Antioxidant protection by PECAM-targeted delivery of a novel NADPH-oxidase inhibitor to the endothelium in vitro and in vivo

Journal of Controlled Release

Volumn 163, Issue 2, 2012, Pages 161-169

  Hood, Elizabeth D ^a   Greineder, Colin F ^a   Dodia, Chandra ^a   Han, Jingyan ^a   Mesaros, Clementina ^a   Shuvaev, Vladimir V ^a   Blair, Ian A ^a   Fisher, Aron B ^a   Muzykantov, Vladimir R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antioxidant therapy; Endothelial targeting; Inflammation; Liposomes; NOX2 inhibition; Targeted therapeutics

Indexed keywords

ANTIOXIDANT PROTECTION; ANTIOXIDANT THERAPY; BENEFICIAL EFFECTS; CYTOKINES; ENDOTHELIAL MARKER; ENDOTHELIAL PERMEABILITY; ENDOTHELIAL TARGETING; IMMUNOLIPOSOMES; IN-VITRO; INFLAMMATION; LIPOPOLYSACCHARIDES; NADPH OXIDASE; OXIDANT STRESS; PLATELET ENDOTHELIAL CELL ADHESION MOLECULES; REACTIVE OXYGEN SPECIES; TARGETED THERAPEUTICS; VASCULAR CELL ADHESION; VASCULAR ENDOTHELIAL GROWTH FACTOR; VASCULAR LUMEN; VASCULAR OXIDATIVE STRESS;

ANIMALS; BIOMOLECULES; LIPOSOMES; PATHOLOGY;

ENDOTHELIAL CELLS;

1 HEXADECYL 3 TRIFLUOROETHYLGLYCERO SN 2 PHOSPHOMETHANOL LITHIUM; ANGIOTENSIN II; CD31 ANTIGEN; CYTOKINE; IMMUNOLIPOSOME; LIPOPOLYSACCHARIDE; MJ 33; OXIDOREDUCTASE INHIBITOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; ENCAPSULATION; ENDOTHELIUM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE DISTRIBUTION; UMBILICAL VEIN ENDOTHELIAL CELL;

ACUTE LUNG INJURY; ANGIOTENSIN II; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD31; ANTIOXIDANTS; CAPILLARY PERMEABILITY; ENZYME INHIBITORS; GLYCEROPHOSPHATES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNOGLOBULIN G; LIPOPOLYSACCHARIDES; LIPOSOMES; LUNG; MALE; MICE; MICE, INBRED C57BL; NADPH OXIDASE; PHOSPHOLIPASES A; REACTIVE OXYGEN SPECIES; STREPTAVIDIN; TISSUE DISTRIBUTION; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84866549847     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.08.031     Document Type: Article

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