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Volumn 94, Issue 12, 2012, Pages 1208-1217

Is cytomegalovirus prophylaxis dispensable in patients receiving an mtor inhibitor-based immunosuppression? a systematic review and meta-analysis

Author keywords

Calcineurininhibitors; Cytomegalovirus; Meta analysis; mTOR Inhibitors; Systematic review

Indexed keywords

AZATHIOPRINE; CALCINEURIN INHIBITOR; CYCLOSPORIN A; EVEROLIMUS; GANCICLOVIR; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RAPAMYCIN; TACROLIMUS; VALGANCICLOVIR;

EID: 84872085198     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3182708e56     Document Type: Review
Times cited : (77)

References (69)
  • 1
    • 37349073878 scopus 로고    scopus 로고
    • Infection in solid-organ transplant recipients
    • Fishman JA. Infection in solid-organ transplant recipients. N Engl J Med 2007; 357: 2601.
    • (2007) N Engl J Med , vol.357 , pp. 2601
    • Fishman, J.A.1
  • 2
    • 20444453778 scopus 로고    scopus 로고
    • Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solidorgan transplants: A systematic review of randomised controlled trials
    • Hodson EM, Jones CA, Webster AC, et al. Antiviral medications to prevent cytomegalovirus disease and early death in recipients of solidorgan transplants: a systematic review of randomised controlled trials. Lancet 2005; 365: 2105.
    • (2005) Lancet , vol.365 , pp. 2105
    • Hodson, E.M.1    Jones, C.A.2    Webster, A.C.3
  • 3
    • 8644237321 scopus 로고    scopus 로고
    • Late-onset cytomegalovirus disease in liver transplant recipients despite antiviral prophylaxis
    • Limaye AP, Bakthavatsalam R, Kim HW, et al. Late-onset cytomegalovirus disease in liver transplant recipients despite antiviral prophylaxis. Transplantation 2004; 78: 1390.
    • (2004) Transplantation , vol.78 , pp. 1390
    • Limaye, A.P.1    Bakthavatsalam, R.2    Kim, H.W.3
  • 4
    • 33745441993 scopus 로고    scopus 로고
    • Impact of cytomegalovirus in organ transplant recipients in the era of antiviral prophylaxis
    • Limaye AP, Bakthavatsalam R, Kim HW, et al. Impact of cytomegalovirus in organ transplant recipients in the era of antiviral prophylaxis. Transplantation 2006; 81: 1645.
    • (2006) Transplantation , vol.81 , pp. 1645
    • Limaye, A.P.1    Bakthavatsalam, R.2    Kim, H.W.3
  • 5
    • 3042808460 scopus 로고    scopus 로고
    • Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival
    • Sagedal S, Hartmann A, Nordal KP, et al. Impact of early cytomegalovirus infection and disease on long-term recipient and kidney graft survival. Kidney Int 2004; 66: 329.
    • (2004) Kidney Int , vol.66 , pp. 329
    • Sagedal, S.1    Hartmann, A.2    Nordal, K.P.3
  • 6
    • 0025082513 scopus 로고
    • Epidemiology of cytomegalovirus infections
    • Ho M. Epidemiology of cytomegalovirus infections. Rev Infect Dis 1990; 12 Suppl 7: S701.
    • (1990) Rev Infect Dis , vol.12 , Issue.SUPPL. 7
    • Ho, M.1
  • 7
    • 74949094555 scopus 로고    scopus 로고
    • Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients
    • Kidney Disease: Improving Global Outcomes (KDIGO) Transplant Work Group. KDIGO clinical practice guideline for the care of kidney transplant recipients. Am J Transplant 2009; 9 Suppl 3: S1.
    • (2009) Am J Transplant , vol.9 , Issue.SUPPL. 3
    • Disease, K.1
  • 8
    • 77950468641 scopus 로고    scopus 로고
    • The efficacy and safety of 200 days valganciclovir cytomegalovirus prophylaxis in high-risk kidney transplant recipients
    • Humar A, Lebranchu Y, Vincenti F, et al. The efficacy and safety of 200 days valganciclovir cytomegalovirus prophylaxis in high-risk kidney transplant recipients. Am J Transplant 2010; 10: 1228.
