Measurement of the levels of leptin, BDNF associated with polymorphisms LEP G2548A, LEPR Gln223Arg and BDNF Val66Met in Thai with metabolic syndrome

Diabetology and Metabolic Syndrome

Volumn 6, Issue 1, 2014, Pages

  Suriyaprom, Kanjana ^a   Tungtrongchitr, Rungsunn ^b   Thawnasom, Kittisak ^a  

^a RANGSIT UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

Author keywords

BDNF; Gene polymorphisms; Leptin; Metabolic syndrome

Indexed keywords

EID: 84892595209     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-6-6     Document Type: Article

References (41)

1. Hypoadiponectinemia: a link between visceral obesity and metabolic syndrome. Di Chiara T, Argano C, Corrao S, Scaglione R, Licata G, J Nutr Metab 2012 2012 175245 22013516
2. Leptin and the skin: a new frontier. Poeggeler B, Schulz C, Pappolla MA, Bodó E, Tiede S, Lehnert H, Paus R, Exp Dermatol 2010 19 12 18 10.1111/j.1600-0625.2009.00930.x 19601981
3. Relationship between leptin and body mass and metabolic syndrome in an adult population. Martins M do C, Lima Faleiro L, Fonseca A, Rev Port Cardiol 2012 31 711 719 23040870
4. p.Q223R leptin receptor polymorphism associated with obesity in Brazilian multiethnic subjects. Duarte SFP, Francischetti EA, Genelhu-Abreu V, Barroso SG, Braga JU, Cabello PH, Pimentel MM, Am J Hum Biol 2006 18 448 453 10.1002/ajhb.20519 16788891 (Pubitemid 44083523)
5. Association of leptin receptor polymorphism with insulin resistance. Chiu KC, Chu A, Chuang L-M, Saad MF, Eur J Endocrinol 2004 150 725 729 10.1530/eje.0.1500725 15132731 (Pubitemid 38786545)
6. Genetic variations in the leptin and leptin receptor genes are associated with type 2 diabetes mellitus and metabolic traits in the Korean female population. Han HR, Ryu HJ, Cha HS, Go MJ, Ahn Y, Koo BK, Cho YM, Lee HK, Cho NH, Shin C, Shin HD, Kimm K, Kim HL, Oh B, Park KS, Clin Genet 2008 74 105 115 10.1111/j.1399-0004.2008.01033.x 18564365 (Pubitemid 351974272)
7. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Hoffstedt J, Eriksson P, Mottagui-Tabar S, Arner P, Horm Metab Res 2002 34 355 359 10.1055/s-2002-33466 12189581
8. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D, Mantzoros CS, J Clin Endocrinol Metab 2001 86 4434 4439 11549688 (Pubitemid 32848571)
9. Association between the Gln223Arg polymorphism of the leptin receptor and metabolic syndrome in free-living community elderly. Gottlieb MG, Bodanese LC, Leite LE, Schwanke CH, Piccoli Jda C, da Rocha MI, da Cruz IB, Metab Syndr Relat Disord 2009 7 341 348 10.1089/met.2008.0029 19344216
10. Relationship between leptin G2548A and leptin receptor Q223R gene polymorphisms and obesity and metabolic syndrome risk in Tunisian volunteers. Boumaiza I, Omezzine A, Rejeb J, Rebhi L, Ouedrani A, Ben Rejeb N, Nabli N, Ben Abdelaziz A, Bouslama A, Genet Test Mol Biomarkers 2012 16 726 733 10.1089/gtmb.2011.0324 22734460
11. Leptin receptor gene Gln223Arg polymorphism is not associated with obesity and metabolic syndrome in Turkish children. Komşu-Ornek Z, Demirel F, Dursun A, Ermiş B, Pişkin E, Bideci A, Turk J Pediatr 2012 54 20 24 22397037
12. Physiology of BDNF: focus on hypothalamic function. Tapia-Arancibia L, Rage F, Givalois L, Arancibia S, Front Neuroendocrinol 2004 25 77 107 10.1016/j.yfrne.2004.04.001 15571756 (Pubitemid 39582717)
