Leptin G-2548A and leptin receptor Q223R gene polymorphisms are not associated with obesity in Romanian subjects

Biochemical and Biophysical Research Communications

Volumn 391, Issue 1, 2010, Pages 282-286

  Constantin, Alina ^a   Costache, Gabriela ^a   Sima, Anca V ^a   Glavce, Cristiana S ^b   Vladica, Maria ^c   Popov, Doina L ^a  

^a INSTITUTE OF CELLULAR BIOLOGY AND PATHOLOGY NICOLAE SIMIONESCU   (Romania)

^b Francisc I Rainer Institute of Anthropology   (Romania)

^c Institute of Diabetes   (Romania)

Author keywords

Leptin; Leptin receptor; Obesity; Polymorphism

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LEPTIN; LEPTIN RECEPTOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY MASS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE TRAIT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; ROMANIA; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; URBAN POPULATION;

ADULT; ARGININE; BODY MASS INDEX; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GLUTAMINE; HUMANS; LEPTIN; MALE; MIDDLE AGED; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LEPTIN; ROMANIA;

EID: 72949119318     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.11.050     Document Type: Article

References (36)

1. Cummings D.E., and Schwartz M.W. Genetics and pathophysiology of human obesity. Annu. Rev. Med. 54 (2003) 453-471
2. Walley A.J., Blakemore A.I., and Froguel P. Genetics of obesity and the prediction of risk for health. Hum. Mol. Genet. 15 (2006) R124-R130
3. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homologue. Nature 372 (1994) 425-432
4. Halaas J.L., Gajiwala K.S., Maffei M., Cohen S.L., Chait B.T., Rabinowitz D., Lallone R.L., Burley S.K., and Friedman J.M. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269 (1995) 543-546
5. Paracchini V., Pedotti P., and Taioli E. Genetics of leptin and obesity: a HuGE review. Am. J. Epidemiol. 162 (2005) 101-114
6. Tartaglia L.A. The leptin receptor. J. Biol. Chem. 272 (1997) 6093-6096
7. Isse N., Ogawa Y., Tamura N., Masuzaki H., Mori K., Okazaki T., Satoh N., Shigemoto M., Yoshimasa Y., Nishi S., Hosoda K., Inazawa J., and Nakao K. Structural organization and chromosomal assignment of the human obese gene. J. Biol. Chem. 270 (1995) 27728-27733
8. Fruchbeck G. Intracellular signalling pathways activated by leptin. Biochem. J. 393 (2006) 7-20
9. Mantzoros C.S. The role of leptin in human obesity and disease: a review of current evidence. Annu. Intern. Med. 130 (1999) 671-680
10. Hattori A., Uemura K., Miura H., Ueda M., Tamaya N., Iwata F., Muraguchi M., Ohmoto Y., and Iguchi A. Gender-related difference in relationship between insulin resistance and serum leptin level in Japanese type 2 diabetic and non-diabetic subjects. Endocr. J. 47 (2000) 615-621
11. Roden M., Ludwig C., Nowotny P., Schneider B., Clodi M., Vierhapper H., Roden A., and Waldhäusl W. Relative hypoleptinemia in patients with type 1 and type 2 diabetes mellitus. Int. J. Obes. Relat. Metab. Disord. 24 (2000) 976-981
12. Otero M., Lago R., Lago F., Casanueva F.F., Dieguez C., Gomez-Reino J.J., and Gualillo O. Leptin, from fat to inflammation: old questions and new insights. FEBS Lett. 579 (2005) 295-301
13. Mammès O., Betoulle D., Aubert R., Giraud V., Tuzet S., Petiet A., Colas-Linhart N., and Fumeron F. Novel polymorphisms in the 5′ region of the LEP gene: association with leptin levels and response to low-calorie diet in human obesity. Diabetes 47 (1998) 487-489
14. Le Stunff C., Le Bihan C., Schrk N.J., and Bougneres P. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes 49 (2000) 2196-2200
15. Hoffstedt J., Eriksson P., Mottagui-Tabar S., and Arner P. A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm. Metab. Res. 34 (2002) 355-359
16. Yiannakouris N., Yannakoulia M., Relistas L., Chan J.L., Klimis-Zacas D., and Mantzoros C.S. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J. Clin. Endocrinol. Metab. 86 (2001) 4434-4439
17. Gotoda T., Manning B.S., Goldstone A.P., Imrie H., Evans A.L., Strosberg A.D., McKeigue P.M., Scott J., and Aitman T.J. Leptin receptor gene variation and obesity: lack of association in a white British male population. Hum. Mol. Genet. 6 (1997) 869-876
18. Ren W., Zhang S.H., Wu J., and Ni Y.X. Polymorphism of the leptin gene promoter in pedigrees of type 2 diabetes mellitus in Chongqing, China. Chin. Med. J. 117 (2004) 558-561
