Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation

Cellular Physiology and Biochemistry

Volumn 31, Issue 6, 2013, Pages 914-924

  Borst, Oliver ^a   Walker, Britta ^a   Münzer, Patrick ^a   Russo, Antonella ^a,b   Schmid, Evi ^a   Faggio, Caterina ^b   Bigalke, Boris ^a   Laufer, Stefan ^a   Gawaz, Meinrad ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Aggregation; p38 MAPK; Secretion; Skepinone L; Thromboxane synthesis; Thrombus formation

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; C REACTIVE PROTEIN; FURA 2; HEAT SHOCK PROTEIN 27; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE A2; SKEPINONE L; THROMBIN; THROMBOXANE A2; THROMBOXANE B2; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; CALCIUM; LUCIFERIN; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR;

ARTICLE; CONCENTRATION (PARAMETERS); ENZYME IMMUNOASSAY; FLUORESCENCE; HUMAN; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE RELEASE REACTION; WESTERN BLOTTING; BLOOD CLOTTING; CALCIUM SIGNALING; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG POTENCY; DRUG SELECTIVITY; HEMOSTASIS; HUMAN CELL; MEASUREMENT; NORMAL HUMAN; QUANTITATIVE ANALYSIS; SHEAR STRESS;

EID: 84879491578     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000350110     Document Type: Article

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