Human formyl peptide receptor function. Role of conserved and nonconserved charged residues

European Journal of Biochemistry

Volumn 264, Issue 2, 1999, Pages 495-499

  Lala, Amitabha ^a   Gwinn, Maureen ^a   De Nardin, Ernesto ^a,b  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Charged residue; f Met Leu Phe; fMLF receptor; Ligand binding; Neutrophil

Indexed keywords

AMINO ACID; ARGININE; ASPARTIC ACID; CALCIUM; FORMYLMETHIONYLLEUCYLPHENYLALANINE; LIGAND; LYSINE; PEPTIDE; RECEPTOR;

AMINO ACID SEQUENCE; ARTICLE; HUMAN; HUMAN CELL; LIGAND BINDING; NEUTROPHIL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TERTIARY STRUCTURE; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CALCIUM; CELL LINE; CLONING, MOLECULAR; CONSERVED SEQUENCE; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; PROTEIN BINDING; RECEPTORS, FORMYL PEPTIDE; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PEPTIDE; SEQUENCE ALIGNMENT; TRANSFECTION;

EID: 0033198901     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00647.x     Document Type: Article

References (27)

1. Aswanikumar, S., Corcoran, B.A., Schiffman, E., Day, A.R., Freer, R.J., Showell, H.J., Becker, E.L. & Pert, C.B. (1977) Demonstration of a receptor on rabbit neutrophils for chemotactic peptides. Biophys. Res. Commun. 74, 810-817.
2. Williams, L.T., Snyderman, R., Pike, M.C. & Lefkowitz, R.J. (1977) Specific receptor site for chemotactic peptides on human polymorphonuclear leukocytes. Proc. Natl Acad. Sci. USA 74, 1204-1208.
3. Gallin, J.I. (1992) Mechanical responses of white blood cells. In Inflammation: Basic Principles and Clinical Correlates (Gallin, J.I., Goldstein, I.M. & Snyderman, R., ed.), 2nd edn, pp. 459-475. Raven Press, New York.
4. Snyderman, R. & Uhing, R.J. (1992) Phagocytic cells: stimulus-response coupling mechanisms. In Inflammation: Basic Principles and Clinical Correlates (Gallin, J. I., Goldstein, I. M. & Snyderman, R., eds), pp. 421-439. Raven Press, New York.
5. Marasco, W.A., Phan, S.H., Krutzsch, H., Showell, H.J., Feltner, D.E., Nairn, R., Becker, E.L. & Ward, P.A. (1984) Purification and identification of the formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J. Biol. Chem. 259, 5430-5439.
6. Freer, R.J., Day, A.R., Muthukumaraswamy, N., Pinon, D., Wu, A., Showell, H.J. & Becker, E.L. (1982) Formyl peptidechemoattractants: a model of the receptor on rabbit neutrophils. Biochemistry 21, 257-263.
7. Dentino, A.R., Raj, P.A., Bhandary, K.K., Wilson, M.E. & Levine, M.J. (1991) Role of peptide backbone conformation on biological activity of chemotactic peptides. J. Biol. Chem. 266, 18460-18468.
8. Radel, S.J., Genco, R.J. & De Nardin, E. (1991) Localization of ligand binding regions of the human formyl peptide receptor. Biochem. Inter. 25, 745-753.
9. Quehenberger, O., Prossnitz, E.R., Cavanagh, S.L. Cochrane, C.G. 18175.
10. Quehenberger, O., Pan, Z.K., Prossnitz, E.R., Cavanagh, S.L. Cochrane, C.G. & Ye R.D. (1997) Identification of an N-formyl peptide receptor ligand binding domain by a gain-of-function approach. Biochem. Biophys. Res. Comm. 238, 377-381.
11. Lemke, H.D. & Oesterhelt, D. (1981) Lysine 216 is a binding site of the retinyl moiety in bacteriorhodopsin. FEBS Lett. 128, 255-260.
12. Probst, W.C., Snyder, L.A., Schuster, D.I., Brosius, J. & Sealfon, S.C. (1992) Sequence alignment of the G-protein coupled receptor superfamily. Cell Biol. 11, 1-20.
13. Lala, A. & De Nardin, E. (1996) Role of Asp in ligand binding of human FMLP receptor. J. Dent. Res. 75, (Abstract3204).
14. Lala, A., Sharma, A., Sojar, H.T., Radel, S.J., Genco, R.J. & DeNardin, E. (1993). Recombinant expression and partial characterization of the human formyl peptide receptor. Biochim. Biophys. Act. 1178, 302-306.
15. Sambrook, J., Fritsch, E.F. & Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press, New York.
16. Lala, A., Sojar, H.T. & DeNardin, E. (1997) Purification and characterization of human neutrophil FMLP receptor: generation of a polyclonal antibody against the receptor. Biochem. Pharmacol. 54, 81-90.
17. Radel, S.J., Genco, R.J. & De Nardin, E. (1994) Structural and functional characterization of the human formyl peptide receptor ligand binding region. Infect. Immun. 62, 1726-1732.
18. Schreiber, R.E., Prossnitz, E.R., Ye, R.D., Cochrane, C.G. & Bokoch, G.M. (1994). Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling. Mapping with receptor-derived peptides. J. Biol. Chem. 269, 326-331.
19. Wiltink, A., van den Brink, A.M., Herrmann-Erlee, M.P., van der Meer, J.M., van der Plas, A., Willems, P.H., Van Duijn, B., Nijweide, P.J. & Ypey, D.L. (1993) Heterogeneity of intracellular responses to parathyroid hormone and thrombin in primary osteoblast-like cells and UMR106-01 cells: correlations with culture conditions, intracellular calcium concentration and differentiation state. Cell Calcium 14, 591-600.
20. Didsbury, J.R., Uhing, R.J., Tomhave, E., Gerard, C., Gerard, N. & Snyderman, R. (1992) Functional high efficiency expression of cloned leukocyte chemoattractant receptor cDNAs. FEBS Lett. 297, 275-279.
21. Miettinen, H.M., Mills, J., Gripentrog, J., Dratz, E.A., Granger, B.L. & Jesaitis, A.J. (1997). The ligand binding site of the formyl peptide receptor maps in the transmembrane region. J. Immunol. 159, 4045-4054.
22. Mills, J.S., Miettinen, H.M., Barnidge, D., Vlases, M.J., Wimer-Mackin, S., Dratz, E.A., Sunner, J. & Jesaitis, A.J. (1998) Identification of a ligand binding site in the human neutrophil formyl peptide receptor using a site-specific fluorescent photo-affinity label and mass spectrometry. J. Biol. Chem. 273, 10428-10435.
23. Prossnitz, E.R. & Ye, R.D. (1997) The N-formyl peptide receptor: a model for the study of chemoattractant receptor structure and function. Pharm. Ther. 74, 73-102.
24. von Heijne, G. (1986) The distribution of positively charged residues in bacterial inner membrane proteins correlates with the transmembrane topology. EMBO J. 5, 3021-3027.
25. Engleman, D.M. & Zaccai, G. (1980) Bacteriorhodopsin is an inside out protein. Proc. Natl Acad. Sci. USA 77, 5894-5898.
26. Warschel, A. (1981) Electrostatic basis of structure-function correlation in proteins. Acc. Chem. Res. 14, 284-290.
27. Lodi, P.J., Garrett, D.S., Kuszewski, J., Tsang, M.L., Weatherbee, J.A., Leonard, W.J., Gronenborn, A.M. & Clore, G.M. (1994) High resolution structure of the beta chemokine hMIP-1 beta by multi-dimensional NMR. Science. 263, 1762-1767.