Amphiphilic 1-deoxynojirimycin derivatives through click strategies for chemical chaperoning in N370S gaucher cells

Journal of Organic Chemistry

Volumn 76, Issue 19, 2011, Pages 7757-7768

  Diot, Jennifer D ^a   Moreno, Isabel Garcia ^b   Twigg, Gabriele ^d   Mellet, Carmen Ortiz ^b   Haupt, Karsten ^c   Butters, Terry D ^d   Kovensky, José ^a   Gouin, Sébastien G ^a,e  

^a UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^b UNIVERSITY OF SEVILLE   (Spain)

^c UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e UNIVERSITÉ DE NANTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPOUNDS; AGLYCONS; AMPHIPHILICS; CHAPERONE ACTIVITY; ENDOPLASMIC RETICULUM; GAUCHER DISEASE; HYDROPHOBIC SUBSTITUENTS; IMINOSUGARS; IN-VITRO; INHIBITION ASSAYS; MICROMOLAR INHIBITORS; REFERENCE COMPOUNDS; SYNTHETIC COMPOUNDS;

ENZYME ACTIVITY; HYDROPHOBICITY; MACHINERY;

QUALITY CONTROL;

1 DEOXYNOJIRIMYCIN DERIVATIVE; CHAPERONE; GLUCOSIDASE; IMINOSUGAR; N AZIDOPROPYL 1 DEOXYNOJIRIMYCIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL CHAPERONING; CHEMICAL PROCEDURES; CLICK CHEMISTRY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; GAUCHER DISEASE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY;

1-DEOXYNOJIRIMYCIN; ALKYNES; ANIMALS; AZIDES; CATTLE; CLICK CHEMISTRY; ENZYME INHIBITORS; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; TRIAZOLES;

EID: 80054112943     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo201125x     Document Type: Article

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