메뉴 건너뛰기




Volumn 19, Issue 10, 2010, Pages 1161-1170

Mathematical analysis of antigen selection in somatically mutated immunoglobulin genes associated with autoimmunity

Author keywords

immunoglobulin; selection; systemic lupus erythematosus; Wegener's granulomatosis

Indexed keywords

ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN;

EID: 77956235788     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203310367657     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 13444291211 scopus 로고    scopus 로고
    • Pathogenic autoantibodies in lupus nephritis
    • Waldman M., Madaio MP Pathogenic autoantibodies in lupus nephritis. Lupus 2005 ; 14: 19-24.
    • (2005) Lupus , vol.14 , pp. 19-24
    • Waldman, M.1    Madaio, M.P.2
  • 2
    • 28944449455 scopus 로고    scopus 로고
    • Neutrophil activation in anti-proteinase 3-positive vasculitis-A prospective study
    • Wikman A., Lundahl J., Jacobson SH Neutrophil activation in anti-proteinase 3-positive vasculitis-a prospective study. Scand J Immunol 2005 ; 62: 539-545.
    • (2005) Scand J Immunol , vol.62 , pp. 539-545
    • Wikman, A.1    Lundahl, J.2    Jacobson, S.H.3
  • 3
    • 0026331458 scopus 로고
    • Maturation of the immune response in germinal centers
    • Berek C., Berger A., Apel M. Maturation of the immune response in germinal centers. Cell 1991 ; 67: 1121-1129.
    • (1991) Cell , vol.67 , pp. 1121-1129
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 4
    • 0014642258 scopus 로고
    • Cell selection by antigen in the immune response
    • Siskind GW, Benacerraf B. Cell selection by antigen in the immune response. Adv Immunol 1969 ; 10: 1-150.
    • (1969) Adv Immunol , vol.10 , pp. 1-150
    • Siskind, G.W.1    Benacerraf, B.2
  • 5
    • 0028128577 scopus 로고
    • Development of antibody diversity in single germinal centers: Selective expansion of high-affinity variants
    • Ziegner, M., Steinhauser G., Berek C. Development of antibody diversity in single germinal centers: selective expansion of high-affinity variants. Eur J Immunol 1994 ; 24: 2393-2400.
    • (1994) Eur J Immunol , vol.24 , pp. 2393-2400
    • Ziegner, M.1    Steinhauser, G.2    Berek, C.3
  • 6
    • 0018675871 scopus 로고
    • Evolutionary nucleotide replacements in DNA
    • Jukes TH, King JL Evolutionary nucleotide replacements in DNA. Nature 1979 ; 281: 605-606.
    • (1979) Nature , vol.281 , pp. 605-606
    • Jukes, T.H.1    King, J.L.2
  • 7
    • 0027932998 scopus 로고
    • The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement
    • Chang B., Casali P. The CDR1 sequences of a major proportion of human germline Ig VH genes are inherently susceptible to amino acid replacement. Immunol Today 1994 ; 15: 367-373.
    • (1994) Immunol Today , vol.15 , pp. 367-373
    • Chang, B.1    Casali, P.2
  • 9
    • 42949103482 scopus 로고    scopus 로고
    • Improved methods for detecting selection by mutation analysis of Ig v region sequences
    • Hershberg U., Uduman M., Shlomchik MJ, Kleinstein SH Improved methods for detecting selection by mutation analysis of Ig V region sequences. Int Immunol 2008 ; 20: 683-694.
    • (2008) Int Immunol , vol.20 , pp. 683-694
    • Hershberg, U.1    Uduman, M.2    Shlomchik, M.J.3    Kleinstein, S.H.4
  • 10
    • 0036954862 scopus 로고    scopus 로고
    • Systematic analysis of sequences of anti-DNA antibodies-relevance to theories of origin and pathogenicity