    • (2010) Am J Transplant , vol.10 , pp. 1228
    • Humar, A.1    Lebranchu, Y.2    Vincenti, F.3
  • 9
    • 78650819624 scopus 로고    scopus 로고
    • Extended valganciclovir prophylaxis in D+/R-kidney transplant recipients is associated with long-term reduction in cytomegalovirus disease: Two-year results of the IMPACT study
    • Humar A, Limaye AP, Blumberg EA, et al. Extended valganciclovir prophylaxis in D+/R-kidney transplant recipients is associated with long-term reduction in cytomegalovirus disease: two-year results of the IMPACT study. Transplantation 2010; 90: 1427.
    • (2010) Transplantation , vol.90 , pp. 1427
    • Humar, A.1    Limaye, A.P.2    Blumberg, E.A.3
  • 10
    • 42149132743 scopus 로고    scopus 로고
    • Improvement in long-term renal graft survival due to CMV prophylaxis with oral ganciclovir: Results of a randomized clinical trial
    • Kliem V, Fricke L, Wollbrink T, et al. Improvement in long-term renal graft survival due to CMV prophylaxis with oral ganciclovir: results of a randomized clinical trial. Am J Transplant 2008; 8: 975.
    • (2008) Am J Transplant , vol.8 , pp. 975
    • Kliem, V.1    Fricke, L.2    Wollbrink, T.3
  • 11
    • 1942469969 scopus 로고    scopus 로고
    • Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients
    • Paya C, Humar A, Dominguez E, et al. Efficacy and safety of valganciclovir vs. oral ganciclovir for prevention of cytomegalovirus disease in solid organ transplant recipients. Am J Transplant 2004; 4: 611.
    • (2004) Am J Transplant , vol.4 , pp. 611
    • Paya, C.1    Humar, A.2    Dominguez, E.3
  • 12
    • 0031581506 scopus 로고    scopus 로고
    • Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients. The Oral Ganciclovir International Transplantation Study Group [corrected]
    • Gane E, Saliba F, Valdecasas GJ, et al. Randomised trial of efficacy and safety of oral ganciclovir in the prevention of cytomegalovirus disease in liver-transplant recipients. The Oral Ganciclovir International Transplantation Study Group [corrected]. Lancet 1997; 350: 1729.
    • (1997) Lancet , vol.350 , pp. 1729
    • Gane, E.1    Saliba, F.2    Valdecasas, G.J.3
  • 13
    • 51849151201 scopus 로고    scopus 로고
    • Prevention of posttransplant cytomegalovirus disease and related outcomes with valganciclovir: A systematic review
    • Sun HY, Wagener MM, Singh N. Prevention of posttransplant cytomegalovirus disease and related outcomes with valganciclovir: a systematic review. Am J Transplant 2008; 8: 2111.
    • (2008) Am J Transplant , vol.8 , pp. 2111
    • Sun, H.Y.1    Wagener, M.M.2    Singh, N.3
  • 14
    • 35248844442 scopus 로고    scopus 로고
    • Sirolimus versus cyclosporine in kidney recipients receiving thymoglobulin, mycophenolate mofetil and a 6-month course of steroids
    • Buchler M, Caillard S, Barbier S, et al. Sirolimus versus cyclosporine in kidney recipients receiving thymoglobulin, mycophenolate mofetil and a 6-month course of steroids. Am J Transplant 2007; 7: 2522.
    • (2007) Am J Transplant , vol.7 , pp. 2522
    • Buchler, M.1    Caillard, S.2    Barbier, S.3
  • 15
    • 79952361568 scopus 로고    scopus 로고
    • Everolimus-based calcineurininhibitor-free regimen in recipients of de-novo kidney transplants: An open-label randomised controlled trial
    • Budde K, Becker T, Arns W, et al. Everolimus-based, calcineurininhibitor- free regimen in recipients of de-novo kidney transplants: an open-label, randomised, controlled trial. Lancet 2011; 377: 837.
    • (2011) Lancet , vol.377 , pp. 837
    • Budde, K.1    Becker, T.2    Arns, W.3
  • 16
    • 77954952597 scopus 로고    scopus 로고
    • Renal function efficacy and safety of sirolimus and mycophenolate mofetil after short-term calcineurin inhibitor-based quadruple therapy in de novo renal transplant patients: One-year analysis of a randomized multicenter trial
    • Guba M, Pratschke J, Hugo C, et al. Renal function, efficacy, and safety of sirolimus and mycophenolate mofetil after short-term calcineurin inhibitor-based quadruple therapy in de novo renal transplant patients: one-year analysis of a randomized multicenter trial. Transplantation 2010; 90: 175.
