메뉴 건너뛰기




Volumn 32, Issue 2, 2014, Pages 74-81

Small-molecule based musculoskeletal regenerative engineering

Author keywords

Musculoskeletal tissue; Regenerative engineering; Small molecules; Tissue regeneration

Indexed keywords

BIOACTIVE MOLECULES; SMALL MOLECULES; TISSUE REPAIR;

EID: 84892891393     PISSN: 01677799     EISSN: 18793096     Source Type: Journal    
DOI: 10.1016/j.tibtech.2013.12.002     Document Type: Review
Times cited : (98)

References (82)
  • 3
    • 78650842405 scopus 로고    scopus 로고
    • Growth factor delivery-based tissue engineering: general approaches and a review of recent developments
    • Lee K., et al. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J. R. Soc. Interface 2010, 8:153-170.
    • (2010) J. R. Soc. Interface , vol.8 , pp. 153-170
    • Lee, K.1
  • 4
    • 77958483948 scopus 로고    scopus 로고
    • Pre-clinical considerations in the assessment of immunogenicity for protein therapeutics
    • Baker M., Carr F. Pre-clinical considerations in the assessment of immunogenicity for protein therapeutics. Curr. Drug Saf. 2010, 5:308-313.
    • (2010) Curr. Drug Saf. , vol.5 , pp. 308-313
    • Baker, M.1    Carr, F.2
  • 5
    • 77958552691 scopus 로고    scopus 로고
    • A small-molecule approach to bone regenerative medicine in dentistry
    • Egusa H., et al. A small-molecule approach to bone regenerative medicine in dentistry. J. Oral Biosci. 2010, 52:107-118.
    • (2010) J. Oral Biosci. , vol.52 , pp. 107-118
    • Egusa, H.1
  • 6
    • 80055108494 scopus 로고    scopus 로고
    • Current patents on osteoinductive molecules for bone tissue engineering
    • Lo K.W., et al. Current patents on osteoinductive molecules for bone tissue engineering. Recent Patents Biomed. Eng. 2011, 4:153-167.
    • (2011) Recent Patents Biomed. Eng. , vol.4 , pp. 153-167
    • Lo, K.W.1
  • 7
    • 84880806595 scopus 로고    scopus 로고
    • Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules
    • Segar C.E., et al. Regulation of angiogenesis and bone regeneration with natural and synthetic small molecules. Curr. Pharm. Des. 2013, 19:3403-3419.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 3403-3419
    • Segar, C.E.1
  • 8
    • 80055102634 scopus 로고    scopus 로고
    • Overview: differentiating issues in the development of macromolecules compared with small molecules
    • John Wiley
    • Blaich G., et al. Overview: differentiating issues in the development of macromolecules compared with small molecules. Handbook of Pharmaceutical Biotechnology 2006, 89-123. John Wiley.
    • (2006) Handbook of Pharmaceutical Biotechnology , pp. 89-123
    • Blaich, G.1
  • 9
    • 0033987939 scopus 로고    scopus 로고
    • Protein stability in controlled-release systems
    • Fu K., et al. Protein stability in controlled-release systems. Nat. Biotechnol. 2000, 18:24-25.
    • (2000) Nat. Biotechnol. , vol.18 , pp. 24-25
    • Fu, K.1
  • 10
    • 84864264096 scopus 로고    scopus 로고
    • The role of small molecules in the musculoskeletal regeneration
    • Lo K.W-H., et al. The role of small molecules in the musculoskeletal regeneration. Regen. Med. 2012, 7:535-549.
    • (2012) Regen. Med. , vol.7 , pp. 535-549
    • Lo, K.W.-H.1
  • 11
    • 36349024668 scopus 로고    scopus 로고
    • Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery
    • Bishop G.B., Einhorn T.A. Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery. Int. Orthop. 2007, 31:721-727.
