Acid-base transport by the renal distal nephron

Journal of Nephrology

Volumn 23, Issue SUPPL.16, 2010, Pages

  Carraro Lacroix, Luciene R ^a,b   Malnic, Gerhard ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

AE1; Distal nephron; H+ ATPase; H+ K+ ATPase; Na+ H+ exchanger; Pendrin

Indexed keywords

BICARBONATE CHLORIDE ANTIPORTER; HYDROGEN POTASSIUM ADENOSINE TRIPHOSPHATASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 3; SODIUM-HYDROGEN EXCHANGER 3;

ACID BASE BALANCE; ANIMAL; HUMAN; ION TRANSPORT; KIDNEY DISTAL TUBULE; METABOLISM; NEPHRON; PHYSIOLOGY; REVIEW;

ACID-BASE EQUILIBRIUM; ANIMALS; CHLORIDE-BICARBONATE ANTIPORTERS; H(+)-K(+)-EXCHANGING ATPASE; HUMANS; ION TRANSPORT; KIDNEY TUBULES, DISTAL; NEPHRONS; SODIUM-HYDROGEN ANTIPORTER; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 79952279641     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Giebisch G, Windhager E. Transport of acids and bases. In: Boron WF, Boulpaep EL, eds. Medical physiology. Philadelphia, PA: Saunders; 2009.
2. Kriz W, Kaissling B. Structural organization of the mammalian kidney. In: Alpern RJ, Hebert SC, eds. The kidney, physiology and pathophysiology. Amsterdam: Elsevier; 2008.
3. Reilly RF, Ellison DH. Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy [in process citation]. Physiol Rev. 2000;80:277-313.
4. Wang T, Malnic G, Giebisch G, Chan YL. Renal bicarbonate absorption in the rat: Part 4: bicarbonate transport mechanisms in the early and late distal tubule. J Clin Invest. 1993;91:2776-2784.
5. Chambrey R, Warnock DG, Podevin RA, et al. Immunolocalization of the Na+/H+ exchanger isoform NHE2 in rat kidney. Am J Physiol Renal Physiol. 1998;275:F379-F386.
6. Biemesderfer D, Reilly RF, Exner M, Igarashi P, Aronson PS. Immunocytochemical characterization of Na+-H+ exchanger isoform NHE-1 in rabbit kidney. Am J Physiol Renal Fluid Electrolyte Physiol. 1992;263:F833-F840.
7. Kim J, Kim YH, Cha JH, Tisher CC, Madsen KM. Intercalated cell subtypes in connecting tubule and cortical collecting duct of rat and mouse. J Am Soc Nephrol. 1999;10:1-12.
8. Wagner CA, Devuyst O, Bourgeois S, Mohebbi N. Regulated acid-base transport in the collecting duct. Pflugers Arch. 2009;458:137-156.
9. Bastani B, Purcell H, Hemken P, Trigg D, Gluck S. Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat. J Clin Invest. 1991;88:126-136.
10. Schwartz GJ, Barasch J, Al-Awqati Q. Plasticity of functional epithelial polarity. Nature. 1985;318:368-371.
11. Takito J, Hikita C, Al-Awqati Q. Hensin, a new collecting duct protein involved in the in vitro plasticity of intercalated cell polarity. J Clin Invest. 1996;98:2324-2331.
12. Schwartz GJ, Tsuruoka S, Vijayakumar S, Petrovic S, Mian A, Al Awqati Q. Acid incubation reverses the polarity of intercalated cell transporters, an effect mediated by hensin. J Clin Invest. 2002;109:89-99.
13. Schwartz GJ, Al Awqati Q. Role of hensin in mediating the adaptation of the cortical collecting duct to metabolic acidosis. Curr Opin Nephrol Hypertens. 2005;14:383-388.
14. Biemesderfer D, Pizzonia J, Abu-Alfa A, et al. NHE3: a Na+/ H+ exchanger isoform of renal brush border. Am J Physiol Renal Fluid Electrolyte Physiol. 1993;265:F736-F742.
15. Kinsella JL, Aronson PS. Properties of the Na-H exchanger in renal microvillus membrane vesicles. Am J Physiol. 1980;238:F461-F469.
