
-
(2006)
Cytokine Growth Factor Rev.
, vol.17
, pp. 501-519
-
-
Migeotte, I.1
Communi, D.2
Parmentier, M.3
-
29
-
-
0020033439
-
Formyl peptide chemoattractants. A model of the receptor on rabbit neutrophils
-
Freer, R. J., Day, A. R., Muthukumaraswamy, N., Pinon, D., Wu, A., Showell, H. J., and Becker, E. L. (1982) Formyl peptide chemoattractants. A model of the receptor on rabbit neutrophils. Biochemistry 21, 257-263
-
(1982)
Biochemistry
, vol.21
, pp. 257-263
-
-
Freer, R.J.1
Day, A.R.2
Muthukumaraswamy, N.3
Pinon, D.4
Wu, A.5
Showell, H.J.6
Becker, E.L.7
-
30
-
-
0025021022
-
Fluorescence analysis of the size of a binding pocket of a peptide receptor at natural abundance
-
Sklar, L. A., Fay, S. P., Seligmann, B. E., Freer, R. J., Muthukumaraswamy, N., and Mueller, H. (1990) Fluorescence analysis of the size of a binding pocket of a peptide receptor at natural abundance. Biochemistry 29, 313-316
-
(1990)
Biochemistry
, vol.29
, pp. 313-316
-
-
Sklar, L.A.1
Fay, S.P.2
Seligmann, B.E.3
Freer, R.J.4
Muthukumaraswamy, N.5
Mueller, H.6
-
31
-
-
0345791508
-
Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states
-
Swaminath, G., Xiang, Y., Lee, T. W., Steenhuis, J., Parnot, C., and Kobilka, B. K. (2004) Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states. J. Biol. Chem. 279, 686-691
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 686-691
-
-
Swaminath, G.1
Xiang, Y.2
Lee, T.W.3
Steenhuis, J.4
Parnot, C.5
Kobilka, B.K.6
-
32
-
-
33144459843
-
Molecular mechanism of 7TM receptor activation. A global toggle switch model
-
Schwartz, T. W., Frimurer, T. M., Holst, B., Rosenkilde, M. M., and Elling, C. E. (2006) Molecular mechanism of 7TM receptor activation. A global toggle switch model. Annu. Rev. Pharmacol. Toxicol. 46, 481-519
-
(2006)
Annu. Rev. Pharmacol. Toxicol.
, vol.46
, pp. 481-519
-
-
Schwartz, T.W.1
Frimurer, T.M.2
Holst, B.3
Rosenkilde, M.M.4
Elling, C.E.5
-
33
-
-
0026644385
-
A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family
-
Murphy, P. M., Ozçelik, T., Kenney, R. T., Tiffany, H. L., McDermott, D., and Francke, U. (1992) A structural homologue of the N-formyl peptide receptor. Characterization and chromosome mapping of a peptide chemoattractant receptor family. J. Biol. Chem. 267, 7637-7643
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 7637-7643
-
-
Murphy, P.M.1
Ozçelik, T.2
Kenney, R.T.3
Tiffany, H.L.4
McDermott, D.5
Francke, U.6
-
34
-
-
73849149844
-
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
-
Bokoch, M. P., Zou, Y., Rasmussen, S. G., Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H. J., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L., and Kobilka, B. K. (2010) Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature 463, 108-112
-
(2010)
Nature
, vol.463
, pp. 108-112
-
-
Bokoch, M.P.1
Zou, Y.2
Rasmussen, S.G.3
Liu, C.W.4
Nygaard, R.5
Rosenbaum, D.M.6
Fung, J.J.7
Choi, H.J.8
Thian, F.S.9
Kobilka, T.S.10
Puglisi, J.D.11
Weis, W.I.12
Pardo, L.13
Prosser, R.S.14
Mueller, L.15
Kobilka, B.K.16
-
35
-
-
0035918313
-
The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation
-
Govaerts, C., Blanpain, C., Deupi, X., Ballet, S., Ballesteros, J. A., Wodak, S. J., Vassart, G., Pardo, L., and Parmentier, M. (2001) The TXP motif in the second transmembrane helix of CCR5. A structural determinant of chemokine-induced activation. J. Biol. Chem. 276, 13217-13225
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 13217-13225
-
-
Govaerts, C.1
Blanpain, C.2
Deupi, X.3
Ballet, S.4
Ballesteros, J.A.5
Wodak, S.J.6
Vassart, G.7
Pardo, L.8
Parmentier, M.9
-
36
-
-
74549219527
-
Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition
-
Kirpotina, L. N., Khlebnikov, A. I., Schepetkin, I. A., Ye, R. D., Rabiet, M. J., Jutila, M. A., and Quinn, M. T. (2010) Identification of novel small-molecule agonists for human formyl peptide receptors and pharmacophore models of their recognition. Mol. Pharmacol. 77, 159-170
-
(2010)
Mol. Pharmacol.
, vol.77
, pp. 159-170
-
-
Kirpotina, L.N.1
Khlebnikov, A.I.2
Schepetkin, I.A.3
Ye, R.D.4
Rabiet, M.J.5
Jutila, M.A.6
Quinn, M.T.7
-
37
-
-
84887302240
-
Ligandspecific conformational change of the G-protein-coupled receptor ALX/ FPR2 determines proresolving functional responses
-
Cooray, S. N., Gobbetti, T., Montero-Melendez, T., McArthur, S., Thompson, D., Clark, A. J., Flower, R. J., and Perretti, M. (2013) Ligandspecific conformational change of the G-protein-coupled receptor ALX/ FPR2 determines proresolving functional responses. Proc. Natl. Acad. Sci. U.S.A. 110, 18232-18237
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 18232-18237
-
-
Cooray, S.N.1
Gobbetti, T.2
Montero-Melendez, T.3
McArthur, S.4
Thompson, D.5
Clark, A.J.6
Flower, R.J.7
Perretti, M.8
|