    • (2007) Int. Orthop. , vol.31 , pp. 721-727
    • Bishop, G.B.1    Einhorn, T.A.2
  • 12
    • 49349090133 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)
    • Bessa P.C., et al. Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery). J. Tissue Eng. Regen. Med. 2008, 2:81-96.
    • (2008) J. Tissue Eng. Regen. Med. , vol.2 , pp. 81-96
    • Bessa, P.C.1
  • 13
    • 84865291114 scopus 로고    scopus 로고
    • Studies of bone morphogenetic protein based surgical repair
    • Lo K.W-H., et al. Studies of bone morphogenetic protein based surgical repair. Adv. Drug Deliv. Rev. 2012, 64:1277-1291.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 1277-1291
    • Lo, K.W.-H.1
  • 14
    • 84880722847 scopus 로고    scopus 로고
    • Complications associated with the use of the recombinant human bone morphogenetic proteins for posterior interbody fusions of the lumbar spine
    • Chrastil J., et al. Complications associated with the use of the recombinant human bone morphogenetic proteins for posterior interbody fusions of the lumbar spine. Spine 2013, 38:E1020-E1027.
    • (2013) Spine , vol.38
    • Chrastil, J.1
  • 15
    • 78149281054 scopus 로고    scopus 로고
    • Bone morphogenetic protein binding peptide mechanism and enhancement of osteogenic protein-1 induced bone healing
    • Taghavi C.E., et al. Bone morphogenetic protein binding peptide mechanism and enhancement of osteogenic protein-1 induced bone healing. Spine (Phila Pa 1976) 2010, 35:2049-2056.
    • (2010) Spine (Phila Pa 1976) , vol.35 , pp. 2049-2056
    • Taghavi, C.E.1
  • 16
    • 84883298054 scopus 로고    scopus 로고
    • Cancer after spinal fusion: the role of bone morphogenetic protein
    • Lad S.P., et al. Cancer after spinal fusion: the role of bone morphogenetic protein. Neurosurgery 2013, 73:440-449.
    • (2013) Neurosurgery , vol.73 , pp. 440-449
    • Lad, S.P.1
  • 17
    • 84876433078 scopus 로고    scopus 로고
    • A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair
    • Wong E., et al. A novel low-molecular-weight compound enhances ectopic bone formation and fracture repair. J. Bone Joint Surg. 2013, 95:454-461.
    • (2013) J. Bone Joint Surg. , vol.95 , pp. 454-461
    • Wong, E.1
  • 18
    • 84875092554 scopus 로고    scopus 로고
    • Identification of small molecule activators of BMP signaling
    • Vrijens K., et al. Identification of small molecule activators of BMP signaling. PLoS ONE 2013, 8:e59045.
    • (2013) PLoS ONE , vol.8
    • Vrijens, K.1
  • 19
    • 34547882714 scopus 로고    scopus 로고
    • A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor
    • Chan M.C., et al. A novel regulatory mechanism of the bone morphogenetic protein (BMP) signaling pathway involving the carboxyl-terminal tail domain of BMP type II receptor. Mol. Cell. Biol. 2007, 27:5776-5789.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 5776-5789
    • Chan, M.C.1
  • 20
    • 84874647272 scopus 로고    scopus 로고
    • BMP signaling in development and diseases: a pharmacological perspective
    • Bandyopadhyay A., et al. BMP signaling in development and diseases: a pharmacological perspective. Biochem. Pharmacol. 2013, 85:857-864.
    • (2013) Biochem. Pharmacol. , vol.85 , pp. 857-864
    • Bandyopadhyay, A.1
  • 21
    • 79952283228 scopus 로고    scopus 로고
    • A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype
    • Kato S., et al. A synthetic compound that potentiates bone morphogenetic protein-2-induced transdifferentiation of myoblasts into the osteoblastic phenotype. Mol. Cell. Biochem. 2011, 349:97-106.
