Association of the BDNF Val66Met variation with obesity in women

Molecular Genetics and Metabolism

Volumn 95, Issue 1-2, 2008, Pages 110-112

  Beckers, Sigri ^a   Peeters, Armand ^a   Zegers, Doreen ^a   Mertens, Ilse ^b   Gaal, Luc Van ^b   Van Hul, Wim ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Association; Brain derived neurotrophic factor; Obesity; Polymorphism; Women

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; METHIONINE; VALINE;

ADULT; ALLELE; ARTICLE; CONTROL GROUP; CONTROLLED STUDY; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; OBESITY; PRIORITY JOURNAL;

ADOLESCENT; ADULT; BELGIUM; BRAIN-DERIVED NEUROTROPHIC FACTOR; CASE-CONTROL STUDIES; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MIDDLE AGED; MUTATION, MISSENSE; OBESITY; POLYMORPHISM, GENETIC; VARIATION (GENETICS);

EID: 51849117596     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2008.06.008     Document Type: Article

References (18)

1. Kernie S.G., Liebl D.J., and Parada L.F. BDNF regulates eating behavior and locomotor activity in mice. EMBO J. 19 (2000) 1290-1300
2. Rios M., Fan G., Fekete C., Kelly J., Bates B., Kuehn R., Lechan R.M., and Jaenisch R. Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity. Mol. Endocrinol. 15 (2001) 1748-1757
3. Lyons W.E., Mamounas L.A., Ricaurte G.A., Coppola V., Reid S.W., Bora S.H., Wihler C., Koliatsos V.E., and Tessarollo L. Brain-derived neurotrophic factor-deficient mice develop aggressiveness and hyperphagia in conjunction with brain serotonergic abnormalities. Proc. Natl. Acad. Sci. USA 96 (1999) 15239-15244
4. Friedel S., Horro F.F., Wermter A.K., Geller F., Dempfle A., Reichwald K., Smidt J., Bronner G., Konrad K., Herpertz-Dahlmann B., Warnke A., Hemminger U., Linder M., Kiefl H., Goldschmidt H.P., Siegfried W., Remschmidt H., Hinney A., and Hebebrand J. Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity eating disorders and attention-deficit/hyperactivity disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 132 (2005) 96-99
5. Gray J., Yeo G.S., Cox J.J., Morton J., Adlam A.L., Keogh J.M., Yanovski J.A., El Gharbawy A., Han J.C., Tung Y.C., Hodges J.R., Raymond F.L., O'Rahilly S., and Farooqi I.S. Hyperphagia severe obesity impaired cognitive function and hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 55 (2006) 3366-3371
6. Gray J., Yeo G., Hung C., Keogh J., Clayton P., Banerjee K., McAulay A., O'Rahilly S., and Farooqi I.S. Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity. Int. J. Obes. (Lond) 31 (2007) 359-364
7. Yeo G.S., Connie Hung C.C., Rochford J., Keogh J., Gray J., Sivaramakrishnan S., O'Rahilly S., and Farooqi I.S. A de novo mutation affecting human TrkB associated with severe obesity and developmental delay. Nat. Neurosci. 7 (2004) 1187-1189
8. Ribases M., Gratacos M., Armengol L., de Cid R., Badia A., Jimenez L., Solano R., Vallejo J., Fernandez F., and Estivill X. Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol. Psychiatry 8 (2003) 745-751
9. Ribases M., Gratacos M., Fernandez-Aranda F., Bellodi L., Boni C., Anderluh M., Cavallini M.C., Cellini E., Di Bella D., Erzegovesi S., Foulon C., Gabrovsek M., Gorwood P., Hebebrand J., Hinney A., Holliday J., Hu X., Karwautz A., Kipman A., Komel R., Nacmias B., Remschmidt H., Ricca V., Sorbi S., Wagner G., Treasure J., Collier D.A., and Estivill X. Association of BDNF with anorexia bulimia and age of onset of weight loss in six European populations. Hum. Mol. Genet. 13 (2004) 1205-1212
10. Ribases M., Gratacos M., Fernandez-Aranda F., Bellodi L., Boni C., Anderluh M., Cristina Cavallini M., Cellini E., Di Bella D., Erzegovesi S., Foulon C., Gabrovsek M., Gorwood P., Hebebrand J., Hinney A., Holliday J., Hu X., Karwautz A., Kipman A., Komel R., Nacmias B., Remschmidt H., Ricca V., Sorbi S., Tomori M., Wagner G., Treasure J., Collier D.A., and Estivill X. Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Eur. J. Hum. Genet. 13 (2005) 428-434
11. Beckers S., Mertens I., Peeters A., Van Gaal L., and Van Hul W. Screening for melanocortin-4 receptor mutations in a cohort of Belgian morbidly obese adults and children. Int. J. Obes. (Lond) 30 (2006) 221-225
12. Peeters A., Beckers S., Verrijken A., Roevens P., Peeters P., Van Gaal L., and Van Hul W. Variants in the FTO gene are associated with common obesity in the Belgian population. Mol. Genet. Metab. 93 (2008) 481-484
13. Xu B., Goulding E.H., Zang K., Cepoi D., Cone R.D., Jones K.R., Tecott L.H., and Reichardt L.F. Brain-derived neurotrophic factor regulates energy balance downstream of melanocortin-4 receptor. Nat. Neurosci. 6 (2003) 736-742
14. International HapMap Project. www.hapmap.org Accessed on 12 June 2008.
15. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., Zaitsev E., Gold B., Goldman D., Dean M., Lu B., and Weinberger D.R. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112 (2003) 257-269
16. Chen Z.Y., Patel P.D., Sant G., Meng C.X., Teng K.K., Hempstead B.L., and Lee F.S. Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J. Neurosci. 24 (2004) 4401-4411
17. Oroszi G., Lapteva L., Davis E., Yarboro C.H., Weickert T., Roebuck-Spencer T., Bleiberg J., Rosenstein D., Pao M., Lipsky P.E., Goldman D., Lipsky R.H., and Illei G.G. The Met66 allele of the functional Val66Met polymorphism in the brain-derived neurotrophic factor gene confers protection against neurocognitive dysfunction in systemic lupus erythematosus. Ann. Rheum. Dis. 65 (2006) 1330-1335
18. Lee R., Kermani P., Teng K.K., and Hempstead B.L. Regulation of cell survival by secreted proneurotrophins. Science 294 (2001) 1945-1948