Sgk1 sensitive pendrin expression in murine platelets

Cellular Physiology and Biochemistry

Volumn 32, Issue 7, 2013, Pages 210-220

  Pelzl, Lisann ^a   Fakhri, Hajar ^a   Umbach, Anja T ^a   Gawaz, Meinrad ^a   Paulmichl, Markus ^b   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

Anion exchanger; Deoxycorticosterone (DOCA); Mineralocorticoids; Platelets; Serum and glucocorticoid inducible kinase 1 (SGK1); Slc26a4

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; MESSENGER RNA; PENDRIN; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THROMBOCYTE; UPREGULATION; WESTERN BLOTTING; WILD TYPE; COMPARATIVE STUDY; GENE TARGETING; IN VITRO STUDY; SINGLE DRUG DOSE; THROMBOCYTE AGGREGATION;

ANIMALS; ANION TRANSPORT PROTEINS; BLOOD PLATELETS; DESOXYCORTICOSTERONE ACETATE; EAR, INNER; GENE EXPRESSION REGULATION; GOITER, NODULAR; HEARING LOSS, SENSORINEURAL; IMMEDIATE-EARLY PROTEINS; MICE; PROTEIN-SERINE-THREONINE KINASES; THYROID GLAND;

ANIMALIA; MURINAE; MUS;

EID: 84892911365     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000356640     Document Type: Article

References (112)

1. Dossena S, Nofziger C, Lang F, Valenti G, Paulmichl M: THE ESF Meeting on "The Proteomics, Epigenetics, and Pharmacogenetics of Pendrin". Cell Physiol Biochem 2011;28:377-384.
2. Reimold FR, Heneghan JF, Steward AK, Zelikovic I, Vandorpe DH, Shmukler BE, Alper SL: Pendrin function and regulation in Xenopus oocytes. Cell Physiol Biochem 2011;28:435-450.
3. Choi BY, Muskett J, King KA, Zalewski CK, Shawker T, Reynolds JC, Butman JA, Brewer CC, Stewart AK, Alper SL, Griffith AJ: Hereditary hearing loss with thyroid abnormalities. Adv Otorhinolaryngol 2011;70:43-49.
4. Alesutan I, Daryadel.A., Mohebbi N, Pelzl L, Leibrock C, Voelkl J, Bourgeois S, Dossena S, Nofziger C, Paulmichl M, Wagner CA, Lang F: Impact of bicarbonate, ammonium chloride and acetazolamide on hepatic and renal Slc26A4 expression. Cell Physiol Biochem 2011;28:553-558.
5. Bizhanova A, Kopp P: Genetics and phenomics of Pendred syndrome. Mol Cell Endocrinol 2010;322:83-90.
6. Wagner CA, Mohebbi N, Capasso G, Geibel JP: The anion exchange pendrin (SLC26A4) and renal-acid-base homeostasis. Cell Physiol Biochem 2011;28:497-504.
7. Dror AA, Brownstein ZN, Avraham KB: Integration of Human and Mouse Genetics Reveals Pendrin Function in Hearing and Deafness. Cell Physiol Biochem 2011;28:535-544.
8. Ito T, Choi BY, King KA, Zalewski CK, Muskett J, Chattaraj P, Shawker T, Reynolds JC, Butman JA, Brewer CC, Wangemann P, Alper SL: SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct. Cell Physiol Biochem 2011;28:545-552.
9. Bizhanova A, Kopp P: Controversies concerning the role of pendrin as apical iodide transporter in thyroid follicular cells. Cell Physiol Biochem 2011;28:485-490.
10. Twyffels L, Massart C, Golstein PE, Raspe E, Van Sande J, Dumont JE, Beauwens R, Kruys V: Pendrin: the thyrocyte apical membrane iodide transporter? Cell Physiol Biochem 2011;28:491-496.
11. Izuhara K, Ohta S, Shiraishi H, Suzuki S, Taniguchi K, Toda S, Tanabe T, Yasuo M, Kubo K, Hoshino T, Aizawa H: The mechanism of mucus production in bronchial asthma. Curr Med Chem 2009;16:2867-2875.
12. Nofziger C, Dossena S, Suzuki S, Izuhara K, Paulmichl M: Pendrin function in Airway Epithelia. Cell Physiol Biochem 2011;28:571-578.