19. Salopuro T., Pulkkinen L., Lindström J., Eriksson J.G., Valle T.T., Hämäläinen H., Ilanne-Parikka P., Keinänen-Kiukaanniemi S., Tuomilehto J., Laakso M., Uusitupa M., and Finnish Diabetes Prevention Study Group. Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: the Finnish Diabetes Prevention Study. Int. J. Obes. 29 (2005) 1245-1251
20. Chiu K.C., Chu A., Chuang L.M., and Saad M.F. Association of leptin receptor polymorphism with insulin resistance. Eur. J. Endocrinol. 150 (2004) 725-729
21. Alberti K.G., and Zimmet P.Z. Definition, diagnosis, and classification of diabetes mellitus and its complications: Part 1. Diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet. Med. 15 (1998) 539-553
22. Nieters A., Becker N., and Linseisen J. Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort. Eur. J. Clin. Nutr. 41 (2002) 210-221
23. Chagnon Y.C., Wilmore J.H., Borecki I.B., Gagnon J., Pérusse L., Chagnon M., Collier G.R., Leon A.S., Skinner J.S., Rao D.C., and Bouchard C. Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J. Clin. Endocrinol. Metab. 85 (2000) 29-34
24. Mammes O., Betoulle D., Aubert R., Herbeth B., Siest G., and Fumeron F. Association of the G-2548A polymorphism in the 5′ region of the LEP gene with overweight. Ann. Hum. Genet. 64 (2000) 391-394
25. Wang T.N., Huang M.C., Chang W.T., Ko A.M., Tsai E.M., Liu C.S., Lee C.H., and Ko Y.C. G-2548A polymorphism of the leptin gene is correlated with extreme obesity in Taiwanese aborigines. Obesity 14 (2006) 183-187
26. Mattevi V.S., Zembrzuski V.M., and Hutz M.H. Association analysis of genes involved in the leptin-signaling pathway with obesity in Brazil. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 1179-1185
27. Portoles O., Sorli J.V., Frances F., Coltell O., Gonzalez J.I., Saiz C., and Corella D. Effect of genetic variation in the leptin gene promoter and the leptin receptor gene on obesity risk in a population-based case-control study in Spain. Eur. J. Epidemiol. 21 (2006) 605-612
28. Hinuy H.M., Hirata M.H., Forti N., Diament J., Sampaio M.F., Armaganijan D., Salazar L.A., and Hirata R.D. Leptin G-2548A promoter polymorphism is associated with increased plasma leptin and BMI in Brazilian women. Arq. Bras. Endocrinol. Metabol. 52 (2008) 611-616
29. Ben Ali S., Kallel A., Ftouhi B., Sediri Y., Feki M., Slimane H., Jemaa R., and Kaabachi N. Association of G-2548A LEP polymorphism with plasma leptin levels in Tunisian obese patients. Clin. Biochem. 42 (2009) 584-588
30. Yiannakouris N., Relistas L., Yannakoulia M., Mungal K., and Mantzoros C.S. The-2548G/A polymorphism in the human leptin gene promoter region is associated with plasma free leptin levels: interaction with adiposity and gender in healthy subjects. Hormones (Athens) 2 (2003) 229-236
31. Heo M., Leibel R.L., Fontaine K.R., Boyer B.B., Chung W.K., Koulu M., et al. A meta-analytic investigation of linkage and association of common leptin receptor (LEPR) polymorphisms with body mass index and waist circumference. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 640-646
32. Stefan N., Vozarova B., Del Parigi A., Ossowski V., Thompson D.B., and Hanson R.L. The Gln223Arg polymorphism of the leptin receptor in Pima Indians: influence on energy expenditure, physical activity and lipid metabolism. Int. J. Obes. Relat. Metab. Disord. 26 (2002) 1629-1632
33. Wauters M., Mertens I., Rankinen T., Chagnon M., Bouchard C., and Van Gaal L. Leptin receptor gene polymorphisms are associated with insulin in obese women with impaired glucose tolerance. J. Clin. Endocrinol. Metab. 86 (2001) 3227-3232
34. Van Rossum C.T., Hoebee B., Van Baak M.A., Mars M., Saris W.H., and Seidell J.C. Genetic variation in the leptin receptor gene, leptin, and weight gain in young Dutch adults. Obes. Res. 11 (2003) 377-386
35. Rosmond R., Chagnon Y.C., Holm G., Chagnon M., Perusse L., Lindell K., et al. Hypertension in obesity and the leptin receptor gene locus. J. Clin. Endocrinol. Metab. 85 (2000) 3126-3131
36. Takahashi-Yasuno A., Masuzaki H., Miyawaki T., Ogawa Y., Matsuoka N., Hayashi T., et al. Leptin receptor polymorphism is associated with serum lipid levels and impairment of cholesterol lowering effect by simvastatin in Japanese men. Diabetes Res. Clin. Pract. 62 (2003) 169-175