    • (2011) Mol. Cell. Biochem. , vol.349 , pp. 97-106
    • Kato, S.1
  • 22
    • 84880733168 scopus 로고    scopus 로고
    • Short term treatment of small molecule phenamil induced a protracted osteogenic effect on osteoblast-like MC3T3-E1 cells
    • Lo K-W.H., et al. Short term treatment of small molecule phenamil induced a protracted osteogenic effect on osteoblast-like MC3T3-E1 cells. J. Tissue Eng. Regen. Med. 2013, 10.1002/term.1786.
    • (2013) J. Tissue Eng. Regen. Med.
    • Lo, K.-W.H.1
  • 23
    • 84906940659 scopus 로고    scopus 로고
    • Evaluating the feasibility of utilizing small molecule phenamil as a novel biofactor factor for bone regenerative engineering
    • Lo K.W-H., et al. Evaluating the feasibility of utilizing small molecule phenamil as a novel biofactor factor for bone regenerative engineering. J. Tissue Eng. Regen. Med. 2012, 10.1002/term.1573.
    • (2012) J. Tissue Eng. Regen. Med.
    • Lo, K.W.-H.1
  • 24
    • 67650091148 scopus 로고    scopus 로고
    • The small molecule phenamil induces osteoblast differentiation and mineralization
    • Park K.W., et al. The small molecule phenamil induces osteoblast differentiation and mineralization. Mol. Cell. Biol. 2009, 29:3905-3914.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3905-3914
    • Park, K.W.1
  • 25
    • 84860835899 scopus 로고    scopus 로고
    • A novel library screen identifies immunosuppressors that promote osteoblast differentiation
    • Darcy A., et al. A novel library screen identifies immunosuppressors that promote osteoblast differentiation. Bone 2012, 50:1294-1303.
    • (2012) Bone , vol.50 , pp. 1294-1303
    • Darcy, A.1
  • 26
    • 84878245379 scopus 로고    scopus 로고
    • Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo
    • Leppäranta O., et al. Bone morphogenetic protein-inducer tilorone identified by high-throughput screening is antifibrotic in vivo. Am. J. Respir. Cell Mol. Biol. 2013, 48:448-455.
    • (2013) Am. J. Respir. Cell Mol. Biol. , vol.48 , pp. 448-455
    • Leppäranta, O.1
  • 27
    • 79955563790 scopus 로고    scopus 로고
    • Organic synthesis toward small-molecule probes and drugs
    • Schreiber S.L. Organic synthesis toward small-molecule probes and drugs. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:6699-6702.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 6699-6702
    • Schreiber, S.L.1
  • 28
    • 84867350005 scopus 로고    scopus 로고
    • Identification of novel 2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl) benzoic acid analogues as BMP-2 stimulators
    • Balaramnavar V.M., et al. Identification of novel 2-((1-(benzyl(2-hydroxy-2-phenylethyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamoyl) benzoic acid analogues as BMP-2 stimulators. J. Med. Chem. 2012, 55:8248-8259.
    • (2012) J. Med. Chem. , vol.55 , pp. 8248-8259
    • Balaramnavar, V.M.1
  • 29
    • 84869386452 scopus 로고    scopus 로고
    • Reawakening atlas: chemical approaches to repair or replace dysfunctional musculature
    • Jung D.W., Williams D.R. Reawakening atlas: chemical approaches to repair or replace dysfunctional musculature. ACS Chem. Biol. 2012, 7:1773-1790.
    • (2012) ACS Chem. Biol. , vol.7 , pp. 1773-1790
    • Jung, D.W.1    Williams, D.R.2
  • 30
    • 84873956758 scopus 로고    scopus 로고
    • Crosslinking strategies facilitate tunable structural properties of fibrin microthreads
    • Grasman J.M., et al. Crosslinking strategies facilitate tunable structural properties of fibrin microthreads. Acta Biomater. 2012, 8:4020-4230.
    • (2012) Acta Biomater. , vol.8 , pp. 4020-4230
    • Grasman, J.M.1
  • 31
    • 84887395504 scopus 로고    scopus 로고
    • Bone morphogenetic proteins for bone regeneration and their alternatives
    • Laurencin C.T., Lo K.W. Bone morphogenetic proteins for bone regeneration and their alternatives. Curr. Pharm. Des. 2013, 19:3353.