13. Carraro-Lacroix LR, Malnic G: Acid-base transport by the renal distal nephron. J Nephrol 2010;23 Suppl 16:S19-S27.
14. Wall SM, Pech V: Pendrin and sodium channels: relevance to hypertension. J Nephrol 2010;23:S118-S123.
15. Amlal H, Soleimani M: Pendrin as a novel target for diuretic therapy. Cell Physiol Biochem 2011;28:521-526.
16. Eladari D, Chambrey R, Frische S, Vallet M, Edwards A: Pendrin as a regulator of ECF and blood pressure. Curr Opin Nephrol Hypertens 2009;18:356-362.
17. Hadchouel J, Buesst C, Procino G, Valenti G, Chambrey R, Eladari D: Regulation of the extracellular fluid volume and blood pressure by pendrin. Cell Physiol Biochem 2011;28:505-512.
18. Verlander JW, Hassell KA, Royaux IE, Glapion DM, Wang ME, Everett LA, Green ED, Wall SM: Deoxycorticosterone upregulates PDS (Slc26a4) in mouse kidney: role of pendrin in mineralocorticoid-induced hypertension. Hypertension 2003;42:356-362.
19. Rodighiero S, Botta G, Bazzini C, Meyer G: Pendrin overexpression affects cell volume recovery, intracellular pH and chloride concentration after hypotonicity-induced cell swelling. Cell Physiol Biochem 2011;28:559-570.
20. Bizhanova A, Chew TL, Khuon S, Kopp P: Analysis of cellular localization and function of carboxy-terminal truncations mutants of pendrin. Cell Physiol Biochem 2011;28:423-434.
21. Dossena S, Nofziger C, Brownstein ZN, Kanaan M., Avraham KB, Paulmichl M: Functional characterization of Pendrin mutations found in Israeli and Palestinian populations. Cell Physiol Biochem 2011;28:477-484.
22. Dossena S, Bizhanova A, Nofziger C, Bernardinelli E, Ramsauer J, Kopp P, Paulmichl M: Identification of allelic variants of pendrin (SLC26A4) with loss and gain of function. Cell Physiol Biochem 2011;28:467-476.
23. Dossena S, Nofziger C, Tamma G, Bernardinelli E, Vanoni S, Nowak C, Grabmayer E, Koessler S, Stephan S, Patsch W, Paulmichl M: Molecular and functional characterization of human pendrin and its allelic variants. Cell Physiol Biochem 2011;28:451-466.
24. Sharma AK, Rigby AC, Alper SL: STAS domain structure and function. Cell Physiol Biochem 2011;28:407-422.
25. Dossena S, Rodighiero S, Vezzoli V, Nofziger C, Salvioni E, Boccazzi M, Grabmayer E, Botta G, Meyer G, Fugazzola L, Beck-Peccoz P, Paulmichl M: Functional characterization of wild-type and mutated pendrin (SLC26A4), the anion transporter involved in Pendred syndrome. J Mol Endocrinol 2009;43:93-103.
26. Calebiro D, Porazzi P, Bonomi M, Lisi S, Grindati A, De Nittis D, Fugazzola L, Marino M, Botta G, Persani L: Absence of primary hypothyroidism and goiter in Slc26a4-/-Mice Fed on a Low Iodine Diet. J Endocrinol Invest 2010;34:593-8.
27. Rozenfeld J, Efrati E, Adler L, Tal O, Carrithers S, Alper SL, Zelikovic I: Transcriptional Regulation of the Pendrin Gene. Cell Physiol Biochem 2011;28:385-396.
28. Pelzl L, Pakladok T, Pathare G, Fakhri H, Michael D, Wagner CA, Paulmichl M, Lang F: DOCA sensitive pendrin expression in kidney, heart, lung and thyroid tissues. Cell Physiol Biochem 2012;30:1491-1501.
29. Yang J, Young MJ: The mineralocorticoid receptor and its coregulators. J Mol Endocrinol 2009;43:53-64.
30. Shigaev A, Asher C, Latter H, Garty H, Reuveny E: Regulation of sgk by aldosterone and its effects on the epithelial Na+ channel. Am J Physiol Renal Physiol 2000;278:F613-F619.
31. Caprio M, Feve B, Claes A, Viengchareun S, Lombes M, Zennaro MC: Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis. FASEB J 2007;21:2185-2194.
32. Lombes M, Oblin ME, Gasc JM, Baulieu EE, Farman N, Bonvalet JP: Immunohistochemical and biochemical evidence for a cardiovascular mineralocorticoid receptor. Circ Res 1992;71:503-510.