16. Ikeda T, Schmitt B, Pouysségur J, Wakabayashi S, Shigekawa M. Identification of cytoplasmic subdomains that control pH-sensing of the Na+/H+ exchanger (NHE1): pH-maintenance, ATP-Sensitive, and flexible loop domains. J Biochem (Tokyo). 1997;121:295-303.
17. Becker AM, Zhang J, Goyal S, et al. Ontogeny of NHE8 in the rat proximal tubule. Am J Physiol Renal Physiol. 2007;293:F255-F261.
18. Good DW, Watts BA III, George T, Meyer JW, Shull GE. Transepithelial HCO3- absorption is defective in renal thick ascending limbs from Na+/H+ exchanger NHE1 null mutant mice. Am J Physiol Renal Physiol. 2004;287:F1244-F1249.
19. Chambrey R, St John PL, Eladari D, et al. Localization and functional characterization of Na+/H+ exchanger isoform NHE4 in rat thick ascending limbs. Am J Physiol Renal Physiol. 2001;281:F707-F717.
20. Beltran AR, Ramirez MA, Carraro-Lacroix LR, Hiraki Y, Reboucas NA, Malnic G. NHE1, NHE2, and NHE4 contribute to regulation of cell pH in T84 colon cancer cells. Pflugers Arch. 2008;455:799-810.
21. Ramirez MA, Toriano R, Parisi M, Malnic G. Control of cell pH in the T84 colon cell line [in process citation]. J Membr Biol. 2000;177:149-157.
22. Ghishan FK, Knobel S, Barnard JA, Breyer M. Expression of a novel sodium-hydrogen exchanger in the gastrointestinal tract and kidney. J Membr Biol. 1995;144:267-271.
23. Bailey MA, Giebisch G, Abbiati T, et al. NHE2-mediated bicarbonate reabsorption in the distal tubule of NHE3 null mice. J Physiol. 2004;561:765-775.
24. Carraro-Lacroix LR, Lessa LM, Fernandez R, Malnic G. Physiological implications of the regulation of vacuolar H+-ATPase by chloride ions. Braz J Med Biol Res. 2009;42:155-163.
25. Gluck SL, Underhill DM, Iyori M, Holliday LS, Kostrominova TY, Lee BS. Physiology and biochemistry of the kidney vacuolar H+-ATPase. Annu Rev Physiol. 1996;58:427-445.
26. Qi J, Wang Y, Forgac M. The vacuolar (H+)-ATPase: subunit arrangement and in vivo regulation. J Bioenerg Biomembr. 2007;39:423-426.
27. Wagner CA, Finberg KE, Breton S, Marshansky V, Brown D, Geibel JP. Renal vacuolar H+-ATPase. Physiol Rev. 2004;84:1263-1314.
28. Kovacikova J, Winter C, Loffing-Cueni D, et al. The connecting tubule is the main site of the furosemide-induced urinary acidification by the vacuolar H(+)-ATPase. Kidney Int. 2006;70:1706-1716.
29. Weinstein AM. A mathematical model of rat collecting duct: Part III: paradigms for distal acidification defects. Am J Physiol Renal Physiol. 2002;283:F1267-F1280.
30. Capasso G. A crucial nephron segment in acid-base and electrolyte transport: the connecting tubule. Kidney Int. 2006;70:1674-1676.
31. Jacobson HR, Furuya H, Breyer MD. Mechanism and regulation of proton transport in the outer medullary collecting duct. Kidney Int. 1991;40(Suppl 33):S51-S56.
32. Fernandez R, Bosqueiro JR, Cassola AC, Malnic G. Role of Cl- in electrogenic H+ secretion by cortical distal tubule. J Membr Biol. 1997;157:193-201.
33. Malnic G, Fernandez R, Cassola AC, Barreto-Chaves ML, Souza MO, Mello-Aires M. Mechanisms and regulation of H+ transport in distal tubule epithelial cells. Wiener Klin Wochenschr. 1997;109:429-434.
34. Tararthuch AL, Fernandez R, Malnic G. Cl- and regulation of pH by MDCK-C11 cells. Braz J Med Biol Res. 2007;40:687-696.
