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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 16, 2012, Pages 5264-5267

Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1

(14) Zhang, Zhongsheng a Ojo, Kayode K a Johnson, Steven M b Larson, Eric T a He, Penqing a Geiger, Jennifer A c Castellanos Gonzalez, Alejandro d White Jr , A Clinton d Parsons, Marilyn c Merritt, Ethan A a Maly, Dustin J b Verlinde, Christophe L M J a Van Voorhis, Wesley C a Fan, Erkang a

a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE (United States)

b UNIVERSITY OF WASHINGTON (United States)

c SEATTLE BIOMEDICAL RESEARCH INSTITUTE (United States)

d University of Texas Medical Branch School of Medicine (United States)

Author keywords

Calcium dependent protein kinase 1; Cryptosporidium parvum; Enzyme inhibitor; Selectivity; Toxoplasma gondii

Indexed keywords

ANTIPROTOZOAL AGENT; BENZIMIDAZOLE DERIVATIVE; BENZOYLBENZIMIDAZOLE DERIVATIVE; CALCIUM DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CRYPTOSPORIDIUM PARVUM; DRUG POTENCY; DRUG SELECTIVITY; DRUG SOLUBILITY; ENZYME INHIBITION; IC 50; NONHUMAN; TOXOPLASMA GONDII;

BENZIMIDAZOLES; CRYPTOSPORIDIUM PARVUM; DRUG DESIGN; HUMANS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-ABL; PROTOZOAN PROTEINS; SOLUBILITY; SRC-FAMILY KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TOXOPLASMA;

CRYPTOSPORIDIUM PARVUM; PROTOZOA; PYRONIA TITHONUS; TOXOPLASMA GONDII;

EID: 84864397034 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.06.050 Document Type: Article

Times cited : (45)

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