Menadione is a metabolite of oral vitamin K

British Journal of Nutrition

Volumn 95, Issue 2, 2006, Pages 260-266

  Thijssen, Henk H W ^a   Vervoot, Lily M T ^a   Schurgers, Leon J ^b   Shearer, Martin J ^c  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

Menadione; Menaquinone 4; Metabolism; Phylloquinone; Vitamin K

Indexed keywords

MENADIONE; MENAQUINONE; MENATETRENONE; PHYTOMENADIONE; DIHYDROPHYLLOQUINONE; DRUG DERIVATIVE; FARNOQUINONE; HEMOSTATIC AGENT; VITAMIN; VITAMIN K GROUP; VITAMIN MK 7;

ANIMAL CELL; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; DRUG EXCRETION; DRUG METABOLISM; DRUG UPTAKE; DRUG URINE LEVEL; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INTESTINE ABSORPTION; MALE; NONHUMAN; NORMAL HUMAN; PRENYLATION; RAT; SINGLE DRUG DOSE; VITAMIN INTAKE; VITAMIN SUPPLEMENTATION; VOLUNTEER; CELL CULTURE; CELL LINE; DIET SUPPLEMENTATION; INTRADERMAL DRUG ADMINISTRATION; METABOLISM; ORAL DRUG ADMINISTRATION; URINE;

ANIMALIA;

ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; CELL LINE; CELLS, CULTURED; DIETARY SUPPLEMENTS; HEMOSTATICS; HUMANS; MALE; VITAMIN K; VITAMIN K 1; VITAMIN K 2; VITAMIN K 3; VITAMINS;

EID: 33644921501     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1079/BJN20051630     Document Type: Article

References (33)

1. Berkner KL & Runge KW (2005) The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis. J Thromb Haemost 2, 2118-2132.
2. Billeter M, Bollinger W & Martius C (1964) Untersuchungen über die Umwandlung von verfütterten K-vitaminen durch austauch der Seitenkette und die rolle der Darmbakterien hierbei. Biochem Z 340, 290-303.
3. 2(20) in Tierkörper. Biochem Z 333, 430-439.
4. Booth SL, Lichtenstein AH, O'Brien-Morse M, McKeown NM, Wood RJ, Saltzman E & Gundberg CM (2001) Effects of a hydrogenated form of vitamin K on bone formation and resorption. Am J Clin Nutr 74, 783-790.
5. Carrie I, Portoukalian J, Vicaretti R, Rochford J, Potvin S & Ferland G (2004) Menaquinone-4 concentration is correlated with sphingolipid concentrations in rat brain. J Nutr 134, 167-172.
6. 2) by intestinal bacteria and their role in maintaining coagulation homeostasis. Prog Food Nutr Sci 16, 307-343.
7. Davidson RT, Foley AL, Engelke JA & Suttie JW (1998) Conversion of dietary phylloquinone to tissue menaquinone-4 in rats is not dependent on gut bacteria. J Nutr 128, 220-223.
8. 1 supplementation in women of childbearing age: effects on hemostasis. Thromb Haemost 74, 1486-1490.
9. 2). J Chromatogr 384, 383-389.
10. Harrington DJ, Soper R, Edwards C, Savidge GF, Hodges SJ & Shearer MJ (2005) Determination of the urinary aglycone metabolites of vitamin K by HPLC with redox-mode electrochemical detection. J Lipid Res 46, 1053-1060.
11. 3 in plasma by high-performance liquid chromatography. J Chromatogr 666, 299-305.
12. Imada I, Watanabe M, Matsumoto N & Morimoto H (1970) Metabolism of ubiquinone-7. Biochemistry 9, 2870-2878.
13. Kohlmeier M, Salomon A, Saupe J & Shearer MJ (1996) Transport of vitamin K to bone in humans. J Nutr 126, Suppl., 1192S-1196S.
14. 1) in humans. Am J Clin Nutr 67, 1226-1231.
15. 14C]menadione. Biochemistry 6, 62-68.
16. Resh MD (2004) Membrane targeting of lipid modified signal transduction proteins. Subcell Biochem 37, 217-232.
17. Ronden JE, Drittij-Reijnders MJ, Vermeer C & Thijssen HHW (1998) Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat. Biochim Biophys Acta 1379, 69-75.
18. Roskoski R (2003) Protein prenylation: a pivotal posttranslational process. Biochem Biophys Res Commun 303, 1-7.
19. Sakamoto N, Kimura M, Hiraike H & Itokawa Y (1996) Changes of phylloquinone and menaquinone-4 concentrations in rat live rafter oral, intravenous and intraperitoneal administration. Int J Vitam Nutr Res 66, 322-328.
20. Sato T, Ozaki R, Kamo S, Hara Y, Konishi S, Isobe Y, Saitoh S & Harada H (2003) The biological activity and tissue distribution of 2′,3′-dihydrophylloquinone in rats. Biochim Biophys Acta 1622, 145-150.
21. Schurgers LJ & Vermeer C (2000) Determination of phylloquinone and menaquinones in food. Effect of food matrix on circulating vitamin K concentrations. Haemostasis 30, 298-307.
22. Schurgers LJ & Vermeer C (2002) Differential lipoprotein transport pathways of K-vitamins in healthy subjects. Biochim Biophys Acta 1570, 27-32.
23. Shearer MJ (1995) Vitamin K. Lancet 345, 229-234.
24. Shearer MJ (2000) Role of vitamin K and Gla proteins in the pathophysioloy of osteoporosis and vascular calcification. Curr Opin Clin Nutr Metab Care 3, 433-438.
25. 1) in man. Vitam Horm 32, 513-542.
26. Sundaram KS, Fan J-H, Engelke JA, Foley AL, Suttie JW & Lev M (1996) Vitamin K status influences brain sulfatide metabolism in young mice and rats. J Nutr 126, 2746-2751.
27. Taggart WV & Matschiner JT (1969) Metabolism of menadione-6,7-3H in the rat. Biochemistry 8, 1141-1146.
28. Thijssen HHW & Drittij-Reijnders MJ (1994) Vitamin K distribution in rat tissues: dietary phylloquinone is a source of tissue menaquinone-4. Br J Nutr 72, 415-425.
29. Thijssen HHW & Drittij-Reijnders MJ (1996) Vitamin K status in human tissues: tissue-specific accumulation of phylloquinone and menaquinone-4. Br J Nutr 75, 121-127.
30. Thijssen HHW, Drittij-Reijnders MJ & Fischer MAJG (1996) Phylloquinone and menaquinone-4 distribution in rats: synthesis rather than uptake determines menaquinone-4 organ concentrations. J Nutr 126, 537-543.
31. Thijssen HHW, Drittij MJ, Vermeer C & Schoffelen E (2002) Menaquinone-4 in breast milk is derived from dietary phylloquinone. Br J Nutr 87, 219-226.
32. Thomas DD, Krzykowski KJ, Engelke JA & Groblewski GE (2004) Exocrine pancreatic secretion of phospholipid, menaquinone-4, and caveolin-1 in vivo. Biochem Biophys Res Commun 319, 974-979.
33. Usui Y, Nishimura N, Kobayashi N, Okanone T, Kimoto M & Ozawa K (1989) Measurement of vitamin K in human liver by gradient elution high-performance liquid chromatography using platinum-black catalyst reduction and fluorometric detection. J Chromatogr 489, 291-301.