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Volumn 37, Issue 3, 2013, Pages 469-474

Animal models of the sporadic form of Alzheimer's disease: Focus on the disease and not just the lesions

Author keywords

Asparaginyl endopeptidase; non transgenic rat model of sporadic Alzheimer's disease; protein phosphatase 2A; rat model of sporadic Alzheimer's disease; tau protein; tauopathies

Indexed keywords

BRAIN PROTEIN; I 2 PP2A PROTEIN; I 2CTF PROTEIN; I 2NTF PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2A; TAU PROTEIN; UNCLASSIFIED DRUG;

EID: 84892776614     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-130827     Document Type: Review
Times cited : (16)

References (64)
  • 3
    • 0022297190 scopus 로고
    • Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are anti-genically related
    • Wong CW, Quaranta V, Glenner GG (1985) Neuritic plaques and cerebrovascular amyloid in Alzheimer disease are anti-genically related. Proc Natl Acad Sci USA 82, 8729-8732.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 8729-8732
    • Wong, C.W.1    Quaranta, V.2    Glenner, G.G.3
  • 8
    • 0015733914 scopus 로고
    • Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys
    • Wisniewski HM, Ghetti B, Terry RD (1973) Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol 32, 566-584.
    • (1973) J Neuropathol Exp Neurol , vol.32 , pp. 566-584
    • Wisniewski, H.M.1    Ghetti, B.2    Terry, R.D.3
  • 9
    • 33644761191 scopus 로고    scopus 로고
    • Microcebus murinus: A useful primate model for human cerebral aging and Alzheimer's disease?
    • Bons N, Rieger F, Prudhomme D, Fisher A, Krause KH (2006) Microcebus murinus: A useful primate model for human cerebral aging and Alzheimer's disease? Genes Brain Behav 5, 120-130.
    • (2006) Genes Brain Behav , vol.5 , pp. 120-130
    • Bons, N.1    Rieger, F.2    Prudhomme, D.3    Fisher, A.4    Krause, K.H.5
  • 10
    • 0030751791 scopus 로고    scopus 로고
    • Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus
    • Giannakopoulos P, Silhol S, Jallageas V, Mallet J, Bons N, Bouras C, Delaere P (1997) Quantitative analysis of tau protein-immunoreactive accumulations and beta amyloid protein deposits in the cerebral cortex of the mouse lemur, Microcebus murinus. Acta Neuropathol 94, 131-139.
    • (1997) Acta Neuropathol , vol.94 , pp. 131-139
    • Giannakopoulos, P.1    Silhol, S.2    Jallageas, V.3    Mallet, J.4    Bons, N.5    Bouras, C.6    Delaere, P.7
  • 14
  • 23
    • 0035863188 scopus 로고    scopus 로고
    • Decreased nuclear beta-catenin, tau hyperphos-phorylation and neurodegeneration in GSK-3beta conditional transgenic mice
    • Lucas JJ, Hernandez F, Gomez-Ramos P, Moran MA, Hen R, Avila J (2001) Decreased nuclear beta-catenin, tau hyperphos-phorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J 20, 27-39.
    • (2001) EMBO J , vol.20 , pp. 27-39
    • Lucas, J.J.1    Hernandez, F.2    Gomez-Ramos, P.3    Moran, M.A.4    Hen, R.5    Avila, J.6
  • 24
    • 64549107543 scopus 로고    scopus 로고
    • Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the trans-genic rat model of tauopathy
    • Zilka N, Stozicka Z, Kovac A, Pilipcinec E, Bugos O, Novak M (2009) Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the trans-genic rat model of tauopathy. J Neuroimmunol 209, 16-25.
    • (2009) J Neuroimmunol , vol.209 , pp. 16-25
    • Zilka, N.1    Stozicka, Z.2    Kovac, A.3    Pilipcinec, E.4    Bugos, O.5    Novak, M.6
  • 25
    • 0028458037 scopus 로고
    • Truncated tau protein as a new marker for Alzheimer's disease
    • Novak M (1994) Truncated tau protein as a new marker for Alzheimer's disease. Acta Virol 38, 173-189.
    • (1994) Acta Virol , vol.38 , pp. 173-189
    • Novak, M.1
  • 26
    • 0031450192 scopus 로고    scopus 로고
    • Co-localization of truncated tau and DNA fragmentation in Alzheimer's disease neurones
    • Ugolini G, Cattaneo A, Novak M (1997) Co-localization of truncated tau and DNA fragmentation in Alzheimer's disease neurones. Neuroreport 8, 3709-3712.
