Targeted reengineering of protein geranylgeranyltransferase type i selectivity functionally implicates active-site residues in protein-substrate recognition

Biochemistry

Volumn 53, Issue 2, 2014, Pages 434-446

  Gangopadhyay, Soumyashree A ^a   Losito, Erica L ^a   Hougland, James L ^a  

^a SYRACUSE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYSTALLOGRAPHIC STRUCTURE; GERANYLGERANYLTRANSFERASE; POST-TRANSLATIONAL MODIFICATIONS; PROTEIN FARNESYLTRANSFERASE; SITE DIRECTED MUTAGENESIS; STRUCTURE-ACTIVITY STUDIES; SUBSTRATE RECOGNITION; SUBSTRATE SELECTIVITY;

AMINO ACIDS; ENZYMES; PROTEINS; RATS;

SUBSTRATES;

GERANYLGERANYLTRANSFERASE TYPE I; GERANYLTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ENGINEERING; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME SELECTIVITY; MUTATION; PRIORITY JOURNAL; PROTEIN PROCESSING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; ANIMALS; BIOCATALYSIS; CATALYTIC DOMAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDE LIBRARY; PEPTIDES; PROTEIN ENGINEERING; RATS; SUBSTRATE SPECIFICITY;

EID: 84892708883     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi4011732     Document Type: Article

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