Model for high-throughput screening of drug immunotoxicity - Study of the anti-microbial G1 over peritoneal macrophages using flow cytometry

European Journal of Medicinal Chemistry

Volumn 72, Issue , 2014, Pages 206-220

  Tenorio Borroto, Esvieta ^a,b   Peñuelas Rivas, Claudia G ^b   Vásquez Chagoyán, Juan C ^b   Castañedo, Nilo ^c   Prado Prado, Francisco J ^d   García Mera, Xerardo ^a   González Díaz, Humberto ^e,f  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UNIVERSIDAD AUTÓNOMA DEL ESTADO DE MORELOS   (Mexico)

^c CENTRAL UNIVERSITY OF LAS VILLAS   (Cuba)

^d UNIVERSIDAD DE QUINTANA ROO   (Mexico)

^e UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^f BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

ChEMBL; Drug immunotoxicity; Flow cytometry; High throughput model; Macrophage; Multiplex assay endpoints; QSAR model

Indexed keywords

1 5 BROMOFUR 2-IL 2 BROMO 2 NITROETHENE; ANTIINFECTIVE AGENT; ANTIPARASITIC AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BAGG ALBINO MOUSE; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG CYTOTOXICITY; FEMALE; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; HUMAN; IMMUNOTOXICITY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; VALIDATION STUDY; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; CYTOLOGY; DISCRIMINANT ANALYSIS; DRUG EFFECTS; MACROPHAGE; TOXICITY;

ANIMALS; ANTI-INFECTIVE AGENTS; CELL SURVIVAL; CELLS, CULTURED; DISCRIMINANT ANALYSIS; FLOW CYTOMETRY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MACROPHAGES; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892752876     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.035     Document Type: Article

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