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Volumn 7, Issue 2, 2012, Pages 143-148

Current clinical therapies for cartilage repair, their limitation and the role of stem cells

Author keywords

Fibrocartilage; Hyaline cartilage; Knee; Mesenchymal stem cells; Osteoarthritis; Osteochondral defect

Indexed keywords

ABRASION ARTHROPLASTY; ADIPOSE TISSUE; ARTICLE; ARTICULAR CARTILAGE; AUTOLOGOUS CHONDROCYTE IMPLANTATION; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE MARROW; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; CHONDROGENESIS; CHONDROPATHY; FIBROCARTILAGE; HUMAN; HYALINE CARTILAGE; IN VITRO STUDY; IN VIVO STUDY; MESENCHYMAL STEM CELL TRANSPLANTATION; MORBIDITY; PRIORITY JOURNAL; SYNOVIUM;

EID: 84857770165     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488812799219009     Document Type: Article
Times cited : (67)

References (82)
  • 1
    • 0036083985 scopus 로고    scopus 로고
    • Articular cartilage repair: Basic science and clinical progress. A review of the current status and prospects
    • Hunziker EB. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects. Osteoarthritis Cartilage 2002; 10: 432-63.
    • (2002) Osteoarthritis Cartilage , vol.10 , pp. 432-463
    • Hunziker, E.B.1
  • 2
    • 0031856463 scopus 로고    scopus 로고
    • Articular cartilage repair and transplantation
    • Buckwalter JA, Mankin HJ. Articular cartilage repair and transplantation. Arthritis Rheum 1998; 41: 1331-42.
    • (1998) Arthritis Rheum , vol.41 , pp. 1331-1342
    • Buckwalter, J.A.1    Mankin, H.J.2
  • 4
    • 63649120787 scopus 로고    scopus 로고
    • Mesenchymal stem cells in connective tissue engineering and regenerative medicine: Applications in cartilage repair and osteoarthritis therapy
    • Mobasheri A, Csaki C, Clutterbuck AL, Rahmanzadeh M, Shakibaei M. Mesenchymal stem cells in connective tissue engineering and regenerative medicine: applications in cartilage repair and osteoarthritis therapy. Histol Histopathol 2009; 24(3): 347-66.
    • (2009) Histol Histopathol , vol.24 , Issue.3 , pp. 347-366
    • Mobasheri, A.1    Csaki, C.2    Clutterbuck, A.L.3    Rahmanzadeh, M.4    Shakibaei, M.5
  • 5
    • 0015263120 scopus 로고
    • The repair of large osteochondral defects. An experimental study in horses
    • Convery FR, Akeson WH, Keown GH. The repair of large osteochondral defects. An experimental study in horses. Clin Orthop Relat Res 1972; 82: 253-62.
    • (1972) Clin Orthop Relat Res , vol.82 , pp. 253-262
    • Convery, F.R.1    Akeson, W.H.2    Keown, G.H.3
  • 6
    • 0020053076 scopus 로고
    • The response of articular cartilage to mechanical injury
    • Mankin HJ. The response of articular cartilage to mechanical injury. J Bone Joint Surg Am 1982; 64: 460-6.
    • (1982) J Bone Joint Surg Am , vol.64 , pp. 460-466
    • Mankin, H.J.1
  • 9
    • 0027288061 scopus 로고
    • Cell origin and differentiation in the repair of full-thickness defects of articular cartilage
    • Shapiro F, Koide S, Glimcher MJ. Cell origin and differentiation in the repair of full-thickness defects of articular cartilage. J Bone Joint Surg Am 1993; 75; 532-53.
    • (1993) J Bone Joint Surg Am , vol.75 , pp. 532-553
    • Shapiro, F.1    Koide, S.2    Glimcher, M.J.3
  • 11
    • 33745437125 scopus 로고    scopus 로고
    • Mechanobiological conditioning of stem cells for cartilage tissue engineering
    • Schumann D, Kujat R, Nerlich M, Angele P. Mechanobiological conditioning of stem cells for cartilage tissue engineering. Biomed Mater Eng 2006; 16(4 Suppl): S37-52.
    • (2006) Biomed Mater Eng , vol.16 , Issue.4 SUPPL.