    • (2010) Transplantation , vol.90 , pp. 175
    • Guba, M.1    Pratschke, J.2    Hugo, C.3
  • 17
    • 33744473322 scopus 로고    scopus 로고
    • Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: A systematic review and meta-analysis of randomized trials
    • Webster AC, Lee VW, Chapman JR, et al. Target of rapamycin inhibitors (sirolimus and everolimus) for primary immunosuppression of kidney transplant recipients: a systematic review and meta-analysis of randomized trials. Transplantation 2006; 81: 1234.
    • (2006) Transplantation , vol.81 , pp. 1234
    • Webster, A.C.1    Lee, V.W.2    Chapman, J.R.3
  • 18
    • 37349034394 scopus 로고    scopus 로고
    • Reduced exposure to calcineurin inhibitors in renal transplantation
    • Ekberg H, Tedesco-Silva H, Demirbas A, et al. Reduced exposure to calcineurin inhibitors in renal transplantation. N Engl J Med 2007; 357: 2562.
    • (2007) N Engl J Med , vol.357 , pp. 2562
    • Ekberg, H.1    Tedesco-Silva, H.2    Demirbas, A.3
  • 19
    • 84862290097 scopus 로고    scopus 로고
    • Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients
    • Nashan B, Gaston R, Emery V, et al. Review of cytomegalovirus infection findings with mammalian target of rapamycin inhibitor-based immunosuppressive therapy in de novo renal transplant recipients. Transplantation 2012; 93: 1075.
    • (2012) Transplantation , vol.93 , pp. 1075
    • Nashan, B.1    Gaston, R.2    Emery, V.3
  • 20
    • 34247582790 scopus 로고    scopus 로고
    • Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs
    • Flechner SM, Goldfarb D, Solez K, et al. Kidney transplantation with sirolimus and mycophenolate mofetil-based immunosuppression: 5-year results of a randomized prospective trial compared to calcineurin inhibitor drugs. Transplantation 2007; 83: 883.
    • (2007) Transplantation , vol.83 , pp. 883
    • Flechner, S.M.1    Goldfarb, D.2    Solez, K.3
  • 21
    • 33644889043 scopus 로고    scopus 로고
    • Complete avoidance of calcineurin inhibitors in renal transplantation: A randomized trial comparing sirolimus and tacrolimus
    • Larson TS, Dean PG, Stegall MD, et al. Complete avoidance of calcineurin inhibitors in renal transplantation: a randomized trial comparing sirolimus and tacrolimus. Am J Transplant 2006; 6: 514.
    • (2006) Am J Transplant , vol.6 , pp. 514
    • Larson, T.S.1    Dean, P.G.2    Stegall, M.D.3
  • 22
    • 77954088420 scopus 로고    scopus 로고
    • Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids
    • Glotz D, Charpentier B, Abramovicz D, et al. Thymoglobulin induction and sirolimus versus tacrolimus in kidney transplant recipients receiving mycophenolate mofetil and steroids. Transplantation 2010; 89: 1511.
    • (2010) Transplantation , vol.89 , pp. 1511
    • Glotz, D.1    Charpentier, B.2    Abramovicz, D.3
  • 23
    • 41149159682 scopus 로고    scopus 로고
    • Prospective comparison of the use of sirolimus and cyclosporine in recipients of a kidney from an expanded criteria donor
    • Durrbach A, Rostaing L, Tricot L, et al. Prospective comparison of the use of sirolimus and cyclosporine in recipients of a kidney from an expanded criteria donor. Transplantation 2008; 85: 486.
    • (2008) Transplantation , vol.85 , pp. 486
    • Durrbach, A.1    Rostaing, L.2    Tricot, L.3
  • 24
    • 79953243656 scopus 로고    scopus 로고
    • Mycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: A randomized, controlled spare the nephron trial
    • Weir MR, Mulgaonkar S, Chan L, et al. Mycophenolate mofetil-based immunosuppression with sirolimus in renal transplantation: a randomized, controlled spare-the-nephron trial. Kidney Int 2011; 79: 897.
