A systematic investigation of iminosugar click clusters as pharmacological chaperones for the treatment of gaucher disease

ChemBioChem

Volumn 15, Issue 2, 2014, Pages 309-319

  Joosten, Antoine ^a   Decroocq, Camille ^a   De Sousa, Julien ^a,b   Schneider, Jérémy P ^a   Etamé, Emile ^a   Bodlenner, Anne ^a   Butters, Terry D ^b   Compain, Philippe ^a,c  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c INSTITUT UNIVERSITAIRE DE FRANCE   (France)

Author keywords

Gaucher disease; iminosugars; multivalency; pharmacological chaperones; prodrugs; structure activity relationships

Indexed keywords

1 DEOXYNOJIRIMYCIN; ACETIC ACID; CHAPERONE; GLUCOSYLCERAMIDASE; IMINOSUGAR; PRODRUG;

ACETYLATION; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DEACETYLATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; GAUCHER DISEASE; PRIORITY JOURNAL;

GAUCHER DISEASE; IMINOSUGARS; MULTIVALENCY; PHARMACOLOGICAL CHAPERONES; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIPS;

DRUG DISCOVERY; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; IMINO SUGARS;

EID: 84892823834     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300442     Document Type: Article

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