    • Schumann, D.1    Kujat, R.2    Nerlich, M.3    Angele, P.4
  • 12
    • 0037544387 scopus 로고    scopus 로고
    • Outcomes of microfracture for traumatic chondral defects of the knee: Average 11-year follow-up
    • Steadman JR, Briggs KK, Rodrigo JJ, Kocher MS, Gill TJ, Rodkey WG. Outcomes of microfracture for traumatic chondral defects of the knee: average 11-year follow-up. Arthroscopy 2003; 19: 477-84.
    • (2003) Arthroscopy , vol.19 , pp. 477-484
    • Steadman, J.R.1    Briggs, K.K.2    Rodrigo, J.J.3    Kocher, M.S.4    Gill, T.J.5    Rodkey, W.G.6
  • 13
    • 0031307632 scopus 로고    scopus 로고
    • Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects. A preliminary report
    • Hangody L, Kish G, Karpati Z, Szerb I, Udvarhelyi I. Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects. A preliminary report. Knee Surg Sports Traumatol Arthrosc 1997; 5: 262-7.
    • (1997) Knee Surg Sports Traumatol Arthrosc , vol.5 , pp. 262-267
    • Hangody, L.1    Kish, G.2    Karpati, Z.3    Szerb, I.4    Udvarhelyi, I.5
  • 14
    • 0022501923 scopus 로고
    • Bone and cartilage allotransplantation. A review of 14 years of research and clinical studies
    • Czitrom AA, Langer F, McKee N, Gross AE. Bone and cartilage allotransplantation. A review of 14 years of research and clinical studies. Clin Orthop 1986; 208: 141-5.
    • (1986) Clin Orthop , vol.208 , pp. 141-145
    • Czitrom, A.A.1    Langer, F.2    McKee, N.3    Gross, A.E.4
  • 17
    • 0023196015 scopus 로고
    • The immune response to osteochondral allografts in dogs
    • Stevenson S. The immune response to osteochondral allografts in dogs. J Bone Joint Surg Am 1987; 69: 573-82.
    • (1987) J Bone Joint Surg Am , vol.69 , pp. 573-582
    • Stevenson, S.1
  • 18
    • 0032722231 scopus 로고    scopus 로고
    • Comparative study of the reconstruction of articular cartilage defects with free costal perichondrial grafts and free tibial periosteal grafts: An experimental study on rabbits
    • Carranza-Bencano A, Perez-Tinao M, Ballesteros-Vazquez P, Armas-Padron JR, Hevia-Alonso A, Martos Crespo F. Comparative study of the reconstruction of articular cartilage defects with free costal perichondrial grafts and free tibial periosteal grafts: an experimental study on rabbits. Calcif Tissue Int 1999; 65: 402-7.
    • (1999) Calcif Tissue Int , vol.65 , pp. 402-407
    • Carranza-Bencano, A.1    Perez-Tinao, M.2    Ballesteros-Vazquez, P.3    Armas-Padron, J.R.4    Hevia-Alonso, A.5    Martos, C.F.6
  • 19
    • 18944373370 scopus 로고    scopus 로고
    • Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: A prospective, randomised study
    • Bartlett W, Skinner JA, Gooding CR, et al. Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee: a prospective, randomised study. J Bone Joint Surg Br 2005; 87-B: 640-5.
    • (2005) J Bone Joint Surg Br , vol.87 B , pp. 640-645
    • Bartlett, W.1    Skinner, J.A.2    Gooding, C.R.3
  • 20
    • 0028031550 scopus 로고
    • Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
    • Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L. Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 1994; 331: 889-95.
    • (1994) N Engl J Med , vol.331 , pp. 889-895
    • Brittberg, M.1    Lindahl, A.2    Nilsson, A.3    Ohlsson, C.4    Isaksson, O.5    Peterson, L.6
  • 21
    • 0032199210 scopus 로고    scopus 로고
    • Chondrocyte implantation in the repair of chondral lesions of the knee: Economics and quality of life
    • Minas T. Chondrocyte implantation in the repair of chondral lesions of the knee: economics and quality of life. Am J Orthop 1998; 27: 739-44.
    • (1998) Am J Orthop , vol.27 , pp. 739-744
    • Minas, T.1
  • 24
    • 0020369710 scopus 로고
    • Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels
    • Benya PD, Shaffer JD. Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels. Cell 1982; 30: 215-24.
