Streptogramins - Two are better than one!

International Journal of Medical Microbiology

Volumn 304, Issue 1, 2014, Pages 44-50

  Mast, Yvonne ^a   Wohlleben, Wolfgang ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Nonribosomal peptide antibiotic; Polyketide; Pristinamycin; Synergism; Virginiamycin

Indexed keywords

DALFOPRISTIN; MIKAMYCIN B; PRISTINAMYCIN; STREPTOGRAMIN DERIVATIVE; VIRGINIAMYCIN;

ANTIBIOTIC BIOSYNTHESIS; ANTIBIOTIC RESISTANCE; DRUG DEVELOPMENT; DRUG MECHANISM; EVOLUTION; FOOD INDUSTRY; HUMAN; MEDICINE; NONHUMAN; REGULATORY MECHANISM; SHORT SURVEY;

4-N,N DIMETHYLAMINO-N-METHYL-L-PHENYLALANINE; AA-TRNA; ABC; AMINO-ACYL-TRNA; ATP-BINDING CASSETTE; DMAPA; FDA; GBL; LINCOSAMIDE-STREPTOGRAMIN-PLEUROMUTILIN A; LS(A)P; MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN B; MAJOR FACILITATOR SUPERFAMILY ANTIPORTER; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MFS; MLS(B); MRSA; NONRIBOSOMAL PEPTIDE ANTIBIOTIC; NONRIBOSOMAL PEPTIDE SYNTHETHASE; NRPS; PEPTIDYL TRANSFERASE CENTRE; PEPTIDYL-TRNA; PI; PII; PKS; POLYKETIDE; POLYKETIDE SYNTHASE; PP-TRNA; PRISTINAMYCIN; PRISTINAMYCIN I; PRISTINAMYCIN II; PTC; S(A); S(B); SARP; STREPTOGRAMIN A; STREPTOGRAMIN B; STREPTOMYCES ANTIBIOTIC REGULATORY PROTEINS; SYNERGISM; THE U.S. FOOD AND DRUG ADMINISTRATION; VANCOMYCIN-RESISTANT ENTEROCOCCUS FEACIUM; VANCOMYCIN-RESISTANT STAPHYLOCOCCUS AUREUS; VIRGINIAMYCIN; VIRGINIAMYCIN M; VIRGINIAMYCIN S; VM; VREF; VRSA; VS; WHO; WORLD HEALTH ORGANIZATION; Γ-BUTYROLACTONE;

ANTI-BACTERIAL AGENTS; BIOSYNTHETIC PATHWAYS; DRUG RESISTANCE, BACTERIAL; DRUG SYNERGISM; FOOD INDUSTRY; HUMANS; MICROBIAL VIABILITY; PRISTINAMYCIN; VIRGINIAMYCIN;

EID: 84892499604     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2013.08.008     Document Type: Short Survey

References (73)

