Analysis of Hypoxia-Inducible Factor 1α Expression and its Effects on Invasion and Metastasis

Methods in Enzymology

Volumn 435, Issue , 2007, Pages 347-354

  Krishnamachary, Balaji ^a   Semenza, Gregg L ^a  

^a Institute for Cell Engineering   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA;

CANCER CELL; CANCER DIAGNOSIS; CANCER INVASION; CELL ADHESION; CELL INVASION; EX VIVO STUDY; HUMAN; IMMUNOHISTOCHEMISTRY; METASTASIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; TUMOR BIOPSY; ARTICLE; BIOASSAY; GENETICS; METABOLISM; METHODOLOGY; NEOPLASM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BIOLOGICAL ASSAY; CELL ADHESION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 39749129742     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0076-6879(07)35017-9     Document Type: Review

References (27)

1. Aebersold D.M., Burri P., Beer K.T., Laissue J., Djonov V., Greiner R.H., and Semenza G.L. Expression of hypoxia-inducible factor 1α: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 61 (2001) 2911-2916
2. Bachtiary B., Schindl M., Potter R., Dreier B., Knocke T.H., Hainfellner J.A., Horvat R., and Birner P. Overexpression of hypoxia-inducible factor 1alpha indicates diminished response to radiotherapy and unfavorable prognosis in patients receiving radical radiotherapy for cervical cancer. Clin. Cancer Res. 9 (2003) 2234-2240
3. Behrens J., Mareel M.M., Van Roy F.M., and Birchmeier W. Dissecting tumor cell invasion: Epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J. Cell Biol. 108 (1989) 2435-2447
4. Birner P., Schindl M., Obermair A., Plank C., Breitenecker G., and Oberhuber G. Overexpression of hypoxia-inducible factor 1α is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 60 (2000) 4693-4696
5. Birner P., Schindl M., Obermair A., Breitenecker G., and Oberhuber G. Expression of hypoxia-inducible factor 1α in epithelial ovarian tumors: Its impact on prognosis and on response to chemotherapy. Clin. Cancer Res. 7 (2001) 1661-1668
6. Birner P., Gatterbauer B., Oberhuber G., Schindl M., Rossler K., Prodinger A., Budka H., and Hainfellner J.A. Expression of hypoxia-inducible factor-1α in oligodendrogliomas: Its impact on prognosis and on neoangiogenesis. Cancer 92 (2001) 165-171
7. Bos R., Zhong H., Hanrahan C.F., Mommers E.C., Semenza G.L., Pinedo H.M., Abeloff M.D., Simons J.W., van Diest P.J., and van der Wall E. Levels of hypoxia-inducible factor 1α during breast carcinogenesis. J. Natl. Cancer Inst. 93 (2001) 309-314
8. Cavallaro U., and Christofori G. Cell adhesion and signalling by cadherins and Ig-CAMs in cancer. Nat. Rev. Cancer 4 (2004) 118-132
9. Esteban M.A., Tran M.G., Harten S.K., Hill P., Castellanos M.C., Chandra A., Raval R., O'Brien T.S., and Maxwell P.H. Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res. 66 (2006) 3567-3575
10. Evans A.J., Russell R.C., Roche O., Burry T.N., Fish J.E., Chow V.W., Kim W.Y., Saravanan A., Maynard M.A., Gervais M.L., Sufan R.I., Roberts A.M., et al. VHL promotes E2 box-dependent E-cadherin transcription by HIF-mediated regulation of SIP1 and Snail. Mol. Cell Biol. 27 (2007) 157-169
11. Hanahan D., and Weinberg R.A. The hallmarks of cancer. Cell 100 (2000) 57-70
12. Hockel M., and Vaupel P. Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 93 (2001) 266-276
13. 2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 12 (1998) 149-162
14. Korkolopoulou P., Patsouris E., Konstantinidou A.E., Pavlopoulos P.M., Kavantzas N., Boviatsis E., Thymara I., Perdiki M., Thomas-Tsagli E., Angelidakis D., Rologis D., and Sakkas D. Hypoxia-inducible factor 1α/vascular endothelial growth factor axis in astrocytomas: Associations with microvessel morphometry, proliferation and prognosis. Neuropathol. Appl. Neurobiol. 30 (2004) 267-278
15. Krishnamachary B., Zagzag D., Nagasawa H., Rainey K., Okuyama H., Baek J.H., and Semenza G.L. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 66 (2006) 2725-2731
16. Krishnamachary B., Berg-Dixon S., Kelly B., Agani F., Feldser D., Ferreira G., Iyer N., LaRusch J., Pak B., Taghavi P., and Semenza G.L. Regulation of colon carcinoma cell invasion by hypoxia-inducible factor 1. Cancer Res. 63 (2003) 1138-1143
17. Kronblad A., Jirstrom K., Ryden L., Nordenskjold B., and Landberg G. Hypoxia inducible factor 1α is a prognostic marker in premenopausal patients with intermediate to highly differentiated breast cancer but not a predictive marker for tamoxifen response. Int. J. Cancer 118 (2006) 2609-2916
18. Liotta L.A., and Kohn E.C. Invasion and metastasis. In: Bast Jr. R.C., Kufe D.W., Pollock R.E., et al. (Eds). "Cancer Medicine, edn. 5" (2000), B.C. Decker, Ontario, Canada 121-131
19. Schindl M., Schoppmann S.F., Samonigg H., Hausmaninger H., Kwasny W., Gnant M., Jakesz R., Kubista E., Birner P., Oberhuber G., and Austrian Breast Colorectal Cancer Study Group. Overexpression of hypoxia-inducible factor 1α is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin. Cancer Res. 8 (2002) 1831-1837
20. Shi S.R., Key M.E., and Kalra K.L. Antigen retrieval in formalin-fixed, paraffin-embedded tissues: An enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections. J. Histochem. Cytochem. 39 (1991) 741-748
21. Talks K.L., Turley H., Gatter K.C., Maxwell P.H., Pugh C.W., Ratcliffe P.J., and Harris A.L. The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol. 157 (2000) 411-421
22. Theodoropoulos V.E., Lazaris A.Ch., Sofras F., Gerzelis I., Tsoukala V., Ghikonti I., Manikas K., and Kastriotis I. Hypoxia-inducible factor 1α expression correlates with angiogenesis and unfavorable prognosis in bladder cancer. Eur. Urol. 46 (2004) 200-208
23. Thiery J.P. Epithelial-mesenchymal transitions in tumor progression. Nat. Rev. Cancer 2 (2002) 442-454
24. Vleugel M.M., Greijer A.E., Shvarts A., van der Groep P., van Berkel M., Aarbodem Y., van Tinteren H., Harris A.L., van Diest P.J., and van der Wall E. Differential prognostic impact of hypoxia-induced and diffuse HIF-1α expression in invasive breast cancer. J. Clin. Pathol. 58 (2005) 172-177
25. 2 tension. Proc. Natl. Acad. Sci. USA 92 (1995) 5510-5514
26. Zagzag D., Zhong H., Scalzitti J.M., Laughner E., Simons J.W., and Semenza G.L. Expression of hypoxia-inducible factor 1α in brain tumors: Association with angiogenesis, invasion, and progression. Cancer 88 (2000) 2606-2618
27. Zhong H., De Marzo A.M., Laughner E., Lim M., Hilton D.A., Zagzag D., Buechler P., Isaacs W.B., Semenza G.L., and Simons J.W. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 59 (1999) 5830-5835