Chrysin reduced acrylamide-induced neurotoxicity in both in vitro and in vivo assessments

Iranian Biomedical Journal

Volumn 18, Issue 2, 2014, Pages 101-106

  Mehri, Soghra ^a   Veis Karami, Hamed ^b   Vahdati Hassani, Faezeh ^b   Hosseinzadeh, Hossein ^a  

^a MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Acrylamide; Antioxidant; Chrysin; Neurotoxicity

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACRYLAMIDE; ALPHA TOCOPHEROL; CHRYSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; DRUG EFFECT; GAIT DISORDER; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OUTCOME ASSESSMENT; PC12 CELL; RAT; WISTAR RAT;

ACRYLAMIDE; ANIMALS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; LAMENESS, ANIMAL; MALE; NEUROPROTECTIVE AGENTS; PC12 CELLS; RATS; RATS, WISTAR;

EID: 84893080635     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: 10.6091/ibj.1291.2013     Document Type: Article

References (32)

1. LoPachin RM. The changing view of acrylamide neurotoxicity. NeuroToxicology. 2004 Jun; 25(4):617-630.
2. LoPachin RM. Acrylamide neurotoxicity: Neurological, morhological and molecular endpoints in animal models. Adv Exp Med Biol. 2005; 561:21-37.
3. Claus A, Carle R, Schieber A. Acrylamide in cereal products: A review. J Cereal Sci. 2008 Mar; 47(2):118-133.
4. Shipp A, Lawrence G, Gentry R, McDonald T, Bartow H, Bounds J, et al. Acrylamide: Review of toxicity data and dose-response analyses for cancer and noncancer effects. Crit Rev Toxicol. 2006 Jul-Aug; 36(6-7):481-608.
5. Sumizawa T, Igisu H. Apoptosis induced by acrylamide in SH-SY5Y cells. Arch Toxicol. 2007 Apr; 81(4):279-782.
6. Sumizawa T, Igisu H. Suppression of acrylamide toxicity by carboxyfullerene in human neuroblastoma cells in vitro. Archiv Toxicol. 2009 May; 1-8.
7. Sumizawa T, Igisu H. Release of heat shock proteins from human neuroblastoma cells exposed to acrylamide. J Toxicol Sci. 2008 Feb; 33(1):117-122.
8. Alturfan AA, Tozan-Beceren A, Sehirli AO, Demiralp E, Sener G, Omurtag GZ. Resveratrol ameliorates oxidative DNA damage and protects against acrylamideinduced oxidative stress in rats. Mol Biol Rep. 2012 Apr; 39(4):4589-96.
9. Lakshmi D, Gopinath K, Jayanthy G, Anjum S, Prakash D, Sudhandiran G. Ameliorating effect of fish oil on acrylamide induced oxidative stress and neuronal apoptosis in cerebral cortex. Neurochem Res. 2012 Sep; 37(9):1859-67.
10. Zhu YJ, Zeng T, Zhu YB, Yu SF, Wang QS, Zhang LP, et al. Effects of acrylamide on the nervous tissue antioxidant system and sciatic nerve electrophysiology in the rat. Neurocheml Res. 2008 Nov; 33(11):2310-7.
11. Mehri S, Abnous K, Mousavi S, Shariaty V, Hosseinzadeh H. Neuroprotective effect of crocin on acrylamide-induced cytotoxicity in PC12 cells. Cell Mol Neurobiol. 2012 Mar; 32(2):227-35.
12. Razavi M, Hosseinzadeh H, Abnous K, Motamedshariaty VS, Imenshahidi M. Crocin restores hypotensive effect of subchronic administration of diazinon in rats. Iran J Basic Med Sci. 2013 Jan; 16(1): 64-72.
13. Razavi BM, Hosseinzadeh H, Movassaghi AR, Imenshahidi M, Abnous K. Protective effect of crocin on diazinon induced cardiotoxicity in rats in subchronic exposure. Chem Biol Interact. 2013 May; 203(3):547-55.
14. Hariri AT, Moallem SA, Mahmoudi M, Hosseinzadeh H. The effect of crocin and safranal, constituents of saffron, against subacute effect of diazinon on hematological and genotoxicity indices in rats. Phytomedicine. 2011 Apr; 18(6):499-504.