35. Günther W, Lüchow A, Cluzeaud F, Vandewalle A, Jentsch TJ. ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells. Proc Natl Acad Sci U S A. 1998;95:8075-8080.
36. Moulin P, Igarashi T, Van der Smissen P, et al. Altered polarity and expression of H+-ATPase without ultrastructural changes in kidneys of Dent's disease patients. Kidney Int. 2003;63:1285-1295.
37. Finberg KE, Wagner CA, Bailey MA, et al. The B1-subunit of the H(+) ATPase is required for maximal urinary acidification. Proc Natl Acad Sci U S A. 2005;102:13616-13621.
38. Paunescu TG, Russo LM, Da SN, et al. Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice. Am J Physiol Renal Physiol. 2007;293:F1915-F1926.
39. Brown D, Paunescu TG, Breton S, Marshansky V. Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking. J Exp Biol. 2009;212:1762-1772.
40. Karet FE. Physiological and metabolic implications of VATPase isoforms in the kidney. J Bioenerg Biomembr. 2005;37:425-429.
41. Oka T, Murata Y, Namba M, et al. A4, a unique kidney-specific isoform of mouse vacuolar H+-ATPase subunit A. J Biol Chem. 2001;276:40050-40054.
42. Gumz ML, Lynch IJ, Greenlee MM, Cain BD, Wingo CS. The renal H+-K+-ATPases: physiology, regulation, and structure. Am J Physiol Renal Physiol. 2010;298:F12-F21.
43. Wingo CS, Smolka AJ. Function and structure of H-K-ATPase in the kidney. Am J Physiol Renal Fluid Electrolyte Physiol. 1995;269:F1-F16.
44. Ahn KY, Kone BC. Expression and cellular localization of mRNA encoding the "gastric" isoform of H+-K+-ATPase asubunit in rat kidney. Am J Physiol Renal Fluid Electrolyte Physiol. 1995;268:F99-F109.
45. Verlander JW, Moudy RM, Campbell WG, Cain BD, Wingo CS. Immunohistochemical localization of H-K-ATPase alpha(2c)-subunit in rabbit kidney. Am J Physiol Renal Physiol. 2001;281:F357-F365.
46. Ahn KY, Turner PB, Madsen KM, Kone BC. Effects of chronic hypokalemia on renal expression of the "gastric" H+-K+- ATPase a-subunit gene. Am J Physiol Renal Fluid Electrolyte Physiol. 1996;270:F557-F566.
47. Petrovic S, Spicer Z, Greeley T, Shull GE, Soleimani M. Novel Schering and ouabain-insensitive potassium-dependent proton secretion in the mouse cortical collecting duct. Am J Physiol Renal Physiol. 2002;282:F133-F143.
48. Doucet A. H+,K+-ATPase in the kidney: localisation and function in the nephron. Exp Nephrol. 1997;5:271-276.
49. Younes-Ibrahim M, Barlet-Bas C, Buffin-Meyer B, Cheval L, Rajerison R, Doucet A. Ouabain-sensitive and -insensitive KATPase in rat nephron: effect of K depletion. Am J Physiol. 1995;268:F1141-F1147.
50. Cheval L, Morla L, Elalouf JM, Doucet A. Kidney collecting duct acid-base "regulon". Physiol Genomics. 2006;27:271-281.
51. Silver RB, Mennitt P, Satlin LM. Stimulation of apical H-KATPase in intercalated cells of cortical collecting duct with chronic metabolic acidosis. Am J Physiol Renal Fluid Electrolyte Physiol. 1996;270:F539-F547.
52. Dherbecourt O, Cheval L, Bloch-Faure M, Meneton P, Doucet A. Molecular identification of Sch28080-sensitive K-ATPase activities in the mouse kidney. Pflugers Arch. 2006;451:769-775.
53. Spicer Z, Miller ML, Andringa A, et al. Stomachs of mice lacking the gastric H,K-ATPase alpha-subunit have achlorhydria, abnormal parietal cells, and ciliated metaplasia. J Biol Chem. 2000;275:21555-21565.
