Apoptosis induced by acrylamide in SH-SY5Y cells

Archives of Toxicology

Volumn 81, Issue 4, 2007, Pages 279-282

  Sumizawa, Tomoyuki ^a   Igisu, Hideki ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Acrylamide; Apoptosis; Caspase 3; ERK; SH SY5Y cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ACRYLAMIDE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE 3;

APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL POPULATION; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROTOXICITY; PRIORITY JOURNAL;

ACRYLAMIDE; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; L-LACTATE DEHYDROGENASE; NEURONS;

EID: 33947282401     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-006-0145-6     Document Type: Article

References (11)

1. DeJongh J, Nordin-Andersson M, Ploeger BA, Forsby A (1999) Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations. Toxicol Appl Pharmacol 158:261-268
2. Gold BG, Schaumburg HH (2000) Acrylamide. In: Spencer PS, Schaumburg HH (eds) Experimental and clinical neurotoxicology, 2nd edn. Oxford University Press, New York pp 124-132
3. Hartley CL, Anderson VE, Anderton BH, Robertson J (1997) Acrylamide and 2,5-hexanedione induce collapse of neurofilaments in SH-SY5Y human neuroblastoma cells to form perikaryal inclusion bodies. Neuropathol Appl Neurobiol 23:364-372
4. Johnson GL, Lapadat R (2002) Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298:1911-1912
5. Li SX, Cui N, Zhang CL, Zhao XL, Yu SF, Xie KQ (2006) Effect of subchronic exposure to acrylamide induced on the expression of bcl-2, bax and caspase-3 in the rat nervous system. Toxicology 217:46-53
6. Morrison RS, Kinoshita Y, Johnson MD, Guo W, Garden GA (2003) p53-Dependent cell death signaling in neurons. Neurochem Res 28:15-27
7. Okuno T, Matsuoka M, Sumizawa T, Igisu H (2006) Involvement of the extracellular signal-regulated protein kinase pathway in phosphorylation of p53 protein and exerting cytotoxicity in human neuroblastoma cells (SH-SY5Y) exposed to acrylamide. Arch Toxicol 80:146-153
8. Stanciu M, Wang Y, Kentor R, Burke N, Watkins S, Kress G, Reynolds I, Klann E, Angiolieri MR, Johnson JW, DeFranco DB (2000) Persistent activation of ERK contributes to glutamate-induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures. J Biol Chem 275:12200-12206
9. Subramaniam S, Zirrgiebel U, von Bohlen Und Halbach O, Strelau J, Laliberte C, Kaplan DR, Unsicker K (2004) ERK activation promotes neuronal degeneration predominantly through plasma membrane damage and independently of caspase-3. J Cell Biol 165:357-369
10. Vousden KH (2000) p53: death star. Cell 103:691-694
11. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME (1995) Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270:1326-1331