    • (2011) Kidney Int , vol.79 , pp. 897
    • Weir, M.R.1    Mulgaonkar, S.2    Chan, L.3
  • 25
    • 70350126186 scopus 로고    scopus 로고
    • Interstitial fibrosis quantification in renal transplant recipients randomized to continue cyclosporine or convert to sirolimus
    • Servais A, Meas-Yedid V, Toupance O, et al. Interstitial fibrosis quantification in renal transplant recipients randomized to continue cyclosporine or convert to sirolimus. Am J Transplant 2009; 9: 2552.
    • (2009) Am J Transplant , vol.9 , pp. 2552
    • Servais, A.1    Meas-Yedid, V.2    Toupance, O.3
  • 26
    • 65249134974 scopus 로고    scopus 로고
    • Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: Concept study
    • Lebranchu Y, Thierry A, Toupance O, et al. Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: concept study. Am J Transplant 2009; 9: 1115.
    • (2009) Am J Transplant , vol.9 , pp. 1115
    • Lebranchu, Y.1    Thierry, A.2    Toupance, O.3
  • 27
    • 67651008877 scopus 로고    scopus 로고
    • Everolimus with reduced cyclosporine versus MMF with standard cyclosporine in de novo heart transplant recipients
    • Lehmkuhl HB, Arizon J, Vigano M, et al. Everolimus with reduced cyclosporine versus MMF with standard cyclosporine in de novo heart transplant recipients. Transplantation 2009; 88: 115.
    • (2009) Transplantation , vol.88 , pp. 115
    • Lehmkuhl, H.B.1    Arizon, J.2    Vigano, M.3
  • 28
    • 77149153725 scopus 로고    scopus 로고
    • Lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: A randomized multicenter study
    • Vigano M, Dengler T, Mattei MF, et al. Lower incidence of cytomegalovirus infection with everolimus versus mycophenolate mofetil in de novo cardiac transplant recipients: a randomized, multicenter study. Transpl Infect Dis 2010; 12: 23.
    • (2010) Transpl Infect Dis , vol.12 , pp. 23
    • Vigano, M.1    Dengler, T.2    Mattei, M.F.3
  • 29
    • 77952945224 scopus 로고    scopus 로고
    • Everolimus plus reduced-exposure CsA versus mycophenolic acid plus standardexposure CsA in renal-transplant recipients
    • Tedesco Silva H Jr, Cibrik D, Johnston T, et al. Everolimus plus reduced-exposure CsA versus mycophenolic acid plus standardexposure CsA in renal-transplant recipients. Am J Transplant 2010; 10: 1401.
    • (2010) Am J Transplant , vol.10 , pp. 1401
    • Tedesco Silva Jr., H.1    Cibrik, D.2    Johnston, T.3
  • 30
    • 19244366021 scopus 로고    scopus 로고
    • Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients
    • Eisen HJ, Tuzcu EM, Dorent R, et al. Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients. N Engl J Med 2003; 349: 847.
    • (2003) N Engl J Med , vol.349 , pp. 847
    • Eisen, H.J.1    Tuzcu, E.M.2    Dorent, R.3
  • 31
    • 37349084974 scopus 로고    scopus 로고
    • A lower incidence of cytomegalovirus infection in de novo heart transplant recipients randomized to everolimus
    • Hill JA, Hummel M, Starling RC, et al. A lower incidence of cytomegalovirus infection in de novo heart transplant recipients randomized to everolimus. Transplantation 2007; 84: 1436.
    • (2007) Transplantation , vol.84 , pp. 1436
    • Hill, J.A.1    Hummel, M.2    Starling, R.C.3
  • 32
    • 34249279808 scopus 로고    scopus 로고
    • Prevention of acute rejection and allograft vasculopathy by everolimus in cardiac transplants recipients: A 24-month analysis
    • Vigano M, Tuzcu M, Benza R, et al. Prevention of acute rejection and allograft vasculopathy by everolimus in cardiac transplants recipients: a 24-month analysis. J Heart Lung Transplant 2007; 26: 584.
    • (2007) J Heart Lung Transplant , vol.26 , pp. 584
    • Vigano, M.1    Tuzcu, M.2    Benza, R.3
  • 33
    • 20844461132 scopus 로고    scopus 로고
    • Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: A randomized clinical trial
    • Keogh A, Richardson M, Ruygrok P, et al. Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. Circulation 2004; 110: 2694.