54. Schultheis PJ, Clarke LL, Meneton P, et al. Targeted disruption of the murine Na+/H+ exchanger isoform 2 gene causes reduced viability of gastric parietal cells and loss of net acid secretion. J Clin Invest. 1998;101:1243-1253.
55. Cornelius F, Mahmmoud YA. Direct activation of gastric H,K-ATPase by N-terminal protein kinase C phosphorylation: comparison of the acute regulation mechanisms of H,K-ATPase and Na,K-ATPase. Biophys J. 2003;84:1690-1700.
56. Laroche-Joubert N, Marsy S, Doucet A. Cellular origin and hormonal regulation of K(+)-ATPase activities sensitive to sch-28080 in rat collecting duct [in process citation]. Am J Physiol Renal Physiol. 2000;279:F1053-F1059.
57. Codina J, Liu J, Bleyer AJ, Penn RB, Dubose TD Jr. Phosphorylation of S955 at the protein kinase A consensus promotes maturation of the alpha subunit of the colonic H+,K+- ATPase. J Am Soc Nephrol. 2006;17:1833-1840.
58. Nicoletta JA, Schwartz GJ. Distal renal tubular acidosis. Curr Opin Pediatr. 2004;16:194-198.
59. Petrovic S, Barone S, Xu J, et al. SLC26A7: a basolateral Cl- /. Am J Physiol Renal Physiol. 2004;286:F161-F169.
60. Stehberger PA, Shmukler BE, Stuart-Tilley AK, Peters LL, Alper SL, Wagner CA. Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). J Am Soc Nephrol. 2007;18:1408-1418.
61. Sun X, Petrovic S. Increased acid load and deletion of AE1 increase Slc26a7 expression. Nephron Physiol. 2008;109:29-35.
62. Ko SB, Luo X, Hager H, et al. AE4 is a DIDS-sensitive Cl(-)/ HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct. Am J Physiol Cell Physiol. 2002;283:C1206-C1218.
63. Tsuganezawa H, Kobayashi K, Iyori M, et al. A new member of the HCO3- transporter superfamily is an apical anion exchanger of beta-intercalated cells in the kidney. J Biol Chem. 2001;276:8180-8189.
64. Bruce LJ, Cope DL, Jones GK, et al. Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (band 3, AE1) gene. J Clin Invest. 1997;100:1693-1707.
65. Han JS, Kim GH, Kim J, et al. Secretory-defect distal renal tubular acidosis is associated with transporter defect in H(+)-ATPase and anion exchanger-1. J Am Soc Nephrol. 2002;13:1425-1432.
66. Devonald MA, Smith AN, Poon JP, Ihrke G, Karet FE. Nonpolarized targeting of AE1 causes autosomal dominant distal renal tubular acidosis. Nat Genet. 2003;33:125-127.
67. Shayakul C, Jarolim P, Zachlederova M, et al. Characterization of a highly polymorphic marker adjacent to the SLC4A1 gene and of kidney immunostaining in a family with distal renal tubular acidosis. Nephrol Dial Transplant. 2004;19: 371-379.
68. Eladari D, Chambrey R, Frische S, Vallet M, Edwards A. Pendrin as a regulator of ECF and blood pressure. Curr Opin Nephrol Hypertens. 2009;18:356-362.
69. Soleimani M, Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE. Pendrin: an apical Cl(-)/OH(-)/HCO(3)(-) exchanger in the kidney cortex. Am J Physiol Renal Physiol. 2001;280:F356-F364.
70. Royaux IE, Wall SM, Karniski LP, et al. Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A. 2001;98:4221-4226.
71. Frische S, Kwon TH, Frokiaer J, Madsen KM, Nielsen S. Regulated expression of pendrin in rat kidney in response to chronic NH4Cl or NaHCO3 loading. Am J Physiol Renal Physiol. 2003;284:F584-F593.
72. Hafner P, Grimaldi R, Capuano P, Capasso G, Wagner CA. Pendrin in the mouse kidney is primarily regulated by Cl- excretion but also by systemic metabolic acidosis. Am J Physiol Cell Physiol. 2008;295:C1658-C1667.