33. Meijer OC: Coregulator proteins and corticosteroid action in the brain. J Neuroendocrinol 2002;14:499-505.
34. Pearce D, Bhargava A, Cole TJ: Aldosterone: its receptor, target genes, and actions. Vitam Horm 2003;66:29-76.
35. Lombes M, Farman N, Bonvalet JP, Zennaro MC: Identification and role of aldosterone receptors in the cardiovascular system. Ann Endocrinol (Paris) 2000;61:41-46.
36. Vallon V, Huang DY, Grahammer F, Wyatt AW, Osswald H, Wulff P, Kuhl D, Lang F: SGK1 as a determinant of kidney function and salt intake in response to mineralocorticoid excess. Am J Physiol Regul Integr Comp Physiol 2005;289:R395-R401.
37. Funder JW: Aldosterone, hypertension and heart failure: insights from clinical trials. Hypertens Res 2010;33:872-875.
38. Latouche C, Sainte-Marie Y, Steenman M, Castro CP, Naray-Fejes-Toth A, Fejes-Toth G, Farman N, Jaisser F: Molecular signature of mineralocorticoid receptor signaling in cardiomyocytes: from cultured cells to mouse heart. Endocrinology 2010;151:4467-4476.
39. Fejes-Toth G, Naray-Fejes-Toth A: Early aldosterone-regulated genes in cardiomyocytes: clues to cardiac remodeling? Endocrinology 2007;148:1502-1510.
40. Fagart J, Huyet J, Pinon GM, Rochel M, Mayer C, Rafestin-Oblin ME: Crystal structure of a mutant mineralocorticoid receptor responsible for hypertension. Nat Struct Mol Biol 2005;12:554-555.
41. Young M, Funder JW: Aldosterone and the heart. Trends Endocrinol Metab 2000;11:224-226.
42. Oberleithner H: Is the vascular endothelium under the control of aldosterone? Facts and hypothesis. Pflugers Arch 2007;454:187-193.
43. Lang F: Stiff endothelial cell syndrome in vascular inflammation and mineralocorticoid excess. Hypertension 2011;57:146-147.
44. Lacolley P, Challande P, Osborne-Pellegrin M, Regnault V: Genetics and pathophysiology of arterial stiffness. Cardiovasc Res 2009;81:637-648.
45. Jaffe IZ, Tintut Y, Newfell BG, Demer LL, Mendelsohn ME: Mineralocorticoid receptor activation promotes vascular cell calcification. Arterioscler Thromb Vasc Biol 2007;27:799-805.
46. Voelkl J, Alesutan I, Leibrock CB, Quintanilla-Martinez L, Kuhn V, Feger M, Mia S, Ahmed MS, Rosenblatt KP, Kuro O, Lang F: Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice. J Clin Invest 2013;123:812-22.
47. de Kloet ER, Joels M, Holsboer F: Stress and the brain: from adaptation to disease. Nat Rev Neurosci 2005;6:463-475.
48. Firsov D: Revisiting sodium and water reabsorption with functional genomics tools. Curr Opin Nephrol Hypertens 2004;13:59-65.
49. Kellner M, Peiter A, Hafner M, Feuring M, Christ M, Wehling M, Falkenstein E, Losel R: Early aldosterone up-regulated genes: new pathways for renal disease? Kidney Int 2003; 64: 1199-1207.
50. Sekizawa N, Yoshimoto T, Hayakawa E, Suzuki N, Sugiyama T, Hirata Y: Transcriptome analysis of aldosterone-regulated genes in human vascular endothelial cell lines stably expressing mineralocorticoid receptor. Mol Cell Endocrinol 2011;341:78-88.
51. Boulos C, Jiang H, Balazy M: Diffusion of peroxynitrite into the human platelet inhibits cyclooxygenase via nitration of tyrosine residues. J Pharmacol Exp Ther 2000;293:222-229.
52. Gende OA: Functional interaction of carbonic anhydrase and chloride/bicarbonate exchange in human platelets. Platelets 2005;16:392-397.
53. Gende OA: Thrombin stimulation of Cl-/. Thromb Res 2005;116:67-73.
54. 3 -/C1-Exchange Contribute to Cytoplasmic pH Regulation in the Human Platelet. Platelets 1995;6:221-232.
55. Yokoyama K, Kudo I, Nakamura H, Inoue K: A possible role for extracellular bicarbonate in U-46619-induced rat platelet aggregation. Thromb Res 1994;74:369-376.