    • (1982) Cell , vol.30 , pp. 215-224
    • Benya, P.D.1    Shaffer, J.D.2
  • 25
    • 1242315546 scopus 로고    scopus 로고
    • The use of chondrogide membrane in autologous chondrocyte implantation
    • Haddo O, Mahroof S, Higgs D, et al. The use of chondrogide membrane in autologous chondrocyte implantation. Knee 2004; 11: 51-5.
    • (2004) Knee , vol.11 , pp. 51-55
    • Haddo, O.1    Mahroof, S.2    Higgs, D.3
  • 26
    • 35748983190 scopus 로고    scopus 로고
    • Classification of graft hypertrophy after autologous chondrocyte implantation of fullthickness chondral defects in the knee
    • Kreuz PC, Steinwachs M, Erggelet C, et al. Classification of graft hypertrophy after autologous chondrocyte implantation of fullthickness chondral defects in the knee. Osteoarthritis Cartilage 2007; 15: 1339-47.
    • (2007) Osteoarthritis Cartilage , vol.15 , pp. 1339-1347
    • Kreuz, P.C.1    Steinwachs, M.2    Erggelet, C.3
  • 28
    • 4544362083 scopus 로고    scopus 로고
    • MRI in the follow- up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture
    • Bachmann G, Basad E, Lommel D, Steinmeyer J. MRI in the follow- up of matrix-supported autologous chondrocyte transplantation (MACI) and microfracture. Radiologe 2004; 44: 773-82.
    • (2004) Radiologe , vol.44 , pp. 773-782
    • Bachmann, G.1    Basad, E.2    Lommel, D.3    Steinmeyer, J.4
  • 29
  • 30
    • 0347951317 scopus 로고    scopus 로고
    • Arthroscopic autologous chondrocyte implantation for the treatment of a chondral defect in the tibial plateau of the knee
    • Ronga M, Grassi FA, Bulgheroni P. Arthroscopic autologous chondrocyte implantation for the treatment of a chondral defect in the tibial plateau of the knee. Arthroscopy 2004; 20: 79-84.
    • (2004) Arthroscopy , vol.20 , pp. 79-84
    • Ronga, M.1    Grassi, F.A.2    Bulgheroni, P.3
  • 31
    • 0028534864 scopus 로고
    • The effects of dexamethasone and 1,25-dihydroxyvitamin D3 on osteogenic differentiation of human marrow stromal cells in vitro
    • Beresford JN, Joyner CJ, Devlin C, Triffitt JT. The effects of dexamethasone and 1,25-dihydroxyvitamin D3 on osteogenic differentiation of human marrow stromal cells in vitro. Arch Oral Biol 1994; 39: 941-7.
    • (1994) Arch Oral Biol , vol.39 , pp. 941-947
    • Beresford, J.N.1    Joyner, C.J.2    Devlin, C.3    Triffitt, J.T.4
  • 32
    • 0035758094 scopus 로고    scopus 로고
    • Adipocyte differentiation: From fibroblast to endocrine cell
    • Gregoire FM. Adipocyte differentiation: from fibroblast to endocrine cell. Exp Biol Med 2001; 226: 997-1002.
    • (2001) Exp Biol Med , vol.226 , pp. 997-1002
    • Gregoire, F.M.1
  • 34
    • 0026793195 scopus 로고
    • Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O
    • Ramirez-Zacarias JL, Castro-Munozledo F, Kuri-Harcuch W. Quantitation of adipose conversion and triglycerides by staining intracytoplasmic lipids with Oil red O. Histochem 1992; 97: 493-7.
    • (1992) Histochem , vol.97 , pp. 493-497
    • Ramirez-Zacarias, J.L.1    Castro-Munozledo, F.2    Kuri-Harcuch, W.3
  • 35
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-7.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 36
    • 21744438592 scopus 로고    scopus 로고
    • Mesenchymal stem cells from the outer ear: A novel adult stem cell model system for the study of adipogenesis
    • Rim JS, Mynatt RL, Gawronska-Kozak B. Mesenchymal stem cells from the outer ear: a novel adult stem cell model system for the study of adipogenesis. FASEB J 2005; 19: 1205-7.
    • (2005) FASEB J , vol.19 , pp. 1205-1207
    • Rim, J.S.1    Mynatt, R.L.2    Gawronska-Kozak, B.3
  • 37
    • 0035067539 scopus 로고    scopus 로고
    • Multilineage cells from human adipose tissue: Implications for cell-based therapies
    • Zuk PA, Zhu M, Mizino H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7: 211-28.
