SCOPUS 정보 검색 플랫폼

Volumn 10, Issue 15, 2012, Pages 2923-2927

Synthesis of N-substituted ε-hexonolactams as pharmacological chaperones for the treatment of N370S mutant Gaucher disease

(7) Wang, Guan Nan a Twigg, Gabriele b Butters, Terry D b Zhang, Siwei a Zhang, Liangren a Zhang, Li He a Ye, Xin Shan a

a PEKING UNIVERSITY HEALTH SCIENCE CENTER (China)

b UNIVERSITY OF OXFORD (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONYL GROUPS; COMPUTATIONAL STUDIES; GAUCHER DISEASE; GLUCOCEREBROSIDASE; IMINOSUGARS; MUTANT ENZYMES; PROTEIN FOLDS; RING-EXPANSION REACTION; STRUCTURE ACTIVITY RELATIONSHIPS;

PROTEIN FOLDING;

SUBSTITUTION REACTIONS;

1 DEOXYNOJIRIMYCIN; DRUG DERIVATIVE; ENZYME ACTIVATOR; GLUCOSYLCERAMIDASE; IMINOSUGAR; LACTAM; N NONYL 1 DEOXYNOJIRIMYCIN; N-NONYL-1-DEOXYNOJIRIMYCIN;

ARTICLE; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; GAUCHER DISEASE; GENETICS; HUMAN; KINETICS; METABOLISM; MUTATION; PATHOLOGY; PROTEIN FOLDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

1-DEOXYNOJIRIMYCIN; CELL SURVIVAL; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME ACTIVATORS; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; IMINO SUGARS; KINETICS; LACTAMS; MODELS, MOLECULAR; MUTATION; PROTEIN FOLDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84858992784 PISSN: 14770520 EISSN: None Source Type: Journal
DOI: 10.1039/c2ob06987c Document Type: Article

Times cited : (23)

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