    • (1997) Neuroreport , vol.8 , pp. 3709-3712
    • Ugolini, G.1    Cattaneo, A.2    Novak, M.3
  • 27
    • 33747606218 scopus 로고    scopus 로고
    • Expression of a truncated tau protein induces oxidative stress in a rodent model of tauopathy
    • Cente M, Filipcik P, Pevalova M, Novak M (2006) Expression of a truncated tau protein induces oxidative stress in a rodent model of tauopathy. Eur J Neurosci 24, 1085-1090.
    • (2006) Eur J Neurosci , vol.24 , pp. 1085-1090
    • Cente, M.1    Filipcik, P.2    Pevalova, M.3    Novak, M.4
  • 29
    • 38449088511 scopus 로고    scopus 로고
    • Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: An experimental approach
    • Salkovic-Petrisic M, Hoyer S (2007) Central insulin resistance as a trigger for sporadic Alzheimer-like pathology: An experimental approach. J Neural Transm Suppl 217-233.
    • (2007) J Neural Transm Suppl , pp. 217-233
    • Salkovic-Petrisic, M.1    Hoyer, S.2
  • 30
    • 74949100388 scopus 로고    scopus 로고
    • Modeling sporadic Alzheimer's disease: The insulin resistant brain state generates multiple long-term mor-phobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta
    • Salkovic-Petrisic M, Osmanovic J, Grunblatt E, Riederer P, Hoyer S (2009) Modeling sporadic Alzheimer's disease: The insulin resistant brain state generates multiple long-term mor-phobiological abnormalities including hyperphosphorylated tau protein and amyloid-beta. J Alzheimers Dis 18, 729-750.
    • (2009) J Alzheimers Dis , vol.18 , pp. 729-750
    • Salkovic-Petrisic, M.1    Osmanovic, J.2    Grunblatt, E.3    Riederer, P.4    Hoyer, S.5
  • 31
    • 84889263487 scopus 로고    scopus 로고
    • A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: Similarities to and differences from the transgenic model (3xTg-AD mouse)
    • Chen Y, Liang Z, Blanchard J, Dai CL, Sun S, Lee MH, Grundke-Iqbal I, Iqbal K, Liu F, Gong CX (2013) A non-transgenic mouse model (icv-STZ mouse) of Alzheimer's disease: Similarities to and differences from the transgenic model (3xTg-AD mouse). Mol Neurobiol 47, 711-725.
    • (2013) Mol Neurobiol , vol.47 , pp. 711-725
    • Chen, Y.1    Liang, Z.2    Blanchard, J.3    Dai, C.L.4    Sun, S.5    Lee, M.H.6    Grundke-Iqbal, I.7    Iqbal, K.8    Liu, F.9    Gong, C.X.10
  • 32
    • 0027361281 scopus 로고
    • Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
    • Kopke E, Tung YC, Shaikh S, Alonso AC, Iqbal K, Grundke-Iqbal I (1993) Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem 268, 24374-24384.
    • (1993) J Biol Chem , vol.268 , pp. 24374-24384
    • Kopke, E.1    Tung, Y.C.2    Shaikh, S.3    Alonso, A.C.4    Iqbal, K.5    Grundke-Iqbal, I.6
  • 34
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of micro-tubules in Alzheimer disease
    • Alonso AD, Zaidi T, Grundke-Iqbal I, Iqbal K (1994) Role of abnormally phosphorylated tau in the breakdown of micro-tubules in Alzheimer disease. Proc Natl Acad Sci USA 91, 5562-5566.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5562-5566
    • Alonso, A.D.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 35
    • 0029999787 scopus 로고    scopus 로고
    • Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
    • Alonso AD, Grundke-Iqbal I, Iqbal K (1996) Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2, 783-787.
    • (1996) Nat Med , vol.2 , pp. 783-787
    • Alonso, A.D.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 36
    • 33745024475 scopus 로고    scopus 로고
    • Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity
    • Alonso AD, Li B, Grundke-Iqbal I, Iqbal K (2006) Polymerization of hyperphosphorylated tau into filaments eliminates its inhibitory activity. Proc Natl Acad Sci USA 23, 8864-8869.
    • (2006) Proc Natl Acad Sci USA , vol.23 , pp. 8864-8869
    • Alonso, A.D.1    Li, B.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 37
    • 34247574162 scopus 로고    scopus 로고
    • Disruption of microtubule network by Alzheimer abnormally hyperphos-phorylated tau
