Targeted adenovirus mediated inhibition of NF-κB-dependent inflammatory gene expression in endothelial cells in vitro and in vivo

Journal of Controlled Release

Volumn 166, Issue 1, 2013, Pages 57-65

  Kuldo J M ^a   Asgeirsdottir S A ^a   Zwiers, P J ^a   Bellu, A R ^b   Rots, M G ^a,b   Schalk, J A C ^c   Ogawara, K I ^d   Trautwein, C ^e   Banas, B ^f   Haisma, H J ^b   Molema, G ^a   Kamps, J A A M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

^c NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^d OKAYAMA UNIVERSITY   (Japan)

^e UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^f UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Adenoviral gene therapy; E selectin targeting; Endothelium; Inflammation; NF B inhibition

Indexed keywords

ADENOVIRAL GENE THERAPY; ADHESION MOLECULES; CHEMOKINES; CHRONIC INFLAMMATORY DISEASE; CYTOKINES; DESIGN AND OPTIMIZATION; DOWN-REGULATION; E-SELECTIN TARGETING; ENDOTHELIUM; IN-VITRO; IN-VIVO; INFLAMMATION; INFLAMMATORY DISEASE; INFLAMMATORY GENES; MICROVASCULAR; NUCLEAR FACTORS; PHARMACOLOGICAL EFFECTS; PROINFLAMMATORY; TARGETED DELIVERY; THERAPEUTIC TRANSGENE; TRANSGENE; TRANSGENE EXPRESSION;

ADHESION; DISEASES; ENDOTHELIAL CELLS; GENE THERAPY; MOLECULES; PATHOLOGY; POLYETHYLENE GLYCOLS; SIGNAL TRANSDUCTION; VIRUSES;

GENE EXPRESSION;

CELL ADHESION MOLECULE; CHEMOKINE; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MACROGOL; VASCULAR CELL ADHESION MOLECULE 1;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENE THERAPY; GLOMERULONEPHRITIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ADENOVIRIDAE; ANIMALS; BINDING, COMPETITIVE; CELL CULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; E-SELECTIN; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION; GLOMERULONEPHRITIS; HEK293 CELLS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; I-KAPPA B PROTEINS; MICE; MICE, INBRED C57BL; NF-KAPPA B; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSGENES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84872152705     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.12.016     Document Type: Article

References (38)