15. Hariri AT, Moallem SA, Mahmoudi M, Memar B, Hosseinzadeh H. Sub-acute effects of diazinon on biochemical indices and specific biomarkers in rats: Protective effects of crocin and safranal. Food Chem Toxicol. 2010 Oct; 48(10):2803-8.
16. Williams CA, Harborne JB, Newman M, Greenham J, Eagles J. Chrysin and other leaf exudate flavonoids in the genus Pelargonium. Phytochemistry. 1997 Dec; 46(8):1349-53.
17. Li X, Huang Q, Ong CN, Yang XF, Shen HM. Chrysin sensitizes tumor necrosis factor-alpha-induced apoptosis in human tumor cells via suppression of nuclear factorkappaB. Cancer Lett. 2010 Jul; 293(1):109-16.
18. Khoo BY, Chua SL, Balaram P. Apoptotic effects of chrysin in human cancer Cell Lines. Int J Mol Sci. 2010; 11(5):2188-99.
19. Woo KJ, Jeong YJ, Park JW, Kwon TK. Chrysininduced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochem Biophys Res Commun. 2004 Dec; 325(4):1215-22.
20. Zhang T, Chen X, Qu L, Wu J, Cui R, Zhao Y. Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells. Bioorg Med Chem. 2004 Dec; 12(23):6097-105.
21. Cho H, Yun CW, Park WK, Kong JY, Kim KS, Park Y, et al. Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives. Pharmacol Res. 2004 Jan; 49(1):37-43.
22. Mercer LD, Kelly BL, Horne MK, Beart PM. Dietary polyphenols protect dopamine neurons from oxidative insults and apoptosis: investigations in primary rat mesencephalic cultures. Biochem Pharmacol. 2005 Jan; 69(2):339-45.
23. Chaudhuri S, Banerjee A, Basu K, Sengupta B, Sengupta PK. Interaction of flavonoids with red blood cell membrane lipids and proteins: antioxidant and antihemolytic effects. Int J Biol Macromol. 2007 Jun; 41(1):42-8.
24. Pushpavalli G, Kalaiarasi P, Veeramani C, Pugalendi KV. Effect of chrysin on hepatoprotective and antioxidant status in d-galactosamine-induced hepatitis in rats. Eur J Pharmacol. 2010 Apr; 631(1-3):636-41.
25. Villar IC, Jimenoz, R., Galisteo, M., Garcio-Saura, MF, Zarzuelo A, Luarte J. Effect of chronic chysin treatment in spontaneously hypertensive rats. Planta Med. 2002 Sep; 68(9):847-50.
26. Brechbuhl HM, Kachadourian R, Min E, Chan D, Day BJ. Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione. Toxicol Appl Pharmacol. 2012 Jan; 258(1):1-9.
27. He XL, Wang YH, Bi MG, Du GH. Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats. Eur J Pharmacol. 2012 Apr; 680(1-3):41-8.
28. Izuta H, Shimazawa M, Tazawa S, Araki Y, Mishima S, Hara H. Protective effects of Chinese propolis and its component, chrysin, against neuronal cell death via inhibition of mitochondrial apoptosis pathway in SHSY5Y cells. J Agric Food Chem. 2008 Oct; 56(19):8944-53.
29. Shukla PK, Khanna VK, Ali MM, Maurya RR, Handa SS, Srimal RC. Protective effect of Acorus calamus against acrylamide induced neurotoxicity. Phytother Res. 2002 May; 16(3):256-60.
30. Park HR, Kim M-S, Kim SJ, Park M, Kong KH, Kim HS, et al. Acrylamide induces cell death in neural progenitor cells and impairs hippocampal neurogenesis. Toxicol Lett. 2010 Mar;193(1):86-93.
31. Yun JS, Na HK, Park KS, Lee YH, Kim EY, Lee SY, et al. Protective effects of Vitamin E on endocrine disruptors, PCB-induced dopaminergic neurotoxicity. Toxicology. 2005 Dec; 216(2-3):140-6.
32. Gumustas K, Guzeyli F, Atukeren P, Sanus GZ, Kemerdere R, Tanriverdi T, et al. The effects of vitamin E on lipid peroxidation, nitric oxide production and superoxide dismutase expression in hyperglycemic rats with ceberal ischemia-reperfusion injury. Turk Neurosurg. 2007 Apr; 17(2):78-82.