56. Ruggeri ZM: Platelets in atherothrombosis. Nat Med 2002;8:1227-1234.
57. Borst O, Munzer P, Gatidis S, Schmidt EM, Schonberger T, Schmid E, Towhid ST, Stellos K, Seizer P, May AE, Lang F, Gawaz M: The inflammatory chemokine CXC motif ligand 16 triggers platelet activation and adhesion via CXC motif receptor 6-dependent phosphatidylinositide 3-kinase/Akt signaling. Circ Res 2012;111:1297-1307.
58. Gawaz M, Reininger A, Neumann FJ: Platelet function and platelet-leukocyte adhesion in symptomatic coronary heart disease. Effects of intravenous magnesium. Thromb Res 1996;83:341-349.
59. Stellos K, Bigalke B, Langer H, Geisler T, Schad A, Kogel A, Pfaff F, Stakos D, Seizer P, Muller I, Htun P, Lindemann S, Gawaz M: Expression of stromal-cell-derived factor-1 on circulating platelets is increased in patients with acute coronary syndrome and correlates with the number of CD34+ progenitor cells. Eur Heart J 2009;30:584-593.
60. Lang F, Munzer P, Gawaz M, Borst O: Regulation of STIM1/Orai1-dependent Ca2+ signalling in platelets. Thromb Haemost 2013;110.
61. Bigalke B, Stellos K, Geisler T, Kremmer E, Seizer P, May AE, Lindemann S, Melms A, Luft A, Gawaz M: Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke. Eur J Neurol 2010;17:111-117.
62. Wulff P, Vallon V, Huang DY, Volkl H, Yu F, Richter K, Jansen M, Schlunz M, Klingel K, Loffing J, Kauselmann G, Bosl MR, Lang F, Kuhl D: Impaired renal Na+ retention in the sgk1-knockout mouse. J Clin Invest 2002;110:1263-1268.
63. Borst O, Schmidt EM, Munzer P, Schonberger T, Towhid ST, Elvers M, Leibrock C, Schmid E, Eylenstein A, Kuhl D, May AE, Gawaz M, Lang F: The serum-and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Blood 2012;119:251-261.
64. Borst O, Walker B, Munzer P, Russo A, Schmid E, Faggio C, Bigalke B, Laufer S, Gawaz M, Lang F: Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation. Cell Physiol Biochem 2013;31:914-924.
65. Szteyn K, Schmid E, Nurbaeva MK, Yang W, Munzer P, Kunzelmann K, Lang F, Shumilina E: Expression and functional significance of the Ca2+-activated Cl-channel ANO6 in dendritic cells. Cell Physiol Biochem 2012;30:1319-1332.
66. Hafner P, Grimaldi R, Capuano P, Capasso G, Wagner CA: Pendrin in the mouse kidney is primarily regulated by Cl-excretion but also by systemic metabolic acidosis. Am J Physiol Cell Physiol 2008;295:C1658-C1667.
67. Lang F, Bohmer C, Palmada M, Seebohm G, Strutz-Seebohm N, Vallon V: (Patho)physiological significance of the serum-and glucocorticoid-inducible kinase isoforms. Physiol Rev 2006;86:1151-1178.
68. Eylenstein A, Schmidt S, Gu S, Yang W, Schmid E, Schmidt EM, Alesutan I, Szteyn K, Regel I, Shumilina E, Lang F: Transcription factor NF-kappaB regulates expression of pore-forming Ca2+ channel unit, Orai1, and its activator, STIM1, to control Ca2+ entry and affect cellular functions. J Biol Chem 2012;287:2719-2730.
69. Zhu CJ, Wang QQ, Zhou JL, Liu HZ, Hua F, Yang HZ, Hu ZW: The mineralocorticoid receptor-p38MAPK-NFkappaB or ERK-Sp1 signal pathways mediate aldosterone-stimulated inflammatory and profibrotic responses in rat vascular smooth muscle cells. Acta Pharmacol Sin 2012;33:873-878.
70. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, Fratto CM, Tolley E, Kraiss LW, McIntyre TM, Zimmerman GA, Weyrich AS: Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell 2005;122:379-391.
71. Pabla R, Weyrich AS, Dixon DA, Bray PF, McIntyre TM, Prescott SM, Zimmerman GA: Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets. J Cell Biol 1999;144:175-184.