    • Rahman A., Giles I., Haley J., Isenberg D. Systematic analysis of sequences of anti-DNA antibodies-relevance to theories of origin and pathogenicity. Lupus 2002 ; 11: 807-823.
    • (2002) Lupus , vol.11 , pp. 807-823
    • Rahman, A.1    Giles, I.2    Haley, J.3    Isenberg, D.4
  • 11
    • 55449110759 scopus 로고    scopus 로고
    • Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions
    • Voswinkel J., Assmann G., Held G., et al. Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions. Clin Exp Immunol 2008 ; 154: 339-345.
    • (2008) Clin Exp Immunol , vol.154 , pp. 339-345
    • Voswinkel, J.1    Assmann, G.2    Held, G.3
  • 12
    • 0030756394 scopus 로고    scopus 로고
    • Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans
    • Quan CP, Berneman A., Pires R., Avrameas S., Bouvet JP Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans. Infect Immun 1997 ; 65: 3997-4004.
    • (1997) Infect Immun , vol.65 , pp. 3997-4004
    • Quan, C.P.1    Berneman, A.2    Pires, R.3    Avrameas, S.4    Bouvet, J.P.5
  • 13
    • 0032031498 scopus 로고    scopus 로고
    • Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes
    • Dunn-Walters DK, Dogan A., Boursier L., MacDonald CM, Spencer J. Base-specific sequences that bias somatic hypermutation deduced by analysis of out-of-frame human IgVH genes. J Immunol 1998 ; 160: 2360-2364.
    • (1998) J Immunol , vol.160 , pp. 2360-2364
    • Dunn-Walters, D.K.1    Dogan, A.2    Boursier, L.3    MacDonald, C.M.4    Spencer, J.5
  • 14
    • 0032588688 scopus 로고    scopus 로고
    • Characteristics of IgVH genes used by human intestinal plasma cells from childhood
    • Boursier L., Dunn-Walters DK, Spencer J. Characteristics of IgVH genes used by human intestinal plasma cells from childhood. Immunology 1999 ; 97: 558-564.
    • (1999) Immunology , vol.97 , pp. 558-564
    • Boursier, L.1    Dunn-Walters, D.K.2    Spencer, J.3
  • 15
    • 0142242098 scopus 로고    scopus 로고
    • Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires
    • Weitkamp JH, Kallewaard N., Kusuhara K., et al. Infant and adult human B cell responses to rotavirus share common immunodominant variable gene repertoires. J Immunol 2003 ; 171: 4680-4688.
    • (2003) J Immunol , vol.171 , pp. 4680-4688
    • Weitkamp, J.H.1    Kallewaard, N.2    Kusuhara, K.3
  • 16
    • 0027275899 scopus 로고
    • Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation
    • Ikematsu H., Harindranath N., Ueki Y., Notkins AL, Casali P. Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation. J Immunol 1993 ; 150: 1325-1337.
    • (1993) J Immunol , vol.150 , pp. 1325-1337
    • Ikematsu, H.1    Harindranath, N.2    Ueki, Y.3    Notkins, A.L.4    Casali, P.5
  • 17
    • 33646024606 scopus 로고    scopus 로고
    • Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing
    • Meijer PJ, Andersen PS, Hansen Haahr, M., et al. Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing. J Mol Biol 2006 ; 358: 764-772.
    • (2006) J Mol Biol , vol.358 , pp. 764-772
    • Meijer, P.J.1    Andersen, P.S.2    Hansen Haahr, M.3
  • 18
    • 52949088297 scopus 로고    scopus 로고
    • Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors
    • Yu X., Tsibane T., McGraw PA, et al. Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. Nature 2008 ; 455: 532-536.
    • (2008) Nature , vol.455 , pp. 532-536
    • Yu, X.1    Tsibane, T.2    McGraw, P.A.3
  • 19
    • 33745697938 scopus 로고    scopus 로고
    • B lymphocyte maturation in Wegener's granulomatosis: A comparative analysis of VH genes from endonasal lesions
