RAD51-dependent break-induced replication differs in kinetics and checkpoint responses from RAD51-mediated gene conversion

Molecular and Cellular Biology

Volumn 25, Issue 3, 2005, Pages 933-944

  Malkova, Anna ^a,b   Naylor, Maria L ^a,c   Yamaguchi, Miyuki ^a   Ira, Grzegorz ^a   Haber, James E ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; ENDONUCLEASE; RAD50 PROTEIN; RAD51 PROTEIN;

ARTICLE; BREAK INDUCED REPLICATION; CELL CYCLE G2 PHASE; CENTROMERE; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA STRAND BREAKAGE; DNA SYNTHESIS; FLUORESCENCE ACTIVATED CELL SORTING; GENE CONVERSION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; SACCHAROMYCES; SEQUENCE HOMOLOGY;

CELL CYCLE; CHROMOSOMES, FUNGAL; DNA REPAIR; DNA REPLICATION; DNA-BINDING PROTEINS; GENE CONVERSION; GENES, CDC; RAD51 RECOMBINASE; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES;

EID: 12844289007     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.3.933-944.2005     Document Type: Article

References (39)

1. Bosco, G., and J. E. Haber. 1998. Chromosome break-induced DNA replication leads to non-reciprocal translocations and telomere capture. Genetics 150:1037-1047.
2. Church, G. M., and W. Gilbert. 1984. Genomic sequencing. Proc. Natl. Acad. Sci. USA 81:1991-1995.
3. Clikeman, J., G. Khalsa, S. Barton, and J. Nickoloff. 2001. Homologous recombinational repair of double-strand breaks in yeast is enhanced by MAT heterozygosity through yKU-dependent and -independent mechanisms. Genetics 157:579-589.
4. Colaiácovo, M. P., F. Päques, and J. E. Haber. 1999. Removal of one nonhomologous DNA end during gene conversion by a RAD1- and MSH2-independent pathway. Genetics 151:1409-1423.
5. Davis, A. P., and L. S. Symington. 2004. RAD51-dependent break-induced replication in yeast. Mol. Cell. Biol. 24:2344-2351.
6. Dunn, B., P. Szauter, M. L. Pardue, and J. W. Szostak. 1984. Transfer of yeast telomeres to linear plasmids by recombination. Cell 39:191-201.
7. Esposito, M. S. 1978. Evidence that spontaneous mitotic recombination occurs at the two-strand stage. Proc. Natl. Acad. Sci. USA 75:4436-4440.
8. Galgoczy, D. J., and D. P. Toczyski. 2001. Checkpoint adaptation precedes spontaneous and damage-induced genomic instability in yeast. Mol. Cell. Biol. 21:1710-1718.
9. Holmes, A., and J. E. Haber. 1999. Double-strand break repair in yeast requires both leading and lagging strand DNA polymerases. Cell 96:415-424.
10. Inbar, O., B. Liefshitz, G. Bitan, and M. Kupiec. 2000. The relationship between homology length and crossing-over during the repair of a broken chromosome. J. Biol. Chem. 275:30833-30838.
11. Ira, G., and J. E. Haber. 2002. Characterization of RAD51-independent break-induced replication that acts preferentially with short homologous sequences. Mol. Cell. Biol. 22:6384-6392.
12. Ira, G., A. Malkova, G. Liberi, M. Foiani, and J. E. Haber. 2003. Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell 115:401-411.
13. Jia, X., T. Weinert, and D. Lydall. 2004. Mcc1 and Rad53 inhibit formation of single-stranded DNA at telomeres of Saccharomyces cerevisiae cdc13-1 mutants. Genetics 166:753-764.
14. Kaiser, C., S. Michaelis, and A. Mitchell. 1994. Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
15. Kraus, E., W. Y. Leung, and J. E. Haber. 2001. Break-induced replication: a review and an example in budding yeast. Proc. Natl. Acad. Sci. USA 98:8255-8262.
