Lack of association between the leptin receptor gene (LEPR) Gln223Arg polymorphism and late-onset alzheimer disease

Alzheimer Disease and Associated Disorders

Volumn 24, Issue 1, 2010, Pages 101-103

  Utsunomiya, Kensuke ^a,b   Shinkai, Takahiro ^a   Sakata, Shinichi ^a   Hwang, Rudi ^c   Yamada, Kenji ^a   Chen, Hsin I ^a,d   Fukunaka, Yuko ^a   Ohmori, Osamu ^e   Nakamura, Jun ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^b MITSUBISHI HEAVY INDUSTRIES LTD   (Japan)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^e Wakato Hospital   (United States)

Author keywords

Genetic association; Late onset Alzheimer disease; Leptin receptor; Polymorphism

Indexed keywords

LEPTIN RECEPTOR;

AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; JAPANESE; MALE; PRIORITY JOURNAL;

AGE OF ONSET; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, LEPTIN;

EID: 77949442622     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/WAD.0b013e3181b982dc     Document Type: Article

References (18)

1. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002;297:353-356.
2. Frö lich L, Blum-Degen D, Bernstein HG, et al. Brain insulin and insulin receptors in aging and sporadic Alzheimer's disease. J Neural Transm. 1998;105:423-438.
3. Ott A, Stolk RP, van Harskamp F, et al. Diabetes mellitus and the risk of dementia: the Rotterdam study. Neurology. 1999;53: 1937-1942.
4. Biessels GJ, Staekenborg S, Brunner E, et al. Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 2006;5: 64-74.
5. Golden PL, Maccagnan TJ, Pardridge WM. Human bloodbrain barrier leptin receptor- binding and endocytosis in isolated human brain microvessels. J Clin Invest. 1997;99: 14-18.
6. Chiu KC, Chu A, Chuang LM, et al. Association of leptin receptor polymorphism with insulin resistance. Euro J Endocrinol. 2004;150:725-729.
7. Salopuro T, Pulkkinen L, Lindström J, et al. Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: The Finnish Diabetes Prevention Study. Int J Obes (Lond). 2005;29:1245-1251.
8. Quinton ND, Lee AJ, Ross RJ, et al. A single nucleotide polymorphism (SNP) in the leptin receptor is associated with BMI, fat mass and leptin levels in postmenopausal Caucasian women. Hum Genet. 2001;108:233-236.
9. McKhann G, Drachman D, Folstein M, et al. Clinical diagnosis of Alzheimer's disease: report of the NINCDSADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology. 1984;34:939-944.
10. Folstein MF, Folstein SE, McHigh PR. "Mini-Mental State": a practical method of grading the cognitive function of patients for the clinician. J Psychiatr Res. 1978;12;189-12;198.
11. Ciulla TA, Sklar RM, Hauser SL. A simple method for DNA purification from peripheral blood. Anal Biochem. 1988;174: 485-488.
12. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695-699.
13. Takahashi-Yasuno A, Masuzaki H, Miyawaki T, et al. Association of Ob-R gene polymorphism and insulin resistance in Japanese men. Metabolism. 2004;53:650-654.
14. Dicou E, Attoub S, Gressens P. Neuroprotective effects of leptin in vivo and in vitro. NeuroReport. 2001;12:3947-3951.
15. Lu JN, Park CS, Lee SK, et al. Leptin inhibits 1-methyl-4- phenylpyridinium-induced cell death in SH-SY5Y cells. Neurosci Lett. 2006;407:240-243.
16. Ghilardi N, Skoda RC. The leptin receptor activates Janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol. 1997;11:393-399.
17. Fewlass DC, Noboa K, Pi-Sunyer FX, et al. Obesity-related leptin regulates Alzheimer's Abeta. FASEB J. 2004;18: 1870-1878.
18. Farr SA, Banks WA, Morley JE. Effects of leptin on memory processing. Peptides. 2006;27:1420-1425.