13. Brain-derived neurotrophic factor, food intake regulation, and obesity. Rosas-Vargas H, Martínez-Ezquerro JD, Bienvenu T, Arch Med Res 2011 42 482 494 10.1016/j.arcmed.2011.09.005 21945389
14. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, Fischer CP, Lindegaard B, Petersen AM, Taudorf S, Secher NH, Pilegaard H, Bruunsgaard H, Pedersen BK, Diabetologia 2007 50 431 438 10.1007/s00125-006-0537-4 17151862
15. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. Chen Z-Y, Patel PD, Sant G, Meng C-X, Teng KK, Hempstead BL, Lee FS, J Neurosci 2004 24 4401 4411 10.1523/JNEUROSCI.0348-04.2004 15128854 (Pubitemid 38608151)
16. Brain-derived neurotrophic factor not associated with metabolic syndrome but inversely correlated with vascular cell adhesion molecule-1 in men without diabetes. Lee IT, Lee WJ, Tsai IC, Liang KW, Lin SY, Wan CJ, Fu CP, Sheu WH, Clin Chim Acta 2012 413 944 948 10.1016/j.cca.2012.02.013 22374129
17. NGF, BDNF, leptin, and mast cells in human coronary atherosclerosis and metabolic syndrome. Chaldakov GN, Fiore M, Stankulov IS, Hristova M, Antonelli A, Manni L, Ghenev PI, Angelucci F, Aloe L, Arch Physiol Biochem 2001 09 357 360 (Pubitemid 35216883)
18. Comprehensive assessment of metabolic syndrome among rural Bangladeshi women. Jesmin S, Islam MR, Islam AM, Mia MS, Sultana SN, Zaedi S, Yamaguchi N, Iwashima Y, Hiroe M, Watanabe T, BMC Public Health 2012 12 49 10.1186/1471-2458-12-49 22257743
19. The triceps skinfold as a predictive measure of body density and body fat in obese adolescent girls. Seltzer CC, Goldman RF, Mayer J, Pediatrics 1965 36 212 218 14320030
20. Using middle upper arm circumference to assess severe adult malnutrition during famine. Collins S, JAMA 1996 276 391 395 10.1001/jama.1996.03540050051023 8683818 (Pubitemid 26257302)
21. Association study of brain-derived neurotrophic factor gene polymorphism and alcoholism. Matsushita S, Kimura M, Miyakawa T, Yoshino A, Murayama M, Masaki T, Higuchi S, Alcohol Clin Exp Res 2004 28 1609 1612 10.1097/01.ALC. 0000145697.81741.D2 15547445 (Pubitemid 39551819)
22. Human leptin: from an adipocyte hormone to an endocrine mediator. Wauters M, Considine RV, Van Gaal LF, Eur J Endocrinol 2000 143 293 311 10.1530/eje.0.1430293 11022169
23. Serum leptin is associated with metabolic syndrome in obese and nonobese Korean populations. Yun JE, Kimm H, Jo J, Jee SH, Metabolism 2010 59 424 429 10.1016/j.metabol.2009.08.012 19846168
24. Serum adiponectin and leptin levels in relation to the metabolic syndrome, androgenic profile and somatotropic axis in healthy non-diabetic elderly men. Gannagé-Yared M-H, Khalife S, Semaan M, Fares F, Jambart S, Halaby G, Eur J Endocrinol 2006 155 167 176 10.1530/eje.1.02175 16793964 (Pubitemid 44103386)
25. Adipose tissue dysfunction in nascent metabolic syndrome. Bremer AA, Jialal I, J Obes 2013 2013 393192 23653857
26. Peripheral and hypothalamic leptin resistance with age-related obesity. Scarpace PJ, Tümer N, Physiol Behav 2001 74 721 727 10.1016/S0031-9384(01) 00616-3 11790435 (Pubitemid 34076620)
27. Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: the finnish diabetes prevention study. Salopuro T, Pulkkinen L, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Tuomilehto J, Laakso M, Uusitupa M, Int J Obes 2005 29 1245 1251 10.1038/sj.ijo.0803024 (Pubitemid 43080304)
28. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Van Rossum CTM, Hoebee B, van Baak MA, Mars M, Saris WHM, Seidell JC, Obes Res 2003 11 377 386 10.1038/oby.2003.51 12634434 (Pubitemid 41151625)
29. Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects. Constantin A, Costache G, Sima AV, Glavce CS, Vladica M, Popov DL, Biochem Biophys Res Commun 2010 391 282 286 10.1016/j.bbrc.2009.11.050 19913498
30. Lack of association between the leptin receptor gene (LEPR) Gln223Arg polymorphism and late-onset Alzheimer disease. Utsunomiya K, Shinkai T, Sakata S, Hwang R, Yamada K, Chen HI, Fukunaka Y, Ohmori O, Nakamura J, Alzheimer Dis Assoc Disor 2010 24 101 103 10.1097/WAD.0b013e3181b982dc
31. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF, J Clin Endocrinol Metab 1999 84 670 676 10022436 (Pubitemid 29075704)
32. Urbanization, lifestyle changes and the nutrition transition. Popkin BM, World Dev 1999 27 1905 1916 10.1016/S0305-750X(99)00094-7
33. Prevalence of metabolic syndrome in Nakhon Sawan population. Santibhavank P, J Med Assoc Thai 2007 90 1109 1115 17624204 (Pubitemid 47013733)
34. Association between the leptin gene 2548G/A polymorphism, the plasma leptin and the metabolic syndrome with psoriasis. Abdel Hay RM, Rashed LA, Exp Dermatol 2011 20 715 719 10.1111/j.1600-0625.2011.01299.x 21569107
35. The serum leptin level and body mass index in Melanesian and Micronesian Solomon Islanders: focus on genetic factors and urbanization. Furusawa T, Naka I, Yamauchi T, Natsuhara K, Kimura R, Nakazawa M, Ishida T, Nishida N, Eddie R, Ohtsuka R, Ohashi J, Am J Hum Biol 2011 23 435 444 10.1002/ajhb.21124 21648011
36. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Xu B, Goulding EH, Zang K, Cepoi D, Cone RD, Jones KR, Tecott LH, Reichardt LF, Nat Neurosci 2003 6 736 742 10.1038/nn1073 12796784 (Pubitemid 36792889)
37. Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus. Komori T, Morikawa Y, Nanjo K, Senba E, Neuroscience 2006 139 1107 1115 10.1016/j.neuroscience.2005.12.066 16564638
38. Plasma brain-derived neurotrophic factor in prepubertal obese children: results from a 2-year lifestyle intervention programme. Corripio R, Gónzalez-Clemente JM, Jacobo PS, Silvia N, Lluis G, Joan V, Assumpta C, Clin Endocrinol (Oxf) 2012 77 715 720 10.1111/j.1365-2265.2012.04431.x 22563866
39. Plasma brain-derived neurotrophic factor in prepubertal obese children: results from a 2-year lifestyle intervention programme. Golden E, Emiliano A, Maudsley S, Windham BG, Carlson OD, Egan JM, Driscoll I, Ferrucci L, Martin B, Mattson MP, PLoS One 2010 5 10099 10.1371/journal.pone.0010099 20404913
40. Association of the BDNF Val66Met variation with obesity in women. Beckers S, Peeters A, Zegers D, Mertens I, Van Gaal L, Van Hul W, Mol Genet Metab 2008 95 110 112 10.1016/j.ymgme.2008.06.008 18667348
41. Polymorphisms of genes for brain-derived neurotrophic factor, methylenetetrahydrofolate reductase, tyrosine hydroxylase, and endothelial nitric oxide synthase in depression and metabolic syndrome. Zeman M, Jáchymová M, Jirák R, Vecka M, Tvrzická E, Stanková B, Zák A, Folia Biol (Praha) 2010 56 19 26 20163778