16. 1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol. Biol. Cell 12:3658-3667.
17. Le, S., J. K. Moore, J. E. Haber, and C. Greider. 1999. RAD50 and RAD51 define two different pathways that collaborate to maintain telomeres in the absence of telomerase. Genetics 152:143-152.
18. 2/M arrest DNA damage. Cell 94:399-409.
19. 2/M arrest induced by a double-strand break. Curr. Biol. 11:1053-1057.
20. Lovett, S. T. 2003. Connecting replication and recombination. Mol. Cell 11:554-556.
21. - senescence. Cell 73:347-360.
22. Malkova, A., E. L. Ivanov, and J. E. Haber. 1996. Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication. Proc. Natl. Acad. Sci. USA 93:7131-7136.
23. Malkova, A., L. Signon, C. B. Schaefer, M. Naylor, J. F. Theis, C. S. Newlon, and J. E. Haber. 2001. RAD51-independent break-induced replication to repair a broken chromosome depends on a distant enhancer site. Genes Dev. 15:1055-1060.
24. Marians, K. J. 2000. PriA-directed replication fork restart in Escherichia coli. Trends Biochem. Sci. 25:185-189.
25. Morrow, D. M., C. Connelly, and P. Hieter. 1997. "Break copy" duplication: a model for chromosome fragment formation in Saccharomyces cerevisiae. Genetics 147:371-382.
26. Nguyen, V. Q., C. Co, K. Irie, and J. J. Li. 2000. Clb/Cdc28 kinases promote nuclear export of the replication initiator proteins Mcm2-7. Curr. Biol. 10:195-205.
27. Nickoloff, J. A., D. B. Sweetser, G. J. Khalsa, and S. L. Wheeler. 1999. Multiple heterologies increase the length of double-strand break-induced allelic gene conversion tracts. Genetics 153:665-679.
28. Päques, F., and J. E. Haber. 1999. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 63:349-404.
29. Päques, F., W. Y. Leung, and J. E. Haber. 1998. Expansions and contractions in a tandem repeat induced by double-strand break repair. Mol. Cell. Biol. 18:2045-2054.
30. 2/M arrest. Mol. Cell 7:293-300.
31. Raghuraman, M. K., E. A. Winzeler, D. Collingwood, S. Hunt, L. Wodicka, A. Conway, D. J. Lockhart, R. W. Davis, B. J. Brewer, and W. L. Fangman. 2001. Replication dynamics of the yeast genome. Science 294:115-121.
32. Signon, L., A. Malkava, M. Naylor, and J. E. Haber. 2001. Genetic requirements for RAD51- and RAD54-independent break-induced replication repair of a chromosomal double-strand break. Mol. Cell. Biol. 21:2048-2056.
33. Sugawara, N., X. Wang, and J. E. Haber. 2003. In vivo roles of Rad52, Rad54, and Rad55 proteins in Rad51-mediated recombination. Mol. Cell 12:209-219.
34. Symington, L. S. 2002. Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol. Mol. Biol. Rev. 66:630-670.
35. Teng, S., J. Chang, B. McCowan, and V. A. Zakian. 2000. Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Mol. Cell 6:947-952.
36. Teng, S. C., and V. A. Zakian. 1999. Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol. Cell. Biol. 19:8083-8093.
37. Toh, G. W., and N. F. Lowndes. 2003. Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage. Biochem. Soc. Trans. 31:242-246.
38. Vaze, M., A. Pellicioli, S. Lee, G. Ira, G. Liberi, A. Arbel-Eden, M. Foiani, and J. Haber. 2002. Recovery from checkpoint-mediated arrest after repair of a double-strand break requires srs2 helicase. Mol. Cell 10:373.
39. White, C. I., and J. E. Haber. 1990. Intermediates of recombination during mating type switching in Saccharomyces cerevisiae. EMBO J. 9:663-673.