    • (2001) Tissue Eng , vol.7 , pp. 211-228
    • Zuk, P.A.1    Zhu, M.2    Mizino, H.3
  • 39
    • 67650249147 scopus 로고    scopus 로고
    • Stem Cell Applications and Tissue Engineering Approaches in Surgical Practice
    • Khan WS, Malik AA, Hardingham TE. Stem Cell Applications and Tissue Engineering Approaches in Surgical Practice. J Perioper Pract 2009; 19(4): 130-5.
    • (2009) J Perioper Pract , vol.19 , Issue.4 , pp. 130-135
    • Khan, W.S.1    Malik, A.A.2    Hardingham, T.E.3
  • 40
    • 39749154084 scopus 로고    scopus 로고
    • Increased proliferation of human synovial mesenchymal stem cells with autologous human serum: Comparisons with bone marrow mesenchymal stem cells and with fetal bovine serum
    • Nimura A, Muneta T, Koga H, et al. Increased proliferation of human synovial mesenchymal stem cells with autologous human serum: comparisons with bone marrow mesenchymal stem cells and with fetal bovine serum. Arthritis Rheum 2008; 58: 501-10.
    • (2008) Arthritis Rheum , vol.58 , pp. 501-510
    • Nimura, A.1    Muneta, T.2    Koga, H.3
  • 41
    • 31644434203 scopus 로고    scopus 로고
    • Transgene-activated mesenchymal cells for articular cartilage repair: A comparison of primary bone marrow-, perichondrium/ periosteum- and fat-derived cells
    • Park J, Gelse K, Frank S, von der Mark K, Aigner T, Schneider H. Transgene-activated mesenchymal cells for articular cartilage repair: a comparison of primary bone marrow-, perichondrium/ periosteum- and fat-derived cells. J Gene Med 2006; 8: 112-25.
    • (2006) J Gene Med , vol.8 , pp. 112-125
    • Park, J.1    Gelse, K.2    Frank, S.3    von der Mark, K.4    Aigner, T.5    Schneider, H.6
  • 42
    • 23644456193 scopus 로고    scopus 로고
    • Comparison of human stem cells derived from various mesenchymal tissues: Superiority of synovium as a cell source
    • Sakaguchi Y, Sekiya I, Yagishita K, Muneta T. Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 2005: 52: 2521-9.
    • (2005) Arthritis Rheum , vol.52 , pp. 2521-2529
    • Sakaguchi, Y.1    Sekiya, I.2    Yagishita, K.3    Muneta, T.4
  • 43
    • 27644565830 scopus 로고    scopus 로고
    • Chondrogenic potential of progenitor cells derived from human bone marrow and adipose tissue: A patient-matched comparison
    • Huang JI, Kazmi N, Durbhakula MM, Hering TM, Yoo JU, Johnstone B. Chondrogenic potential of progenitor cells derived from human bone marrow and adipose tissue: a patient-matched comparison. J Orthop Res 2005; 23: 1383-9.
    • (2005) J Orthop Res , vol.23 , pp. 1383-1389
    • Huang, J.I.1    Kazmi, N.2    Durbhakula, M.M.3    Hering, T.M.4    Yoo, J.U.5    Johnstone, B.6
  • 44
    • 33847650121 scopus 로고    scopus 로고
    • Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages
    • Liu TM, Martina M, Hutmacher DW, Hui JH, Lee EH, Lim B. Identification of common pathways mediating differentiation of bone marrow- and adipose tissue-derived human mesenchymal stem cells into three mesenchymal lineages. Stem Cells 2007; 25: 750-60.
    • (2007) Stem Cells , vol.25 , pp. 750-760
    • Liu, T.M.1    Martina, M.2    Hutmacher, D.W.3    Hui, J.H.4    Lee, E.H.5    Lim, B.6
  • 45
    • 48249095121 scopus 로고    scopus 로고
    • Autocrine fibroblast growth factor 2 increases the multipotentiality of human adiposederived mesenchymal stem cells
    • Rider DA, Dombrowski C, Sawyer AA, et al. Autocrine fibroblast growth factor 2 increases the multipotentiality of human adiposederived mesenchymal stem cells. Stem Cells 2008; 26: 1598-608.