    • (2004) Circulation , vol.110 , pp. 2694
    • Keogh, A.1    Richardson, M.2    Ruygrok, P.3
  • 34
    • 16244378141 scopus 로고    scopus 로고
    • Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: A 3-year randomized multicenter phase III study
    • Lorber MI, Mulgaonkar S, Butt KM, et al. Everolimus versus mycophenolate mofetil in the prevention of rejection in de novo renal transplant recipients: a 3-year randomized, multicenter, phase III study. Transplantation 2005; 80: 244.
    • (2005) Transplantation , vol.80 , pp. 244
    • Lorber, M.I.1    Mulgaonkar, S.2    Butt, K.M.3
  • 35
    • 33644696712 scopus 로고    scopus 로고
    • Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients
    • Vitko S, Margreiter R, Weimar W, et al. Three-year efficacy and safety results from a study of everolimus versus mycophenolate mofetil in de novo renal transplant patients. Am J Transplant 2005; 5: 2521.
    • (2005) Am J Transplant , vol.5 , pp. 2521
    • Vitko, S.1    Margreiter, R.2    Weimar, W.3
  • 36
    • 9244246780 scopus 로고    scopus 로고
    • Everolimus (Certican) 12-month safety and efficacy versus mycophenolate mofetil in de novo renal transplant recipients
    • Vitko S, Margreiter R, Weimar W, et al. Everolimus (Certican) 12-month safety and efficacy versus mycophenolate mofetil in de novo renal transplant recipients. Transplantation 2004; 78: 1532.
    • (2004) Transplantation , vol.78 , pp. 1532
    • Vitko, S.1    Margreiter, R.2    Weimar, W.3
  • 37
    • 33746530366 scopus 로고    scopus 로고
    • Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: A randomised multicentre study the Rapamune US Study Group
    • Kahan BD. Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. The Rapamune US Study Group. Lancet 2000; 356: 194.
    • (2000) Lancet , vol.356 , pp. 194
    • Kahan, B.D.1
  • 38
    • 77957192348 scopus 로고    scopus 로고
    • Early withdrawal of calcineurin inhibitors and everolimus monotherapy in de novo liver transplant recipients preserves renal function
    • Masetti M, Montalti R, Rompianesi G, et al. Early withdrawal of calcineurin inhibitors and everolimus monotherapy in de novo liver transplant recipients preserves renal function. Am J Transplant 2010; 10: 2252.
    • (2010) Am J Transplant , vol.10 , pp. 2252
    • Masetti, M.1    Montalti, R.2    Rompianesi, G.3
  • 39
    • 41049097858 scopus 로고    scopus 로고
    • Mycophenolate mofetil vs. sirolimus in kidney transplant recipients receiving tacrolimus-based immunosuppressive regimen
    • Sampaio EL, Pinheiro-Machado PG, Garcia R, et al. Mycophenolate mofetil vs. sirolimus in kidney transplant recipients receiving tacrolimus-based immunosuppressive regimen. Clin Transplant 2008; 22: 141.
    • (2008) Clin Transplant , vol.22 , pp. 141
    • Sampaio, E.L.1    Pinheiro-Machado, P.G.2    Garcia, R.3
  • 40
    • 79955867676 scopus 로고    scopus 로고
    • Comparable renal function at 6 months with tacrolimus combined with fixed-dose sirolimus or MMF: Results of a randomized multicenter trial in renal transplantation
    • Van Gurp E, Bustamante J, Franco A, et al. Comparable renal function at 6 months with tacrolimus combined with fixed-dose sirolimus or MMF: results of a randomized multicenter trial in renal transplantation. J Transplant 2010; 2010.
    • J Transplant , vol.2010 , pp. 2010
    • Van Gurp, E.1    Bustamante, J.2    Franco, A.3
  • 41
    • 10744225688 scopus 로고    scopus 로고
    • A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. II. Survival, function, and protocol compliance at 1 year
    • Ciancio G, Burke GW, Gaynor JJ, et al. A randomized long-term trial of tacrolimus/sirolimus versus tacrolimus/mycophenolate mofetil versus cyclosporine (NEORAL)/sirolimus in renal transplantation. II. Survival, function, and protocol compliance at 1 year. Transplantation 2004; 77: 252.
