Cdm1, the smallest subunit of DNA polymerase δ in the fission yeast Schizosaccharomyces pombe, is non-essential for growth and division

Current Genetics

Volumn 34, Issue 4, 1998, Pages 250-258

  Reynolds, Nicola ^a   Watt, Alistair ^a   Fantes, Peter A ^a   MacNeill, Stuart A ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cell cycle; DNA polymerase; DNA replication; Fission yeast

Indexed keywords

DNA DIRECTED DNA POLYMERASE DELTA; FUNGAL DNA; FUNGAL PROTEIN;

ARTICLE; CELL DIVISION; CONTROLLED STUDY; ENZYME SUBUNIT; FUNGAL GENETICS; FUNGUS GROWTH; FUNGUS MUTANT; GENE ISOLATION; GENE OVEREXPRESSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SCHIZOSACCHAROMYCES POMBE; TEMPERATURE SENSITIVE MUTANT;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL COUNT; CELL CYCLE PROTEINS; CELL DIVISION; CHROMOSOMES; CLONING, MOLECULAR; DNA POLYMERASE III; FUNGAL PROTEINS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MOLECULAR SEQUENCE DATA; MUTATION; PROTO-ONCOGENE PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; SEQUENCE ANALYSIS, DNA; SUPPRESSION, GENETIC; TEMPERATURE;

EID: 0031757126     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050394     Document Type: Article

References (29)

1. Arndt G M, Atkins D, Patrikakis M, Izant J G (1995) Gene-regulation by antisense RNA in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet 248:293-300
2. Budd ME, Campbell JL (1995) A yeast gene required for DNA-replication encodes a protein with homology to DNA helicases. Proc Natl Acad Sci USA 92:7642-7646
3. Budd ME, Campbell JL (1997) A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function. Mol Cell Biol 17:2136-2142
4. Burgers PMJ (1996) Enzymology of the replication fork. In: Blow JJ (ed) Eukaryotic DNA replication. IRL Press, Oxford, UK
5. Crowe JS, Cooper HJ, Smith MA, Sims MJ, Parker D, Gewert D (1991) Improved cloning efficiency of polymerase chain-reaction (PCR) products after proteinase K digestion. Nucleic Acids Res 19:184-184
6. Eissenberg JC, Ayyagari R, Gomes XV, Burgers PMJ (1997) Mutations in yeast proliferating-cell nuclear antigen define distinct sites for interaction with DNA polymerase δ and DNA polymerase ε. Mol Cell Biol 17:6367-6378
7. Francesconi S, Park H, Wang TSF (1993) Fission yeast with DNA polymerase δ temperature-sensitive alleles exhibits a cell-division-cycle phenotype. Nucleic Acids Res 21:3821-3828
8. Giot L, Chanet R, Simon M, Facca C, Faye G (1997) Involvement of the yeast DNA polymerase δ in DNA repair in vivo. Genetics 146:1239-1251
9. + encodes a novel replication factor required for chromosome integrity. Genetics 149:1221-1233
10. + associates with the fission yeast spindle-pole body and is essential for viability. J Cell Biol 129:1033-1047
11. Hashimoto K, Nakashima N, Ohara T, Maki S, Sugino A (1998) The second subunit of DNA polymerase III (δ) is encoded by the HYS2 gene in Saccharomyces cerevisiae. Nucleic Acids Res 26:477-485
12. Hindges R, Hubscher U (1997) DNA polymerase δ, an essential enzyme for DNA transactions. Biol Chem 378:345-362
13. Kostrub CF, Knudsen K, Subramani S, Enoch T (1998) Hus1p, a conserved fission yeast checkpoint protein, interacts with Rad1p and is phosphorylated in response to DNA damage. EMBO J 17:2055-2066
14. MacNeill SA, Fantes PA (1996) Methods for analysis of the fission yeast cell cycle. In: Fantes PA, Brooks R (eds) The cell cycle - a practical approach. IRL Press, Oxford, UK
15. MacNeill SA, Fantes PA (1997) Genetic and physiological analysis of DNA replication in fission yeast. Methods Enzymol 283:440-459
16. MacNeill SA, Moreno S, Reynolds N, Nurse P, Fantes PA (1996) The fission yeast Cdc1 protein, a homolog of the small subunit of DNA polymerase δ, binds to Pol3 and Cdc27. EMBO J 15:4613-4628
17. 1-arrest phenotype. Proc Natl Acad Sci USA 85:4426-4430
18. 2+ suppression, are members of the Cdc46/Mcm2 family. Mol Biol Cell 4:1003-1015
19. Moreno S, Klar A, Nurse P (1991) Molecular genetic-analysis of fission yeast Schizosaccharomyces pombe. Methods Enzymol 194:795-823
20. Nasmyth KA (1977) Temperature-sensitive lethal mutants in the structural gene for DNA ligase in the yeast Schizosaccharomyces pombe. Cell 12:1109-1120
21. Nasmyth K, Nurse P (1981) Cell division cycle mutants altered in DNA replication and mitosis in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet 182:119-124
22. Nurse P, Thuriaux P, Nasmyth K (1976) Genetic control of the cell division cycle in the fission yeast Schizosaccharomyces pombe. Mol Gen Genet 146:167-178
23. Rothstein RJ (1983) One-step gene disruption in yeast. Methods Enzymol 101:202-211
24. Sambrook J, Fritsch EF, Maniatas T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor. New York
25. Stillman B (1994) Smart machines at the DNA replication fork. Cell 78:725-728
26. Sugino A (1995) Yeast DNA polymerases and their role at the replication fork. Trends Biochem Sci 20:319-323
27. Takahashi K, Yamada H, Yanagida M (1994) Fission yeast minichromosome loss mutants mis cause lethal aneuploidy and replication abnormality. Mol Biol Cell 5:1145-1158
28. Waseem NH, Labib K, Nurse P, Lane DP (1992) Isolation and analysis of the fission yeast gene encoding polymerase δ accessory protein PCNA. EMBO J 11:5111-5120
29. Zuo SJ, Gibbs E, Kelman Z, Wang TSF, O'Donnell M, MacNeill SA, Hurwitz J (1997) DNA polymerase δ isolated from Schizosaccharomyces pombe contains five subunits. Proc Natl Acad Sci USA 94:11244-11249