    • (2008) Stem Cells , vol.26 , pp. 1598-1608
    • Rider, D.A.1    Dombrowski, C.2    Sawyer, A.A.3
  • 46
    • 0036456669 scopus 로고    scopus 로고
    • Expansion of human adult stem cells from bone marrow stroma: Conditions that maximize the yields of early progenitors and evaluate their quality
    • Sekiya I, Larson BL, Smith JR, Pochampally R, Cui JG, Prockop DJ. Expansion of human adult stem cells from bone marrow stroma: conditions that maximize the yields of early progenitors and evaluate their quality. Stem Cells 2002; 20: 530-41.
    • (2002) Stem Cells , vol.20 , pp. 530-541
    • Sekiya, I.1    Larson, B.L.2    Smith, J.R.3    Pochampally, R.4    Cui, J.G.5    Prockop, D.J.6
  • 47
    • 33846935035 scopus 로고    scopus 로고
    • Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle
    • Yoshimura H, Muneta T, Nimura A, Yokoyama A, Koga H, Sekiya I. Comparison of rat mesenchymal stem cells derived from bone marrow, synovium, periosteum, adipose tissue, and muscle. Cell Tissue Res 2007; 327: 449-62.
    • (2007) Cell Tissue Res , vol.327 , pp. 449-462
    • Yoshimura, H.1    Muneta, T.2    Nimura, A.3    Yokoyama, A.4    Koga, H.5    Sekiya, I.6
  • 48
    • 0034724369 scopus 로고    scopus 로고
    • Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow
    • Colter DC, Class R, DiGirolamo CM, Prockop DJ. Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci USA 2000; 97: 3213-18.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 3213-3218
    • Colter, D.C.1    Class, R.2    DiGirolamo, C.M.3    Prockop, D.J.4
  • 49
    • 0017119380 scopus 로고
    • Fibroblast precursors in normal and irradiated mouse hematopoietic organs
    • Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 1976; 4: 267-74.
    • (1976) Exp Hematol , vol.4 , pp. 267-274
    • Friedenstein, A.J.1    Gorskaja, J.F.2    Kulagina, N.N.3
  • 50
    • 20444429578 scopus 로고    scopus 로고
    • Adult mesenchymal stem cells: Characterization, differentiation, and application in cell and gene therapy
    • Baksh D, Song L, Tuan RS. Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 2004; 8(3): 301-16.
    • (2004) J Cell Mol Med , vol.8 , Issue.3 , pp. 301-316
    • Baksh, D.1    Song, L.2    Tuan, R.S.3
  • 51
    • 14844303713 scopus 로고    scopus 로고
    • Smad3 induces chondrogenesis through the activation of SOX9 via CREBbinding protein/p300 recruitment
    • Furumatsu T, Tsuda M, Taniguchi N, Tajima Y, Asahara H. Smad3 induces chondrogenesis through the activation of SOX9 via CREBbinding protein/p300 recruitment. J Biol Chem 2005; 280: 8343-50.
    • (2005) J Biol Chem , vol.280 , pp. 8343-8350
    • Furumatsu, T.1    Tsuda, M.2    Taniguchi, N.3    Tajima, Y.4    Asahara, H.5
  • 53
    • 0036830491 scopus 로고    scopus 로고
    • The transcription factor SOX9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for the expression of SOX5 and SOX6
    • Akiyama H, Chaboissier MC, Martin JF, Schedl A, de Crombrugghe B. The transcription factor SOX9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for the expression of SOX5 and SOX6. Genes Dev 2002; 16: 2813-28.
    • (2002) Genes Dev , vol.16 , pp. 2813-2828
    • Akiyama, H.1    Chaboissier, M.C.2    Martin, J.F.3    Schedl, A.4    de Crombrugghe, B.5
  • 54
    • 34547872387 scopus 로고    scopus 로고
    • The matrix forming phenotype of human meniscus cells is enhanced by expansion in the presence of fibroblast growth factor 2 and hypoxia
    • Adesida AB, Brady LM, Khan WS, Hardingham TE. The matrix forming phenotype of human meniscus cells is enhanced by expansion in the presence of fibroblast growth factor 2 and hypoxia. Arthritis Res Ther 2006; 8: R61.