1. Ahmed F., Donaldson W.A. Chemistry and biology of the streptogramin A. Mini-Rev. Org. Chem. 2007, 4:159-181.
2. Allignet J., el Solh N. Diversity among the gram-positive acetyltransferases inactivating streptogramin A and structurally related compounds and characterization of a new staphylococcal determinant, vatB. Antimicrob. Agents Chemother. 1995, 39:2027-2036.
3. Amin R., Reuther J., Bera A., Wohlleben W., Mast Y. Novel GlnR-target gene nnaR is in nitrate/nitrite assimilation in Streptomyces coelicolor. Microbiology 2012, 158:1172-1182.
4. Aumercier M., Bouhallab S., Capmau M.L., Le Goffic F. RP 59500 a proposed mechanism for its bactericidal activity. J. Antimicrob. Chemother. 1992, 30(Suppl. A):9-14.
5. A (streptogramin A) to ribosomes explains its "lasting damage" effect. J. Antibiot. (Tokyo) 1986, 39:1322-1328.
6. Bamas-Jacques N., Lorenzon S., Lacroix P., de Swetschin C., Crouzet J. Cluster organisation of the genes of Streptomyces pristinaespiralis involved in pristinamycin biosynthesis and resistance elucidated by pulsed-field gel electrophoresis. J. Appl. Microbiol. 1999, 87:939-948.
7. Barrière J.C., Bouanchaud D.H., Desnottes J.-F., Paris J.M. Streptogramin analogues. Expert Opin. Invest. Drugs 1994, 3:115-131.
8. Barrière J.C., Berthaud N., Beyer D., Dutka-Malen S., Paris J.M., Desnottes J.F. Recent development in streptogramin research. Curr. Pharm. Des. 1998, 4:155-180.
9. Batts D.H., Lavin B.S., Eliopoulos G.M. Quinupristin/dalfopristin and linezolid: spectrum of activity and potential roles in therapy-a status report. Curr. Clin. Top. Infect. Dis. 2001, 21:227-251.
10. Blanc V., Salah-Bey K., Folcher M., Thompson C.J. Molecular characterization and transcriptional analysis of a multidrug resistance gene cloned from the pristinamycin-producing organism, Streptomyces pristinaespiralis. Mol. Microbiol. 1995, 17:989-999.
11. A synthase and NADH:riboflavin 5'-phosphate oxidoreductase. J. Bacteriol. 1995, 177:5206-5214.
12. Blanc V., Gil P., Bamas-Jacques N., Lorenzon S., Zagorec M., Schleuniger J., Bisch D., Blanche F., Debussche L., Crouzet J., Thibaut D. Identification and analysis of genes from Streptomyces pristinaespiralis encoding enzymes involved in the biosynthesis of the 4-dimethylamino-l-phenylalanine precursor of pristinamycin I. Mol. Microbiol. 1997, 23:191-202.
13. Brachmann A.O., Reimer D., Lorenzen W., Alonso E.A., Kopp Y., Piel J., Bode H.B. Reciprocal cross talk between fatty acid and antibiotic biosynthesis in a nematode symbiont. Angew. Chem. Int. Ed. Engl. 2012, 51:12086-12089.
14. Casewell M., Friis C., Marco E., McMullin P., Phillips I. The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. J. Antimicrob. Chemother. 2003, 52:159-161.
15. Challis G.L., Hopwood D.A. Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(Suppl. 2):14555-14561.
16. Charney J., Fisher W.P., Curran C., Machlowitz R.A., Tyteli A.A. Streptogramin, a new antibiotic. Antibiot. Chemother. 1953, 3:1283.
17. Cocito C., Di Giambattista M., Nyssen E., Vannuffel P. Inhibition of protein synthesis by streptogramins and related antibiotics. J. Antimicrob. Chemother. 1997, 39:7-13.
18. Contreras A., Vázquez D. Synergistic interaction of the streptogramins with the ribosome. Eur. J. Biochem. 1977, 74:549-551.
19. Corvini P.F., Gautier H., Rondags E., Vivier H., Goergen J.L., Germain P. Intracellular pH determination of pristinamycin-producing Streptomyces pristinaespiralis by image analysis. Microbiology 2000, 164:2671-2678.
