Stiff endothelial cell syndrome in vascular inflammation and mineralocorticoid excess

Hypertension

Volumn 57, Issue 2, 2011, Pages 146-147

  Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; AMILORIDE; ANGIOTENSIN II; C REACTIVE PROTEIN; CONNECTIVE TISSUE GROWTH FACTOR; EPITHELIAL SODIUM CHANNEL; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MINERALOCORTICOID; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM; SPIRONOLACTONE; VON WILLEBRAND FACTOR;

ATOMIC FORCE MICROSCOPY; CELL SWELLING; DRUG EFFICACY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; HUMAN; IMMUNOFLUORESCENCE; KIDNEY FIBROSIS; NEPHRON; NOTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; STIFF ENDOTHELIAL CELL SYNDROME; UPREGULATION; VASCULITIS; VASODILATATION;

ALDOSTERONE; AMILORIDE; ANIMALS; AORTA; C-REACTIVE PROTEIN; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CHROMONES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME INHIBITORS; EPITHELIAL SODIUM CHANNEL; HUMANS; MODELS, BIOLOGICAL; MORPHOLINES; PHOSPHATIDYLINOSITOL 3-KINASES; SODIUM AZIDE; VASODILATOR AGENTS;

EID: 79551469279     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.110.164558     Document Type: Note

References (10)

1. Schild L. The epithelial sodium channel: from molecule to disease. Rev Physiol Biochem Pharmacol. 2004;151:93-107.
2. Schiffrin EL. Effects of aldosterone on the vasculature. Hypertension. 2006;47:312-318.
3. Brown NJ. Aldosterone and vascular inflammation. Hypertension. 2008; 51:161-167.
4. Lang F, Görlach A, Vallon V. Targeting SGK1 in diabetes. Expert Opin Ther Targets. 2009;13:1303-1311.
5. Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ. Aldosterone activates endothelial exocytosis. Proc Natl Acad Sci USA. 2009;106:3782-3787.
6. Fels J, Oberleithner H, Kusche-Vihrog K. Ménage à trois: aldosterone, sodium and nitric oxide in vascular endothelium. Biochim Biophys Acta. 2010; 1802:1193-1202.
7. Pérez FR, Venegas F, González M, Andrés S, Vallejos C, Riquelme G, Sierralta J, Michea L. Endothelial epithelial sodium channel inhibition activates endothelial nitric oxide synthase via phosphoinositide 3-ki-nase/Akt in small-diameter mesenteric arteries. Hypertension. 2009;53: 1000-1007.
8. Kusche-Vihrog K, Urbanova K, Blanqué A, Wilhelmi M, Schillers H, Kliche K, Pavenstädt H, Brand E, Oberleithner H. C-reactive protein makes human endothelium stiff and tight. Hypertension. 2011;57: 231-237.
9. Virdis A, Ghiadoni L, Plantinga Y, Taddei S, Salvetti A. C-Reactive protein and hypertension: is there a causal relationship? Curr Pharm Des. 2007;13:1693-1698.
10. Fernandes D, Assreuy J. Nitric oxide and vascular reactivity in sepsis. Shock. 2008;30:10-13.