Characterization of the N370S Mutant of Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry

ChemBioChem

Volumn 13, Issue 15, 2012, Pages 2243-2250

  Tang, Liangjie ^a,b   Coales, Stephen J ^a   Morrow, Jeffrey A ^c   Edmunds, Tim ^d   Hamuro, Yoshitomo ^a  

^a ExSAR Corporation   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c Sierra Analytics Inc   (United States)

^d SANOFI   (France)

Author keywords

Ambroxol; Gaucher's disease; Glucocerebrosidases; Hydrogen deuterium exchange mass spectrometry; Isofagomine

Indexed keywords

ENZYME INHIBITOR; GLUCOSYLCERAMIDASE; GUANIDINE; IMIGLUCERASE; ISOFAGOMINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DEUTERIUM HYDROGEN EXCHANGE; DRUG PROTEIN BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME STABILITY; ENZYME STRUCTURE; LIGAND BINDING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MELTING POINT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; X RAY CRYSTALLOGRAPHY;

AMINO ACID SUBSTITUTION; DEUTERIUM; GAUCHER DISEASE; GLUCOSYLCERAMIDASE; HUMANS; HYDROGEN; IMINO PYRANOSES; LIGANDS; MASS SPECTROMETRY; POINT MUTATION; PROTEIN STABILITY; PROTEIN UNFOLDING;

EID: 84867190795     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201200302     Document Type: Article

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