    • (2004) Transplantation , vol.77 , pp. 252
    • Ciancio, G.1    Burke, G.W.2    Gaynor, J.J.3
  • 42
    • 0038637990 scopus 로고    scopus 로고
    • Two-year results of multicenter phase III trials on the effect of the addition of sirolimus to cyclosporine-based immunosuppressive regimens in renal transplantation
    • Kahan BD. Two-year results of multicenter phase III trials on the effect of the addition of sirolimus to cyclosporine-based immunosuppressive regimens in renal transplantation. Transplant Proc 2003; 35(3 Suppl): 37S.
    • (2003) Transplant Proc , vol.35 , Issue.3 SUPPL.
    • Kahan, B.D.1
  • 43
    • 0035956745 scopus 로고    scopus 로고
    • A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts
    • MacDonald AS. A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. Transplantation 2001; 71: 271.
    • (2001) Transplantation , vol.71 , pp. 271
    • MacDonald, A.S.1
  • 44
    • 33644918830 scopus 로고    scopus 로고
    • Tacrolimus combined with two different dosages of sirolimus in kidney transplantation: Results of a multicenter study
    • Vitko S, Wlodarczyk Z, Kyllonen L, et al. Tacrolimus combined with two different dosages of sirolimus in kidney transplantation: results of a multicenter study. Am J Transplant 2006; 6: 531.
    • (2006) Am J Transplant , vol.6 , pp. 531
    • Vitko, S.1    Wlodarczyk, Z.2    Kyllonen, L.3
  • 45
    • 20544470400 scopus 로고    scopus 로고
    • A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipientsYan interim analysis
    • Kandaswamy R, Melancon JK, Dunn T, et al. A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipientsYan interim analysis. Am J Transplant 2005; 5: 1529.
    • (2005) Am J Transplant , vol.5 , pp. 1529
    • Kandaswamy, R.1    Melancon, J.K.2    Dunn, T.3
  • 46
    • 33745393847 scopus 로고    scopus 로고
    • Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report
    • Kobashigawa JA, Miller LW, Russell SD, et al. Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report. Am J Transplant 2006; 6: 1377.
    • (2006) Am J Transplant , vol.6 , pp. 1377
    • Kobashigawa, J.A.1    Miller, L.W.2    Russell, S.D.3
  • 47
    • 33746058731 scopus 로고    scopus 로고
    • Safety tolerability and efficacy of everolimus in de novo liver transplant recipients: 12-and 36-month results
    • Levy G, Schmidli H, Punch J, et al. Safety, tolerability, and efficacy of everolimus in de novo liver transplant recipients: 12-and 36-month results. Liver Transpl 2006; 12: 1640.
    • (2006) Liver Transpl , vol.12 , pp. 1640
    • Levy, G.1    Schmidli, H.2    Punch, J.3
  • 48
    • 40949116686 scopus 로고    scopus 로고
    • The TORrid affairs of viruses: Effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway
    • Buchkovich NJ, Yu Y, Zampieri CA, et al. The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K-Akt-mTOR signalling pathway. Nat Rev Microbiol 2008; 6: 266.
    • (2008) Nat Rev Microbiol , vol.6 , pp. 266
    • Buchkovich, N.J.1    Yu, Y.2    Zampieri, C.A.3
  • 49
    • 80755144030 scopus 로고    scopus 로고
    • Do wound complications or lymphoceles occur more often in solid organ transplant recipients on mTOR inhibitors? A systematic review of randomized controlled trials
    • Pengel LH, Liu LQ, Morris PJ. Do wound complications or lymphoceles occur more often in solid organ transplant recipients on mTOR inhibitors? A systematic review of randomized controlled trials. Transpl Int 2011; 24: 1216.
    • (2011) Transpl Int , vol.24 , pp. 1216
    • Pengel, L.H.1    Liu, L.Q.2    Morris, P.J.3
  • 50
    • 13444259647 scopus 로고    scopus 로고
    • Regulation of cap-dependent translation by eIF4E inhibitory proteins
    • Richter JD, Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature 2005; 433: 477.
    • (2005) Nature , vol.433 , pp. 477
    • Richter, J.D.1    Sonenberg, N.2
  • 51
    • 77951480815 scopus 로고    scopus 로고
    • Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication
    • Moorman NJ, Shenk T. Rapamycin-resistant mTORC1 kinase activity is required for herpesvirus replication. J Virol 2010; 84: 5260.