72. Weyrich AS, Schwertz H, Kraiss LW, Zimmerman GA: Protein synthesis by platelets: historical and new perspectives. J Thromb Haemost 2009;7:241-246.
73. Lindemann S, Tolley ND, Eyre JR, Kraiss LW, Mahoney TM, Weyrich AS: Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control. J Biol Chem 2001;276:33947-33951.
74. Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, Buerke M, Tilley RE, Rondina MT, Harris EM, Kraiss LW, Mackman N, Zimmerman GA, Weyrich AS: Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med 2006;203:2433-2440.
75. Munzer P, Tolios A, Pelzl L, Schmid E, Schmidt EM, Walker B, Frohlich H, Borst O, Gawaz M, Lang F: Thrombin-sensitive expression of the store operated Ca2+ channel Orai1 in platelets. Biochem Biophys Res Commun 2013;436:25-30.
76. Zhang J, Fry MJ, Waterfield MD, Jaken S, Liao L, Fox JE, Rittenhouse SE: Activated phosphoinositide 3-kinase associates with membrane skeleton in thrombin-exposed platelets. J Biol Chem 1992;267:4686-4692.
77. Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA: Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci USA 1998;95:5556-5561.
78. Briet M, Schiffrin EL: Vascular actions of aldosterone. J Vasc Res 2013;50:89-99.
79. Deutsch SI, Mastropaolo J: Discriminative stimulus properties of midazolam are shared by a GABA-receptor positive steroid. Pharmacol Biochem Behav 1993;46:963-965.
80. Mohammed SF, Ohtani T, Korinek J, Lam CS, Larsen K, Simari RD, Valencik ML, Burnett JC, Jr., Redfield MM: Mineralocorticoid accelerates transition to heart failure with preserved ejection fraction via "nongenomic effects". Circulation 2010;122:370-378.
81. Pietranera L, Saravia FE, McEwen BS, Lucas LL, Johnson AK, De Nicola AF: Changes in Fos expression in various brain regions during deoxycorticosterone acetate treatment: relation to salt appetite, vasopressin mRNA and the mineralocorticoid receptor. Neuroendocrinology 2001;74:396-406.
82. Roy JW, Hill E, Ruan YC, Vedovelli L, Paunescu TG, Brown D, Breton S: Circulating aldosterone induces the apical accumulation of the proton pumping V-ATPase and increases proton secretion in clear cells in the caput epididymis. Am J Physiol Cell Physiol 2013;305:C436-C446.
83. Rupprecht R, Holsboer F: Neuroactive steroids: mechanisms of action and neuropsychopharmacological perspectives. Trends Neurosci 1999;22:410-416.
84. Sakai RR, McEwen BS, Fluharty SJ, Ma LY: The amygdala: site of genomic and nongenomic arousal of aldosterone-induced sodium intake. Kidney Int 2000;57:1337-1345.
85. Wehling M, Christ M, Theisen K: Membrane receptors for aldosterone: a novel pathway for mineralocorticoid action. Am J Physiol 1992;263:E974-E979.
86. Wendler A, Albrecht C, Wehling M: Nongenomic actions of aldosterone and progesterone revisited. Steroids 2012;77:1002-1006.
87. Young M, Funder J: Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis. Endocrinology 2003;144:3848-3851.
88. Christ M, Sippel K, Eisen C, Wehling M: Non-classical receptors for aldosterone in plasma membranes from pig kidneys. Mol Cell Endocrinol 1994;99:R31-R34.
89. Williams JS: Evolving research in nongenomic actions of aldosterone. Curr Opin Endocrinol Diabetes Obes 2013;20:198-203.
90. Liu SL, Schmuck S, Chorazcyzewski JZ, Gros R, Feldman RD: Aldosterone regulates vascular reactivity: short-term effects mediated by phosphatidylinositol 3-kinase-dependent nitric oxide synthase activation. Circulation 2003;108:2400-2406.
91. Mutoh A, Isshiki M, Fujita T: Aldosterone enhances ligand-stimulated nitric oxide production in endothelial cells. Hypertens Res 2008;31:1811-1820.
92. Hoffmann EK, Lambert IH, Pedersen SF: Physiology of cell volume regulation in vertebrates. Physiol Rev 2009;89:193-277.
93. Lang F, Busch GL, Ritter M, Volkl H, Waldegger S, Gulbins E, Haussinger D: Functional significance of cell volume regulatory mechanisms. Physiol Rev 1998;78:247-306.