20. Cundliffe E. Antibiotic production by actinomycetes: the janus faces of regulation. J. Ind. Microbiol. Biotechnol. 2006, 33:500-506.
21. Cundliffe E., Demain A.L. Avoidance of suicide in antibiotic-producing microbes. J. Ind. Microbiol. Biotechnol. 2010, 37:643-672.
22. de Crécy-Lagard V., Saurin W., Thibaut D., Gil P., Naudin L., Crouzet J., Blanc V. Streptogramin B biosynthesis in Streptomyces pristinaespiralis and Streptomyces virginiae: molecular characterization of the last structural peptide synthetase gene. Antimicrob. Agents Chemother. 1997, 41:1904-1909.
23. Delgado G., Neuhauser M.M., Bearden D.T., Danziger L.H. Quinupristin-dalfopristin: an overview. Pharmacotherapy 2000, 20:1469-1485.
24. Eliopoulos G.M., Ferraro M.J., Wennersten C.B., Moellering R.C. In vitro activity of an oral streptogramin antimicrobial, XRP2868, against gram-positive bacteria. Antimicrob. Agents Chemother. 2005, 49:3034-3039.
25. Felmingham D., Robbins M.J., Shackcloth J., Dencer C., Williams L., Couturier C., Bryskier A. Comparative in vitro activity of XRP 2868, a new, oral streptogramin. Conference Abstract P1555, 15th ECCMID Copenhagen 2005.
26. Folcher M., Gaillard H., Nguyen L.T., Nguyen K.T., Lacroix P., Bamas-Jacques N., Rinkel M., Thompson C.J. Pleiotropic functions of a Streptomyces pristinaespiralis Autoregulator receptor in development, antibiotic biosynthesis, and expression of a superoxide dismutase. J. Biol. Chem. 2001, 276:44297-44306.
27. Giambattisti M., Chinali G., Cocito C. The molecular basis of the inhibitory activities of type A and type B synergimycins and related antibiotics on ribosomes. J. Antimicrob. Chemother. 1989, 24:485-507.
28. Goldstein E.J., Citron D.M., Merriam C.V., Warren Y.A., Tyrrell K.L., Fernandez H.T., Bryskier A. Comparative in vitro activities of XRP 2868, pristinamycin, quinupristin-dalfopristin, vancomycin, daptomycin, linezolid, clarithromycin, telithromycin, clindamycin, and ampicillin against anaerobic gram-positive species, actinomycetes, and lactobacilli. Antimicrob. Agents Chemother. 2005, 49:408-413.
29. Gómez-Lus R. Evolution of bacterial resistance to antibiotics during the last three decades. Int. Microbiol. 1998, 1:279-284.
30. ® From Aventis. (Release date: December 31th, 2002) 2002, http://www.sec.gov/Archives/edgar/data/1047699/000095014402013139/g80000exv99w1.txt (called: 10th December, 2012).
31. Greenwood D. Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph 2008, Oxford University Press, Oxford UK, ISBN 10:0199534845.
32. Harms J.M., Schlünzen F., Fucini P., Bartels H., Yonath A. Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin. BMC Biol. 2004, 2:4.
33. Jin Q., Yin H., Hong X., Jin Z. Isolation and functional analysis of spy1 responsible for pristinamycin yield in Streptomyces pristinaespiralis. J. Microbiol. Biotechnol. 2012, 22:793-799.
34. 1 resistance. Mol. Microbiol. 2000, 36:302-313.
35. Kim C.H., Otake N., Yonehara H. Studies on mikamycin B lactonase degradation of mikamycin B by Streptomyces mitakaensis. J. Antibiot. 1974, 27:903-908.
36. Kim C.H., Endo T., Yonehara H. Purification and some properties of mikamycin B lactonase. Agric. Biol. Chem. 1976, 40:1559-1564.
37. Lee C.K., Minami M., Sakuda S., Nihira T., Yamada Y. Stereospecific reduction of virginiamycin M1 as the virginiamycin resistance pathway in Streptomyces virginiae. Antimicrob. Agents Chemother. 1996, 40:595-601.
38. Lee C.K., Kamitani Y., Nihira T., Yamada Y. Identification and in vivo functional analysis of a virginiamycin S resistance gene (varS) from Streptomyces virginiae. J. Bacteriol. 1999, 181:3293-3297.