    • (2010) J Virol , vol.84 , pp. 5260
    • Moorman, N.J.1    Shenk, T.2
  • 52
    • 67650074206 scopus 로고    scopus 로고
    • MTOR regulates memory CD8 T-cell differentiation
    • Araki K, Turner AP, Shaffer VO, et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009; 460: 108.
    • (2009) Nature , vol.460 , pp. 108
    • Araki, K.1    Turner, A.P.2    Shaffer, V.O.3
  • 53
    • 59849119429 scopus 로고    scopus 로고
    • Human cytomegalovirus paralyzes macrophage motility through down-regulation of chemokine receptors, reorganization of the cytoskeleton, and release of macrophage migration inhibitory factor
    • Frascaroli G, Varani S, Blankenhorn N, et al. Human cytomegalovirus paralyzes macrophage motility through down-regulation of chemokine receptors, reorganization of the cytoskeleton, and release of macrophage migration inhibitory factor. J Immunol 2009; 182: 477.
    • (2009) J Immunol , vol.182 , pp. 477
    • Frascaroli, G.1    Varani, S.2    Blankenhorn, N.3
  • 54
    • 55649099181 scopus 로고    scopus 로고
    • Human cytomegalovirus impairs the function of plasmacytoid dendritic cells in lymphoid organs
    • Schneider K, Meyer-Koenig U, Hufert FT. Human cytomegalovirus impairs the function of plasmacytoid dendritic cells in lymphoid organs. PLoS One 2008; 3: e3482.
    • (2008) PLoS One , vol.3
    • Schneider, K.1    Meyer-Koenig, U.2    Hufert, F.T.3
  • 55
    • 84861818332 scopus 로고    scopus 로고
    • CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages
    • Poglitsch M, Weichhart T, Hecking M, et al. CMV late phase-induced mTOR activation is essential for efficient virus replication in polarized human macrophages. Am J Transplant 2012; 12: 1458.
    • (2012) Am J Transplant , vol.12 , pp. 1458
    • Poglitsch, M.1    Weichhart, T.2    Hecking, M.3
  • 56
    • 72449147738 scopus 로고    scopus 로고
    • The multifunctional role of mTOR in innate immunity: Implications for transplant immunity
    • Saemann MD, Haidinger M, Hecking M, et al. The multifunctional role of mTOR in innate immunity: implications for transplant immunity. Am J Transplant 2009; 9: 2655.
    • (2009) Am J Transplant , vol.9 , pp. 2655
    • Saemann, M.D.1    Haidinger, M.2    Hecking, M.3
  • 57
    • 79955973785 scopus 로고    scopus 로고
    • Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells
    • Weichhart T, Haidinger M, Katholnig K, et al. Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 2011; 117: 4273.
    • (2011) Blood , vol.117 , pp. 4273
    • Weichhart, T.1    Haidinger, M.2    Katholnig, K.3
  • 58
    • 32044442513 scopus 로고    scopus 로고
    • Persistent cytomegalovirusspecific memory responses in the lung allograft and blood following primary infection in lung transplant recipients
    • Shlobin OA, West EE, Lechtzin N, et al. Persistent cytomegalovirusspecific memory responses in the lung allograft and blood following primary infection in lung transplant recipients. J Immunol 2006; 176: 2625.
    • (2006) J Immunol , vol.176 , pp. 2625
    • Shlobin, O.A.1    West, E.E.2    Lechtzin, N.3
  • 59
    • 77954736362 scopus 로고    scopus 로고
    • Evaluation of cytomegalovirus (CMV)-specific T cell immune reconstitution revealed that baseline antiviral immunity, prophylaxis, or preemptive therapy but not antithymocyte globulin treatment contribute to CMV-specific T cell reconstitution in kidney transplant recipients
    • Abate D, Saldan A, Fiscon M, et al. Evaluation of cytomegalovirus (CMV)-specific T cell immune reconstitution revealed that baseline antiviral immunity, prophylaxis, or preemptive therapy but not antithymocyte globulin treatment contribute to CMV-specific T cell reconstitution in kidney transplant recipients. J Infect Dis 2010; 202: 585.