    • (2013) Curr. Pharm. Des. , vol.19 , pp. 3353
    • Laurencin, C.T.1    Lo, K.W.2
  • 32
    • 84882367798 scopus 로고    scopus 로고
    • Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration
    • Yoshida T., et al. Angiotensin II inhibits satellite cell proliferation and prevents skeletal muscle regeneration. J. Biol. Chem. 2013, 288:23823-23832.
    • (2013) J. Biol. Chem. , vol.288 , pp. 23823-23832
    • Yoshida, T.1
  • 33
    • 84866160682 scopus 로고    scopus 로고
    • Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation
    • Bernacchioni C., et al. Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation. Skelet. Muscle 2012, 2:15.
    • (2012) Skelet. Muscle , vol.2 , pp. 15
    • Bernacchioni, C.1
  • 34
    • 77749264598 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration
    • Danieli-Betto D., et al. Sphingosine 1-phosphate signaling is involved in skeletal muscle regeneration. Am. J. Physiol. Cell Physiol. 2010, 298:C550-C558.
    • (2010) Am. J. Physiol. Cell Physiol. , vol.298
    • Danieli-Betto, D.1
  • 35
    • 84880886286 scopus 로고    scopus 로고
    • Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice
    • Ieronimakis N., et al. Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice. Skelet. Muscle 2013, 3:20.
    • (2013) Skelet. Muscle , vol.3 , pp. 20
    • Ieronimakis, N.1
  • 36
    • 70449512215 scopus 로고    scopus 로고
    • Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin
    • Kennedy K.A., et al. Retinoic acid enhances skeletal muscle progenitor formation and bypasses inhibition by bone morphogenetic protein 4 but not dominant negative beta-catenin. BMC Biol. 2009, 7:67.
    • (2009) BMC Biol. , vol.7 , pp. 67
    • Kennedy, K.A.1
  • 37
    • 84860138073 scopus 로고    scopus 로고
    • Small molecules that recapitulate the early steps of urodele amphibian limb regeneration and confer multipotency
    • Kim W.H., et al. Small molecules that recapitulate the early steps of urodele amphibian limb regeneration and confer multipotency. ACS Chem. Biol. 2012, 7:732-743.
    • (2012) ACS Chem. Biol. , vol.7 , pp. 732-743
    • Kim, W.H.1
  • 38
    • 84857770165 scopus 로고    scopus 로고
    • Current clinical therapies for cartilage repair, their limitation and the role of stem cells
    • Dhinsa B.S., Adesida A.B. Current clinical therapies for cartilage repair, their limitation and the role of stem cells. Curr. Stem Cell Res. Ther. 2012, 7:143-148.
    • (2012) Curr. Stem Cell Res. Ther. , vol.7 , pp. 143-148
    • Dhinsa, B.S.1    Adesida, A.B.2
  • 39
    • 84885512597 scopus 로고    scopus 로고
    • Articular cartilage repair
    • AAOS, Rosemont, IL, T.A. Einhorn, R.J.O. Keefe, J.A. Buckwalter (Eds.)
    • O'Driscoll S.W., Saris D.B.F. Articular cartilage repair. Orthopaedic Basic Science 2007, AAOS, Rosemont, IL. T.A. Einhorn, R.J.O. Keefe, J.A. Buckwalter (Eds.).
    • (2007) Orthopaedic Basic Science
    • O'Driscoll, S.W.1    Saris, D.B.F.2
  • 41
    • 77950659332 scopus 로고    scopus 로고
    • Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    • Goldring M.B., Goldring S.R. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann. N. Y. Acad. Sci. 2010, 1192:230-237.