    • (2006) Arthritis Res Ther , vol.8
    • Adesida, A.B.1    Brady, L.M.2    Khan, W.S.3    Hardingham, T.E.4
  • 55
    • 84855279374 scopus 로고    scopus 로고
    • The Effect of Changes in Oxygen Tension During Fracture Repair on Mesenchymal Stem Cell and Bone Activities
    • Gidado S, Khan WS, Marsh DR. The Effect of Changes in Oxygen Tension During Fracture Repair on Mesenchymal Stem Cell and Bone Activities. Current Research Journal of Biological Sciences 2009; 1(1): 7-10.
    • (2009) Current Research Journal of Biological Sciences , vol.1 , Issue.1 , pp. 7-10
    • Gidado, S.1    Khan, W.S.2    Marsh, D.R.3
  • 56
    • 77951458865 scopus 로고    scopus 로고
    • Bone Marrow Derived Mesenchymal Stem Cells Express the Pericyte Marker 3G5 in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions
    • Khan WS, Adesida AB, Tew SR, Lowe ET, Hardingham TE. Bone Marrow Derived Mesenchymal Stem Cells Express the Pericyte Marker 3G5 in Culture and Show Enhanced Chondrogenesis in Hypoxic Conditions. J Orthop Res 2010; 28(6): 834-40.
    • (2010) J Orthop Res , vol.28 , Issue.6 , pp. 834-840
    • Khan, W.S.1    Adesida, A.B.2    Tew, S.R.3    Lowe, E.T.4    Hardingham, T.E.5
  • 57
    • 34347206376 scopus 로고    scopus 로고
    • Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients
    • Khan WS, Adesida AB, Hardingham TE. Hypoxic conditions increase hypoxia-inducible transcription factor 2alpha and enhance chondrogenesis in stem cells from the infrapatellar fat pad of osteoarthritis patients. Arthritis Res Ther 2007; 9: R55.
    • (2007) Arthritis Res Ther , vol.9
    • Khan, W.S.1    Adesida, A.B.2    Hardingham, T.E.3
  • 58
    • 3543022679 scopus 로고    scopus 로고
    • Plasticity of bone marrowderived stem cells
    • Grove JE, Bruscia E, Krause DS. Plasticity of bone marrowderived stem cells. Stem Cells 2004; 22: 487-500.
    • (2004) Stem Cells , vol.22 , pp. 487-500
    • Grove, J.E.1    Bruscia, E.2    Krause, D.S.3
  • 59
    • 0025486630 scopus 로고
    • The collagens and glycosaminoglycans of the extracellular matrices secreted by bone marrow stromal cells cultured in vivo in diffusion chambers
    • Ashhurst DE, Ashton BA, Owen ME. The collagens and glycosaminoglycans of the extracellular matrices secreted by bone marrow stromal cells cultured in vivo in diffusion chambers. J Orthop Res 1990; 8: 741-9.
    • (1990) J Orthop Res , vol.8 , pp. 741-749
    • Ashhurst, D.E.1    Ashton, B.A.2    Owen, M.E.3
  • 60
  • 61
    • 0037331874 scopus 로고    scopus 로고
    • Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells
    • Gelse K, von der Mark K, Aigner T, Park J, Schneider H. Articular cartilage repair by gene therapy using growth factor-producing mesenchymal cells. Arthritis Rheum 2003; 48: 430-41.
    • (2003) Arthritis Rheum , vol.48 , pp. 430-441
    • Gelse, K.1    von der Mark, K.2    Aigner, T.3    Park, J.4    Schneider, H.5
  • 62
    • 19944431434 scopus 로고    scopus 로고
    • Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage
    • Nawata M, Wakitani S, Nakaya H, et al. Use of bone morphogenetic protein 2 and diffusion chambers to engineer cartilage tissue for the repair of defects in articular cartilage. Arthritis Rheum 2005; 52: 155-63.
    • (2005) Arthritis Rheum , vol.52 , pp. 155-163
    • Nawata, M.1    Wakitani, S.2    Nakaya, H.3
  • 63
    • 0034804599 scopus 로고    scopus 로고
    • BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells
    • Sekiya I, Colter DC, Prockop DJ. BMP-6 enhances chondrogenesis in a subpopulation of human marrow stromal cells. Biochem Biophys Res Commun 2001; 284: 411-8.