    • Li B, Chohan MO, Grundke-Iqbal I, Iqbal K (2007) Disruption of microtubule network by Alzheimer abnormally hyperphos-phorylated tau. Acta Neuropathol (Berl) 113, 501-511.
    • (2007) Acta Neuropathol (Berl) , vol.113 , pp. 501-511
    • Li, B.1    Chohan, M.O.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 40
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45, 675-688.
    • (2005) Neuron , vol.45 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    Laferla, F.M.5
  • 41
    • 67349213205 scopus 로고    scopus 로고
    • Synaptic degeneration in Alzheimer's disease
    • Arendt T (2009) Synaptic degeneration in Alzheimer's disease. Acta Neuropathol 118, 167-179.
    • (2009) Acta Neuropathol , vol.118 , pp. 167-179
    • Arendt, T.1
  • 42
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 30, 572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 44
    • 27644478606 scopus 로고    scopus 로고
    • Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
    • Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22, 1942-1950.
    • (2005) Eur J Neurosci , vol.22 , pp. 1942-1950
    • Liu, F.1    Grundke-Iqbal, I.2    Iqbal, K.3    Gong, C.X.4
  • 45
    • 0029113874 scopus 로고
    • Phosphatase activity toward abnormally phosphory-lated tau: Decrease in Alzheimer disease brain
    • Gong CX, Shaikh S, Wang JZ, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Phosphatase activity toward abnormally phosphory-lated tau: Decrease in Alzheimer disease brain. J Neurochem 65, 732-738.
    • (1995) J Neurochem , vol.65 , pp. 732-738
    • Gong, C.X.1    Shaikh, S.2    Wang, J.Z.3    Zaidi, T.4    Grundke-Iqbal, I.5    Iqbal, K.6
  • 46
    • 0027214404 scopus 로고
    • Phos-phoprotein phosphatase activities in Alzheimer disease brain
    • Gong CX, Singh TJ, Grundke-Iqbal I, Iqbal K (1993) Phos-phoprotein phosphatase activities in Alzheimer disease brain. J Neurochem 61, 921-927.
    • (1993) J Neurochem , vol.61 , pp. 921-927
    • Gong, C.X.1    Singh, T.J.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 47
    • 47849120642 scopus 로고    scopus 로고
    • Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome
    • Liang Z, Liu F, Iqbal K, Grundke-Iqbal I, Wegiel J, Gong CX (2008) Decrease of protein phosphatase 2A and its association with accumulation and hyperphosphorylation of tau in Down syndrome. J Alzheimers Dis 13, 295-302.
    • (2008) J Alzheimers Dis , vol.13 , pp. 295-302
    • Liang, Z.1    Liu, F.2    Iqbal, K.3    Grundke-Iqbal, I.4    Wegiel, J.5    Gong, C.X.6
  • 48
    • 19544362550 scopus 로고    scopus 로고
    • Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease
    • Tanimukai H, Grundke-Iqbal I, Iqbal K (2005) Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. Am J Pathol 166, 1761-1771.
    • (2005) Am J Pathol , vol.166 , pp. 1761-1771
    • Tanimukai, H.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 49
    • 78649859760 scopus 로고    scopus 로고
    • The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment
    • Wang X, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A, Grundke-Iqbal I, Iqbal K (2010) The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment. FASEB J 24, 4420-4432.
    • (2010) FASEB J , vol.24 , pp. 4420-4432
    • Wang, X.1    Blanchard, J.2    Kohlbrenner, E.3    Clement, N.4    Linden, R.M.5    Radu, A.6    Grundke-Iqbal, I.7    Iqbal, K.8
  • 50
    • 80052259754 scopus 로고    scopus 로고
    • Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by i (2) (PP2A)/SET
    • Arnaud L, Chen S, Liu F, Li B, Khatoon S, Grundke-Iqbal I, Iqbal K (2011) Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I (2) (PP2A)/SET. FEBS Lett 585, 2653-2659.
    • (2011) FEBS Lett , vol.585 , pp. 2653-2659
    • Arnaud, L.1    Chen, S.2    Liu, F.3    Li, B.4    Khatoon, S.5    Grundke-Iqbal, I.6    Iqbal, K.7
  • 52
    • 84879047960 scopus 로고    scopus 로고
    • Activation of asparaginyl endopeptidase leads to tau hyperphosphorylation in Alzheimer's disease
    • Basurto-Islas G, Grundke-Iqbal I, Tung YC, Liu F, Iqbal K (2013) Activation of asparaginyl endopeptidase leads to tau hyperphosphorylation in Alzheimer's disease. J Biol Chem 288, 17495-17507.