    • (2010) Ann. N. Y. Acad. Sci. , vol.1192 , pp. 230-237
    • Goldring, M.B.1    Goldring, S.R.2
  • 42
    • 77956875270 scopus 로고    scopus 로고
    • Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease
    • Strassle B.W., et al. Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease. Osteoarthritis Cartilage 2010, 18:1319-1328.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 1319-1328
    • Strassle, B.W.1
  • 43
    • 77955438432 scopus 로고    scopus 로고
    • Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling
    • Kadri A., et al. Inhibition of bone resorption blunts osteoarthritis in mice with high bone remodelling. Ann. Rheum. Dis. 2010, 69:1533-1538.
    • (2010) Ann. Rheum. Dis. , vol.69 , pp. 1533-1538
    • Kadri, A.1
  • 44
    • 79959277624 scopus 로고    scopus 로고
    • Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model
    • Moreau M., et al. Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model. Arthritis Res. Ther. 2011, 13:R98.
    • (2011) Arthritis Res. Ther. , vol.13
    • Moreau, M.1
  • 45
    • 84455202518 scopus 로고    scopus 로고
    • Subchondral bone as a key target for osteoarthritis treatment
    • Castañeda S., et al. Subchondral bone as a key target for osteoarthritis treatment. Biochem. Pharmacol. 2012, 83:315-323.
    • (2012) Biochem. Pharmacol. , vol.83 , pp. 315-323
    • Castañeda, S.1
  • 46
    • 1842632402 scopus 로고    scopus 로고
    • The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model
    • Hayami T., et al. The role of subchondral bone remodeling in osteoarthritis: reduction of cartilage degeneration and prevention of osteophyte formation by alendronate in the rat anterior cruciate ligament transection model. Arthritis Rheum. 2004, 50:1193-1206.
    • (2004) Arthritis Rheum. , vol.50 , pp. 1193-1206
    • Hayami, T.1
  • 47
    • 1542286076 scopus 로고    scopus 로고
    • The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K
    • Pelletier J.P., et al. The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone 2004, 34:527-538.
    • (2004) Bone , vol.34 , pp. 527-538
    • Pelletier, J.P.1
  • 48
    • 84875153784 scopus 로고    scopus 로고
    • Effect of treatment with the cathepsin-k inhibitor, balicatib, on cartilage volume and biochemical markers of bone and cartilage degradation in patients with painful knee osteoarthritis
    • Manicourt D., et al. Effect of treatment with the cathepsin-k inhibitor, balicatib, on cartilage volume and biochemical markers of bone and cartilage degradation in patients with painful knee osteoarthritis. Osteoarthritis Cartilage 2007, 15:C130.
    • (2007) Osteoarthritis Cartilage , vol.15
    • Manicourt, D.1
  • 49
    • 67449128722 scopus 로고    scopus 로고
    • Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
    • Raynauld J.P., et al. Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI. Ann. Rheumat. Dis. 2009, 68:938-947.
    • (2009) Ann. Rheumat. Dis. , vol.68 , pp. 938-947
    • Raynauld, J.P.1
  • 50
    • 0035143316 scopus 로고    scopus 로고
    • Strontium ranelate increases cartilage matrix formation
    • Henrotin Y., et al. Strontium ranelate increases cartilage matrix formation. J. Bone Miner. Res. 2001, 16:299-308.
    • (2001) J. Bone Miner. Res. , vol.16 , pp. 299-308
    • Henrotin, Y.1
  • 51
    • 84872070437 scopus 로고    scopus 로고
    • Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1beta in the synovium
    • Pelletier J.P., et al. Strontium ranelate reduces the progression of experimental dog osteoarthritis by inhibiting the expression of key proteases in cartilage and of IL-1beta in the synovium. Ann. Rheum. Dis. 2013, 72:250-257.
    • (2013) Ann. Rheum. Dis. , vol.72 , pp. 250-257
    • Pelletier, J.P.1
  • 52
    • 84874606888 scopus 로고    scopus 로고
    • Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model
    • Yu D.G., et al. Strontium ranelate reduces cartilage degeneration and subchondral bone remodeling in rat osteoarthritis model. Acta Pharmacol. Sin. 2013, 34:393-402.