1. J.M. Kuldo, K.I. Ogawara, N. Werner, S.A. Asgeirsdottir, J.A. Kamps, R.J. Kok, and G. Molema Molecular pathways of endothelial cell activation for (targeted) pharmacological intervention of chronic inflammatory diseases Curr. Vasc. Pharmacol. 3 1 Jan. 2005 11 39
2. M. Ashizawa, M. Miyazaki, K. Abe, A. Furusu, H. Isomoto, and T. Harada Detection of nuclear factor-kappaB in IgA nephropathy using southwestern histochemistry Am. J. Kidney Dis. 42 1 Jul. 2003 76 86
3. S. Mezzano, C. Aros, A. Droguett, M.E. Burgos, L. Ardiles, and C. Flores NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy Nephrol. Dial. Transplant. 19 10 Oct. 2004 2505 2512
4. C. Stambe, R.C. Atkins, P.A. Hill, and D.J. Nikolic-Paterson Activation and cellular localization of the p38 and JNK MAPK pathways in rat crescentic glomerulonephritis Kidney Int. 64 6 Dec. 2003 2121 2132
5. J.H. Kim, I.S. Ha, C.I. Hwang, Y.J. Lee, J. Kim, and S.H. Yang Gene expression profiling of anti-GBM glomerulonephritis model: the role of NF-kappaB in immune complex kidney disease Kidney Int. 66 5 Nov. 2004 1826 1837
6. C. Ponticelli, P. Passerini, M. Salvadori, C. Manno, B.F. Viola, and S. Pasquali A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy Am. J. Kidney Dis. 47 2 Feb. 2006 233 240
7. C. Grootscholten, G. Ligtenberg, E.C. Hagen, A.W. van den Wall Bake, J.W. de Glas-Vos, and M. Bijl Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial Kidney Int. 70 4 Aug. 2006 732 742
8. S. Kumar, J. Boehm, and J.C. Lee p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases Nat. Rev. Drug Discov. 2 9 Sep. 2003 717 726
9. E.A. van der Wouden, M. Sandovici, R.H. Henning, D. de Zeeuw, and L.E. Deelman Approaches and methods in gene therapy for kidney disease J. Pharmacol. Toxicol. Methods 50 1 Jul.-Aug. 2004 13 24
10. S.A. Asgeirsdottir, R.J. Kok, M. Everts, D.K. Meijer, and G. Molema Delivery of pharmacologically active dexamethasone into activated endothelial cells by dexamethasone-anti-E-selectin immunoconjugate Biochem. Pharmacol. 65 10 May 15 2003 1729 1739
11. M. Everts, R.J. Kok, S.A. Asgeirsdottir, B.N. Melgert, T.J. Moolenaar, and G.A. Koning Selective intracellular delivery of dexamethasone into activated endothelial cells using an E-selectin-directed immunoconjugate J. Immunol. 168 2 Jan. 15 2002 883 889
12. S.A. Asgeirsdottir, P.J. Zwiers, H.W. Morselt, H.E. Moorlag, H.I. Bakker, and P. Heeringa Inhibition of proinflammatory genes in anti-GBM glomerulonephritis by targeted dexamethasone-loaded AbEsel liposomes Am. J. Physiol. Renal Physiol. 294 3 Mar. 2008 F554 F561
13. Y. Isaka Gene therapy targeting kidney diseases: routes and vehicles Clin. Exp. Nephrol. 10 4 Dec. 2006 229 235
14. K. Ogawara, M.G. Rots, R.J. Kok, H.E. Moorlag, A.M. Van Loenen, and D.K. Meijer A novel strategy to modify adenovirus tropism and enhance transgene delivery to activated vascular endothelial cells in vitro and in vivo Hum. Gene Ther. 15 5 May 2004 433 443
15. Y. Eto, J.Q. Gao, F. Sekiguchi, S. Kurachi, K. Katayama, and H. Mizuguchi Neutralizing antibody evasion ability of adenovirus vector induced by the bioconjugation of methoxypolyethylene glycol succinimidyl propionate (MPEG-SPA) Biol. Pharm. Bull. 27 6 Jun. 2004 936 938
16. Y. Iimuro, T. Nishiura, C. Hellerbrand, K.E. Behrns, R. Schoonhoven, and J.W. Grisham NFkappaB prevents apoptosis and liver dysfunction during liver regeneration J. Clin. Invest. 101 4 Feb. 15 1998 802 811
17. R. Alemany, and D.T. Curiel CAR-binding ablation does not change biodistribution and toxicity of adenoviral vectors Gene Ther. 8 17 Sep. 2001 1347 1353
18. J.A. Kamps, P.J. Swart, H.W. Morselt, R. Pauwels, M.P. De Bethune, and E. De Clercq Preparation and characterization of conjugates of (modified) human serum albumin and liposomes: drug carriers with an intrinsic anti-HIV activity Biochim. Biophys. Acta 1278 2 Jan. 31 1996 183 190
19. J.M. Kuldo, J. Westra, S.A. Asgeirsdottir, R.J. Kok, K. Oosterhuis, and M.G. Rots Differential effects of NF-{kappa}B and p38 MAPK inhibitors and combinations thereof on TNF-{alpha}- and IL-1{beta}-induced proinflammatory status of endothelial cells in vitro Am. J. Physiol. Cell Physiol. 289 5 Nov. 2005 C1229 C1239