94. Lang F, Foller M, Lang K, Lang P, Ritter M, Vereninov A, Szabo I, Huber SM, Gulbins E: Cell volume regulatory ion channels in cell proliferation and cell death. Methods Enzymol 2007;428:209-225.
95. Weigt M, Dietl P, Silbernagl S, Oberleithner H: Activation of luminal Na+/H+ exchange in distal nephron of frog kidney. An early response to aldosterone. Pflugers Arch 1987;408:609-614.
96. Zhang M, Chen J, Lai L, You L, Lin S, Hao C, Gu Y: Aldosterone promotes fibronectin synthesis in rat mesangial cells via ERK1/2-stimulated Na-H+ exchanger isoform 1. Am J Nephrol 2010;31:75-82.
97. De Giusti VC, Nolly MB, Yeves AM, Caldiz CI, Villa-Abrille MC, Chiappe de Cingolani GE, Ennis IL, Cingolani HE, Aiello EA: Aldosterone stimulates the cardiac Na+/H+ exchanger via transactivation of the epidermal growth factor receptor. Hypertension 2011;58:912-919.
98. Korichneva I, Puceat M, Millanvoye-Van Brussel E, Geraud G, Vassort G: Aldosterone modulates both the Na/H antiport and Cl/HCO3 exchanger in cultured neonatal rat cardiac cells. J Mol Cell Cardiol 1995;27:2521-2528.
99. Young M, Funder J: Mineralocorticoid action and sodium-hydrogen exchange: studies in experimental cardiac fibrosis. Endocrinology 2003;144:3848-3851.
100. Caligiuri A, De Franco RM, Romanelli RG, Gentilini A, Meucci M, Failli P, Mazzetti L, Rombouts K, Geerts A, Vanasia M, Gentilini P, Marra F, Pinzani M: Antifibrogenic effects of canrenone, an antialdosteronic drug, on human hepatic stellate cells. Gastroenterology 2003;124:504-520.
101. Cho JH, Musch MW, Bookstein CM, McSwine RL, Rabenau K, Chang EB: Aldosterone stimulates intestinal Na+ absorption in rats by increasing NHE3 expression of the proximal colon. Am J Physiol 1998;274:C586-C594.
102. Christ M, Douwes K, Eisen C, Bechtner G, Theisen K, Wehling M: Rapid effects of aldosterone on sodium transport in vascular smooth muscle cells. Hypertension 1995;25:117-123.
103. Delva P, Pastori C, Degan M, Montesi G, Bassi A, Lechi A: Erythrocyte Na+/H+ exchanger and Na+-Li+ countertransport activity in primary aldosteronism. Eur J Clin Invest 1994;24:794-798.
104. Eisen C, Meyer C, Christ M, Theisen K, Wehling M: Novel membrane receptors for aldosterone in human lymphocytes: a 50 kDa protein on SDS-PAGE. Cell Mol Biol (Noisy-le-grand) 1994;40:351-358.
105. Ivanova L, Bernhardt R, Bernhardt I: Nongenomic effect of aldosterone on ion transport pathways of red blood cells. Cell Physiol Biochem 2008;22:269-278.
106. Michea L, Delpiano AM, Hitschfeld C, Lobos L, Lavandero S, Marusic ET: Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels. Endocrinology 2005;146:973-980.
107. Musch MW, Lucioni A, Chang EB: Aldosterone regulation of intestinal Na absorption involves SGK-mediated changes in NHE3 and Na+ pump activity. Am J Physiol Gastrointest Liver Physiol 2008;295:G909-G919.
108. Schiffrin EL: The many targets of aldosterone. Hypertension 2004;43:938-940.
109. Speake PF, Glazier JD, Greenwood SL, Sibley CP: Aldosterone and cortisol acutely stimulate Na+/H+ exchanger activity in the syncytiotrophoblast of the human placenta: effect of fetal sex. Placenta 2010;31:289-294.
110. Wehling M, Kasmayr J, Theisen K: Fast effects of aldosterone on electrolytes in human lymphocytes are mediated by the sodium-proton-exchanger of the cell membrane. Biochem Biophys Res Commun 1989;164:961-967.
111. Rondina MT, Weyrich AS, Zimmerman GA: Platelets as cellular effectors of inflammation in vascular diseases. Circ Res 2013;112:1506-1519.
112. Meier DJ, Pitt B, Rajagopalan S: Eplerenone: will it have a role in the treatment of acute coronary syndromes? Curr Cardiol Rep 2004;6:259-263.