    • (2010) J Infect Dis , vol.202 , pp. 585
    • Abate, D.1    Saldan, A.2    Fiscon, M.3
  • 60
    • 33748494938 scopus 로고    scopus 로고
    • Monitoring of human cytomegalovirus-specific CD4 and CD8 T-cell immunity in patients receiving solid organ transplantation
    • Gerna G, Lilleri D, Fornara C, et al. Monitoring of human cytomegalovirus-specific CD4 and CD8 T-cell immunity in patients receiving solid organ transplantation. Am J Transplant 2006; 6: 2356.
    • (2006) Am J Transplant , vol.6 , pp. 2356
    • Gerna, G.1    Lilleri, D.2    Fornara, C.3
  • 61
    • 55949127402 scopus 로고    scopus 로고
    • Polyfunctional cytomegalovirusspecific CD4+ and pp65 CD8+ T cells protect against high-level replication after liver transplantation
    • Nebbia G, Mattes FM, Smith C, et al. Polyfunctional cytomegalovirusspecific CD4+ and pp65 CD8+ T cells protect against high-level replication after liver transplantation. Am J Transplant 2008; 8: 2590.
    • (2008) Am J Transplant , vol.8 , pp. 2590
    • Nebbia, G.1    Mattes, F.M.2    Smith, C.3
  • 62
    • 45949083381 scopus 로고    scopus 로고
    • Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients
    • Egli A, Binet I, Binggeli S, et al. Cytomegalovirus-specific T-cell responses and viral replication in kidney transplant recipients. J Transl Med 2008; 6: 29.
    • (2008) J Transl Med , vol.6 , pp. 29
    • Egli, A.1    Binet, I.2    Binggeli, S.3
  • 63
    • 37549024633 scopus 로고    scopus 로고
    • Valacyclovir prophylaxis versus preemptive valganciclovir therapy to prevent cytomegalovirus disease after renal transplantation
    • Reischig T, Jindra P, Hes O, et al. Valacyclovir prophylaxis versus preemptive valganciclovir therapy to prevent cytomegalovirus disease after renal transplantation. Am J Transplant 2008; 8: 69.
    • (2008) Am J Transplant , vol.8 , pp. 69
    • Reischig, T.1    Jindra, P.2    Hes, O.3
  • 64
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M, et al. Bias in meta-analysis detected by a simple, graphical test. BMJ 1997; 315: 629.
    • (1997) BMJ , vol.315 , pp. 629
    • Egger, M.1    Davey Smith, G.2    Schneider, M.3
  • 65
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a metaanalysis
    • Higgins JP, Thompson SG. Quantifying heterogeneity in a metaanalysis. Stat Med 2002; 21: 1539.
    • (2002) Stat Med , vol.21 , pp. 1539
    • Higgins, J.P.1    Thompson, S.G.2
  • 66
    • 27544512687 scopus 로고    scopus 로고
    • Bias and efficiency of meta-analytic variance estimators in the random-effects model
    • Viechtbauer W. Bias and efficiency of meta-analytic variance estimators in the random-effects model. J Educ Behav Stat 2005; 30: 261.
    • (2005) J Educ Behav Stat , vol.30 , pp. 261
    • Viechtbauer, W.1
  • 67
    • 0029914622 scopus 로고    scopus 로고
    • Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
    • Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 1996; 17: 1.
    • (1996) Control Clin Trials , vol.17 , pp. 1
    • Jadad, A.R.1    Moore, R.A.2    Carroll, D.3
  • 68
    • 61849135251 scopus 로고    scopus 로고
    • The quality of reporting of randomized controlled trials in solid organ transplantation
    • Pengel LH, Barcena L, Morris PJ. The quality of reporting of randomized controlled trials in solid organ transplantation. Transpl Int 2009; 22: 377.
    • (2009) Transpl Int , vol.22 , pp. 377
    • Pengel, L.H.1    Barcena, L.2    Morris, P.J.3
  • 69
    • 80755144030 scopus 로고    scopus 로고
    • Do wound complications or lymphoceles occur more often in solid organ transplant recipients on mTOR inhibitors? A systematic review of randomized controlled trials
    • Pengel LH, Liu LQ, Morris PJ. Do wound complications or lymphoceles occur more often in solid organ transplant recipients on mTOR inhibitors? A systematic review of randomized controlled trials. Transpl Int 2011; 24: 1216.
    • (2011) Transpl Int , vol.24 , pp. 1216
    • Pengel, L.H.1    Liu, L.Q.2    Morris, P.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.