Protein phosphatase 2A in Alzheimer's disease

Pathophysiology

Volumn 16, Issue 4, 2009, Pages 273-277

  Liu, Rong ^a   Wang, Jian Zhi ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Alzheimer's disease; Holoenzyme composition; Leu309 demethylation; PP2A inhibitors; Protein phosphatase 2A; Tyr307 phosphorylation

Indexed keywords

AMYLOID BETA PROTEIN; HOLOENZYME; HOMOCYSTEINE; LEUCINE; PHOSPHOPROTEIN PHOSPHATASE 2A; TAU PROTEIN; TYROSINE;

ALZHEIMER DISEASE; AMINO ACID METABOLISM; ARTICLE; CELL ACTIVATION; DEGENERATIVE DISEASE; DEMETHYLATION; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME SUBSTRATE; HUMAN; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; TAUOPATHY;

EID: 69249221553     PISSN: 09284680     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pathophys.2009.02.008     Document Type: Article

References (47)

1. Janssens V., and Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signaling. Biochem. J. 53 (2001) 417-439
2. Cohen P.T.W., Brewis N.D., Hughes V., and Mann D.J. Protein serine/threonine phosphatases; an expanding family. FEBS Lett. 268 (1990) 355-359
3. Mumby M.C., Russel K.L., Garrard L.J., and Green D.D. Cardiac contractile protein phosphatases. J. Biol. Chem. 262 (1987) 6257-6265
4. Agostinis P., Goris J., Pinna L.A., Marchiori F., Perich J.W., Meyer H.E., and Merlevede W. Synthetic peptides as model substrates for the study of the specificity of the polycation-stimulated protein phosphatases. Eur. J. Biochem. 189 (1990) 235-241
5. Grundke-Iqbal I., Iqbal K., Tung Y.C., Quinlan M., Wisniewski H.M., and Binder L.I. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. U.S.A. 83 (1986) 4913-4917
6. Grundke-Iqbal I., Iqbal K., Quinlan M., Tung Y.C., Zaidi M.S., and Wisniewski H.M. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J. Biol. Chem. 261 (1986) 6084-6089
7. Lee V.M., Balin B.J., Otvos Jr. L., and Trojanowski J.Q. A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 251 (1991) 675-678
8. Ishiguro K., Shiratsuchi A., Sato S., Omori A., Arioka M., Kobayashi S., Uchida T., and Imahori K. Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments. FEBS Lett. 325 (1993) 167-172
9. Liu F., Grundke-Iqbal I., Iqbal K., and Gong C.X. Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur. J. Neurosci. 22 (2005) 1942-1950
10. Pei J.J., Braak E., Braak H., Grundke-Iqbal I., Iqbal K., Winblad B., and Cowburn R.F. Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J. Neuropathol. Exp. Neurol. 58 (1999) 1010-1019
11. Gong C.X., Singh T.J., Grundke-Iqbal I., and Iqbal K. Phosphoprotein phosphatase activities in Alzheimer disease brain. J. Neurochem. 61 (1993) 921-927
12. Gong C.X., Shaikh S., Wang J.Z., Zaidi T., Grundke-Iqbal I., and Iqbal K. Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain. J. Neurochem. 65 (1995) 732-738
13. Wang J.Z., Gong C.X., Zaidi T., Grundke-Iqbal I., and Iqbal K. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and -2B. J. Biol. Chem. 270 (1995) 4854-4860
14. Sontag E., Nunbhakdi-Craig V., Sontag J.M., Diaz-Arrastia R., Ogris E., Dayal S., Lentz S.R., Arning E., and Bottiglieri T. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. J. Neurosci. 27 (2007) 2751-2759
15. Saito T., Ishiguro K., Uchida T., Miyamoto E., Kishimoto T., and Hisanaga S. In situ dephosphorylation of tau by protein phosphatase 2A and 2B in fetal rat primary cultured neurons. FEBS Lett. 376 (1995) 238-242
16. Wang J.Z., Grundke-Iqbal I., and Iqbal K. Restoration of biological activity of Alzheimer abnormally phosphorylated tau by dephosphorylation with protein phosphatase-2A, -2B and -1. Brain Res. Mol. Brain Res. 38 (1996) 200-208
17. Gong C.X., Lidsky T., Wegiel J., Zuck L., Grundke-Iqbal I., and Iqbal K. Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J. Biol. Chem. 275 (2000) 5535-5544
18. Tanaka T., Zhong J., Iqbal K., Trenkner E., and Grundke-Iqbal I. The regulation of phosphorylation of tau in SY5Y neuroblastoma cells: the role of protein phosphatases. FEBS Lett. 426 (1998) 248-254
19. Sun L., Liu S.Y., Zhou X.W., Wang X.C., Liu R., Wang Q., and Wang J.Z. Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats. Neuroscience 118 (2003) 1175-1182
20. Tian Q., Lin Z.Q., Wang X.C., Chen J., Wang Q., Gong C.X., and Wang J.Z. Injection of okadaic acid into the meynert nucleus basalis of rat brain induces decreased acetylcholine level and spatial memory deficit. Neuroscience 126 (2004) 277-284
21. Kins S., Crameri A., Evans D.R., Hemmings B.A., Nitsch R.M., and Gotz J. Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J. Biol. Chem. 276 (2001) 38193-38200
22. Gandy S.E., Caporaso G.L., Buxbaum J.D., de Cruz S.O., Iverfeldt K., Nordstedt C., Suzuki T., Czernik A.J., Nairn A.C., and Greengard P. Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein. Ann. N.Y. Acad. Sci. 695 (1993) 117-121