    • Voswinkel J., Mueller A., Kraemer JA, et al. B lymphocyte maturation in Wegener's granulomatosis: a comparative analysis of VH genes from endonasal lesions. Ann Rheum Dis 2006 ; 65: 859-864.
    • (2006) Ann Rheum Dis , vol.65 , pp. 859-864
    • Voswinkel, J.1    Mueller, A.2    Kraemer, J.A.3
  • 21
    • 0029153488 scopus 로고
    • Anti-DNA and anti-platelet specificities of SLE-derived autoantibodies: Evidence for CDR2H mutations and CDR3H motifs
    • Rioux JD, Zdársky E., Newkirk MM, Rauch J. Anti-DNA and anti-platelet specificities of SLE-derived autoantibodies: evidence for CDR2H mutations and CDR3H motifs. Mol Immunol 1995 ; 32: 683-696.
    • (1995) Mol Immunol , vol.32 , pp. 683-696
    • Rioux, J.D.1    Zdársky, E.2    Newkirk, M.M.3    Rauch, J.4
  • 23
    • 0031921834 scopus 로고    scopus 로고
    • Molecular and genetic characterization of two anti-DNA antibodies derived from patients with systemic lupus erythematosus
    • Song YW, Kim HA, Lee EB, et al. Molecular and genetic characterization of two anti-DNA antibodies derived from patients with systemic lupus erythematosus. Rheumatol Int 1998 ; 17: 223-228.
    • (1998) Rheumatol Int , vol.17 , pp. 223-228
    • Song, Y.W.1    Kim, H.A.2    Lee, E.B.3
  • 24
    • 0028354751 scopus 로고
    • Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype
    • Ehrenstein MR, Longhurst CM, Latchman DS, Isenberg DA Serological and genetic characterization of a human monoclonal immunoglobulin G anti-DNA idiotype. J Clin Invest 1994 ; 93: 1787-1797.
    • (1994) J Clin Invest , vol.93 , pp. 1787-1797
    • Ehrenstein, M.R.1    Longhurst, C.M.2    Latchman, D.S.3    Isenberg, D.A.4
  • 25
    • 0027787933 scopus 로고
    • Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus
    • Stevenson FK, Longhurst C., Chapman CJ, et al. Utilization of the VH4-21 gene segment by anti-DNA antibodies from patients with systemic lupus erythematosus. J Autoimmun 1993 ; 6: 809-825.
    • (1993) J Autoimmun , vol.6 , pp. 809-825
    • Stevenson, F.K.1    Longhurst, C.2    Chapman, C.J.3
  • 26
    • 0027738894 scopus 로고
    • Characterization of two human anti-DNA antibodies bearing the pathogenic idiotype 8.12
    • Paul E., Diamond B. Characterization of two human anti-DNA antibodies bearing the pathogenic idiotype 8.12. Autoimmunity 1993 ; 16: 13-21.
    • (1993) Autoimmunity , vol.16 , pp. 13-21
    • Paul, E.1    Diamond, B.2
  • 27
    • 0025325145 scopus 로고
    • Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes
    • Davidson A., Manheimer-Lory A., Aranow C., Peterson R., Hannigan N., Diamond B. Molecular characterization of a somatically mutated anti-DNA antibody bearing two systemic lupus erythematosus-related idiotypes. J Clin Invest 1990 ; 85: 1401-1409.
    • (1990) J Clin Invest , vol.85 , pp. 1401-1409
    • Davidson, A.1    Manheimer-Lory, A.2    Aranow, C.3    Peterson, R.4    Hannigan, N.5    Diamond, B.6
  • 28
    • 0027463332 scopus 로고
    • Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: Correlation with severity of renal histology
    • Okamura M., Kanayama Y., Amastu K., et al. Significance of enzyme linked immunosorbent assay (ELISA) for antibodies to double stranded and single stranded DNA in patients with lupus nephritis: correlation with severity of renal histology. Ann Rheum Dis 1993 ; 52: 14-20.
    • (1993) Ann Rheum Dis , vol.52 , pp. 14-20
    • Okamura, M.1    Kanayama, Y.2    Amastu, K.3
  • 29
    • 0031764112 scopus 로고    scopus 로고