39. Lee Y.J., Kitani S., Kinoshita H., Nihira T. Identification by gene deletion analysis of barS2, a gene involved in the biosynthesis of γ-butyrolactone autoregulator in Streptomyces virginiae. Arch. Microbiol. 2008, 189:367-374.
40. Lee Y.J., Kitani S., Nihira T. Null mutation analysis of an afsA-family gene, barX, that is involved in biosynthesis of the γ-butyrolactone autoregulator in Streptomyces virginiae. Microbiology 2010, 156:206-210.
41. Longworth D.L. Microbial drug resistance and the roles of the new antibiotics. Cleve. Clin. J. Med. 2001, 68:501-502.
42. Mast Y., Weber T., Gölz M., Ort-Winklbauer R., Gondran A., Wohlleben W., Schinko E. Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis. Microb. Biotechnol. 2011, 4:192-206.
43. Mast Y.J., Wohlleben W., Schinko E. Identification and functional characterization of phenylglycine biosynthetic genes involved in pristinamycin biosynthesis in Streptomyces pristinaespiralis. J. Biotechnol. 2011, 155:63-67.
44. Matsuno K., Yamada Y., Lee C., Nihira T. Identification by gene deletion analysis of barB as a negative regulator controlling an early process of virginiamycin biosynthesis in Streptomyces virginiae. Arch. Microbiol. 2004, 181:52-59.
45. McDermott P.F., Cullen P., Hubert S.K., McDermott S.D., Bartholomew M., Simjee S., Wagner D.D. Changes in antimicrobial susceptibility of native Enterococcus faecium in chickens fed virginiamycin. Appl. Environ. Microbiol. 2005, 71:4986-4991.
46. Mehmood N., Olmos E., Goergen J.L., Blanchard F., Ullisch D., Klöckner W., Büchs J., Delaunay S. Oxygen supply controls the onset of pristinamycins production by Streptomyces pristinaespiralis in shaking flasks. Biotechnol. Bioeng. 2011, 108:2151-2161.
47. Mukhtar T., Wright G.D. Streptogramins, oxazolidinones, and other inhibitors of bacterial protein synthesis. Chem. Rev. 2005, 105:529-542.
48. Musiol E., Weber T. Discrete acyltransferases involved in polyketide biosynthesis. Med. Chem. Commun. 2012, 3:871-886.
49. Nakano H., Lee C.-K., Nihira T., Yamada Y. A null mutant of Streptomyces virginiae barA gene encoding a butyrolactone autoregulator receptor and its phenotypic and transcriptional analysis. J. Biosci. Bioeng. 2000, 90:204-207.
50. Namwat W., Lee C.K., Kinoshita H., Yamada Y., Nihira T. Identification of the varR gene as a transcriptional regulator of virginiamycin S resistance in Streptomyces virginiae. J. Bacteriol. 2001, 183:2025-2031.
51. Nishida H., Ohnishi Y., Beppu T., Horinouchi S. Evolution of γ-butyrolactone synthases and receptors in Streptomyces. Environ. Microbiol. 2007, 9:1986-1994.
52. Olmstead J. Bugs in the System: How the FDA fails to Regulate Antibiotics in Ethanol Production. Institute for Agriculture and Trade Policy (Release date: May 1st, 2012) 2012, http://www.iatp.org/documents/bugs-in-the-system (called: 10th December, 2012).
53. Paquet V., Goma G., Soucaille P. Induction of pristinamycins production in Streptomyces pristinaespiralis. Biotechnol. Lett. 1992, 14:1065-1071.
54. Poehlsgaard D., Douthwaite S. The bacterial ribosome as a target for antibiotics. Nat. Rev. Microbiol. 2005, 3:870-881.
55. Politano A.D., Sawyer R.G. NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA. Curr. Opin. Investig. Drugs 2010, 11:225-236.
56. Pulsawat N., Kitani S., Nihira T. Characterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae. Gene 2007, 393:31-42.