23. da Cruz e Silva E.F., da Cruz e Silva O.A., Zaia C.T., and Greengard P. Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein. Mol. Med. 1 (1995) 535-541
24. Holzer M., Bruckner M.K., Beck M., Bigl V., and Arendt T. Modulation of APP processing and secretion by okadaic acid in primary guinea pig neurons. J. Neural. Transm. 107 (2000) 451-461
25. Henriques A.G., Domingues S.C., Fardilha M., da Cruz e Silva E.F., and da Cruz e Silva O.A. Sodium azide and 2-deoxy-D-glucose-induced cellular stress affects phosphorylation-dependent AbetaPP processing. J. Alzheimers Dis. 7 (2005) 201-212
26. Buxbaum J.D., Koo E.H., and Greengard P. Protein phosphorylation inhibits production of Alzheimer amyloid beta/A4 peptide. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 9195-9198
27. Arendt T., Holzer M., Fruth R., Bruckner M.K., and Gartner U. Phosphorylation of tau, Abeta formation, and apoptosis after in vivo inhibition of PP-1 and PP-2A. Neurobiol. Aging 19 (1998) 3-13
28. Sun X., Cole G.M., Chu T., Xia W., Galasko D., Yamaguchi H., Tanemura K., Frautschy S.A., and Takashima A. Intracellular Abeta is increased by okadaic acid exposure in transfected neuronal and non-neuronal cell lines. Neurobiol. Aging 23 (2002) 195-203
29. Ando K., Iijima K.I., Elliott J.I., Kirino Y., and Suzuki T. Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J. Biol. Chem. 276 (2001) 40353-40361
30. Phiel C.J., Wilson C.A., Lee V.M., and Klein P.S. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 423 (2003) 435-439
31. Pierrot N., Santos S.F., Feyt C., Morel M., Brion J.P., and Octave J.N. Calcium mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation. J. Biol. Chem. 281 (2006) 39907-39914
32. Vogelsberg-Ragaglia V., Schuck T., Trojanowski J.Q., and Lee V.M. PP2A mRNA expression is quantitatively decreased in Alzheimer's disease hippocampus. Exp. Neurol. 168 (2001) 402-412
33. Sontag E., Luangpirom A., Hladik C., Mudrak I., Ogris E., Speciale S., and White III C.L. Altered expression levels of the protein phosphatase 2A ABalphaC enzyme are associated with Alzheimer disease pathology. J. Neuropathol. Exp. Neurol. 63 (2004) 287-301
34. Liu R., Zhou X.W., Tanila H., Bjorkdahl C., Wang J.Z., Guan Z.Z., Cao Y., Gustafsson J.A., Winblad B., and Pei J.J. Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J. Cell. Mol. Med. 12 (2008) 241-257
35. Sontag E., Nunbhakdi-Craig V., Lee G., Bloom G.S., and Mumby M.C. Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. Neuron 17 (1996) 1201-1207
36. Li M., Guo H., and Damuni Z. Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney. Biochemistry 34 (1995) 1988-1996
37. Chen S., Li B., Grundke-Iqbal I., and Iqbal K. I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J. Biol. Chem. 283 (2008) 10513-10521
38. Tanimukai H., Grundke-Iqbal I., and Iqbal K. Up-regulation of inhibitors of protein phosphatase-2A in Alzheimer's disease. Am. J. Pathol. 166 (2005) 1761-1771
39. Chung H., Nairn A.C., Murata K., and Brautigan D.L. Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2. Biochemistry 38 (1999) 10371-10376
40. Kremmer E., Ohst K., Kiefer J., Brewis N., and Walter G. Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: abundant expression of both forms in cells. Mol. Cell. Biol. 17 (1997) 1692-1701
41. Sontag E. Protein phosphatase 2A: the Trojan Horse of cellular signaling. Cell. Signal. 13 (2001) 7-16
42. Sontag E., Hladik C., Montgomery L., Luangpirom A., Mudrak I., Ogris E., and White III C.L. Downregulation of protein phosphatase 2A carboxyl methylation and methyltransferase may contribute to Alzheimer disease pathogenesis. J. Neuropathol. Exp. Neurol. 63 (2004) 1080-1091
43. Gentry M.S., Li Y., Wei H., Syed F.F., Patel S.H., Hallberg R.L., and Pallas D.C. A novel assay for protein phosphatase 2A (PP2A) complexes in vivo reveals differential effects of covalent modifications on different Saccharomyces cerevisiae PP2A heterotrimers. Eukaryot. Cell. 4 (2005) 1029-1040
44. Zhou X.W., Gustafsson J.A., Tanila H., Bjorkdahl C., Liu R., Winblad B., and Pei J.J. Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A. Neurobiol. Dis. 31 (2008) 386-394
45. Guo H., Reddy S.A., and Damuni Z. Purification and characterization of an autophosphorylation-activated protein serine threonine kinase that phosphorylates and inactivates protein phosphatase 2A. J. Biol. Chem. 268 (1993) 11193-11198
46. Brautigan D.L. Flicking the switches: phosphorylation of serine/threonine protein phosphatases. Semin. Cancer Biol. 6 (1995) 211-217
47. Chen J., Martin B.L., and Brautigan D.L. Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257 (1992) 1261-1264