    • (2013) Acta Pharmacol. Sin. , vol.34 , pp. 393-402
    • Yu, D.G.1
  • 53
    • 33845191832 scopus 로고    scopus 로고
    • Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women
    • Alexandersen P., et al. Strontium ranelate reduces the urinary level of cartilage degradation biomarker CTX-II in postmenopausal women. Bone 2007, 40:218-222.
    • (2007) Bone , vol.40 , pp. 218-222
    • Alexandersen, P.1
  • 54
    • 79952792784 scopus 로고    scopus 로고
    • Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis
    • Alexandersen P., et al. Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis. Climacteric 2011, 14:236-243.
    • (2011) Climacteric , vol.14 , pp. 236-243
    • Alexandersen, P.1
  • 55
    • 84893581176 scopus 로고    scopus 로고
    • Autograft versus nonirradiated allograft tissue for anterior cruciate ligament reconstruction: a systematic review
    • Mariscalco M.W., et al. Autograft versus nonirradiated allograft tissue for anterior cruciate ligament reconstruction: a systematic review. Am. J. Sports Med. 2013, 10.1177/0363546513497566.
    • (2013) Am. J. Sports Med.
    • Mariscalco, M.W.1
  • 56
    • 85047690810 scopus 로고    scopus 로고
    • Anterior cruciate ligament reconstruction: which graft is bestα
    • Sherman O.H., Banffy M.B. Anterior cruciate ligament reconstruction: which graft is bestα. Arthroscopy 2004, 20:974-980.
    • (2004) Arthroscopy , vol.20 , pp. 974-980
    • Sherman, O.H.1    Banffy, M.B.2
  • 57
    • 84887135964 scopus 로고    scopus 로고
    • Metalloproteases and tendinopathy
    • Del Buono A., et al. Metalloproteases and tendinopathy. Muscles Ligaments Tendons J. 2013, 3:51-57.
    • (2013) Muscles Ligaments Tendons J. , vol.3 , pp. 51-57
    • Del Buono, A.1
  • 58
    • 27544462442 scopus 로고    scopus 로고
    • Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases
    • Demirag B., et al. Enhancement of tendon-bone healing of anterior cruciate ligament grafts by blockage of matrix metalloproteinases. J. Bone Joint Surg. 2005, 87:2401-2410.
    • (2005) J. Bone Joint Surg. , vol.87 , pp. 2401-2410
    • Demirag, B.1
  • 59
    • 84878386693 scopus 로고    scopus 로고
    • Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction
    • Lui P.P., et al. Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction. Eur. Cells Mater. 2013, 25:78-96.
    • (2013) Eur. Cells Mater. , vol.25 , pp. 78-96
    • Lui, P.P.1
  • 60
    • 84886296304 scopus 로고    scopus 로고
    • Local administration of alendronate reduced peri-tunnel bone loss and promoted graft-bone tunnel healing with minimal systemic effect on bone in contralateral knee
    • Lui P.P., et al. Local administration of alendronate reduced peri-tunnel bone loss and promoted graft-bone tunnel healing with minimal systemic effect on bone in contralateral knee. J. Orthop. Res. 2013, 31:1897-1906.
    • (2013) J. Orthop. Res. , vol.31 , pp. 1897-1906
    • Lui, P.P.1
  • 61
    • 34047201901 scopus 로고    scopus 로고
    • Alendronate prevents bone loss and improves tendon-to-bone repair strength in a canine model
    • Thomopoulos S., et al. Alendronate prevents bone loss and improves tendon-to-bone repair strength in a canine model. J. Orthop. Res. 2007, 25:473-479.
    • (2007) J. Orthop. Res. , vol.25 , pp. 473-479
    • Thomopoulos, S.1
  • 62
    • 40349091848 scopus 로고    scopus 로고
    • The role of macrophages in early healing of a tendon graft in a bone tunnel
    • Hays P.L., et al. The role of macrophages in early healing of a tendon graft in a bone tunnel. J. Bone Joint Surg. 2008, 90:565-579.