57. Pulsawat N., Kitani S., Fukushima E., Nihira T. Hierarchical control of virginiamycin production in Streptomyces virginiae by three pathway-specific regulators: VmsS, VmsT and VmsR. Microbiology 2009, 155:1250-1259.
58. Ramos J.L., Martinez-Bueno M., Molina-Henares A.J., Teran W., Watanabe K., Zhang X., Gallegos M.T., Brennan R., Tobes R. The TetR family of transcriptional repressors. Microbiol. Mol. Biol. Rev. 2005, 69:326-356.
59. Reuther J., Wohlleben W. Nitrogen metabolism in Streptomyces coelicolor: transcriptional and post-translational regulation. J. Mol. Microbiol. Biotechnol. 2007, 12:139-146.
60. Roberts M.C. Resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics. Mol. Biotechnol. 2004, 28:47-62.
61. Roberts M.C. Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria. Front. Microbiol. 2011, 2:40.
62. Shikura N., Yamamura J., Nihira T. barS1, a gene for biosynthesis of a gamma-butyrolactone autoregulator, a microbial signaling molecule eliciting antibiotic production in Streptomyces species. J. Bacteriol. 2002, 184:5151-5157.
63. Singh K.V., Weinstock G.M., Murray B.E. An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin. Antimicrob. Agents Chemother. 2002, 46:1845-1850.
64. Stille W., Brodt H.-R., Groll A.H., Just-Nübling G. Antibiotika-Therapie: Klinik und Praxis der antiinfektiösen Behandlung 2005, Schattauer Verlag.
65. Thal L.A., Zervos M.J. Occurrence and epidemiology of resistance to virginiamycin and streptogramins. J. Antimicrob. Chemother. 1999, 43:171-176.
66. Thibaut D., Ratet N., Bisch D., Faucher D., Debussche L., Blanche F. Purification of the two-enzyme system catalyzing the oxidation of the d-proline residue of pristinamycin IIB during the last step of pristinamycin IIA biosynthesis. J. Bacteriol. 1995, 177:5199-5205.
67. Tiffert Y., Franz-Wachtel M., Fladerer C., Nordheim A., Reuther J., Wohlleben W., Mast Y. Proteomic analysis of the GlnR-mediated response to nitrogen limitation in Streptomyces coelicolor M145. Appl. Microbiol. Biotechnol. 2011, 89:1149-1159.
68. Voelker F., Altaba S. Nitrogen source governs the patterns of growth and pristinamycin production in 'Streptomyces pristinaespiralis'. Microbiology 2001, 147:2447-2459.
69. Waldvogel E., Herbig A., Battke F., Amin R., Nentwich M., Nieselt K., Ellingsen T.E., Wentzel A., Hodgson D.A., Wohlleben W., Mast Y. The PII protein GlnK is a pleiotropic regulator for morphological differentiation and secondary metabolism in Streptomyces coelicolor. Appl. Microbiol. Biotechnol. 2011, 92:1219-1236.
70. Wang R., Zhu H., Zheng G., Mast Y., Yang S., Wohlleben W., Lu Y., Jiang W. Identification of two-component system AfsQ1/Q2 regulon and cross-regulation with GlnR in nitrogen metabolism in Streptomyces coelicolor. Mol. Microbiol. 2012, 10.1111/mmi.12080.
71. Wohlleben W., Mast Y., Muth G., Röttgen M., Stegmann E., Weber T. Synthetic biology of secondary metabolite biosynthesis in actinomycetes: engineering precursor supply as a way to optimize antibiotic production. FEBS Lett. 2012, 586:2171-2176.
72. Xie Y., Wang B., Liu J., Ma J., Huang H., Ju J. Identification of the biosynthetic gene cluster and regulatory cascade for the synergistic antibacterial antibiotics griseoviridin and viridogrisein in Streptomyces griseoviridis. Chembiochem 2012, 10.1002/cbic.201200584.
73. Zhang L.J., Jin Z.H., Chen X.G., Jin Q.C., Feng.F M.G. Glycine feeding improves pristinamycin production during fermentation including resin for in situ separation. Bioprocess Biosyst. Eng. 2012, 35:513-517.