PI3Kδ inhibition augments the efficacy of rapamycin in suppressing proliferation of Epstein-Barr virus (EBV)+ B cell lymphomas

American Journal of Transplantation

Volumn 13, Issue 8, 2013, Pages 2035-2043

  Furukawa, S ^a,b   Wei, L ^a   Krams, S M ^a   Esquivel, C O ^a   Martinez, O M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ASTELLAS PHARMA INC   (Japan)

Author keywords

Epstein Barr Virus; mTOR; PI3kinase Akt pathway; posttransplant lymphoproliferative disorder

Indexed keywords

1 (1 CYANO 1 METHYLETHYL) 3 METHYL 8 (3 QUINOLINYL)IMIDAZO[4,5 C]QUINOLIN 2(1H,3H) ONE; AZD 8055; GLYCOGEN SYNTHASE KINASE 3; IDELALISIB; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE DELTA; PROTEIN BAD; PROTEIN KINASE B; PROTEIN P110; RAPAMYCIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; B CELL LYMPHOMA; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; LYMPHOPROLIFERATIVE DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING;

EPSTEIN-BARR VIRUS; MTOR; PI3KINASE/AKT PATHWAY; POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER;

BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SYNERGISM; EPSTEIN-BARR VIRUS INFECTIONS; HERPESVIRUS 4, HUMAN; HUMANS; IMIDAZOLES; LYMPHOMA, B-CELL; LYMPHOPROLIFERATIVE DISORDERS; MULTIPROTEIN COMPLEXES; ORGAN TRANSPLANTATION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; POSTOPERATIVE COMPLICATIONS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; QUINOLINES; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84881370978     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/ajt.12328     Document Type: Article

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