20. B. Banas, B. Luckow, M. Moller, C. Klier, P.J. Nelson, and E. Schadde Chemokine and chemokine receptor expression in a novel human mesangial cell line J. Am. Soc. Nephrol. 10 11 Nov. 1999 2314 2322
21. S.A. Asgeirsdottir, J.A. Kamps, H.I. Bakker, P.J. Zwiers, P. Heeringa, and K. van der Weide Site-specific inhibition of glomerulonephritis progression by targeted delivery of dexamethasone to glomerular endothelium Mol. Pharmacol. 72 1 Jul. 2007 121 131
22. W.M. Gommans, P.M. McLaughlin, J.A. Schalk, G.M. Groothuis, H.J. Haisma, and M.G. Rots Highly efficient and carcinoma-specific adenoviral replication restricted by the EGP-2 promoter J. Control. Release 117 1 Jan. 22 2007 1 10
23. S.A. Mezzano, M. Barria, M.A. Droguett, M.E. Burgos, L.G. Ardiles, and C. Flores Tubular NF-kappaB and AP-1 activation in human proteinuric renal disease Kidney Int. 60 4 Oct. 2001 1366 1377
24. L. Zheng, R. Sinniah, and S.I. Hsu Renal cell apoptosis and proliferation may be linked to nuclear factor-kappaB activation and expression of inducible nitric oxide synthase in patients with lupus nephritis Hum. Pathol. 37 6 Jun. 2006 637 647
25. A.B. Sanz, M.D. Sanchez-Nino, A.M. Ramos, J.A. Moreno, B. Santamaria, and M. Ruiz-Ortega NF-kappaB in renal inflammation J. Am. Soc. Nephrol. 21 8 Aug. 2010 1254 1262
26. C. Gomez-Guerrero, P. Hernandez-Vargas, O. Lopez-Franco, G. Ortiz-Munoz, and J. Egido Mesangial cells and glomerular inflammation: from the pathogenesis to novel therapeutic approaches Curr. Drug Targets Inflamm. Allergy 4 3 Jun. 2005 341 351
27. N. Tomita, R. Morishita, K. Yamamoto, J. Higaki, V.J. Dzau, and T. Ogihara Targeted gene therapy for rat glomerulonephritis using HVJ-immunoliposomes J. Gene Med. 4 5 Sep.-Oct. 2002 527 535
28. H.M. Wilson, S. Chettibi, C. Jobin, D. Walbaum, A.J. Rees, and D.C. Kluth Inhibition of macrophage nuclear factor-kappaB leads to a dominant anti-inflammatory phenotype that attenuates glomerular inflammation in vivo Am. J. Pathol. 167 1 Jul. 2005 27 37
29. S. Huang, Y. Jiang, Z. Li, E. Nishida, P. Mathias, and S. Lin Apoptosis signaling pathway in T cells is composed of ICE/Ced-3 family proteases and MAP kinase kinase 6b Immunity 6 6 Jun. 1997 739 749
30. H. Mizuguchi, and T. Hayakawa Targeted adenovirus vectors Hum. Gene Ther. 15 11 Nov. 2004 1034 1044
31. M. Everts, G.A. Koning, R.J. Kok, S.A. Asgeirsdottir, D. Vestweber, and D.K. Meijer In vitro cellular handling and in vivo targeting of E-selectin-directed immunoconjugates and immunoliposomes used for drug delivery to inflamed endothelium Pharm. Res. 20 1 Jan. 2003 64 72
32. J.E. Adrian, H.W. Morselt, R. Suss, S. Barnert, J.W. Kok, and S.A. Asgeirsdottir Targeted SAINT-O-somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells J. Control. Release 144 3 Jun. 15 2010 341 349
33. M. Voinea, I. Manduteanu, E. Dragomir, M. Capraru, and M. Simionescu Immunoliposomes directed toward VCAM-1 interact specifically with activated endothelial cells - a potential tool for specific drug delivery Pharm. Res. 22 11 Nov. 2005 1906 1917
34. A. Asija, S.J. Peterson, D.E. Stec, and N.G. Abraham Targeting endothelial cells with heme oxygenase-1 gene using VE-cadherin promoter attenuates hyperglycemia-mediated cell injury and apoptosis Antioxid. Redox Signal. 9 12 Dec. 2007 2065 2074
35. K. Levanon, N. Varda-Bloom, S. Greenberger, I. Barshack, I. Goldberg, and A. Orenstein Vascular wall maturation and prolonged angiogenic effect by endothelial-specific platelet-derived growth factor expression Pathobiology 73 3 2006 149 158
36. M. Everts, S.A. Kim-Park, M.A. Preuss, M.J. Passineau, J.N. Glasgow, and A.V. Pereboev Selective induction of tumor-associated antigens in murine pulmonary vasculature using double-targeted adenoviral vectors Gene Ther. 12 13 Jul. 2005 1042 1048
37. J. Pan, L. Xia, and R.P. McEver Comparison of promoters for the murine and human P-selectin genes suggests species-specific and conserved mechanisms for transcriptional regulation in endothelial cells J. Biol. Chem. 273 16 Apr. 17 1998 10058 10067
38. G. Molema Heterogeneity in endothelial responsiveness to cytokines, molecular causes, and pharmacological consequences Semin. Thromb. Hemost. 36 3 Apr. 2010 246 264