    • (2001) Biochem Biophys Res Commun , vol.284 , pp. 411-418
    • Sekiya, I.1    Colter, D.C.2    Prockop, D.J.3
  • 64
    • 33646190866 scopus 로고    scopus 로고
    • Ex vivo gene therapyapproaches to cartilage repair
    • Gelse K, Schneider H. Ex vivo gene therapyapproaches to cartilage repair. Adv Drug Deliv Rev 2006; 58: 259-84.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 259-284
    • Gelse, K.1    Schneider, H.2
  • 65
    • 0024958251 scopus 로고
    • Reactions to a bovine collagen implant. Clinical and immunologic study in 705 patients
    • Charriere G, Bejot M, Schnitzler L, Ville G, Hartmann DJ. Reactions to a bovine collagen implant. Clinical and immunologic study in 705 patients. J Am Acad Dermatol 1989; 21: 1203-8.
    • (1989) J Am Acad Dermatol , vol.21 , pp. 1203-1208
    • Charriere, G.1    Bejot, M.2    Schnitzler, L.3    Ville, G.4    Hartmann, D.J.5
  • 66
    • 0141889330 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect
    • Arinzeh TL, Peter SJ, Archambault MP, et al. Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect. J Bone Joint Surg Am 2003; 85-A: 1927-35.
    • (2003) J Bone Joint Surg Am , vol.85 A , pp. 1927-1935
    • Arinzeh, T.L.1    Peter, S.J.2    Archambault, M.P.3
  • 67
    • 2342522072 scopus 로고    scopus 로고
    • Electric field-induced molecular vibration for noninvasive, highefficiency DNA transfection
    • Song L, Chau L, Sakamoto Y, Nakashima J, Koide M, Tuan RS. Electric field-induced molecular vibration for noninvasive, highefficiency DNA transfection. Mol Ther 2004; 9: 607-16.
    • (2004) Mol Ther , vol.9 , pp. 607-616
    • Song, L.1    Chau, L.2    Sakamoto, Y.3    Nakashima, J.4    Koide, M.5    Tuan, R.S.6
  • 68
    • 33846630795 scopus 로고    scopus 로고
    • Repair of full-thickness cartilage defects with cells of different origin in a rabbit model
    • Yan H, Yu C. Repair of full-thickness cartilage defects with cells of different origin in a rabbit model. Arthroscopy 2007; 23: 178-87.
    • (2007) Arthroscopy , vol.23 , pp. 178-187
    • Yan, H.1    Yu, C.2
  • 69
    • 0028236527 scopus 로고
    • Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage
    • Wakitani S, Goto T, Pineda SJ, et al. Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg Am 1994; 76: 579-92.
    • (1994) J Bone Joint Surg Am , vol.76 , pp. 579-592
    • Wakitani, S.1    Goto, T.2    Pineda, S.J.3
  • 70
    • 0036731957 scopus 로고    scopus 로고
    • Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defect
    • Adachi N, Sato K, Usas A, et al. Muscle derived, cell based ex vivo gene therapy for treatment of full thickness articular cartilage defect. J Rheumatol 2002; 29: 1920-30.
    • (2002) J Rheumatol , vol.29 , pp. 1920-1930
    • Adachi, N.1    Sato, K.2    Usas, A.3
  • 71
    • 0036027614 scopus 로고    scopus 로고
    • Fluorescently labeled mesenchymal stem cells (MSCs) maintain multilineage potential and can be detected following implantation into articular cartilage defects
    • Quintavalla J, Uziel-Fusi S, Yin J, et al. Fluorescently labeled mesenchymal stem cells (MSCs) maintain multilineage potential and can be detected following implantation into articular cartilage defects. Biomaterials 2002; 23; 109-19.
    • (2002) Biomaterials , vol.23 , pp. 109-119
    • Quintavalla, J.1    Uziel-Fusi, S.2    Yin, J.3
  • 72
    • 0035814241 scopus 로고    scopus 로고
    • Three-dimensional cartilage formation by bone marrow-derived cells seeded in polylactide/ alginate amalgam
    • Caterson EJ, Nesti LJ, Li WJ, et al. Three-dimensional cartilage formation by bone marrow-derived cells seeded in polylactide/ alginate amalgam. J Biomed Mater Res 2001; 57: 394-03.