    • Strong intrinsic biases towards mutation and conservation of bases in human IgVH genes during somatic hypermutation prevent statistical analysis of antigen selection
    • Dunn-Walters DK, Spencer J. Strong intrinsic biases towards mutation and conservation of bases in human IgVH genes during somatic hypermutation prevent statistical analysis of antigen selection. Immunology 1998 ; 95: 339-345.
    • (1998) Immunology , vol.95 , pp. 339-345
    • Dunn-Walters, D.K.1    Spencer, J.2
  • 30
    • 0030610529 scopus 로고    scopus 로고
    • Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5+/IgM+ and CD5-/IgM+ B cells
    • Brezinschek HP, Foster SJ, Brezinschek RI, Dörner T., DomiatiSaad R., Lipsky PE Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5+/IgM+ and CD5-/IgM+ B cells. J Clin Invest 1997 ; 99: 2488-2501.
    • (1997) J Clin Invest , vol.99 , pp. 2488-2501
    • Brezinschek, H.P.1    Foster, S.J.2    Brezinschek, R.I.3    Dörner, T.4    Domiatisaad, R.5    Lipsky, P.E.6
  • 31
    • 0029063311 scopus 로고
    • Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction
    • Brezinschek HP, Brezinschek RI, Lipsky PE Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J Immunol 1995 ; 155: 190-202.
    • (1995) J Immunol , vol.155 , pp. 190-202
    • Brezinschek, H.P.1    Brezinschek, R.I.2    Lipsky, P.E.3
  • 32
    • 49049109922 scopus 로고    scopus 로고
    • Lambda light chain revision in the human intestinal IgA response
    • Su W., Gordon JN, Barone F., et al. Lambda light chain revision in the human intestinal IgA response. J Immunol 2008 ; 181: 1264-1271.
    • (2008) J Immunol , vol.181 , pp. 1264-1271
    • Su, W.1    Gordon, J.N.2    Barone, F.3
  • 33
    • 48449094247 scopus 로고    scopus 로고
    • IMGT/V-QUEST: The highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis
    • Brochet X., Lefranc MP, Giudicelli V. IMGT/V-QUEST: the highly customized and integrated system for IG and TR standardized V-J and V-D-J sequence analysis. Nucl Acids Res 2008 ; 36: W503 - W508.
    • (2008) Nucl Acids Res , vol.36
    • Brochet, X.1    Lefranc, M.P.2    Giudicelli, V.3
  • 34
    • 0036499127 scopus 로고    scopus 로고
    • Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation
    • Shapiro GS, Aviszus K., Murphy J., Wysocki LJ Evolution of Ig DNA sequence to target specific base positions within codons for somatic hypermutation. J Immunol 2002 ; 168: 2302-2306.
    • (2002) J Immunol , vol.168 , pp. 2302-2306
    • Shapiro, G.S.1    Aviszus, K.2    Murphy, J.3    Wysocki, L.J.4
  • 35
    • 0037718449 scopus 로고    scopus 로고
    • Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments
    • Boursier L., Su W., Spencer J. Imprint of somatic hypermutation differs in human immunoglobulin heavy and lambda chain variable gene segments. Mol Immunol 2003 ; 39: 1025-1034.
    • (2003) Mol Immunol , vol.39 , pp. 1025-1034
    • Boursier, L.1    Su, W.2    Spencer, J.3
  • 36
    • 77956261093 scopus 로고    scopus 로고
    • GraphPad Software, San Diego California USA
    • GraphPad Software, San Diego California USA, www.graphpad.com
  • 38
    • 77956237683 scopus 로고    scopus 로고
    • Subepithelial dendritic B cells in orofacial granulomatosis
    • Patel P., Barone F., Nunes C., et al. Subepithelial dendritic B cells in orofacial granulomatosis. Inflamm Bowel Dis 2009 ; (Epub ahead of print).
    • (2009) Inflamm Bowel Dis
    • Patel, P.1    Barone, F.2    Nunes, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.