    • (2008) J. Bone Joint Surg. , vol.90 , pp. 565-579
    • Hays, P.L.1
  • 63
    • 70349148159 scopus 로고    scopus 로고
    • Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after a mechanical injury: involvement of the p65 subunit of NF-kappaB
    • Tang Z., et al. Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in anterior cruciate ligament and medial collateral ligament fibroblasts after a mechanical injury: involvement of the p65 subunit of NF-kappaB. Wound Repair Regen. 2009, 17:709-716.
    • (2009) Wound Repair Regen. , vol.17 , pp. 709-716
    • Tang, Z.1
  • 64
    • 79955689544 scopus 로고    scopus 로고
    • TGF-β1 promoted MMP-2 mediated wound healing of anterior cruciate ligament fibroblasts through NF-κB
    • Wang Y., et al. TGF-β1 promoted MMP-2 mediated wound healing of anterior cruciate ligament fibroblasts through NF-κB. Connect. Tissue Res. 2011, 52:218-225.
    • (2011) Connect. Tissue Res. , vol.52 , pp. 218-225
    • Wang, Y.1
  • 65
    • 34547662965 scopus 로고    scopus 로고
    • Peripheral regerenation
    • Chen Z.L., et al. Peripheral regerenation. Annu. Rev. Neurosci. 2007, 30:209-233.
    • (2007) Annu. Rev. Neurosci. , vol.30 , pp. 209-233
    • Chen, Z.L.1
  • 67
    • 67649399222 scopus 로고    scopus 로고
    • Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice
    • Mehanna A., et al. Polysialic acid glycomimetics promote myelination and functional recovery after peripheral nerve injury in mice. Brain 2009, 132:1449-1462.
    • (2009) Brain , vol.132 , pp. 1449-1462
    • Mehanna, A.1
  • 68
    • 81155137857 scopus 로고    scopus 로고
    • Neural cell type-specific responses to glycomimetic functionalized collagen
    • Masand S.N., et al. Neural cell type-specific responses to glycomimetic functionalized collagen. Biomaterials 2012, 33:790-797.
    • (2012) Biomaterials , vol.33 , pp. 790-797
    • Masand, S.N.1
  • 69
    • 84866143296 scopus 로고    scopus 로고
    • The effect of glycomimetic functionalized collagen on peripheral nerve repair
    • Masand S.N., et al. The effect of glycomimetic functionalized collagen on peripheral nerve repair. Biomaterials 2012, 33:8353-8362.
    • (2012) Biomaterials , vol.33 , pp. 8353-8362
    • Masand, S.N.1
  • 70
    • 84890803714 scopus 로고    scopus 로고
    • Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture
    • Loers G., et al. Nonyloxytryptamine mimics polysialic acid and modulates neuronal and glial functions in cell culture. J. Neurochem. 2013, 10.1111/jnc.12408.
    • (2013) J. Neurochem.
    • Loers, G.1
  • 71
    • 77953786885 scopus 로고    scopus 로고
    • Db-Cyclic adenosine monophosphate promotes axon regeneration and motor function recovery in cerebral ischemia-reperfusion rats
    • Niu L., et al. db-Cyclic adenosine monophosphate promotes axon regeneration and motor function recovery in cerebral ischemia-reperfusion rats. Neurol. India 2010, 58:195-200.
    • (2010) Neurol. India , vol.58 , pp. 195-200
    • Niu, L.1
  • 72
    • 79959726079 scopus 로고    scopus 로고
    • Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats
    • Kim H., et al. Effects of dibutyryl cyclic-AMP on survival and neuronal differentiation of neural stem/progenitor cells transplanted into spinal cord injured rats. PLoS ONE 2011, 6:e21744.
    • (2011) PLoS ONE , vol.6
    • Kim, H.1
  • 73
    • 36249031068 scopus 로고    scopus 로고
    • Recognizing and exploiting differences between RNAi and small-molecule inhibitors
    • Weiss W.A., et al. Recognizing and exploiting differences between RNAi and small-molecule inhibitors. Nat. Chem. Biol. 2007, 3:739-744.