    • (2001) J Biomed Mater Res , vol.57 , pp. 394-403
    • Caterson, E.J.1    Nesti, L.J.2    Li, W.J.3
  • 73
    • 0036901021 scopus 로고    scopus 로고
    • Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells
    • Jones EA, Kinsey SE, English A, et al. Isolation and characterization of bone marrow multipotential mesenchymal progenitor cells. Arthritis Rheum 2002; 46: 3349-60.
    • (2002) Arthritis Rheum , vol.46 , pp. 3349-3360
    • Jones, E.A.1    Kinsey, S.E.2    English, A.3
  • 75
    • 0035984714 scopus 로고    scopus 로고
    • Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells
    • Simonsen JL, Rosada C, Serakinci N, et al. Telomerase expression extends the proliferative life-span and maintains the osteogenic potential of human bone marrow stromal cells. Nat Biotechnol 2002; 20: 592-6.
    • (2002) Nat Biotechnol , vol.20 , pp. 592-596
    • Simonsen, J.L.1    Rosada, C.2    Serakinci, N.3
  • 76
    • 0038424780 scopus 로고    scopus 로고
    • Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin
    • Gronthos S, Chen S, Wang CY, Robey PG, Shi S. Telomerase accelerates osteogenesis of bone marrow stromal stem cells by upregulation of CBFA1, osterix, and osteocalcin. J Bone Miner Res 2003; 18: 716-22.
    • (2003) J Bone Miner Res , vol.18 , pp. 716-722
    • Gronthos, S.1    Chen, S.2    Wang, C.Y.3    Robey, P.G.4    Shi, S.5
  • 77
    • 0029122355 scopus 로고
    • Cytochalasin D induces changes in cell shape and promotes in vitro chondrogenesis: A morphological study
    • Loty S, Forest N, boulekbache H, Sautier JM. Cytochalasin D induces changes in cell shape and promotes in vitro chondrogenesis: a morphological study. Biol Cell 1995; 83: 149-61.
    • (1995) Biol Cell , vol.83 , pp. 149-161
    • Loty, S.1    Forest, N.2    Boulekbache, H.3    Sautier, J.M.4
  • 78
    • 48249127947 scopus 로고    scopus 로고
    • Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2
    • Khan WS, Tew SR, Adesida AB, Hardingham TE. Human infrapatellar fat pad-derived stem cells express the pericyte marker 3G5 and show enhanced chondrogenesis after expansion in fibroblast growth factor-2. Arthritis Res Ther 2008; 10: R74.
    • (2008) Arthritis Res Ther , vol.10
    • Khan, W.S.1    Tew, S.R.2    Adesida, A.B.3    Hardingham, T.E.4
  • 79
    • 0028914071 scopus 로고
    • Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation
    • Wroblewski J, Edwall-Arvidsson C. Inhibitory effects of basic fibroblast growth factor on chondrocyte differentiation. J Bone Miner Res 1995; 10: 735-42.
    • (1995) J Bone Miner Res , vol.10 , pp. 735-742
    • Wroblewski, J.1    Edwall-Arvidsson, C.2
  • 80
    • 33845985323 scopus 로고    scopus 로고
    • Regulation of SOX9 mRNA in Human Articular Chondrocytes Involving p38 MAPK Activation and mRNA Stabilization
    • Tew SR, Hardingham TE. Regulation of SOX9 mRNA in Human Articular Chondrocytes Involving p38 MAPK Activation and mRNA Stabilization. J Biol Chem 2006; 281: 39471-9.
    • (2006) J Biol Chem , vol.281 , pp. 39471-39479
    • Tew, S.R.1    Hardingham, T.E.2
  • 81
    • 1542286220 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Clinical applications and biological characterization
    • Barry FP, Murphy JM. Mesenchymal stem cells: clinical applications and biological characterization. Int J Biochem Cell Biol 2004; 36: 568-84.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 568-584
    • Barry, F.P.1    Murphy, J.M.2
  • 82
    • 33750321974 scopus 로고    scopus 로고
    • Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice
    • Pelttari K, Winter A, Steck E, et al. Premature induction of hypertrophy during in vitro chondrogenesis of human mesenchymal stem cells correlates with calcification and vascular invasion after ectopic transplantation in SCID mice. Arthritis Rheum 2006; 54(10): 3254-66.
    • (2006) Arthritis Rheum , vol.54 , Issue.10 , pp. 3254-3266
    • Pelttari, K.1    Winter, A.2    Steck, E.3


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