    • (2013) J Biol Chem , vol.288 , pp. 17495-17507
    • Basurto-Islas, G.1    Grundke-Iqbal, I.2    Tung, Y.C.3    Liu, F.4    Iqbal, K.5
  • 53
    • 0032582565 scopus 로고    scopus 로고
    • Autocatalytic activation of human legumain at aspartic acid residues
    • Halfon S, Patel S, Vega F, Zurawski S, Zurawski G (1998) Autocatalytic activation of human legumain at aspartic acid residues. FEBS Lett 438, 114-118.
    • (1998) FEBS Lett , vol.438 , pp. 114-118
    • Halfon, S.1    Patel, S.2    Vega, F.3    Zurawski, S.4    Zurawski, G.5
  • 54
    • 0141755165 scopus 로고    scopus 로고
    • Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo
    • Li DN, Matthews SP, Antoniou AN, Mazzeo D, Watts C (2003) Multistep autoactivation of asparaginyl endopeptidase in vitro and in vivo. J Biol Chem 278, 38980-38990.
    • (2003) J Biol Chem , vol.278 , pp. 38980-38990
    • Li, D.N.1    Matthews, S.P.2    Antoniou, A.N.3    Mazzeo, D.4    Watts, C.5
  • 55
    • 0025011401 scopus 로고
    • Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias
    • Yates CM, Butterworth J, Tennant MC, Gordon A (1990) Enzyme activities in relation to pH and lactate in postmortem brain in Alzheimer-type and other dementias. J Neurochem 55, 1624-1630.
    • (1990) J Neurochem , vol.55 , pp. 1624-1630
    • Yates, C.M.1    Butterworth, J.2    Tennant, M.C.3    Gordon, A.4
  • 56
    • 79959346473 scopus 로고    scopus 로고
    • Does acidosis in brain play a role in Alzheimer's disease?
    • Pirchl M, Humpel C (2009) Does acidosis in brain play a role in Alzheimer's disease? Neuropsychiatrie 23, 187-192.
    • (2009) Neuropsychiatrie , vol.23 , pp. 187-192
    • Pirchl, M.1    Humpel, C.2
  • 58
    • 84892727965 scopus 로고    scopus 로고
    • A non-transgenic rat model of sporadic Alzheimer's disease
    • Avila J, Lucas J, Hernandez F, eds. Royal Societyof Chemistry
    • Iqbal K, Wang X, Blanchard J, Grundke-Iqbal I (2011) A non-transgenic rat model of sporadic Alzheimer's disease. In Animal Models for Neurodegenerative Disease, Avila J, Lucas J, Hernandez F, eds. Royal Societyof Chemistry, pp. 274-283.
    • (2011) Animal Models for Neurodegenerative Disease , pp. 274-283
    • Iqbal, K.1    Wang, X.2    Blanchard, J.3    Grundke-Iqbal, I.4
  • 59
    • 78149414428 scopus 로고    scopus 로고
    • Pharmaco-logic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Abeta and tau pathologies in 3xTg-AD mice
    • Blanchard J, Wanka L, Tung YC, Cardenas-Aguayo Mdel C, LaFerla FM, Iqbal K, Grundke-Iqbal I (2010) Pharmaco-logic reversal of neurogenic and neuroplastic abnormalities and cognitive impairments without affecting Abeta and tau pathologies in 3xTg-AD mice. Acta Neuropathol 120, 605-621.
    • (2010) Acta Neuropathol , vol.120 , pp. 605-621
    • Blanchard, J.1    Wanka, L.2    Tung, Y.C.3    Cardenas-Aguayo Mdel, C.4    Laferla, F.M.5    Iqbal, K.6    Grundke-Iqbal, I.7
  • 61
    • 0034125535 scopus 로고    scopus 로고
    • Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons
    • Holzer M, Bruckner MK, Beck M, Bigl V, Arendt T (2000) Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons. J Neural Transm107, 451-461.
    • (2000) J Neural Transm , vol.107 , pp. 451-461
    • Holzer, M.1    Bruckner, M.K.2    Beck, M.3    Bigl, V.4    Arendt, T.5
  • 62
    • 69249221553 scopus 로고    scopus 로고
    • Protein phosphatase 2 Ain Alzheimer's disease
    • Liu R, Wang JZ (2009) Protein phosphatase 2 Ain Alzheimer's disease. Pathophysiology 16, 273-277.
    • (2009) Pathophysiology , vol.16 , pp. 273-277
    • Liu, R.1    Wang, J.Z.2
  • 63
    • 4043167747 scopus 로고    scopus 로고
    • Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the protea-some
    • Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the protea-some. Neuron 43, 321-332.
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    Laferla, F.M.5
  • 64
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298, 789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.