    • (2007) Nat. Chem. Biol. , vol.3 , pp. 739-744
    • Weiss, W.A.1
  • 74
    • 79960238966 scopus 로고    scopus 로고
    • Network neighbors of drug targets contribute to drug side-effect similarity
    • Brouwers L., et al. Network neighbors of drug targets contribute to drug side-effect similarity. PLoS ONE 2011, 6:e22187.
    • (2011) PLoS ONE , vol.6
    • Brouwers, L.1
  • 75
    • 70249124606 scopus 로고    scopus 로고
    • Controlled growth factor delivery for tissue engineering
    • Tayalia P., Mooney D.J. Controlled growth factor delivery for tissue engineering. Adv. Mater. 2009, 21:3269-3285.
    • (2009) Adv. Mater. , vol.21 , pp. 3269-3285
    • Tayalia, P.1    Mooney, D.J.2
  • 76
    • 85027952550 scopus 로고    scopus 로고
    • One-day treatment of small molecule 8-bromo-cyclic AMP analogue induces cell-based VEGF production for in vitro angiogenesis and osteoblastic differentiation
    • Lo K-W.H., et al. One-day treatment of small molecule 8-bromo-cyclic AMP analogue induces cell-based VEGF production for in vitro angiogenesis and osteoblastic differentiation. J. Tissue Eng. Regen. Med. 2013, 10.1002/term.1839.
    • (2013) J. Tissue Eng. Regen. Med.
    • Lo, K.-W.H.1
  • 77
    • 77953311260 scopus 로고    scopus 로고
    • Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads
    • Taylor K.L., et al. Small molecule screening in zebrafish: an in vivo approach to identifying new chemical tools and drug leads. Cell Commun. Signal. 2010, 8:11.
    • (2010) Cell Commun. Signal. , vol.8 , pp. 11
    • Taylor, K.L.1
  • 78
    • 79251511501 scopus 로고    scopus 로고
    • Identification of direct protein targets of small molecules
    • Lomenick B., et al. Identification of direct protein targets of small molecules. ACS Chem. Biol. 2011, 6:34-46.
    • (2011) ACS Chem. Biol. , vol.6 , pp. 34-46
    • Lomenick, B.1
  • 79
    • 73349093728 scopus 로고    scopus 로고
    • High-performance drug discovery: computational screening by combining docking and molecular dynamics simulations
    • Okimoto N., et al. High-performance drug discovery: computational screening by combining docking and molecular dynamics simulations. PLoS Comput. Biol. 2009, 5:e1000528.
    • (2009) PLoS Comput. Biol. , vol.5
    • Okimoto, N.1
  • 80
    • 84858959483 scopus 로고    scopus 로고
    • Nanostructured polymeric scaffolds for orthopaedic regenerative engineering
    • Deng M., et al. Nanostructured polymeric scaffolds for orthopaedic regenerative engineering. IEEE Trans. Nanobioscience 2012, 11:3-14.
    • (2012) IEEE Trans. Nanobioscience , vol.11 , pp. 3-14
    • Deng, M.1
  • 81
    • 0038480134 scopus 로고    scopus 로고
    • Looking back to the embryo: defining transcriptional networks in adult myogenesis
    • Parker M.H., et al. Looking back to the embryo: defining transcriptional networks in adult myogenesis. Nat. Rev. 2003, 4:497-507.
    • (2003) Nat. Rev. , vol.4 , pp. 497-507
    • Parker, M.H.1
  • 82
    • 27744588940 scopus 로고    scopus 로고
    • Mechanism of osteogenic induction by FK506 via BMP/Smad pathways
    • Kugimiya F., et al. Mechanism of osteogenic induction by FK506 via BMP/Smad pathways. Biochem. Biophys. Res. Commun. 2005, 338:872-879.
    • (2005) Biochem. Biophys. Res. Commun. , vol.338 , pp. 872-879
    • Kugimiya, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.