The multivalent effect in glycosidase inhibition: Probing the influence of valency, peripheral ligand structure, and topology with cyclodextrin-based iminosugar click clusters

ChemBioChem

Volumn 14, Issue 15, 2013, Pages 2038-2049

  Decroocq, Camille ^a   Joosten, Antoine ^a   Sergent, Raphaël ^a   Mena Barragán, Teresa ^b   Ortiz Mellet, Carmen ^b   Compain, Philippe ^a,c  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b UNIVERSITY OF SEVILLE   (Spain)

^c INSTITUT UNIVERSITAIRE DE FRANCE   (France)

Author keywords

Cyclodextrins; Glycosidases; Iminosugars; Inhibitors; Multivalency

Indexed keywords

ALPHA GLUCOSIDASE; ALPHA MANNOSIDASE; BETA GALACTOSIDASE; BETA GLUCOSIDASE; BETA MANNOSIDASE; CYCLODEXTRIN; GLYCOSIDASE; IMINOSUGAR; LIGAND;

ARTICLE; CHEMICAL STRUCTURE; CLICK CHEMISTRY; CLICK CLUSTER; COMPLEX FORMATION; CYCLOADDITION; DISSOCIATION; ENTHALPY; ENTROPY; ENZYME INHIBITION; ISOTHERMAL TITRATION CALORIMETRY; PRIORITY JOURNAL;

CANAVALIA ENSIFORMIS;

CYCLODEXTRINS; GLYCOSIDASES; IMINOSUGARS; INHIBITORS; MULTIVALENCY;

BETA-CYCLODEXTRINS; CLICK CHEMISTRY; DRUG DESIGN; ENZYME INHIBITORS; GLYCOSIDE HYDROLASES; IMINO SUGARS; LIGANDS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84885434081     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201300283     Document Type: Article

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