Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cells

Journal of Controlled Release

Volumn 144, Issue 3, 2010, Pages 341-349

  Adrian, Joanna E ^a   Morselt, Henriëtte W M ^a   Süss, Regine ^b   Barnert, Sabine ^b   Kok, Jan Willem ^a   Ásgeirsdóttir, Sigridur A ^a   Ruiters, Marcel H J ^a,c   Molema, Grietje ^a   Kamps, Jan A A M ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Synvolux Therapeutics Inc   (Netherlands)

Author keywords

Endothelial cells; Intracellular release; Liposomes; SAINT; SiRNA; Synthetic amphiphiles

Indexed keywords

CALCEIN; CATIONIC AMPHIPHILE; CYTOTOXIC DRUGS; DOWN-REGULATION; DOXORUBICIN; DRUG CONTENT; DRUG DELIVERY SYSTEM; DRUG RELEASE; HYDROPHILIC DRUGS; IMMUNOLIPOSOMES; INTRACELLULAR DELIVERY; INTRACELLULAR RELEASE; LONG CIRCULATING; PH CONDITION; PHAGOCYTIC CELLS; PROCESSING MACHINERY; PYRIDINIUM; RELEASE CHARACTERISTICS; SELECTINS; SURFACE GRAFTED; VE-CADHERIN;

AMPHIPHILES; BLOOD VESSEL PROSTHESES; DRUG DELIVERY; ETHYLENE; ETHYLENE GLYCOL; GENE EXPRESSION; GENE EXPRESSION REGULATION; LIPOSOMES; MACHINERY; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; RNA; SELF ASSEMBLY;

ENDOTHELIAL CELLS;

1 METHYL 4 (CIS 9 DIOLEYL)METHYL PYRIDINIUM CHLORID; 1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; AMPHOPHILE; ANTIBODY; CALCEIN; CATION; CYTOTOXIC AGENT; DOXORUBICIN; DRUG CARRIER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOLIPOSOME; LIPID; LIPOSOME; MACROGOL; SAINT O SOME; SMALL INTERFERING RNA; SYNTHETIC AMPHIPHILE INTERACTION; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; 1-METHYL-4-(9-DIOLEYL)METHYLPYRIDINIUM; ANTINEOPLASTIC AGENT; PYRIDINIUM DERIVATIVE; SURFACTANT;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; ENDOCYTOSIS; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMISTRY; CONFOCAL MICROSCOPY; CRYOELECTRON MICROSCOPY; DRUG EFFECTS; FLOW CYTOMETRY; GENE EXPRESSION; GENETICS; METABOLISM; MOUSE; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL SURVIVAL; CRYOELECTRON MICROSCOPY; DRUG CARRIERS; DRUG COMPOUNDING; E-SELECTIN; ENDOTHELIAL CELLS; FLOW CYTOMETRY; GENE EXPRESSION; HUMANS; LIPIDS; LIPOSOMES; MICE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; PARTICLE SIZE; PYRIDINIUM COMPOUNDS; RNA, SMALL INTERFERING; SURFACE-ACTIVE AGENTS;

EID: 77953293784     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.03.003     Document Type: Article

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